journal
https://read.qxmd.com/read/38379638/antibody-response-to-influenza-hemagglutinin-conserved-stalk-domain-after-sequential-immunization-with-old-vaccine-strains
#1
JOURNAL ARTICLE
Alita Kongchanagul, Promsin Masrinoul, Chompunuch Boonarkart, Ornpreya Suptawiwat, Prasert Auewarakul
Hemagglutinin (HA) is the major envelope glycoprotein and antigen on the surface of influenza virions. The glycoprotein comprises a globular head and a stalk region. While immunodominant epitopes on influenza HA head are highly variable, the stalk domain is conserved. The variability of the HA head causes the antigenic drift that made the requirement of annual update of vaccine strains. Induction of antibody against the stalk domain has been proposed as an approach for a broadly protective influenza vaccine strategy...
2024: Advances in Virology
https://read.qxmd.com/read/38292215/prevalence-of-influenza-viruses-a-and-b-adenovirus-respiratory-syncytial-virus-and-human-metapneumonia-viruses-among-children-with-acute-respiratory-tract-infection
#2
JOURNAL ARTICLE
Rana Farzi, Neda Pirbonyeh, Mohammad Rahim Kadivar, Afagh Moattari
BACKGROUND: Acute respiratory tract infection (ARTI) is a significant cause of morbidity and mortality among children worldwide. The majority of acute respiratory infections in children are caused by viruses, with respiratory syncytial virus (RSV) being the most frequently encountered. Other important viral pathogens include human metapneumovirus, human coronaviruses, adenovirus, and influenza. These infections can lead to complications such as bronchitis and pneumonia. So, this study aimed to evaluate the prevalence of influenza viruses A and B, adenovirus, respiratory syncytial virus (RSV), and human metapneumovirus (HMPV) in children with ARTI...
2024: Advances in Virology
https://read.qxmd.com/read/38094619/high-transmission-rates-of-early-omicron-subvariant-ba-2-in-bangkok-thailand
#3
JOURNAL ARTICLE
Sininat Petcharat, Ananporn Supataragul, Piyapha Hirunpatrawong, Pattama Torvorapanit, Chonticha Klungthong, Piyawan Chinnawirotpisan, Sasiprapa Ninwattana, Nattakarn Thippamom, Leilani Paitoonpong, Gompol Suwanpimolkul, Watsamon Jantarabenjakul, Rome Buathong, Khajohn Joonlasak, Wudtichai Manasatienkij, Khwankamon Rattanatumhi, Napaporn Chantasrisawad, Nuntana Chumpa, Thomas S Cotrone, Stefan Fernandez, Sira Sriswasdi, Supaporn Wacharapluesadee, Opass Putcharoen
The emergence of Omicron as the fifth variant of concern within the SARS-CoV-2 pandemic in late 2021, characterized by its rapid transmission and distinct spike gene mutations, underscored the pressing need for cost-effective and efficient methods to detect viral variants, especially given their evolving nature. This study sought to address this need by assessing the effectiveness of two SARS-CoV-2 variant classification platforms based on RT-PCR and mass spectrometry. The primary aim was to differentiate between Delta, Omicron BA...
2023: Advances in Virology
https://read.qxmd.com/read/37727368/fraxin-in-combination-with-dexamethasone-attenuates-lps-induced-liver-and-heart-injury-and-their-anticytokine-activity-in-mice
#4
JOURNAL ARTICLE
Nada Sahib Shaker, Hayder Bahaa Sahib
BACKGROUND: Cytokine storm syndrome (CSS) is a major cause of morbidity and mortality in people suffering from hyperinflammatory status, which diverse etiological factors, including pathogens, therapeutic interventions, malignancies, and autoimmune disorders, can instigate. Since there is limited research on the antioxidant properties of fraxin and no studies have investigated its potential as an anticytokine storm agent, it is important to note that most studies have primarily focused on proinflammatory cytokines such as IL-1 β , IL-6, and TNF α during cytokine storm...
2023: Advances in Virology
https://read.qxmd.com/read/37719318/the-single-nucleotide-polymorphism-snp-validity-to-detect-omicron-variants
#5
JOURNAL ARTICLE
Lia Gardenia Partakusuma, Luhung Budiailmiawan, Budiman, Ida Parwati, Aryati, Basti Andriyoko, Louisa Markus, Corine Niswara, Cut Nur Cinthia Alamanda
INTRODUCTION: Mutation of SARS-CoV-2 has generated several variants of concern (VOC) which spread promptly worldwide. These emerging variants affected global strategies to overcome COVID-19. Variants of SARS-CoV-2 are determined by the whole genome sequencing (WGS) assay, which is time-consuming, with limited availability (only in several laboratories). Hence, a faster and more accessible examination is needed. The single-nucleotide polymorphism (SNP) method is one of the options for genomic variation surveillance that can help provide an answer to this challenge...
2023: Advances in Virology
https://read.qxmd.com/read/37693295/therapeutic-promises-of-plant-metabolites-against-monkeypox-virus-an-in-silico-study
#6
JOURNAL ARTICLE
Anik Banik, Sheikh Rashel Ahmed, Sonia Binte Shahid, Tufayel Ahmed, Hafaza Khandaker Tamanna, Hlamrasong Marma
The monkeypox virus was still spreading in May 2022, with the first case identified in a person with travel ties to Nigeria. Using molecular docking-based techniques, we evaluated the efficiency of different bioactive chemicals obtained from plants against the monkeypox virus. A total of 56 plant compounds were evaluated for antimonekypox capabilities, with the top four candidates having a higher binding affinity than the control. We targeted the monkeypox profilin-like protein, which plays a key role in viral replication and assembly...
2023: Advances in Virology
https://read.qxmd.com/read/37475729/ethyl-gallate-promising-cytoprotective-against-hiv-1-induced-cytopathy-and-antiretroviral-induced-cytotoxicity
#7
JOURNAL ARTICLE
C Muddu Krishna, J N Kolla, Hari Babu Bollikolla, T Sravan Kumar Reddy, S Asha
INTRODUCTION: HIV-1 infection in cell culture is typically characterized by certain cytopathic effects such as vacuolization of cells and development of syncytia, which further lead to cell death. In addition, the majority of drugs during HIV treatment exhibit serious adverse effects in patients, apart from their beneficial role. During the screening of cytoprotective agents to protect the cells from HIV-1-associated cell death and also drug-associated toxicity, antioxidants from a natural source are assumed to be a choice...
2023: Advances in Virology
https://read.qxmd.com/read/37384256/contribution-of-the-filmarray-biofire%C3%A2-technology-in-the-diagnosis-of-viral-respiratory-infections-during-the-covid-19-pandemic-at-ibn-sina-university-hospital-center-in-rabat-epidemiological-study-about-503-cases
#8
JOURNAL ARTICLE
Khalid Edderdouri, Hakima Kabbaj, Leila Laamara, Noureddine Lahmouddi, Oumayma Lamdarsi, Amal Zouaki, Ghizlane El Amin, Jalila Zirar, Myriam Seffar
Respiratory viruses are the most involved pathogens in acute respiratory infections. During the COVID-19 pandemic, new elements have been brought to this topic, especially at the diagnostic and therapeutic level. The objective of this work is to describe the epidemiology of respiratory viruses in patients admitted to the Ibn Sina University Hospital of Rabat during a period characterized by the emergence and spread of SARS-CoV-2. We conducted a retrospective study from January 1 to December 31. We included all patients treated for acute respiratory infection and for whom a multiplex respiratory panel PCR was requested...
2023: Advances in Virology
https://read.qxmd.com/read/37275947/the-protective-potential-role-of-ace2-against-covid-19
#9
REVIEW
Fereshteh Golab, Gelareh Vahabzadeh, Leila SadeghRoudbari, Arefeh Shirazi, Robabeh Shabani, Sara Tanbakooei, Lida Kooshesh
Due to the coronavirus disease 2019 (COVID-19), researchers all over the world have tried to find an appropriate therapeutic approach for the disease. The angiotensin-converting enzyme 2 (ACE2) has been shown as a necessary receptor to cell fusion, which is involved in infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is commonly crucial for all organs and systems. When ACE2 is downregulated via the SARS-CoV-2 spike protein, it results in the angiotensin II (Ang II)/angiotensin type 1 receptor axis overactivation...
2023: Advances in Virology
https://read.qxmd.com/read/37234693/hepatitis-b-virus-immunity-gap-a-six-year-laboratory-data-review-of-hepatitis-b-serological-profiles-in-gauteng-province-south-africa
#10
JOURNAL ARTICLE
Nonhlanhla Mbenenge, Kathleen Subramoney, Clement Gascua Adu-Gyamfi, Florette K Treurnicht
BACKGROUND: In 1995, the hepatitis B vaccine in South Africa was incorporated into the childhood expanded programme of immunization. We report on immunity gaps of laboratory-based hepatitis B virus (HBV) among patients in public facilities in Gauteng Province from 1st January 2014 to 31st December 2019. Methodology . We analyzed HBV serological data extracted from the National Health Laboratory Services Central Data Warehouse (NHLS CDW). A descriptive analysis was performed for hepatitis B surface antigen (HBsAg), antibodies to HBV core (anti-HBc) total, anti-HBc IgM, and antibodies to HBV surface antigen (anti-HBs) according to annual distribution, age groups, and sex...
2023: Advances in Virology
https://read.qxmd.com/read/37065904/the-sars-cov-2-utr-s-intrudes-host-rbp-s-and-modulates-cellular-splicing
#11
JOURNAL ARTICLE
Anjali Singh, Kush Kumar Pandey, Shubham Kumar Agrawal, Rupesh K Srivastava, Sankar Bhattacharyya, Bhupendra Verma
SARS-CoV-2 is a novel coronavirus that causes a potentially fatal respiratory disease known as coronavirus disease (COVID-19) and is responsible for the ongoing pandemic with increasing mortality. Understanding the host-virus interaction involved in SARS-CoV-2 pathophysiology will enhance our understanding of the mechanistic basis of COVID-19 infection. The characterization of post-transcriptional gene regulatory networks, particularly pre-mRNA splicing, and the identification and characterization of host proteins interacting with the 5' and 3'UTRs of SARS-CoV-2 will improve our understanding of post-transcriptional gene regulation during SARS-CoV-2 pathogenesis...
2023: Advances in Virology
https://read.qxmd.com/read/36938489/whole-genome-comparison-of-representatives-of-all-variants-of-sars-cov-2-including-subvariant-ba-2-and-the-gka-clade
#12
JOURNAL ARTICLE
Ida B K Suardana, Bayu K Mahardika, Made Pharmawati, Putu H Sudipa, Tri K Sari, Nyoman B Mahendra, Gusti N Mahardika
Since its discovery at the end of 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved into many variants, including the subvariant BA.2 and the GKA clade. Genomic clarification is needed for better management of the current pandemic as well as the possible reemergence of novel variants. The sequence of the reference genome Wuhan-Hu-1 and approximately 20 representatives of each variant were downloaded from GenBank and GISAID. Two representatives with no track of in-definitive nucleotides were selected...
2023: Advances in Virology
https://read.qxmd.com/read/36816885/evaluation-of-the-mascir-sars-cov-2-m-kit-2-0-on-the-sars-cov-2-infection
#13
JOURNAL ARTICLE
Amal Zouaki, Hakima Kabbaj, Ghizlane El Amin, Mouna Ouadghiri, Bouchra Belefquih, Azeddine Ibrahimi, Myriam Seffar
SARS-CoV-2 is a major public health problem worldwide. Since its emergence, several diagnostic kits have been developed to ensure rapid patient management. The aim of our study is to check the performance of the new Moroccan SARS-CoV-2 detection kit: MAScIR SARS-CoV-2 M 2.0. The following parameters were studied: repeatability, reproducibility, analytical specificity, analytical sensitivity, and comparison with the GeneFinder™ COVID-19 Plus RealAmp Kit. In addition, an external quality evaluation comprising five specimens was carried out as part of an international program for the external quality evaluation of sublaboratories of the WHO and the Laboratory Office of the National Institute of Hygiene of Morocco...
2023: Advances in Virology
https://read.qxmd.com/read/36755743/development-and-validation-of-rapid-colorimetric-reverse-transcription-loop-mediated-isothermal-amplification-for-detection-of-rift-valley-fever-virus
#14
JOURNAL ARTICLE
Francis Wekesa, Mark Wamalwa, Richard Oduor, Yatinder Binepal, Leonard Ateya, Noah Okumu, Angela M'kwenda, Christopher Masaba, Eugine Mukhaye
Rift Valley fever virus (RVFV) is a high-priority zoonotic pathogen with the ability to cause massive loss during its outbreak within a very short period of time. Lack of a highly sensitive, instant reading diagnostic method for RVFV, which is more suitable for on-site testing, is a big gap that needs to be addressed. The aim of this study was to develop a novel one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP) method for the rapid detection of RVFV. To achieve this, the selected RVFV M segment nucleotide sequences were aligned using Multiple Sequence Comparison by Log-Expectation (MUSCLE) software in MEGA11 version 11...
2023: Advances in Virology
https://read.qxmd.com/read/36643823/knowledge-and-attitude-towards-human-papilloma-virus-infection-vaccines-and-cervical-cancer-prevention-among-school-students-in-kano-nigeria
#15
JOURNAL ARTICLE
Ismail Rabiu, Zainab Yahuza
The rising cases of human papillomavirus (HPV) infection and cervical cancer cases in Nigeria are alarming. Only a few studies have looked at secondary school students in Nigeria's understanding of HPV infection and vaccine acceptance, whereas earlier studies have mostly focused on screening. In this study, 400 students from two secondary schools in Kano State, Nigeria, were engaged with the aim of assessing their level of knowledge and attitudes regarding HPV infection. The study further seeks to understand the respondent's opinion on HPV vaccination and sensitize them to the health effects of HPV infection, thereby communicating the findings to the authorities concerned with policy making...
2023: Advances in Virology
https://read.qxmd.com/read/36591003/characterization-of-canine-adenovirus-type-2-virus-infection-pattern-in-canine-and-human-cell-lines
#16
JOURNAL ARTICLE
Madison D Hogans, Will P Kretzschmar, Theresa A Higgins, Atonu Chakrabortty, Rebecca L Nance, Bruce F Smith, Deepa Bedi, Maninder Sandey, Payal Agarwal
Canine adenovirus type 2 (CAV2) is a nonhuman adenovirus with a known ability to infect human and canine cells. The cell surface receptors involved in CAV2 transduction are still unknown. Identification of these would provide valuable information to develop enhanced gene delivery tools and better understand CAV2 biology. CAV2 is erroneously grouped with Ad5 based on the knowledge that CAV2 may transduce using CAR. Therefore, we have evaluated CAV2 and Ad5 (CAV2GFP, Ad5G/L) infection patterns in various canine and human cell lines to determine their different tropisms...
2022: Advances in Virology
https://read.qxmd.com/read/36536779/the-use-of-mebendazole-in-covid-19-patients-an-observational-retrospective-single-center-study
#17
JOURNAL ARTICLE
Mostafa W Galal, Mahmoud Ahmed, Yanqiu Shao, Chao Xing, Wael Ali, Abd Elhamid Baly, Abdallah Elfiky, Khaled Amer, John Schoggins, Hesham A Sadek, Zeinab N Gobara
BACKGROUND: An in-silico screen identified mebendazole with potential antiviral activity that could be a repurposed drug against SARS-CoV-2. Mebendazole is a well-tolerated and cheap antihelminthic agent that is readily available worldwide and thus could be a therapeutic tool in the fight against COVID-19. METHODS: This is an observational retrospective study of PCR-confirmed COVID-19 patients who received mebendazole with the intention-to-treat. The study included an inpatient cohort (157 inpatients) and an outpatient cohort (185 outpatients)...
2022: Advances in Virology
https://read.qxmd.com/read/36524015/emergency-use-of-tocilizumab-in-moderate-and-severe-covid-19-patients-over-the-prevaccination-stage-during-the-pandemic-in-mexico
#18
JOURNAL ARTICLE
Yessica Bernal Luna, Alejandro Esquivel Loza, José de Jesús Garduño García
INTRODUCTION: COVID-19 has been associated with the overactivation of the immune system; interleukin-6 (IL-6) seems to have a key role, which made its moderation to be proposed as a therapeutic blank. Tocilizumab has been used as part of treatments to modulate the immune response to infections caused by COVID-19. Material and Methods . An observational, descriptive, retrospective, and transversal study was carried out in patients diagnosed with moderate-severe COVID-19 who were hospitalized in the 251 General Regional Hospital from March to December 2020...
2022: Advances in Virology
https://read.qxmd.com/read/36479562/hepatitis-a-and-e-viruses-in-mussels-from-cherrat-estuary-in-morocco-detection-by-real-time-reverse-transcription-pcr-analysis
#19
JOURNAL ARTICLE
Hanaâ Bazir, Najwa Hassou, Fatiha El Mellouli, Hasnae Zekhnini, Saliha Najib, Moulay Mustapha Ennaji
The aim of the present study was to evaluate hepatitis A virus (HAV) and hepatitis E virus (HEV) contamination in mussels ( Mytilus galloprovincialis ) from Cherrat estuary (Moroccan Atlantic Coast), Morocco. In total, 52 samples ( n  = 12 mussels/each) were collected at four sites in the estuary, monthly, between March 2019 and March 2020. HAV and HEV were detected by real-time reverse transcription polymerase chain reaction (RT-PCR) according to the ISO/TS 15216 method. HAV was detected in 46...
2022: Advances in Virology
https://read.qxmd.com/read/36313590/rab7-investigation-insights-into-the-existence-of-white-spot-syndrome-virus-in-crustaceans-an-in-silico-approach
#20
JOURNAL ARTICLE
Mehedi Mahmudul Hasan, M Nazmul Hoque, Md Robiul Hasan, Mohammad Asaduzzaman, Farha Matin Juliana
In this study, previously published Rab7 sequences from National Center for Biotechnology Information (NCBI) have been investigated from chordates, mollusks, annelids, cnidarians, amphibians, priapulids, brachiopods, and arthropods including decapods and other groups. Among decapod crustacean isolates, amino acid variations were found in 13 locations. Penaeid shrimps had variations in positions 13 (I ⟶ J), 22 (T ⟶ A), 124 (G ⟶ X), and 149 (V ⟶ X) while interestingly the freshwater prawn and mitten crab both had amino acid substitutions in positions 87 (V ⟶ C) and 95 (T ⟶ S) along with the other disagreements in amino acid positions 178 (S ⟶ N), 201 (D ⟶ E), 181 (E ⟶ D), 182 (L ⟶ I), 183 (Y ⟶ G), 184 (N ⟶ H), and 198 (A ⟶ T)...
2022: Advances in Virology
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