Mario Gietl, Francesco Burkert, Stefanie Seiwald, Anna Böhm, Stefanie Hofer, Johanna M Gostner, Talia Piater, Simon Geisler, Guenter Weiss, Judith Loeffler-Ragg, Thomas Sonnweber, Ivan Tancevski, Alex Pizzini, Sabina Sahanic, Dietmar Fuchs, Rosa Bellmann-Weiler, Katharina Kurz
BACKGROUND: Fatigue, sleep disturbance, and neurological symptoms during and after COVID-19 are common and might be associated with inflammation-induced changes in tryptophan (Trp) and phenylalanine (Phe) metabolism. AIM: This pilot study investigated interferon gamma inducible biochemical pathways (namely Trp catabolism, neopterin, tyrosine [Tyr], and nitrite formation) during acute COVID-19 and reconvalescence. PATIENTS AND METHODS: Thirty one patients with moderate to severe COVID-19 admitted to the University Hospital of Innsbruck in early 2020 (March-May) were followed up...
2023: International Journal of Tryptophan Research: IJTR