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Journals International Journal of Oral ...

International Journal of Oral Science

https://read.qxmd.com/read/38311610/cd97-inhibits-osteoclast-differentiation-via-rap1a-erk-pathway-under-compression
#21
JOURNAL ARTICLE
Wen Wang, Qian Wang, Shiying Sun, Pengfei Zhang, Yuyu Li, Weimin Lin, Qiwen Li, Xiao Zhang, Zhe Ma, Haiyan Lu
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force sensing. However, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages...
February 4, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38302479/expert-consensus-on-odontogenic-maxillary-sinusitis-multi-disciplinary-treatment
#22
REVIEW
Jiang Lin, Chengshuo Wang, Xiangdong Wang, Faming Chen, Wei Zhang, Hongchen Sun, Fuhua Yan, Yaping Pan, Dongdong Zhu, Qintai Yang, Shaohua Ge, Yao Sun, Kuiji Wang, Yuan Zhang, Mu Xian, Ming Zheng, Anchun Mo, Xin Xu, Hanguo Wang, Xuedong Zhou, Luo Zhang
Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS...
February 1, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38296940/magnesium-promotes-vascularization-and-osseointegration-in-diabetic-states
#23
JOURNAL ARTICLE
Linfeng Liu, Feiyu Wang, Wei Song, Danting Zhang, Weimin Lin, Qi Yin, Qian Wang, Hanwen Li, Quan Yuan, Shiwen Zhang
Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis...
January 31, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38287007/spatial-transcriptomics-reveals-that-metabolic-characteristics-define-the-tumor-immunosuppression-microenvironment-via-icaf-transformation-in-oral-squamous-cell-carcinoma
#24
JOURNAL ARTICLE
Zheqi Liu, Zhen Zhang, Yu Zhang, Wenkai Zhou, Xu Zhang, Canbang Peng, Tong Ji, Xin Zou, Zhiyuan Zhang, Zhenhu Ren
Tumor progression is closely related to tumor tissue metabolism and reshaping of the microenvironment. Oral squamous cell carcinoma (OSCC), a representative hypoxic tumor, has a heterogeneous internal metabolic environment. To clarify the relationship between different metabolic regions and the tumor immune microenvironment (TME) in OSCC, Single cell (SC) and spatial transcriptomics (ST) sequencing of OSCC tissues were performed. The proportion of TME in the ST data was obtained through SPOTlight deconvolution using SC and GSE103322 data...
January 30, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38272860/publisher-correction-nitrate-reduction-capacity-of-the-oral-microbiota-is-impaired-in-periodontitis-potential-implications-for-systemic-nitric-oxide-availability
#25
Bob T Rosier, William Johnston, Miguel Carda-Diéguez, Annabel Simpson, Elena Cabello-Yeves, Krystyna Piela, Robert Reilly, Alejandro Artacho, Chris Easton, Mia Burleigh, Shauna Culshaw, Alex Mira
No abstract text is available yet for this article.
January 26, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38246919/wnt7a-promotes-tumorigenesis-of-head-and-neck-squamous-cell-carcinoma-via-activating-fzd7-jak1-stat3-signaling
#26
JOURNAL ARTICLE
Qingling Huang, Yi Xiao, Ting Lan, Youguang Lu, Li Huang, Dali Zheng
Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry...
January 22, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38246918/rnps1-stabilizes-nat10-protein-to-facilitate-translation-in-cancer-via-trna-ac-4-c-modification
#27
JOURNAL ARTICLE
Xiaochen Wang, Rongsong Ling, Yurong Peng, Weiqiong Qiu, Demeng Chen
Existing studies have underscored the pivotal role of N-acetyltransferase 10 (NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squamous cell carcinoma (HNSCC) remain unexplored. In this study, we identified a significant upregulation of RNA-binding protein with serine-rich domain 1 (RNPS1) in HNSCC, where RNPS1 inhibits the ubiquitination degradation of NAT10 by E3 ubiquitin ligase, zinc finger SWIM domain-containing protein 6 (ZSWIM6), through direct protein interaction, thereby promoting high NAT10 expression in HNSCC...
January 22, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38238300/sema3a-secreted-by-sensory-nerve-induces-bone-formation-under-mechanical-loads
#28
JOURNAL ARTICLE
Hongxiang Mei, Zhengzheng Li, Qinyi Lv, Xingjian Li, Yumeng Wu, Qingchen Feng, Zhishen Jiang, Yimei Zhou, Yule Zheng, Ziqi Gao, Jiawei Zhou, Chen Jiang, Shishu Huang, Juan Li
Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed by sensory nerves, in mechanical loads-induced bone formation and nerve withdrawal using orthodontic tooth movement (OTM) model. Firstly, bone formation was activated after the 3rd day of OTM, coinciding with a decrease in sensory nerves and an increase in pain threshold. Sema3A, rather than nerve growth factor (NGF), highly expressed in both trigeminal ganglion and the axons of periodontal ligament following the 3rd day of OTM...
January 19, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38221571/emerging-roles-of-exosomes-in-oral-diseases-progression
#29
REVIEW
Jiayi Wang, Junjun Jing, Chenchen Zhou, Yi Fan
Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine. Exosomes, which are characterized as nanometer-sized extracellular vesicles, are secreted by virtually all types of cells...
January 15, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38221531/force-induced-caspase-1-dependent-pyroptosis-regulates-orthodontic-tooth-movement
#30
JOURNAL ARTICLE
Liyuan Chen, Huajie Yu, Zixin Li, Yu Wang, Shanshan Jin, Min Yu, Lisha Zhu, Chengye Ding, Xiaolan Wu, Tianhao Wu, Chunlei Xun, Yanheng Zhou, Danqing He, Yan Liu
Pyroptosis, an inflammatory caspase-dependent programmed cell death, plays a vital role in maintaining tissue homeostasis and activating inflammatory responses. Orthodontic tooth movement (OTM) is an aseptic force-induced inflammatory bone remodeling process mediated by the activation of periodontal ligament (PDL) progenitor cells. However, whether and how force induces PDL progenitor cell pyroptosis, thereby influencing OTM and alveolar bone remodeling remains unknown. In this study, we found that mechanical force induced the expression of pyroptosis-related markers in rat OTM and alveolar bone remodeling process...
January 15, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38195684/omics-for-deciphering-oral-microecology
#31
REVIEW
Yongwang Lin, Xiaoyue Liang, Zhengyi Li, Tao Gong, Biao Ren, Yuqing Li, Xian Peng
The human oral microbiome harbors one of the most diverse microbial communities in the human body, playing critical roles in oral and systemic health. Recent technological innovations are propelling the characterization and manipulation of oral microbiota. High-throughput sequencing enables comprehensive taxonomic and functional profiling of oral microbiomes. New long-read platforms improve genome assembly from complex samples. Single-cell genomics provides insights into uncultured taxa. Advanced imaging modalities including fluorescence, mass spectrometry, and Raman spectroscopy have enabled the visualization of the spatial organization and interactions of oral microbes with increasing resolution...
January 9, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38177101/nitrate-reduction-capacity-of-the-oral-microbiota-is-impaired-in-periodontitis-potential-implications-for-systemic-nitric-oxide-availability
#32
JOURNAL ARTICLE
Bob T Rosier, William Johnston, Miguel Carda-Diéguez, Annabel Simpson, Elena Cabello-Yeves, Krystyna Piela, Robert Reilly, Alejandro Artacho, Chris Easton, Mia Burleigh, Shauna Culshaw, Alex Mira
The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity (NRC) and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota...
January 5, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38155153/neuroimaging-and-artificial-intelligence-for-assessment-of-chronic-painful-temporomandibular-disorders-a-comprehensive-review
#33
REVIEW
Mayank Shrivastava, Liang Ye
Chronic Painful Temporomandibular Disorders (TMD) are challenging to diagnose and manage due to their complexity and lack of understanding of brain mechanism. In the past few decades' neural mechanisms of pain regulation and perception have been clarified by neuroimaging research. Advances in the neuroimaging have bridged the gap between brain activity and the subjective experience of pain. Neuroimaging has also made strides toward separating the neural mechanisms underlying the chronic painful TMD. Recently, Artificial Intelligence (AI) is transforming various sectors by automating tasks that previously required humans' intelligence to complete...
December 28, 2023: International Journal of Oral Science
https://read.qxmd.com/read/38072973/oral-administration-of-bifidobacterium-breve-improves-anti-angiogenic-drugs-derived-oral-mucosal-wound-healing-impairment-via-upregulation-of-interleukin-10
#34
JOURNAL ARTICLE
Qingxiang Li, Yuke Li, Qiao Qiao, Ning Zhao, Yuanning Yang, Lin Wang, Yifei Wang, Chuanbin Guo, Yuxing Guo
Recent studies have suggested that long-term application of anti-angiogenic drugs may impair oral mucosal wound healing. This study investigated the effect of sunitinib on oral mucosal healing impairment in mice and the therapeutic potential of Bifidobacterium breve (B. breve). A mouse hard palate mucosal defect model was used to investigate the influence of sunitinib and/or zoledronate on wound healing. The volume and density of the bone under the mucosal defect were assessed by micro-computed tomography (micro-CT)...
December 11, 2023: International Journal of Oral Science
https://read.qxmd.com/read/38072943/differential-molecular-profiles-and-associated-functionalities-characterize-connective-tissue-grafts-obtained-at-different-locations-and-depths-in-the-human-palate
#35
JOURNAL ARTICLE
Maria B Asparuhova, Xiaoqing Song, Dominic Riedwyl, Geert van Geest, Dieter D Bosshardt, Anton Sculean
The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts (CTGs) obtained at different locations and depths in the human palate. Sixty-four CTGs belonging to anterior deep (AD), anterior superficial (AS), posterior deep (PD), and posterior superficial (PS) groups were subjected to RNA-Sequencing and their transcriptomes were analyzed computationally. Functional correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts (HPFs) extracted from the CTGs...
December 11, 2023: International Journal of Oral Science
https://read.qxmd.com/read/38062012/adult-dental-epithelial-stem-cell-derived-organoids-deposit-hydroxylapatite-biomineral
#36
JOURNAL ARTICLE
Hyun-Yi Kim, Victoria Cooley, Eun-Jung Kim, Shujin Li, Jong-Min Lee, Dina Sheyfer, Wenjun Liu, Ophir D Klein, Derk Joester, Han-Sung Jung
Ameloblasts are specialized cells derived from the dental epithelium that produce enamel, a hierarchically structured tissue comprised of highly elongated hydroxylapatite (OHAp) crystallites. The unique function of the epithelial cells synthesizing crystallites and assembling them in a mechanically robust structure is not fully elucidated yet, partly due to limitations with in vitro experimental models. Herein, we demonstrate the ability to generate mineralizing dental epithelial organoids (DEOs) from adult dental epithelial stem cells (aDESCs) isolated from mouse incisor tissues...
December 7, 2023: International Journal of Oral Science
https://read.qxmd.com/read/38052782/expert-consensus-on-digital-guided-therapy-for-endodontic-diseases
#37
REVIEW
Xi Wei, Yu Du, Xuedong Zhou, Lin Yue, Qing Yu, Benxiang Hou, Zhi Chen, Jingping Liang, Wenxia Chen, Lihong Qiu, Xiangya Huang, Liuyan Meng, Dingming Huang, Xiaoyan Wang, Yu Tian, Zisheng Tang, Qi Zhang, Leiying Miao, Jin Zhao, Deqin Yang, Jian Yang, Junqi Ling
Digital guided therapy (DGT) has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades. The concept of DGT for endodontic diseases is categorized into static guided endodontics (SGE), necessitating a meticulously designed template, and dynamic guided endodontics (DGE), which utilizes an optical triangulation tracking system. Based on cone-beam computed tomography (CBCT) images superimposed with or without oral scan (OS) data, a virtual template is crafted through software and subsequently translated into a 3-dimensional (3D) printing for SGE, while the system guides the drilling path with a real-time navigation in DGE...
December 6, 2023: International Journal of Oral Science
https://read.qxmd.com/read/38052774/dental-impact-of-anti-fibroblast-growth-factor-23-therapy-in-x-linked-hypophosphatemia
#38
JOURNAL ARTICLE
Elis J Lira Dos Santos, Kenta Nakajima, Julien Po, Ayako Hanai, Volha Zhukouskaya, Martin Biosse Duplan, Agnès Linglart, Takashi Shimada, Catherine Chaussain, Claire Bardet
Elevated fibroblast growth factor 23 (FGF23) in X-linked hypophosphatemia (XLH) results in rickets and phosphate wasting, manifesting by severe bone and dental abnormalities. Burosumab, a FGF23-neutralizing antibody, an alternative to conventional treatment (phosphorus and active vitamin D analogs), showed significant improvement in the long bone phenotype. Here, we examined whether FGF23 antibody (FGF23-mAb) also improved the dentoalveolar features associated with XLH. Four-week-old male Hyp mice were injected weekly with 4 or 16 mg·kg-1 of FGF23-mAb for 2 months and compared to wild-type (WT) and vehicle (PBS) treated Hyp mice (n = 3-7 mice)...
December 6, 2023: International Journal of Oral Science
https://read.qxmd.com/read/38040705/molecular-mechanisms-of-cellular-metabolic-homeostasis-in-stem-cells
#39
REVIEW
Xiaoyu Li, Ou Jiang, Songlin Wang
Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management...
December 1, 2023: International Journal of Oral Science
https://read.qxmd.com/read/38040672/mesenchymal-stem-cell-derived-apoptotic-bodies-alleviate-alveolar-bone-destruction-by-regulating-osteoclast-differentiation-and-function
#40
JOURNAL ARTICLE
Xiaoyan Li, Yiyang Jiang, Xu Liu, Jingfei Fu, Juan Du, Zhenhua Luo, Junji Xu, Ujjal Kumar Bhawal, Yi Liu, Lijia Guo
Periodontitis is caused by overactive osteoclast activity that results in the loss of periodontal supporting tissue and mesenchymal stem cells (MSCs) are essential for periodontal regeneration. However, the hypoxic periodontal microenvironment during periodontitis induces the apoptosis of MSCs. Apoptotic bodies (ABs) are the major product of apoptotic cells and have been attracting increased attention as potential mediators for periodontitis treatment, thus we investigated the effects of ABs derived from MSCs on periodontitis...
December 1, 2023: International Journal of Oral Science
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