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Chinese Journal of Natural Medicines

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https://read.qxmd.com/read/30910060/quantification-of-panax-notoginseng-saponins-metabolites-in-rat-plasma-with-in-vivo-gut-microbiota-mediated-biotransformation-by-hplc-ms-ms
#1
Yin-Ping Guo, Man-Yun Chen, Li Shao, Wei Zhang, Tai Rao, Hong-Hao Zhou, Wei-Hua Huang
Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo germ-free rat models were constructed by using broad-spectrum antibiotics to validate the gut microbiota-mediated transformation of PNS in vivo. Moreover, a high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was developed for quantitative analysis of four metabolites of PNS, including ginsenoside F1 (GF1), ginsenoside Rh2 (GRh2), ginsenoside compound K (GCK) and protopanaxatriol (PPT)...
March 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30910059/two-new-nimbolinin-and-trichilin-class-limonoids-isolated-from-the-fruits-of-melia-azedarach
#2
Lu Qiu, Li Heng, Rong Xu, Jun Luo, Yi Li
Two new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC50 being 37.41 μmol·L-1 .
March 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30910058/lower-clearance-of-sodium-tanshinone-iia-sulfonate-in-coronary-heart-disease-patients-and-the-effect-of-total-bilirubin-a-population-pharmacokinetics-analysis
#3
Wei-Wei Qin, Li Wang, Zheng Jiao, Bin Wang, Cheng-Yu Wang, Li-Xuan Qian, Wei-Lin Qi, Ming-Kang Zhong
This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check...
March 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30910057/two-natural-molecules-preferentially-inhibit-azole-resistant-candida-albicans-with-mdr1-hyperactivation
#4
Hong-Zhuo Shi, Wen-Qiang Chang, Ming Zhang, Hong-Xiang Lou
Antifungal drug resistance is a significant clinical problem, and antifungal agents that can evade resistance are urgently needed. In infective niches, resistant organisms often co-existed with sensitive ones, or a subpopulation of antibiotic-susceptible organisms may evolve into resistant ones during antibiotic treatment and eventually dominate the whole population. In this study, we established a co-culture assay in which an azole-resistant Candida albicans strain was mixed with a susceptible strain labeled with green fluorescent protein to mimic in vivo conditions and screen for antifungal drugs...
March 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30910056/the-zuo-jin-wan-formula-increases-chemosensitivity-of-human-primary-gastric-cancer-cells-by-akt-mediated-mitochondrial-translocation-of-cofilin-1
#5
Meng-Yao Sun, Dan-Dan Wang, Jian Sun, Xiao-Hua Zhao, Si Cai, Qiu-Xue Wu, Tao Jie, Zhen-Hua Ni, Jian-Yue Sun, Qing-Feng Tang
Resistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still difficult highly recapitulate the important molecular events in vivo, primary GC cells model derived from clinical patient was constructed in the present study to further evaluate the effect of ZJW and the underlying molecular mechanism...
March 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30910055/houttuynia-cordata-polysaccharide-alleviated-intestinal-injury-and-modulated-intestinal-microbiota-in-h1n1-virus-infected-mice
#6
Mei-Yu Chen, Hong Li, Xiao-Xiao Lu, Li-Jun Ling, Hong-Bo Weng, Wei Sun, Dao-Feng Chen, Yun-Yi Zhang
Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg-1 (d-1 . H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine...
March 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30910054/non-volatile-constituents-and-pharmacology-of-chimonanthus-a-review
#7
REVIEW
Ren-Geng Shu, Yi-Li Wan, Xiao-Min Wang
Chimonanthus plants widely distributed in southern area of China, which have a long history of edibles and medicine. Phytochemical investigations have shown that Chimonanthus produced 143 non-volatile constituents, including alkaloids, flavonoids, terpenoids, coumarins and others, which exhibit significant anti-oxidant, anti-bacterial, anti-cancer, anti-inflammatory, antihyperglycemic, antihyperlipidemic and other biological activities. On the basis of systematic reviewing of literatures, this article overviews the non-volatile constituents and pharmacology of Chimonanthus from domestic and foreign over the last 30 years (until June 2018), and may provide a useful reference for the further development of Chimonanthus...
March 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30797423/progress-in-active-compounds-effective-on-ulcerative-colitis-from-chinese-medicines
#8
Si-Yu Cao, Sheng-Jie Ye, Wei-Wei Wang, Bing Wang, Tong Zhang, Yi-Qiong Pu
Ulcerative colitis (UC), a chronic inflammatory disease affecting the colon, has a rising incidence worldwide. The known pathogenesis is multifactorial and involves genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Nowadays, the drugs for UC include 5-aminosalicylic acid, steroids, and immunosuppressants. Long-term use of these drugs, however, may cause several side effects, such as hepatic and renal toxicity, drug resistance and allergic reactions...
February 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30797422/romipeptides-a-and-b-two-new-romidepsin-derivatives-isolated-from-chromobacterium-violaceum-no-968-and-their-antitumor-activities-in-vitro
#9
Lei Xiong, Chang-Fa Chen, Tao-Ling Min, Hai-Feng Hu
Romipeptides A and B (1 and 2), two new romidepsin derivatives, and three known compounds, chromopeptide A (3), romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No. 968. Their structures were elucidated by interpretation of their UV, HR-ESI-MS and NMR spectra. The absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction analysis. Compounds 1-5 were evaluated for their anti-proliferative activities against three human cancer cell lines, SW620, HL60, and A549...
February 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30797421/peptides-and-polyketides-isolated-from-the-marine-sponge-derived-fungus-aspergillus-terreus-scsio-41008
#10
Xiao-Wei Luo, Yun Lin, Yong-Jun Lu, Xue-Feng Zhou, Yong-Hong Liu
Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 being 5...
February 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30797420/two-symmetrical-unsaturated-acids-isolated-from-viscum-album
#11
Duo Cao, Li-Qing Wang, Xiao-Min Han, Hui-Rui Guan, Meng Lei, Ya-Hui Wei, Liang Cheng, Pei-Ming Yang, Zheng-Liang Sun, Wen Gao, Jia-Kun Dai
In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1...
February 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30797419/transcriptomic-analysis-in-anemone-flaccida-rhizomes-reveals-ancillary-pathway-for-triterpene-saponins-biosynthesis-and-differential-responsiveness-to-phytohormones
#12
Guo-Yan Mo, Fang Huang, Yin Fang, Lin-Tao Han, Kayla K Pennerman, Li-Jing Bu, Xiao-Wei DU, Joan W Bennett, Guo-Hua Yin
Anemone flaccida Fr. Schmidt is a perennial medicinal herb that contains pentacyclic triterpenoid saponins as the major bioactive constituents. In China, the rhizomes are used as treatments for a variety of ailments including arthritis. However, yields of the saponins are low, and little is known about the plant's genetic background or phytohormonal responsiveness. Using one-quarter of the 454 pyrosequencing information from the Roche GS FLX Titanium platform, we performed a transcriptomic analysis to identify 157 genes putatively encoding 26 enzymes involved in the synthesis of the bioactive compounds...
February 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30797418/hesperetin-derivative-12-hdnd-12-regulates-macrophage-polarization-by-modulating-jak2-stat3-signaling-pathway
#13
Ling-Na Kong, Xiang Lin, Cheng Huang, Tao-Tao Ma, Xiao-Ming Meng, Chao-Jie Hu, Qian-Qian Wang, Yan-Hui Liu, Qing-Ping Shi, Jun Li
Macrophages show significant heterogeneity in function and phenotype, which could shift into different populations of cells in response to exposure to various micro-environmental signals. These changes, also termed as macrophage polarization, of which play an important role in the pathogenesis of many diseases. Numerous studies have proved that Hesperidin (HDN), a traditional Chinese medicine, extracted from fruit peels of the genus citrus, play key roles in anti-inflammation, anti-tumor, anti-oxidant and so on...
February 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30797417/characteristics-of-the-traditional-liu-wei-di-huang-prescription-reassessed-in-modern-pharmacology
#14
Xiao-Rui Cheng, Chun-Hui Qi, Tong-Xing Wang, Wen-Xia Zhou, Yong-Xiang Zhang
Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases...
February 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30704625/danshen-a-phytochemical-and-pharmacological-overview
#15
Xiao-Dan MEIm, Yan-Feng Cao, Yan-Yun Che, Jing Li, Zhan-Peng Shang, Wen-Jing Zhao, Yan-Jiang Qiao, Jia-Yu Zhang
Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic diterpenoids, water-soluble phenolic acids, and other constituents, which have showed various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-tumor, anti-atherogenesis, and anti-diabetes...
January 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30704624/potential-protective-effects-of-red-yeast-rice-in-endothelial-function-against-atherosclerotic-cardiovascular-disease
#16
Shu-Jun Feng, Zhi-Han Tang, Ying Wang, Xin-Ying Tang, Tao-Hua Li, Wei Tang, Ze-Min Kuang
Atherosclerotic cardiovascular disease (ASCVD) is the deadliest disease in the world, with endothelial injury occurring throughout the course of the disease. Therefore, improvement in endothelial function is of essential importance in the prevention of ASCVD. Red yeast rice (RYR), a healthy traditional Chinese food, has a lipid modulation function and also plays a vital role in the improvement of endothelial reactivity and cardiovascular protection; thus, it is significant in the prevention and treatment of ASCVD...
January 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30704623/anti-cancer-activities-of-s-allylmercaptocysteine-from-aged-garlic
#17
Yi Lv, Kwok-Fai So, Nai-Kei Wong, Jia Xiao
While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine (SAMC)...
January 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30704622/secondary-metabolites-of-petri-dish-cultured-antrodia-camphorata-and-their-hepatoprotective-activities-against-alcohol-induced-liver-injury-in-mice
#18
Yu Wu, Wen-Jing Tian, Shuo Gao, Zu-Jian Liao, Guang-Hui Wang, Jir-Mehng Lo, Pei-Hsin Lin, De-Quan Zeng, Da-Ren Qiu, Xiang-Zhong Liu, Mi Zhou, Ting Lin, Hai-Feng Chen
Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata (PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A...
January 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30704621/an-insoluble-polysaccharide-from-the-sclerotium-of-poria-cocos-improves-hyperglycemia-hyperlipidemia-and-hepatic-steatosis-in-ob-ob-mice-via-modulation-of-gut-microbiota
#19
Shan-Shan Sun, Kai Wang, Ke Ma, Li Bao, Hong-Wei Liu
Metabolic syndrome characterized by obesity, hyperglycemia and liver steatosis is becoming prevalent all over the world. Herein, a water insoluble polysaccharide (WIP) was isolated and identified from the sclerotium of Poria cocos, a widely used Traditional Chinese Medicine. WIP was confirmed to be a (1-3)-β-D-glucan with an average Mw of 4.486 × 106 Da by NMR and SEC-RI-MALLS analyses. Furthermore, oral treatment with WIP from P. cocos significantly improved glucose and lipid metabolism and alleviated hepatic steatosis in ob/ob mice...
January 2019: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30704620/two-new-ursane-type-nortriterpenes-from-lonicera-macranthoides-and-their-inos-inhibitory-activities
#20
Yu-Dan Mei, Nan Zhang, Wei-Yang Zhang, Jin-Shan Tang, Hua Zhou, Yang Yu, Xin-Sheng Yao
The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data...
January 2019: Chinese Journal of Natural Medicines
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