Sergi Clotet-Freixas, Olga Zaslaver, Max Kotlyar, Chiara Pastrello, Andrew T Quaile, Caitriona M McEvoy, Aninda D Saha, Sofia Farkona, Alex Boshart, Katarina Zorcic, Slaghaniya Neupane, Kieran Manion, Maya Allen, Michael Chan, Xuqi Chen, Arthur P Arnold, Peggy Sekula, Inga Steinbrenner, Anna Köttgen, Allison B Dart, Brandy Wicklow, Jon M McGavock, Tom D Blydt-Hansen, Clara Barrios, Marta Riera, María José Soler, Amandine Isenbrandt, Jérôme Lamontagne-Proulx, Solène Pradeloux, Katherine Coulombe, Denis Soulet, Shravanthi Rajasekar, Boyang Zhang, Rohan John, Aman Mehrotra, Adam Gehring, Maija Puhka, Igor Jurisica, Minna Woo, James W Scholey, Hannes Röst, Ana Konvalinka
Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and progresses faster in males than in females. We identify sex-based differences in kidney metabolism and in the blood metabolome of male and female individuals with diabetes. Primary human proximal tubular epithelial cells (PTECs) from healthy males displayed increased mitochondrial respiration, oxidative stress, apoptosis, and greater injury when exposed to high glucose compared with PTECs from healthy females. Male human PTECs showed increased glucose and glutamine fluxes to the TCA cycle, whereas female human PTECs showed increased pyruvate content...
March 6, 2024: Science Translational Medicine