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Federica Sotgia, Marco Fiorillo, Michael P Lisanti
Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely "energetic" cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. e-CSCs possess a hybrid phenotype, sharing key hallmarks of senescence, "stemness" and cancer...
February 13, 2019: Aging
Chiung-Mei Chen, Wan-Ling Chen, Chen-Ting Hung, Te-Hsien Lin, Ming-Chung Lee, I-Cheng Chen, Chih-Hsin Lin, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Hsiu Mei Hsieh-Li, Guey-Jen Lee-Chen
Spinocerebellar ataxia (SCA) type 17 is an autosomal dominant ataxia caused by expanded polyglutamine (polyQ) tract in the TATA-box binding protein (TBP). Substantial studies have shown involvement of compromised mitochondria biogenesis regulator peroxisome proliferator-activated receptor gamma-coactivator 1 alpha (PGC-1α), nuclear factor erythroid 2-related factor 2 (NRF2), nuclear factor-Y subunit A (NFYA), and their downstream target genes in the pathogenesis of polyQ-expansion diseases. The extracts of Paeonia lactiflora ( P...
February 13, 2019: Aging
Jacqueline Taylor, Andreas Fischer
No abstract text is available yet for this article.
February 13, 2019: Aging
Mario Ezquerra, María-José Martí, Rubén Fernández-Santiago
No abstract text is available yet for this article.
February 11, 2019: Aging
Harris Bell-Temin, Matthew J Yousefzadeh, Andrey Bondarenko, Ellen Quarles, Jacqueline Jones-Laughner, Paul D Robbins, Warren Ladiges, Laura J Niedernhofer, Nathan A Yates
Aging is an ill-defined process that increases the risk of morbidity and mortality. Aging is also heterogeneous meaning that biological and chronological age can differ. Here, we used unbiased differential mass spectrometry to quantify thousands of proteins in mouse liver and select those that that consistently change in expression as mice age. A panel of 14 proteins from inbred C57BL/6 mice was used to equate chronological and biological age in this reference population, against which other mice could be compared...
February 11, 2019: Aging
Jonas W Bartstra, Pim A de Jong, Wilko Spiering
No abstract text is available yet for this article.
February 11, 2019: Aging
Nancy Côté, Philippe Pibarot, Marie-Annick Clavel
No abstract text is available yet for this article.
February 11, 2019: Aging
Rezwana Ahmed, Atsushige Ashimori, Satoshi Iwamoto, Takaaki Matsui, Yasukazu Nakahata, Yasumasa Bessho
Over the last decade, a wide array of evidence has been accumulated that disruption of circadian clock is prone to cause age-related diseases and premature aging. On the other hand, aging has been identified as one of the risk factors linked to the alteration of circadian clock. These evidences suggest that the processes of aging and circadian clock feedback on each other at the animal level. However, at the cellular level, we recently revealed that the primary fibroblast cells derived from Bmal1-/- mouse embryo, in which circadian clock is completely disrupted, do not demonstrate the acceleration of cellular aging, i...
February 9, 2019: Aging
Juan Ureña, María Del Carmen González-Montelongo, Francisco Murillo-Cabezas
No abstract text is available yet for this article.
February 9, 2019: Aging
Daniela Puzzo
No abstract text is available yet for this article.
February 8, 2019: Aging
Zhiguo Zhao, Dan Gao, Tie Ma, Liping Zhang
MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epidermal growth factor receptor (EGFR) were enhanced in tissues with low miR-141 expression but were reduced by miR-141 overexpression, and there was a significant negative correlation between EGFR and miR-141 levels in HNSCC tissues ( P < 0...
February 8, 2019: Aging
Vincent A Pallazola, Vasanth Sathiyakumar, Seth S Martin
No abstract text is available yet for this article.
February 7, 2019: Aging
Valentina Sala, Mingchuan Li, Alessandra Ghigo
No abstract text is available yet for this article.
February 6, 2019: Aging
Jian Tan, Yipin Xu, Fang Han, Xinhai Ye
Adipose-derived stem cells (ASCs) have a demonstrative therapeutic potential in aging-associated facial nerve regeneration, in which ASCs work as a source of Schwann cells therapy as an alternative to autologous nerve grafts. However, the transplantation of ASCs may induce local fibrosis, which causes inferior outcome. Here, we aimed to use genetic modification approaches to reduce the fibrogenic properties of ASCs to improve their therapeutic effects on facial nerve regeneration. Since procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) is essential for hydroxylation of lysine residues in collagen telopeptides and for collagen pyridinoline cross-link formation during fibrosis, and since we found that ASCs expressed high levels of PLOD1, we depleted PLOD1 in ASCs by expression of either a short-hair interfering RNA for PLOD1 (shPLOD1) or a microRNA-449 (miR-449), the latter of which targets PLOD1 mRNA to suppress protein translation...
February 6, 2019: Aging
Jian-Jun Chen, Jing Xie, Li Zeng, Chan-Juan Zhou, Peng Zheng, Peng Xie
The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential biomarkers for young and middle-aged BD patients during depressive episode. Both gas chromatography-mass spectroscopy (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy were used to profile the urine samples from the recruited subjects...
February 5, 2019: Aging
Wei Zhou, Jiapeng Sun, Wenwen Guo, Yi Zhuang, Lizhi Xu, Yaping Wang
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with an unknown etiology. Increased oxidative stress and mitochondrial dysfunction are thought to be involved in its pathogenesis. However, the effect of the AluYb8MUTYH polymorphism on IPF is not known. RESULTS: The mean age of onset for IPF in patients homozygous for the AluYb8MUTYH variant ( P/P ) was 66.5 years old, which was significantly earlier than that in patients with the wild-type ( A/A , 70...
February 4, 2019: Aging
Jing Zhang, Dan Wu, Yue Li, Yidan Fan, Yiqin Dai, Jianjiang Xu
Macular corneal dystrophy (MCD) is an autosomal recessive disease featured by bilateral progressive stromal clouding and loss of vision, consequently necessitating corneal transplantation. Variants in CHST6 gene have been recognized as the most critical genetic components in MCD. Although many CHST6 variants have been described until now, the detailed mechanisms underlying MCD are still far from understood. In this study, we integrated all the reported CHST6 variants described in 408 MCD cases, and performed a comprehensive evaluation to better illustrate the causality of these variants...
February 4, 2019: Aging
Bo Li, Tian-Bi Tan, Liang Wang, Xiao-Yun Zhao, Guo-Jun Tan
Multiple sclerosis (MS) is characterized with multifocal demyelination resulting from activation and infiltration of inflammatory cells into the central nerve system. Recent reports suggest that p38 mitogen-activated protein kinase (MAPK) / serum- and glucocorticoid-inducible protein kinase 1 (SGK1) signaling pathway contributes to the pathology of MS through regulation of immunity. However, the role of this signaling pathway in MS-related macrophage activation and polarization has not been studied. Here, we used an experimental autoimmune encephalomyelitis (EAE) model for MS to study the role of p38MAPK/SGK1 signaling in the macrophage polarization and its effects on the development and severity of EAE...
February 4, 2019: Aging
Perinthottathil Sreejith, Wijeong Jang, Van To, Yong Hun Jo, Benoit Biteau, Changsoo Kim
Age-related decline in stem cell function is observed in many tissues from invertebrates to humans. While cell intrinsic alterations impair stem cells, aging of the stem cell niche also significantly contributes to the loss of tissue homeostasis associated with reduced regenerative capacity. Hub cells, which constitute the stem cell niche in the Drosophila testis, exhibit age-associated decline in number and activities, yet underlying mechanisms are not fully understood. Here we show that Lin28, a highly conserved RNA binding protein, is expressed in hub cells and its expression dramatically declines in old testis...
February 4, 2019: Aging
Zhi-Liang Wang, Zheng Zhao, Zheng Wang, Chuan-Bao Zhang, Tao Jiang
BACKGROUND: Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might influence the clinical management for doctors. Here, we attempted to explore an RNA sequencing computational method to detect 1p/19q status. METHODS: We included 692 samples with 1p/19q status information from TCGA cohort as training set and 222 samples with 1p/19q status information from REMBRANDT cohort as validation set...
February 2, 2019: Aging
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