Hamdi Nsairat, Ali Al-Samydai, Mohamed El-Tanani, Ashok K Shakya, Somaya Ahmad, Shorouq Alsotari, Walhan Alshaer, Ammar Shanneir, Munib M Saket, Tawfiq A Arafat
This study was conducted to compare dissolution profiles of four Jordanian registered sildenafil (SDF) products to the originator. Dissolution samples were analyzed utilizing a validated and stability-indicating HPLC method in human plasma. Validation was performed for specificity, linearity, limit of detection, lower limit of quantification, precision, trueness and stability. SDF was extracted from plasma samples using liquid-liquid extraction. The analysis was performed utilizing isocratic elution on C18 column with 1...
March 18, 2024: Bioanalysis