RanPiao Gan, YuanQiao Zhao, GuiSen Wu, JiaHui Zeng, YeGang Hu, LiHua Xu, YanYan Wei, XiaoChen Tang, XiaoHua Liu, HaiChun Liu, Tao Chen, JiJun Wang, TianHong Zhang
INTRODUCTION: Impaired sensitivity of the skin flush response to niacin is found in approximately 30% of patients with schizophrenia. Although the niacin response abnormality (NRA) may serve as a useful endophenotype for schizophrenia, few studies have directly replicated NRA in patients with first-episode psychosis (FEP). METHODS: In total, 204 patients with FEP, 16 with psychotic mood disorder (PMD), and 68 healthy controls (HC) were included. The log10 (EC50 ) values represent the concentration of methyl nicotinate required to elicit a half-maximal blood flow (MBF) response, and the MBF value was calculated...
June 2, 2022: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists