Maria Cristina Maggio, Salvatore Giordano, Maria Concetta Failla, Martina Gioacchina Campione, Annalisa Alaimo, Giovanni Corsello
BACKGROUND: In Sicily, the first wave of COVID-19 showed a low epidemic impact in paediatric population, while the second and the third waves had a higher impact on clinical presentation of COVID-19 in children and a significantly higher severe outcome in patients with multisystem inflammatory syndrome in children (MIS-C), with a frequent life-threatening progression. METHODS: We describe a cohort of 22 Sicilian children (11 M; 11 F; age: 1.4-14 years), presenting with clinical features compatible with MIS-C...
March 23, 2023: Italian Journal of Pediatrics
Chiara Maria Trovato, Monica Montuori, Beatrice Leter, Ilaria Laudadio, Giusy Russo, Salvatore Oliva
BACKGROUND: Celiac disease (CD) is characterized by elevated serum titers of autoantibodies IgA anti-tissue transglutaminase 2 (TGA-IgA) and IgA anti-endomysial (EMA), with small bowel mucosa atrophy. We evaluated age differences between CD children exhibiting variable antibody titers at diagnosis. METHODS: CD children diagnosed between January 2014 and June 2019, according to 2012 ESPGHAN guidelines were studied. All had EMA and TGA-IgA measurements, while a proportion of them underwent esophagogastroduodenoscopy (EGD)...
March 23, 2023: Italian Journal of Pediatrics
Niccolò Parri, Davide Silvagni, Alberto Chiarugi, Elisabetta Cortis, Antonio D'Avino, Marcello Lanari, Paola Giovanna Marchisio, Cesare Vezzoli, Stefania Zampogna, Annamaria Staiano
BACKGROUND: Acute pain is a common symptom in children of all ages, and is associated with a variety of conditions. Despite the availability of guidelines, pain often remains underestimated and undertreated. Paracetamol and ibuprofen are the most commonly used drugs for analgesia in Pediatrics. Multimodal pain management by using a combination of paracetamol and ibuprofen results in greater analgesia. METHODS: An investigation using the Nominal Group Technique was carried out between May and August 2022...
March 21, 2023: Italian Journal of Pediatrics
Francesca Priolo, Luca Maggio, Simona Fattore, Marta Tedesco, Domenico Umberto De Rose, Alessandro Perri, Giorgia Prontera, Roberto Chioma, Annamaria Sbordone, Maria Letizia Patti, Giovanni Vento
BACKGROUND: To date, no studies on presepsin values in cord blood of term infants with risk factors for early-onset sepsis (EOS) are available, whereas only one study reported presepsin values in cord blood of preterm infants at risk. In this study, we investigated the presepsin values in cord blood of term and preterm infants with documented risk factors for EOS. METHODS: In this single-center prospective pilot study, we enrolled neonates presenting with documented risk factors for EOS...
March 21, 2023: Italian Journal of Pediatrics
Luciano Pinto, Sonia Bianchini, Maria Antonietta Barbieri, Gabriella Cherchi, Andrea Miceli, Maria Pia Mirauda, Valeria Spica Russotto, Irene Raffaldi, Tiziana Zangardi, Domenico Perri, Rino Agostiniani, Simone Rugolotto, Fabio Cardinale, Stefania Zampogna, Annamaria Staiano
BACKGROUND: In Italy, the State Regions Conference on 1st August 2019 approved the Guidelines for Short-Stay Observation (SSO). At the beginning of 2022, the main Scientific Societies of the pediatric hospital emergency-urgency area launched a national survey to identify the extent to which these national guidelines had been adopted in the emergency rooms and pediatric wards of the Italian Regions. METHODS: A survey has been widespread, among Pediatric Wards and Pediatric Emergency Departments (EDs), using both a paper questionnaire and a link to a database on Google Drive, for those who preferred to fill it directly online...
March 21, 2023: Italian Journal of Pediatrics
Mariangela Irrera, Elena Bozzola, Antonello Cardoni, Rita DeVito, Andrea Diociaiuti, Maya El Hachem, Katia Girardi, Alessandra Marchesi, Alberto Villani
BACKGROUND: In literature, a few reports described an association between paraneoplastic pemphigus (PNP) and Castelman's disease (CD), but no consensus have been proposed for the diagnostic-therapeutical approach. Aim of this study is to present a case report and explore the relationship between PNP and CD in pediatric patients, focusing on clinical manifestations, histopathological findings, treatment and outcome to find elements for an early diagnosis. CASE PRESENTATION: We present the clinical case of a 13 years old girl with a challenging diagnosis of PNP and CD who underwent therapy at first with Rituximab and then with Siltuximab, for the control of symptoms...
March 20, 2023: Italian Journal of Pediatrics
Jinying Wu, Meifang Lei, Xuetao Wang, Nan Liu, Xiaowei Xu, Chunyu Gu, Yuping Yu, Wei Liu
No abstract text is available yet for this article.
March 20, 2023: Italian Journal of Pediatrics
Yibing Zhu, Lumin Chen, Yecheng Miao, Jinying Chen, Meng Bai, Haiyan Gao, Zhirong Zhu, Yuxuan Zhang, Jianzhong Zhang, Hafiz Khuram Raza, Guanghua Liu
BACKGROUND: Recurrent wheezing is a common clinical problem in early childhood, which is associated with significant morbidity. There is no international consensus on the management and prevention of recurrent wheezing; therefore, identifying the risk factors associated with recurrent wheezing is crucial to prevent episodes of wheezing in young children. METHODS: In this retrospective study, we collected the data of 24,737 patients who were admitted to our hospital between 27th April 2012 and 11th September 2019...
March 16, 2023: Italian Journal of Pediatrics
Qi Yao, Shanshan Zhan
BACKGROUND: To evaluate the efficacy of corticosteroids in anti-inflammatory treatment of pediatric acute myocarditis. METHODS: We searched PubMed, Embase and Cochrane library and included studies before October 2022 for clinical trials, observational studies and retrospective studies which reported on children with acute myocarditis treated with corticosteroid anti-inflammatory therapy. The quality of the clinical trials was assessed by Jadad score as an exclusion criterion...
March 13, 2023: Italian Journal of Pediatrics
Rosario Valle-Martos, Luis Jiménez-Reina, Ramón Cañete, Rosario Martos, Miguel Valle, María Dolores Cañete
BACKGROUND: Non-alcoholic fatty liver disease is associated with obesity. A subclinical inflammation state, endothelial dysfunction, and parameters related to metabolic syndrome (MetS), have been documented in children with obesity. We aimed to determine the changes that occur in liver enzymes levels in response to the standard treatment of childhood obesity, also assessing any associations with liver enzyme levels, leptin, and markers of insulin resistance (IR), inflammation, and parameters related to MetS in prepubertal children...
March 9, 2023: Italian Journal of Pediatrics
Miriana Guarino, Lorena Matonti, Francesco Chiarelli, Annalisa Blasetti
Childhood obesity is increasing all over the world. It is associated with a reduction in quality of life and a relevant burden on society costs. This systematic review deals with the cost-effectiveness analysis (CEA) of primary prevention programs on childhood overweight/obesity, in order to benefit from cost-effective interventions.We screened and evaluated all the studies with a cost-effectiveness analysis on childhood obesity primary prevention program by PUBMED and Google Scholar, using inclusion and exclusion criteria...
March 2, 2023: Italian Journal of Pediatrics
Tiziana Galeazzi, Sara Quattrini, Dorina Pjetraj, Simona Gatti, Chiara Monachesi, Elisa Franceschini, Luisita Marinelli, Giulia N Catassi, Elena Lionetti, Carlo Catassi
BACKGROUND: Vitamin D is involved in calcium homeostasis and bone metabolism, although its extra-skeletal actions are also well-known. Low serum 25(OH)D levels are common both in adults and children worldwide. METHODS: The purpose of this cross-sectional study was to determine the distribution of 25(OH)D levels in a cohort of healthy Italian school-age children, aged 5-10 years, in relationship to determinants of vitamin D deficiency such as season, BMI, gender, age and ethnicity...
February 22, 2023: Italian Journal of Pediatrics
Martha Caterina Faraguna, Irene Lepri, Antonio Clavenna, Maurizio Bonati, Chiara Vimercati, Debora Sala, Alessandro Cattoni, Maria Luisa Melzi, Andrea Biondi
BACKGROUND: The aim of this study is to compare the 2021-2022 bronchiolitis season to the four previous years (2017-2018, 2018-2019, 2019-2020, 2020-2021) to see if there was an anticipation of the peak, an overall increase of cases, and an increased need of intensive care. METHODS: A retrospective single-centre study in the San Gerardo Hospital Fondazione MBBM, Monza, Italy was performed. Emergency Departments (ED) visits of patients aged < 18 years and ≤ 12 months were analyzed: the incidence of bronchiolitis on total assessments, the urgency level at triage and the hospitalization rate were compared...
February 21, 2023: Italian Journal of Pediatrics
Yupeng Wei, Tongqiang Zhang, Yuting Ma, Jisi Yan, Jianghua Zhan, Jun Zheng, Yongsheng Xu
BACKGROUND: Rapid and accurate identification of pathogens is very important for the treatment of Severe community-acquired pneumonia (SCAP) in children. Metagenomic Next-generation sequencing (mNGS) has been applied in the detection of pathogenic bacteria in recent years, while the overall evaluation the application of SCAP in children is lacking. METHODS: In our study, 84 cases of SCAP were enrolled. Bronchoalveolar lavage fluid (BALF) samples were analysed using mNGS; and sputum, blood, and BALF samples were analysed using conventional technology (CT)...
February 18, 2023: Italian Journal of Pediatrics
Federica Porcaro, Paolo Ciliberti, Francesca Petreschi, Aurelio Secinaro, Annalisa Allegorico, Antonella Coretti, Renato Cutrera
Abnormalities in position and/or branching of the aortic arch can lead to vascular rings that may cause narrowing of the tracheal lumen due to external compression, or constriction of the oesophagus, causing symptoms that vary in relation to the anatomical vascular pattern and the relationship between these structures. Respiratory morbidity related to external airways compression is a major concern in children affected by vascular rings. Clinical presentation depends on the severity of the tracheal lumen reduction and the presence of associated tracheomalacia...
February 17, 2023: Italian Journal of Pediatrics
Jun-Lin Zhao, Zhi-Yuan Wang, Shu-Jun Li, He-Kai Ma, Xue Liu, Xiao-Wen Zhan, Wei-Wei Niu, Peng Shen
BACKGROUND: This study investigated the efficacy of the integrated blood purification mode of early haemoperfusion (HP) combined with continuous venovenous haemodiafiltration (CVVHDF) in children with severe viral encephalitis, and evaluated the correlation of cerebrospinal fluid (CSF) neopterin (NPT) levels with prognosis. METHODS: The records of children with viral encephalitis who received blood purification treatment in the authors' hospital from September 2019 to February 2022 were retrospectively analysed...
February 15, 2023: Italian Journal of Pediatrics
Martina Bevacqua, Idanna Sforzi, Silvia Bressan, Egidio Barbi, Cyril Sahyoun
To date, pain and anxiety are the most common symptoms reported by children who refer to pediatric emergency department. Despite it is well known that the undertreatment of this condition has some negative consequences in a short term and long term of time, gaps in the management of pain in this setting still persist. This subgroup analysis aims to describe the current state of art of pediatric sedation and analgesia in Italian emergency departments and to identify existing gaps to solve. This is a subgroup analysis of a cross-sectional European survey of pediatric emergency departments sedation and analgesia practice undertaken between November 2019 and March 2020...
February 15, 2023: Italian Journal of Pediatrics
Yiyi Ding, Shuo Wang, Rui Guo, Aizhen Zhang, Yufang Zhu
No abstract text is available yet for this article.
February 15, 2023: Italian Journal of Pediatrics
Marco Marano, Marco Roversi, Flavia Severini, Claudia Memoli, Antonio Musolino, Mara Pisani, Corrado Cecchetti, Alberto Villani
BACKGROUND: This study aimed to analyze all the patients who contacted the hospital's pediatric poison control center (PPCC) for exposure to ibuprofen and acetaminophen, in order to assess the incidence of any adverse reactions. METHODS: We retrospectively reported the clinical data of children who accessed the PPCC of the Bambino Gesù Children's Hospital, IRCCS, Rome, from January 1, 2018 to September 30, 2022 due to wrong, accidental or intentional intake of inappropriate doses of acetaminophen and/or ibuprofen...
February 14, 2023: Italian Journal of Pediatrics
Sara Manti, Annamaria Staiano, Luigi Orfeo, Fabio Midulla, Gian Luigi Marseglia, Chiara Ghizzi, Stefania Zampogna, Virgilio Paolo Carnielli, Silvia Favilli, Martino Ruggieri, Domenico Perri, Giuseppe Di Mauro, Guido Castelli Gattinara, Antonio D'Avino, Paolo Becherucci, Arcangelo Prete, Giuseppe Zampino, Marcello Lanari, Paolo Biban, Paolo Manzoni, Susanna Esposito, Giovanni Corsello, Eugenio Baraldi
Bronchiolitis is an acute respiratory illness that is the leading cause of hospitalization in young children. This document aims to update the consensus document published in 2014 to provide guidance on the current best practices for managing bronchiolitis in infants. The document addresses care in both hospitals and primary care. The diagnosis of bronchiolitis is based on the clinical history and physical examination. The mainstays of management are largely supportive, consisting of fluid management and respiratory support...
February 10, 2023: Italian Journal of Pediatrics
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