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International Journal of Oral Science

Yuanjing Jiang, Shixian Zhang, Chuanqing Mao, Yongzhen Lai, Di Wu, Hu Zhao, Caiyu Liao, Weihui Chen
The Hedgehog (Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development. Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the critical period for Hh pathway antagonist-induced frontal bone hypoplasia, we examined patterns of dysmorphology caused by Hh signalling inhibition. Pregnant mice received a single oral administration of Hh signalling inhibitor GDC-0449 at 100 mg•kg- 1 or 150 mg•kg- 1 body weight at preselected time points between embryonic days (E)8...
February 20, 2019: International Journal of Oral Science
Sheng-Jie Cui, Yu Fu, Yan Liu, Xiao-Xing Kou, Jie-Ni Zhang, Ye-Hua Gan, Yan-Heng Zhou, Xue-Dong Wang
Collagen is the building component of temporomandibular joint (TMJ) discs and is often affected by inflammation in temporomandibular disorders. The macromechanical properties of collagen are deteriorated by chronic inflammation. However, the mechanism by which inflammation influences disc function remains unknown. The relationship between the ultrastructure and nanomechanical properties of collagen in inflamed discs should be clarified. Seven-week-old female Sprague-Dawley rats were randomly divided into two groups...
February 20, 2019: International Journal of Oral Science
Alexandra Stähli, Ceeneena Ubaidha Maheen, Franz Josef Strauss, Sigrun Eick, Anton Sculean, Reinhard Gruber
Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester (CAPE), which is a potent inducer of heme oxygenase 1 (HO1), is a central active component of propolis, and the application of propolis improves periodontal status in diabetic patients. Here, primary murine macrophages were exposed to CAPE. Target gene expression was assessed by whole-genome microarray, RT-PCR and Western blotting. The antioxidative and anti-inflammatory activities of CAPE were examined by exposure of the cells to hydrogen peroxide, saliva and periodontal pathogens...
February 20, 2019: International Journal of Oral Science
En Luo, Hanghang Liu, Qiucheng Zhao, Bing Shi, Qianming Chen
Rare diseases are usually genetic, chronic and incurable disorders with a relatively low incidence. Developments in the diagnosis and management of rare diseases have been relatively slow due to a lack of sufficient profit motivation and market to attract research by companies. However, due to the attention of government and society as well as economic development, rare diseases have been gradually become an increasing concern. As several dental-craniofacial manifestations are associated with rare diseases, we summarize them in this study to help dentists and oral maxillofacial surgeons provide an early diagnosis and subsequent management for patients with these rare diseases...
February 20, 2019: International Journal of Oral Science
Jiemei Zhai, Heyu Zhang, Jianyun Zhang, Ran Zhang, Yingying Hong, Jiafei Qu, Feng Chen, Tiejun Li
Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mutations (at ∼80%) are frequently detected in the epithelia of both NBCCS-related and sporadic OKCs, suggesting that PTCH1 inactivation might constitutively activate sonic hedgehog (SHH) signalling and play a major role in disease pathogenesis...
January 5, 2019: International Journal of Oral Science
Mirali Pandya, Thomas G H Diekwisch
Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals configured into decussating enamel rods. In recent years, multiple approaches have been introduced to generate or regenerate this highly attractive biomaterial characterized by great mechanical strength paired with relative resilience and tissue compatibility. In the present review, we discuss five pathways toward enamel tissue engineering, (i) enamel synthesis using physico-chemical means, (ii) protein matrix-guided enamel crystal growth, (iii) enamel surface remineralization, (iv) cell-based enamel engineering, and (v) biological enamel regeneration based on de novo induction of tooth morphogenesis...
January 5, 2019: International Journal of Oral Science
Yuichiro Kusuda, Yusuke Kondo, Yuta Miyagi, Takashi Munemasa, Yusuke Hori, Fumiko Aonuma, Shintaro Tsuka, Taro Mukaibo, Chihiro Masaki, Ryuji Hosokawa
Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gland function. This study aimed to evaluate the effects of dexamethasone on mouse submandibular gland function to gain insight into the mechanism of dexamethasone-induced salivary hypofunction. The muscarinic agonist carbachol (CCh) induced salivary secretion and was not affected by short-term dexamethasone treatment but was decreased following long-term dexamethasone administration...
January 3, 2019: International Journal of Oral Science
Yun Feng, Qian Li, Jiao Chen, Ping Yi, Xin Xu, Yaping Fan, Bomiao Cui, Yu Yu, Xiaoying Li, Yue Du, Qianming Chen, Lingling Zhang, Jingjing Jiang, Xuedong Zhou, Ping Zhang
Proteases are important molecules that are involved in many physiological and pathological processes of the human body, such as growth, apoptosis and metastasis cancer cells. They are potential targets in cancer diagnosis and biotherapy. In this study, we analyzed the salivary protease spectrum of patients with oral squamous cell carcinoma (OSCC), oral benign masses and chronic periodontitis, as well as that of health, using human protease array kits, enzyme-linked immunosorbent assay, western blot and immunofluorescence...
January 3, 2019: International Journal of Oral Science
Ruth Alvarez, Hye-Lim Lee, Christine Hong, Cun-Yu Wang
In the original version of this Article, Figure 1c was inadvertently assembled with a duplicate of Figure 1b. The correct image for Figure 1c, shown below, has been added in the HTML and PDF versions of the Article. This does not affect the conclusions of the study. We sincerely apologize for any inconvenience this may have caused our readers.
January 2, 2019: International Journal of Oral Science
Susan Yost, Philip Stashenko, Yoonhee Choi, Maria Kukuruzinska, Caroline A Genco, Andrew Salama, Ellen O Weinberg, Carolyn D Kramer, Jorge Frias-Lopez
Oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease...
November 12, 2018: International Journal of Oral Science
Helena Ritchie
Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator for dentin mineralization. DSP was first identified in 1981, yet its functional significance is still controversial. Historically, these two proteins were considered to be independently synthesized and secreted by dental pulp cells into the developing dentin matrix. However, with the identification of the DSP coding sequence in 1994, followed 2 years later by the finding that the PP coding sequence was located immediately downstream from the DSP sequence, it became immediately clear that DSP and PP proteins were derived from a single DSP-PP (i...
November 5, 2018: International Journal of Oral Science
Masaharu Noi, Ken-Ichi Mukaisho, Saori Yoshida, Shoko Murakami, Shinya Koshinuma, Takeshi Adachi, Yoshisato Machida, Masashi Yamori, Takahisa Nakayama, Gaku Yamamoto, Hiroyuki Sugihara
To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase (ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expressions were significantly higher in invasive squamous cell carcinoma than in carcinoma in situ. To investigate the roles of ERK and ezrin in cancer development, we used the non-woven silica fibre sheet CellbedTM with a structure resembling the loose connective tissue morphology in a novel 3D culture system...
October 22, 2018: International Journal of Oral Science
Soyoun Um, Joo-Hee Lee, Byoung-Moo Seo
Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by inflammation. Inflammatory conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells (DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed...
October 9, 2018: International Journal of Oral Science
Ting Lu, Meiyi Li, Xiangmin Xu, Jun Xiong, Cheng Huang, Xuelian Zhang, Aiqin Hu, Ling Peng, Decheng Cai, Leitao Zhang, Buling Wu, Fu Xiong
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta (AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. The hereditary dentin disorders comprise a variety of autosomal-dominant genetic symptoms characterized by abnormal dentin structure affecting either the primary or both the primary and secondary teeth...
September 3, 2018: International Journal of Oral Science
R Nicole Howie, Samuel Herberg, Emily Durham, Zachary Grey, Grace Bennfors, Mohammed Elsalanty, Amanda C LaRue, William D Hill, James J Cray
Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors (SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients' ability to heal after sustaining trauma...
September 3, 2018: International Journal of Oral Science
Yu Wang, Qian Li, Fuliang Liu, Shanshan Jin, Yimei Zhang, Ting Zhang, Yunyan Zhu, Yanheng Zhou
The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression, growth and differentiation, has been extensively investigated. However, metabolic regulation in mechanobiology remains largely unexplored. Here, we identified glucose transporter 1 (GLUT1)-the primary glucose transporter in various cells-as a novel mechanosensitive gene in orthodontic tooth movement (OTM). Using an in vivo rat OTM model, we demonstrated the specific induction of Glut1 proteins on the compressive side of a physically strained periodontal ligament...
August 15, 2018: International Journal of Oral Science
Xin Xu, Feng Chen, Zhengwei Huang, Lvyan Ma, Li Chen, Yaping Pan, Jian Xu, Syngcuk Kim, Denis Kinane, Hyun Koo, Xuedong Zhou
The "Biofilms, Microbiomes and Oral Diseases: Challenges and Future Perspectives" symposium jointly organized by Penn Dental Medicine and West China School of Stomatology was held on 30 September 2017 at Penn Wharton China Center (PWCC) in Beijing, China. The topics included the pathogenicity of oral biofilms, novel strategies for the control of biofilm-related diseases, oral microbiome and single-cell approaches, and the link between oral diseases and overall health. Researchers from a number of disciplines, representing institutions from China and Penn Dental Medicine, gathered to discuss advances in our understanding of biofilms, as well as future directions for the control of biofilm-related oral and systemic diseases...
August 15, 2018: International Journal of Oral Science
Xianghong Luan, Xiaofeng Zhou, Afsar Naqvi, Marybeth Francis, Deborah Foyle, Salvador Nares, Thomas G H Diekwisch
MicroRNAs (miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Previous human studies have highlighted some key miRNAs that are dysregulated in periodontitis patients...
August 6, 2018: International Journal of Oral Science
Yuri Song, Hee Sam Na, Eunjoo Park, Mi Hee Park, Hyun Ah Lee, Jin Chung
Streptococcus mutans (S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin (IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogens, and its synthesis, maturation, and secretion are tightly regulated by the activation of the inflammasome, an inflammatory signalling complex. This study examined the signalling mechanism of IL-1β secretion and the inflammasome pathway induced by S...
August 6, 2018: International Journal of Oral Science
Song Wu, Yinan Chen, Jinglu Zhang, Wenjing Chen, Sheng Shao, Huijie Shen, Ling Zhu, Ping Ye, Peter Svensson, Kelun Wang
Low-level laser therapy (LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals (12-33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group (LG) or a placebo group (PG) (1:1). The LG received LLLT (810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm-2 ) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points...
July 2, 2018: International Journal of Oral Science
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