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Italian Journal of Pediatrics

May El Hachem, Damiano Abeni, Andrea Diociaiuti, Roberta Rotunno, Francesco Gesualdo, Giovanna Zambruno, Christine Bodermer
BACKGROUND: Inherited ichthyoses are rare disorders characterized by generalized skin scaling. Among them, autosomal recessive congenital ichthyoses (ARCI) form a major subgroup presenting lifelong and severely disabling cutaneous and extracutaneous features and symptoms for which no curative treatment is available. Management relies on daily time-consuming and distressing topical medications. Disease manifestations, symptoms, and daily care affect not only the patient self-perception, but also different dimensions of patient and family life...
February 19, 2019: Italian Journal of Pediatrics
Elena Bozzola, Stefano Guolo, Enea Bonci, Chiara Rossetti, Mauro Bozzola, Massimiliano Raponi, Alberto Villani
BACKGROUND: Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM. METHODS: We calculate the costs for the hospitalization of pediatric patients affected by MM in the acute phase (HAP) over a nine year period. We performed a MEDLINE search to verify the cost of MM HAP reported in other studies. RESULTS: At Bambino Gesù Children Hospital, the median cost of HAP was of 12,604 euro (range from 9203 to 35,050 euro)...
February 13, 2019: Italian Journal of Pediatrics
Brittany M Stopa, Stefano Amoroso, Luca Ronfani, Elena Neri, Egidio Barbi, Lois K Lee
BACKGROUND: Pediatric head trauma management varies between emergency departments globally. Here we aim to compare the pediatric minor head trauma management between a US and Italian hospital. METHODS: We conducted a retrospective chart review of children 0-18 years old presenting after minor head trauma (Glasgow Coma Scale 14-15) from two emergency departments, in Boston, Massachusetts, United States and Trieste, Italy, between January and December 2013. Frequencies of demographic, clinical, and management characteristic were calculated...
February 11, 2019: Italian Journal of Pediatrics
Stefano Pintaldi, Angela Lora, Katy Vecchiato, Andrea Taddio, Egidio Barbi
BACKGROUND: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult...
February 6, 2019: Italian Journal of Pediatrics
Hamdi H Almaramhy, Abdulmohsen H Al-Zalabani
BACKGROUND: The association between macrolides use and subsequent occurrence of infantile hypertrophic pyloric stenosis (IHPS) is still debatable. The aim of this study was to conduct a systematic review and meta-analysis of the association between perinatal exposure to macrolides, mainly erythromycin, and the development of pyloric stenosis. METHODS: Original studies were identified using MEDLINE, Web of Science, Scopus, Google Scholar, and the Cochrane Library databases...
February 4, 2019: Italian Journal of Pediatrics
Vincenzo Zanardo, Alphonse Simbi, Matteo Parotto, Lorenzo Severino, Riccardo Carta, Pietro Guerrini, Gianluca Straface
The original article [1] contained an error whereby all authors' names were mistakenly inverted.
February 4, 2019: Italian Journal of Pediatrics
Ali Asghar Arastoo, Hesam Khojastehkia, Zahra Rahimi, Morteza Abdullatif Khafaie, Syed Ahmad Hosseini, Mohammad Taghi Mansouri, Shabnam Yosefyshad, Maryam Abshirini, Karimimalekabadi Noshin, Maria Cheraghi
The original article [1] contained an error in author Mohammad Taghi Mansouri's name.
February 4, 2019: Italian Journal of Pediatrics
Jia Zhai, Yingxue Zou, Jie Liu, Xingnan Jin, Cuian Ma, Jiao Li, Run Guo, Bing Huang
BACKGROUND: Clinically, asthma in children under 5 years old is under estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing in infants. METHODS: One hundred forty-five infants under 3-year old hospitalized with respiratory diseases were enrolled into this study. Patients were followed up for one-year period after being discharged from the hospital and were, then, divided into recurrent wheezing group and non-recurrent wheezing group based on whether there was recurrent wheezing or not...
January 29, 2019: Italian Journal of Pediatrics
Stefano Mazzoleni, Giovanna Magni, Daniela Toderini
BACKGROUND: The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600-1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-OH-D) level of at least 30 ng/ml (75 nmol/l) in north Italian children > 12 months. The aim of this study was to analyse the effect of seasonal supplementation with 1500 IU (=37.5 μg) vitamin D3/day. METHODS: DINOS (D-vitamIN Oral Supplementation) study was a pilot, monocentric, non-random case-control register study...
January 28, 2019: Italian Journal of Pediatrics
Guangzhong Zhou, Rongzeng Du
BACKGROUND: Combined simultaneous arginine clonidine stimulation (CSACS) test represents a more appropriate stimulus to detect Ghrelin, for it does not affect glucose metabolism. METHODS: Fifty prepubertal children with dwarfism were recruited and further classified into normal growth hormone (NGH) and growth hormone deficiency (GHD) group with growth hormone (GH) peak cut-off value of 10 μg/l. In both groups, GH and Ghrelin serum levels were determined after the GH provocation test at 30, 60, and 120 min and the height standard deviation score (SDS) for bone age was measured six months later...
January 28, 2019: Italian Journal of Pediatrics
Gianluca Sottile, Giuliana Ferrante, Marta Torregrossa, Fabio Cibella, Giovanna Cilluffo, Salvatore Fasola, Riccardo Alessandro, Gregorio Seidita, Giovanni Viegi, Stefania La Grutta
Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10-15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12.1, 17q12, 6p12.2 and 17q21.1, identifying possible candidate genes responsible for susceptibility to asthma and rhino-conjunctivitis.
January 15, 2019: Italian Journal of Pediatrics
Esayas Aydiko Amele, Birhanu Wondimeneh Demissie, Kalkidan Wondwossen Desta, Emebet Berhane Woldemariam
BACKGROUND: Although Pre-lacteal feeding is a barrier for implementation of optimal breastfeeding practices and increases the risk of neonatal illness and mortality, still it is continued as a deep-rooted nutritional malpractice in developing countries. In Ethiopia pre-lacteal feeding continued as one of the nutritional malpractices in newborns. Therefore the aim of this study was to assess pre-lacteal feeding practice and its determinants among mothers of children less than 24 months of age in Sodo zuria district, Wolaita zone, Southern Ethiopia...
January 15, 2019: Italian Journal of Pediatrics
Maria Vittoria De Vita, Carlo Scolfaro, Bruna Santini, Antonella Lezo, Federico Gobbi, Dora Buonfrate, Elizabeth W Kimani-Murage, Teresiah Macharia, Milka Wanjohi, Jacopo Mattia Rovarini, Gianfranco Morino
BACKGROUND: Malnutrition constitutes one of the major public health challenges throughout the developing world. Urban poverty and malnutrition have been on the rise, with an increased rate of morbidity. We herein explore the relationship between infections and nutritional status and the related association with hygienic conditions as risk of infection in children residing in the slums of Nairobi. METHODS: Case-control study based on a secondary analysis of quantitative data collected from a cluster randomized trial carried out in two slums of Nairobi...
January 14, 2019: Italian Journal of Pediatrics
Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Stefania Arasi, Giuseppina Salzano, Ilenia Panasiti, Andrea Barbalace, Giovanni Battista Pajno
BACKGROUND: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. In recent years there has seen the emergence of an allergic epidemic with increasing food allergy, which represents the main cause of anaphylaxis in children...
January 14, 2019: Italian Journal of Pediatrics
Xiao Hu, Qiuling Xie, Xi Mo, Yanliang Jin
BACKGROUND: To explore the effects of extracellular histones released by activated neutrophils on systemic-onset juvenile idiopathic arthritis (SoJIA), and to study the change of serum histone level between the active and remissive stage of SoJIA, then to clarify the role of serum histone in the pathogenesis of SoJIA. METHODS: Twenty-six patients with SoJIA were recruited, and clinical informations were collected, and the serum histone was detected by ELISA. While neutrophils from normal children were incubated with the serum from the patients with SoJIA, also including incubated with FeCL3 and histone, the extracellular histone was detected, respectively; heparin was added to the above-mentioned groups to observe the changes of extracellular histone levels...
January 14, 2019: Italian Journal of Pediatrics
Nosrat Ghaemi, Martha Ghahraman, Samaneh Noroozi Asl, Rahim Vakili, Fatemeh Fardi Golyan, Meysam Moghbeli, Mohammad Reza Abbaszadegan
BACKGROUND: Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development. Kisspeptin/G protein-coupled receptor-54, is as an essential gatekeeper and regulator of GnRH neurons, and a key factor in initiation of puberty. Loss and gain of functional mutations in the GPR54 gene are associated with hypogonadotropic hypogonadism and precocious puberty, respectively. This study was designed to evaluate variations of GPR54 in familial precocious puberty...
January 11, 2019: Italian Journal of Pediatrics
Silvia Simeoni, Luisa Frova, Mario De Curtis
BACKGROUND: All the children of the world should be born equal, but this is not so: even in Italy, there are striking differences already at birth. Neonatal and infant mortality are accurate indexes to assess the demographic wellbeing and quality of life of a population. The aim of the present study is to analyze the infant (IMR) and neonatal (NMR) mortality rates of Italian and foreign children and to evaluate if there is a disparity among geographical macro-areas. METHODS: Data from 2006 to 2015 were collected by the Italian Statistics Bureau (ISTAT) and extracted from two different national databases, which considered i) underlying cause of death and ii) birth registry...
January 11, 2019: Italian Journal of Pediatrics
Elena Scarpato, Renata Auricchio, Francesca Penagini, Angelo Campanozzi, Gian Vincenzo Zuccotti, Riccardo Troncone
BACKGROUND: Functional gastrointestinal disorders (FGIDs) are characterized by chronic/recurrent gastrointestinal symptoms not related to organic disorders. Due to the limited treatment options and to the perception of subjects with FGIDs suffering from a food intolerance, in recent years there has been an increase in the self-prescription of elimination diets, especially gluten free diet (GFD), for the treatment of these disorders. For this reason, we decided to perform this systematic review with the aim to evaluate the available evidence on the effects of a GFD on gastrointestinal symptoms, in subjects with FGIDs...
January 11, 2019: Italian Journal of Pediatrics
Bruno De Bernardi, Andrea Di Cataldo, Alberto Garaventa, Paolo Massirio, Elisabetta Viscardi, Marta Giorgia Podda, Aurora Castellano, Paolo D'Angelo, Elisa Tirtei, Fraia Melchionda, Simona Vetrella, Francesco De Leonardis, Carmelita D'Ippolito, Annalisa Tondo, Antonella Nonnis, Giovanni Erminio, Anna Rita Gigliotti, Katia Mazzocco, Riccardo Haupt
BACKGROUND: Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the Italian Neuroblastoma Registry to detect changes over time in presenting features, treatment and outcome. METHODS: Of 3355 subjects aged 0-18 years with previously untreated neuroblastoma diagnosed between 1979 and 2013, a total of 280 infants (8...
January 11, 2019: Italian Journal of Pediatrics
Daniale Tekelia Ekubagewargies, Destaye Guadie Kassie, Wubet Worku Takele
INTRODUCTION: Globally, more than 20 million infants are born with low birth weight. The risk of neonatal mortality among low birth weight infants is 25 to 30 times greater than neonates with birth weight ≥ 2500 g. Low birth weight infants are at increased risk of infection, difficulty of feeding, and neurologic problems following birth. So far, the prevalence and factors associated with low birth weight have not been studied in the study area after completion of the time set for millennium development goals...
January 10, 2019: Italian Journal of Pediatrics
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