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Cancer Epidemiology

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https://read.qxmd.com/read/30776583/a-pilot-study-on-clinicopathological-features-and-intestinal-microflora-changes-in-colorectal-cancer-patients-born-over-a-nine-year-period-encompassing-three-years-before-and-after-the-great-chinese-famine
#1
Jiante Li, Zhiliang Wei, Shougen Cao, Xiaojie Tan, Shanglong Liu, Zengwu Yao, Teng Sun, Yi Li, Dongfeng Zhang, Yanbing Zhou
BACKGROUND: Exposure to energy restriction during childhood is associated with a lower risk of developing colorectal cancer (CRC). To date, the association between this critical period of growth and prognosis of CRC has rarely been investigated. Changes in microbiota and epigenetic dysregulation may be key underlying mechanisms. METHODOLOGY: Tissues collected from patients born between 1956 and 1964 were grouped based on time-period. The differences in overall survival among patients from the three time-periods were examined via univariate analysis...
February 15, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30776582/parental-age-and-the-risk-of-childhood-acute-myeloid-leukemia-results-from-the-childhood-leukemia-international-consortium
#2
Paraskevi Panagopoulou, Alkistis Skalkidou, Erin Marcotte, Friederike Erdmann, Xiaomei Ma, Julia E Heck, Anssi Auvinen, Beth A Mueller, Logan G Spector, Eve Roman, Catherine Metayer, Corrado Magnani, Maria S Pombo-de-Oliveira, Michael E Scheurer, Ana-Maria Mora, John D Dockerty, Johnni Hansen, Alice Y Kang, Rong Wang, David R Doody, Eleanor Kane, Joachim Schüz, Christos Christodoulakis, Evangelia Ntzani, Eleni Th Petridou
BACKGROUND: Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent. AIM: To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies. MATERIAL/METHODS: We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]...
February 15, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30772701/proportion-of-cancer-cases-and-deaths-attributable-to-lifestyle-risk-factors-in-brazil
#3
Leandro Fórnias Machado de Rezende, Dong Hoon Lee, Maria Laura da Costa Louzada, Mingyang Song, Edward Giovannucci, José Eluf-Neto
BACKGROUND: Lifestyle risk factors (tobacco smoking, alcohol consumption, overweight and obesity, unhealthy diet, and lack of physical activity) have been associated with increased risk of at least 20 types of cancer. We estimated the proportion of cancer cases and deaths that could be potentially avoided by eliminating or reducing lifestyle risk factors in Brazil. METHODS: We obtained the distribution of lifestyle risk factors by sex and age groups from recent representative health surveys in Brazil; relative risks from pooled analyses of prospective studies and meta-analyses; and cancer cases and deaths in 2012 from GLOBOCAN...
February 14, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30771699/temporal-and-geographical-variations-in-colorectal-cancer-incidence-in-northern-iran-2004-2013
#4
Susan Hasanpour-Heidari, Abdolreza Fazel, Shahryar Semnani, Seyyed-Reza Khandoozi, Taghi Amiriani, SeyedMehdi Sedaghat, Reza Hosseinpoor, Ramin Azarhoush, Mohammad Poorabbasi, Mohammad Naeimi-Tabiei, Gholamreza Roshandel, Freddie Bray, Elisabete Weiderpass
INTRODUCTION: Colorectal cancer (CRC) is one of the most common cancers in the Golestan province, Northern Iran. The purpose of this study is to describe colorectal cancer incidence patterns and trends in the province 2004-2013. METHODS: Data on CRC cases were obtained from the Golestan Population-based Cancer Registry (GPCR). The GPCR is a high-quality cancer registry that collects data on primary cancers according to internationally accepted standard protocols...
February 13, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30771698/contemporary-trends-of-pelvic-lymph-node-dissection-at-radical-cystectomy-for-urothelial-carcinoma-of-urinary-bladder-and-associated-cancer-specific-mortality-and-complications-comparison-between-octogenarian-versus-younger-patients
#5
Francesco A Mistretta, Elio Mazzone, Sophie Knipper, Carlotta Palumbo, Zhe Tian, Sebastiano Nazzani, Fred Saad, Emanuele Montanari, Derya Tilki, Alberto Briganti, Shahrokh F Shariat, Ottavio de Cobelli, Pierre I Karakiewicz
BACKGROUND: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age. MATERIALS AND METHODS: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified...
February 13, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30743224/a-validated-algorithm-for-register-based-identification-of-patients-with-recurrence-of-breast-cancer-based-on-danish-breast-cancer-group-dbcg-data
#6
Linda Aagaard Rasmussen, Henry Jensen, Line Flytkjær Virgilsen, Lise Bech Jellesmark Thorsen, Birgitte Vrou Offersen, Peter Vedsted
BACKGROUND: Cancer recurrence is not routinely and completely registered in Danish national health registers, which challenges register-based research. The aim of this study was to develop and validate a register-based algorithm to identify patients with recurrence of breast cancer (BC). METHODS: We conducted a cohort study based on data from Danish national health registers and used the Danish National Patient Register and the Danish National Pathology Register as sources to identify BC recurrence...
February 8, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30739069/evaluation-of-p16-ki-67-dual-staining-in-the-detection-of-cervical-precancer-and-cancer-in-china
#7
Shao-Kai Zhang, Man-Man Jia, Dong-Mei Zhao, Ze-Ni Wu, Zhen Guo, Yu-Ling Liu, Pei-Pei Guo, Qiong Chen, Xiao-Qin Cao, Shu-Zheng Liu, Wen Chen, Xi-Bin Sun
Background This study aimed to evaluate the clinical performance of p16/Ki-67 dual staining in the detection of cervical intraepithelial neoplasia grade 2 or 3 or worse (CIN2+/CIN3+) in Chinese women. Methods Cervical exfoliated cells were collected from 537 eligible women and were used for liquid-based cytology (LBC), p16/Ki-67 dual staining, and human papillomavirus (HPV) DNA testing. All women received colposcopy with biopsies taken at abnormal sites. Histopathological diagnoses were used as the gold standard...
February 7, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30738284/cancer-diagnostic-delays-and-travel-distance-to-health-services-a-nationwide-cohort-study-in-denmark
#8
Line Flytkjær Virgilsen, Henrik Møller, Peter Vedsted
BACKGROUND: This study aims to investigate the association between distance to health services and intervals in the cancer diagnostic pathway, and explore whether the diagnostic difficulty of the cancer influences this association. METHOD: A nationwide cohort study was conducted based on data from both questionnaires and registries. Danish cancer patients diagnosed in 2005-2016 and their general practitioner (GP) were included if enrolled in the Danish Cancer in Primary Care (CaP) cohort (n = 37,872)...
February 6, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30731403/a-missense-variant-in-ptpn12-associated-with-the-risk-of-colorectal-cancer-by-modifying-ras-mek-erk-signaling
#9
Na Shen, Lu Li, Wang Xu, Jianbo Tian, Yang Yang, Ying Zhu, Yajie Gong, Juntao Ke, Jing Gong, Jiang Chang, Rong Zhong, Xiaoping Miao
BACKGROUND: The classical protein tyrosine phosphatases (PTPs) have been widely reported to be associated with various human malignancies including colorectal cancer (CRC). However, there are few comprehensive analyses of the association between the classical PTP genes and CRC risk. METHODS: First, a bioinformatics analysis was performed to identify missense variants within the classical PTP gene family. Second, exome-wide association data and an independent population study were conducted to evaluate effects of candidate variants on CRC risk...
February 4, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30731402/insurance-status-as-a-modifier-of-the-association-between-race-and-stage-of-prostate-cancer-diagnosis-in-florida-during-1995-and-2013
#10
Evelyn Ramirez, Julieta Morano, Tiffany Beguiristain, Grettel Castro, Pura Rodriguez de la Vega, Alan M Nieder, Noël C Barengo
BACKGROUND: Cancer stage at diagnosis is a critical prognostic factor regarding a patient's health outcomes. It has yet to be shown whether insurance status across different race has any implications on the stage of disease at the time of diagnosis. This study aimed to investigate whether insurance status was a modifier of the association between race and stage of previously undetected prostate cancer at the time of diagnosis in Florida between 1995 and 2013. METHODS: Secondary data analysis of a cross-sectional survey using information from the Florida Cancer Data System (n = 224,819)...
February 4, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30710841/the-burden-of-cervical-cancer-in-vietnam-synthesis-of-the-evidence
#11
REVIEW
Diep Ngoc Thi Nguyen, Kate Simms, Huy Quoc Vu Nguyen, Thuan Van Tran, Nga Hoai Nguyen, D Scott LaMontagne, Philip Castle, Karen Canfell
There is currently no national cervical screening or HPV immunization program in Vietnam. This study aims to synthesize available data on the burden of disease and to project the burden of cervical cancer to 2049 if no major interventions are implemented. We reviewed published data sources on risk factors for HPV prevalence, high-grade lesions, cervical cancer incidence and mortality in Vietnam from 1990 to 2017. We then used the available data to project the number of new cervical cancer cases for the period 2013-2049...
January 30, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30708341/is-pleural-infection-associated-with-longer-survival-in-mesothelioma-a-population-based-cohort-study-using-data-from-hospital-episode-statistics
#12
Anna C Bibby, Duneesha de Fonseka, David J Carslake, Nick A Maskell
BACKGROUND: Historically pleural infection was thought to be associated with longer survival in thoracic malignancies. The aim of this population-based cohort study was to investigate this hypothesis in mesothelioma, using national data from a high incidence country. METHODS: Case records for all patients with mesothelioma seen in English hospitals between 01/01/2005 and 31/12/2014 were extracted from Hospital Episode Statistics using International Classification of Diseases Tenth Edition (ICD-10) codes...
January 29, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30703618/pilot-study-of-dna-methylation-derived-neutrophil-to-lymphocyte-ratio-and-survival-in-pediatric-medulloblastoma
#13
Vidal M Arroyo, Philip J Lupo, Michael E Scheurer, Surya P Rednam, Jeffrey Murray, M Fatih Okcu, Murali M Chintagumpala, Austin L Brown
INTRODUCTION: Methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) has been identified as a potential prognostic biomarker of outcomes in various cancers. We evaluated the prognostic value of blood-derived mdNLR within a retrospective cohort of pediatric medulloblastoma patients. MATERIALS AND METHODS: DNA methylation was measured in archival peripheral blood samples collected on 56 pediatric medulloblastoma patients. Hazard ratios (HR) and 95% confidence intervals (CI) for the association between mdNLR and survival were evaluated using Cox proportional hazard models...
January 28, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30703617/risk-of-mycobacterial-disease-among-cancer-patients-a-population-based-cohort-study-in-a-tb-endemic-area
#14
Yi-Ming Chen, Ching-Heng Lin, Hsin-Hua Chen, Wen-Cheng Chao, Der-Yuan Chen, Che-Chen Lin, Tsai-Ling Liao
OBJECTIVES: Tuberculosis (TB) and nontuberculous mycobacteria (NTM) disease have similar symptoms, which makes them difficult to distinguish clinically and leads to the danger of NTM disease being neglected. The aim of this study was to assess the risk of developing mycobacterial disease among cancer patients. METHODS: We conducted a retrospective cohort study using a population-based database. The multivariable Cox proportional hazards model was adjusted to identify independent factors contributing to the development of mycobacterial disease in the cancer cohort...
January 28, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30690331/aerobic-fitness-in-late-adolescence-and-the-risk-of-cancer-and-cancer-associated-mortality-in-adulthood-a-prospective-nationwide-study-of-1-2-million-swedish-men
#15
G Högström, H Ohlsson, C Crump, J Sundquist, K Sundquist
BACKGROUND: The incidence of cancer has steadily risen. It is important to identify modifiable predictors in early life that may decrease cancer risks and mortality. The present study aims to investigate the relationship between aerobic fitness in adolescence and the subsequent risk of cancer and cancer-associated mortality. METHODS: The study included 1 185 439 Swedish men born between 1950 and 1980 that participated in the military conscription (mean age = 18 years)...
January 25, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30690330/trends-of-incidence-and-survival-of-patients-with-chronic-myelomonocytic-leukemia-between-1999-and-2014-a-comparison-between-swiss-and-american-population-based-cancer-registries
#16
Sonia Benzarti, Michael Daskalakis, Anita Feller, Vera Ulrike Bacher, Annatina Schnegg-Kaufmann, Axel Rüfer, Andreas Holbro, Adrian Schmidt, Rudolf Benz, Max Solenthaler, Georg Stussi, Volker Arndt, Nicolas Bonadies
BACKGROUND: Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy. Treatment with hypomethylating agents (HMA) was introduced between 2004 and 2006 but its impact on population-based survival remains controversial. The aim of this study was to investigate epidemiological characteristics and survival before and after introduction of HMA treatment. METHODS: We performed a population-based analysis of CMML cases reported to the Cantonal Cancer Registries in Switzerland (SWISS) and the Surveillance, Epidemiology, and End Results (SEER) Program from the United States for 1999-2006 (before HMA) and 2007-2014 (after HMA)...
January 25, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30685574/cancer-incidence-in-cotonou-benin-2014-2016-first-results-from-the-cancer-registry-of-cotonou
#17
Marcel Egue, Freddy H R Gnangnon, Marie-Thérèse Akele-Akpo, D Maxwell Parkin
Incidence data from the population cancer registry of Cotonou (Benin) for the three year period 2014-2016 are presented. 1086 cancer cases were recorded, 608 cases (56.0%) in women (corresponding to an age standardized incidence rate (ASR) of 78.4 per 100,000) and 478 cases (44.0%) in men (ASR 91.8 per 100,000). Breast and cervical cancer accounted for 49.2% of all cancers in women. Breast cancer (ASR 22.6 per 100,000) was more common than cervical cancer (ASR 14.9 per 100,000) and the mean age of cases was lower...
January 24, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30669114/time-intervals-from-first-symptom-to-diagnosis-for-head-and-neck-cancers-an-analysis-of-linked-patient-reports-and-medical-records-from-the-uk
#18
Victoria L Allgar, Steven E Oliver, Hong Chen, Osaretin Oviasu, Miriam J Johnson, Una Macleod
BACKGROUND: England has significantly higher mortality risks due to Head and Neck Cancer (HNC) compared with other European countries. Early diagnosis is important as it is likely to increase early-stage diagnosis and improve survival and better quality of life. This study sought to improve understanding of the intervals from first symptom recognition to diagnosis for HNC and investigate associations between patient-reported symptoms and socio-demographic factors. METHODS: People within 3 months of diagnosis, completed a researcher-administered questionnaire and data were extracted from primary and secondary care clinical records...
January 19, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30660075/a-population-based-age-period-cohort-study-of-colorectal-cancer-incidence-comparing-asia-against-the-west
#19
Roger Yat-Nork Chung, Kelvin K F Tsoi, Moe Htet Kyaw, Abdul Rashid Lui, Francisco T T Lai, Joseph Jao-Yiu Sung
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide but incidence varied widely. Despite the role of genetics, CRC is also sensitive to macro-environmental factors. Few studies have ever compared across different countries/regions to suggest possible macro-environmental risk factors of CRC. We estimated the effects of age, period and cohort on the changes of incidence of colorectal cancer across different countries/regions. METHODS: Poisson regression age-period-cohort (APC) models were conducted to estimate the age, period and cohorts effects on CRC incidence across the West (i...
January 16, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30658217/occupational-exposure-to-petroleum-based-and-oxygenated-solvents-and-oral-and-oropharyngeal-cancer-risk-in-men-a-population-based-case-control-study-in-france
#20
Christine Barul, Matthieu Carton, Loredana Radoï, Gwenn Menvielle, Corinne Pilorget, Anne-Sophie Woronoff, Isabelle Stücker, Danièle Luce
OBJECTIVE: To examine the association between occupational exposure to petroleum-based and oxygenated solvents and the risk of oral and oropharyngeal cancer. METHODS: The ICARE study is a large population-based case-control study conducted in France between 2001 and 2007. This present analysis was restricted to men and included 350 and 543 cases of squamous cell-carcinoma of the oral cavity and oropharynx, respectively, and 2780 controls. Lifetime tobacco, alcohol consumption and complete occupational history were assessed through detailed questionnaires...
January 15, 2019: Cancer Epidemiology
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