C Goetz, L Rault, J Cuffel, P Poton, L Finot, G Boullet, M Boutinaud, S Even
Bovine mastitis (BM) is a major disease in dairy industry. The current approaches - mainly antibiotic treatments - are not entirely effective and may contribute to antimicrobial resistance dissemination, rising the need for alternative treatment. The present study aims to evaluate the impact of post-milking application of Lacticaseibacillus paracasei CIRM BIA 1542 (Lp1542) on the teat skin (TS) of 20 Holstein cows in mid lactation, in order to reinforce the barrier effect of the microbiota naturally present on the teat...
May 14, 2024: Beneficial Microbes
C Zhang, L Wang, X Liu, G Wang, X Guo, X Liu, J Zhao, W Chen
Probiotics exert beneficial effects by regulating the intestinal microbiota, metabolism, immune function and other ways of their host. Patients with constipation, a common gastrointestinal disorder, experience disturbances in their intestinal microbiota. In the present study, we investigated the effectiveness of two microbial ecological agents (postbiotic extract PE0401 and a combination of postbiotic extract PE0401 and Lacticaseibacillus paracasei CCFM 2711) in regulating the makeup of the intestinal microbiota and alleviating loperamide hydrochloride-induced constipation in mice...
May 1, 2024: Beneficial Microbes
G Longhi, G A Lugli, M G Bianchi, S M Rizzo, C Tarracchini, L Mancabelli, L M Vergna, G Alessandri, F Fontana, G Taurino, M Chiu, C Milani, D van Sinderen, O Bussolati, M Ventura, F Turroni
Aging is a physiological and immunological process involving the deterioration of human health, characterised by the progressive alteration of organs and their functions. The speed and extent of such decline are dependent on lifestyle, environment, and genetic factors. Moreover, with advancing age, humans become progressively more fragile and prone to acute and chronic diseases. Although the intestinal microbiota is predisposed to perturbations that accompany aging and frailty, it is generally accepted that the gut microbiota engages in multiple interactions that affect host health throughout the host life span...
April 30, 2024: Beneficial Microbes
E Torres-Maravilla, F A Carvalho, S Holowacz, J Delannoy, L Lenoir, E Jacouton, F Barbut, P Langella, L G Bermúdez-Humarán, A-J Waligora-Dupriet
Oral administration of probiotics has been proposed as a promising biotherapy to prevent and treat different diseases related to gastrointestinal disorders, such as irritable bowel syndrome (IBS). Due to the increasing research area on the characterisation of new probiotic bacterial strains, it is necessary to perform suitable in vitro experiments, using pertinent cellular models, in order to establish appropriate readout profiles based on IBS symptoms and subtypes. In this work, a collection of 30 candidate strains, belonging mainly to the Lactobacillus and Bifidobacterium genera, were screened using three different sets of in vitro experiments with different readouts to identify promising probiotic strains with: (1) the ability to inhibit the synthesis of IL-8 production by TNF-α stimulated HT-29 cells, (2) immunomodulatory properties quantified as increased IL-10 levels in peripheral blood mononuclear cell (PBMCs), and (3) the ability to maintain epithelial barrier integrity by increasing the trans-epithelial/endothelial electrical resistance (TEER) values in Caco-2 cells...
April 30, 2024: Beneficial Microbes
M Lee, S A Chae, Y J Lee, H J Jeon, S-C Hong, M Shin, Y H Jung, J Yang
This study investigated the anti-inflammatory effects of cell-free supernatant of Lactococcus lactis IDCC 2301 on lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Expression of inflammatory mediators and cytokines, and the production of nitric oxide (NO) and prostaglandin E2 (PGE2) were qualitatively analysed. The expression of signal transductors in inflammatory cascades was quantified by western blot. Treatment with cell-free supernatant of L. lactis IDCC 2301 significantly decreased the mRNA expression levels of tumour necrosis factor (TNF-α) and interleukins including IL-1β and IL-6...
April 30, 2024: Beneficial Microbes
R An, F Fontana, E Van Daele, M Ventura, A Vlieger, R M van Elburg, J Knol, C Milani, C Belzer
Early life microbiota encompasses of a large percentage of Bifidobacterium, while it is not sufficiently understood how the Bifidobacterium population develops after infant's birth. Current study investigated the longitudinal changes in Bifidobacterium population during the first two years of life in 196 term born infants (1,654 samples) using 16S rRNA-23S rRNA internal transcribed spacer (ITS) sequence analysis. Throughout the first two years of life, Bifidobacterium breve, Bifidobacterium longum subsp. longum and Bifidobacterium adolescentis were most dominant and prevalent in the Bifidobacterium population, while B...
April 30, 2024: Beneficial Microbes
Í M Pérez-Castillo, A Sabag-Daigle, J López-Chicharro, N Mihic, R Rueda, H Bouzamondo
The gut microbiota has been proposed to grant the athlete a metabolic advantage that might be key when optimising performance. While a taxonomic core set of microorganisms characterising the athlete's gut microbiota has not been delineated, some compositional features might be associated with improved metabolic efficiency, which appears to be driven by the production of bacterial metabolites, such as short-chain fatty acids. Not only long-term exercise but also dietary patterns associated with high-level sports practice contribute to this microbial environment, yet isolating the impact of individual dietary components is challenging...
April 26, 2024: Beneficial Microbes
D Salamon, K Kowalska-Duplaga, A Krawczyk, M Duplaga, A Gurgul, T Gosiewski
The changing of microbiome could precede the development of coeliac disease (CeD). We compared the bacterial profile of microbiota of tissues collected simultaneously from the stomach and duodenum in newly diagnosed patients with CeD. Biopsies were collected from 60 children and adolescents aged 2-18 years: (1) 40 patients with CeD; (2) 20 children as control group. The evaluation of the bacterial microbiota was carried out by sequencing the V3-V4 regions of the 16S rRNA subunit, using next-generation sequencing (NGS)...
April 23, 2024: Beneficial Microbes
C M A P Franz, B Pot, M G Vizoso-Pinto, A Arini, R Coppolecchia, W H Holzapfel
Enterococcus faecium SF68 (SF68) is a well-known probiotic with a long history of safe use. Recent changes in the taxonomy of enterococci have shown that a novel species, Enterococcus lactis, is closely related with E. faecium and occurs together with other enterococci in a phylogenetically well-defined E. faecium species group. The close phylogenetic relationship between the species E. faecium and E. lactis prompted a closer investigation into the taxonomic status of E. faecium SF68. Using phylogenomics and ANI, the taxonomic analysis in this study showed that probiotic E...
March 11, 2024: Beneficial Microbes
O Ignatyeva, V Gostev, A Taraskina, I Tsvetkova, P Pavlova, O Sulian, V Ageevets, D Likholetova, P Chulkova, E Nikitina, L Matkava, M Terekhov, D Lisovaya, D Kashtanova, M Ivanov, O Kalinogorskaya, A Avdeeva, A Zhirkov, O Goleva, S Zakharenko, K Zhdanov, V Strizheletsky, Y Gomon, A Kruglov, O Ni, T Noskova, I Gorbova, G Cherenkova, I Shlyk, A Afanasyev, V Yudin, V Makarov, S Sidorenko, S Yudin
COVID-19 is caused by an airborne virus, SARS-CoV-2. The upper respiratory tract (URT) is, therefore, the first system to endure the attack. Inhabited by an assemblage of microbial communities, a healthy URT wards off the invasion. However, once invaded, it becomes destabilised, which could be crucial to the establishment and progression of the infection. We examined 696 URT samples collected from 285 COVID-19 patients at three time-points throughout their hospital stay and 100 URT samples from 100 healthy controls...
February 22, 2024: Beneficial Microbes
C Kaga, T Nagino, A Gomi, A Takagi, K Miyazaki, Y Yoshida, K Shida
Previous studies have demonstrated that soymilk and Lacticaseibacillus paracasei YIT 9029 (strain Shirota: LcS) each beneficially affect the gut microbiota and defecation habits. To investigate the effects of daily consumption of fermented soymilk containing LcS (FSM), we conducted a randomised, double-blind, placebo-controlled study of 112 healthy Japanese adults with a low faecal Bifidobacterium count. They consumed 100 ml FSM or placebo (unfermented soymilk base) once daily for 4 weeks. Their gut microbiota was analysed by 16S rRNA gene amplicon sequencing and quantitative reverse transcription-polymerase chain reaction (PCR), and faecal short-chain fatty acids (SCFAs) and urinary putrefactive products were assessed during the pre- and post-consumption periods...
February 15, 2024: Beneficial Microbes
I Cuevas-Gómez, J de Andrés, N Cardenas, I Espinosa-Martos, E Jiménez
Post-weaning diarrhoea in piglets remains an important cause of economic losses for swine producers. Feed supplementation with probiotics is one of the alternatives to antibiotics used to reduce the impact of such gastrointestinal disease. The aim of the present study was to evaluate the effect of Ligilactobacillus salivarius PS21603 supplementation on the intestinal structure and the gut microbiota composition of weaned piglets. Safety and tolerance of L. salivarius PS21603 were previously evaluated in a 28-days study using 384 weaned piglets (28 ± 2 days old and 7...
January 31, 2024: Beneficial Microbes
C M Kerksick, J M Moon, K E Walden, A M Hagele, L E Allen, C J Gaige, J M Krieger, R Jäger, M Pane, P Mumford
The objective of the study was to examine the impact of a multi-strain probiotic (MSP) on sleep, physical activity, and body composition changes. We used a randomised, double-blind, placebo-controlled approach with 70 healthy men and women (31.0 ± 9.5 years, 173.0 ± 10.4 cm, 73.9 ± 13.8 kg, 24.6 ± 3.5 kg/m2) supplemented daily with MSP (4 × 109 live cells Limosilactobacillus fermentum LF16, Lacticaseibacillus rhamnosus LR06, Lactiplantibacillus plantarum LP01, and Bifidobacterium longum 04; Probiotical S...
January 31, 2024: Beneficial Microbes
P Prukpitikul, J Sirivarasai, N Sutjarit
Metabolic disorders are a major global health problem. Gut microbiota not only affect host metabolism through metabolites, inflammatory processes, and microbial-derived extracellular vesicles, but they also modulate the host microRNA, which may impact the host metabolism. Hence, the underlying mechanisms between gut microbiota-microRNA interaction can potentially be a novel alternative strategy for treating metabolic disorders. This review aims to give an update on the latest evidence and current knowledge of the underlying mechanisms of gut microbiota-miRNA interaction, focusing on metabolic homeostasis...
January 29, 2024: Beneficial Microbes
L Micenková, K Brodı Ková, S Smetanová, J Bosák, D Šmajs, P Andrla, E Budinská
Probiotic supplementation in childhood serves as an additional source of bacterial colonisers and represents an opportunity to beneficially manipulate the intestinal microbiome. Differences in the ability of probiotic strains to colonise the gut may be related to the variously diversified gut microbiome. We report the results of the association between composition of the gut microbiome and the colonisation capacity of the probiotic strain Escherichia coli A0 34/86 (CNB - Colinfant New Born supplement) in the cases of three healthy children in different development stages (infant, toddler, and pre-school), as a preliminary insight to possible future prospective studies of this subject...
January 23, 2024: Beneficial Microbes
S M M Grande, E Argañaraz Martı Nez, J D Babot, E Andrada, M Quiroga, M Garro, F Saguir, A Perez Chaia
Species diversity of the Bifidobacterium genus was scarcely explored in different rearing systems of poultry. The aim of the study was to isolate intestinal species and compare their physiological and traits for adaptation to the avian intestinal niche. Fourteen strains isolated from chickens of intensive rearing farms and free-range hens, were identified by 16S rDNA sequencing, rep-PCR fingerprinting, and carbohydrates fermentation. Strains belonged to species Bifidobacterium pseudolongum subsp. pseudolongum and subsp...
January 23, 2024: Beneficial Microbes
C Chang, M Zong, Y Teng, X Zeng, Y Guo, D Pan, T Zhang, Z Wu
The health benefits of probiotics in the body are predicated on their ability to remain viable in harsh gastrointestinal conditions and complex pathological microenvironments. Casein and gum Arabic (GA), with dual emulsifying and stabilising effects in colloidal systems. Therefore, the objective of this research was to develop a novel microcapsule to encapsulate Lactiplantibacillus plantarum A3 using casein and GA as wall materials to improve the survival of the bacteria during gastrointestinal digestion, storage and lyophilization...
January 23, 2024: Beneficial Microbes
M Casertano, C Fryganas, V Valentino, A D Troise, P Vitaglione, V Fogliano, D Ercolini
The objective of this study was to evaluate the influence of a probiotic formula on the production of neuroactive compounds in different parts of the colon in batch culture and in vitro gut simulator experiments. Thirteen lactic acid bacterial strains, belonging to the species Levilactobacillus brevis, Lactiplantibacillus plantarum, Lacticaseibacillus paracasei, Ligilactobacillus salivarius, Streptococcus thermophilus, were characterised for their in vitro ability to produce neurotransmitters. L. brevis P30021 and L...
January 4, 2024: Beneficial Microbes
M Vajagathali, E Hannah, K Abirami, M Tharanya, J G Jackson, R Karthik, S G Aaron, M Shanmugaraja
Neurotoxicity is caused by damage to the brain tissue by neurotoxic agents present in the environment and artificial substances produced by human beings. Acrylamide (ACR) is one such chemical substance that causes neurotoxicity, affecting the brain cells. This neurotoxicity causes damage to the sensory and metabolic functions. The current research investigates the favourable effect of probiotic EcN (Escherichia coli Nissle 1917) on ACR-induced neurotoxicity in zebrafish. The protective role of EcN against ACR induced toxicity was assessed based on behaviour, biochemical, and gene expression analysis...
December 22, 2023: Beneficial Microbes
F H P Tan, S Shamsuddin, A Zainuddin
The steady decline of physiological function and increased vulnerability to age-related disorders are two features of the complicated biological process of ageing. As a key organ for nutrient absorption, metabolism, and immunological regulation, the gut plays a major part in the ageing process. Drosophila melanogaster, a well-established model organism, has emerged as a significant tool for exploring the intricate rapport between the gut and ageing. Through the use of Drosophila models, the physiological and molecular elements of the gut-brain axis have been thoroughly explored...
December 13, 2023: Beneficial Microbes
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