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Journal of Diabetes

Ching Shan Wan, Sally Abell, Rosalie Aroni, Alison Nankervis, Jacqueline Boyle, Helena Teede
BACKGROUND: Gestational diabetes mellitus (GDM) prevalence is increasing worldwide. Ethnic differences in risk factors and perinatal outcomes are clinically important. Chinese women constitute around 10% of the world's population, and are an increasing migrant population, yet their prevalence, risk factors and outcomes of GDM are insufficiently explored. METHODS: A retrospective study of a large pregnancy dataset comparing GDM prevalence, risk factors and perinatal outcomes between immigrant ethnic Chinese women and Australian-born Caucasian women was conducted using logistic regression...
February 18, 2019: Journal of Diabetes
Chuhui Chen, Weimin Wang, Wen Zhou, Jiewen Jin, Wei Chen, Dalong Zhu, Yan Bi
BACKGROUND: Cardiovascular autonomic neuropathy (CAN) is a risk factor for arrhythmias and adverse cardiovascular events, but the relation between the severity of CAN progression and nocturnal arrhythmias needs to be furthermore clarified. The following study aims to evaluate the association between nocturnal arrhythmias and severity of CAN in patients with type 2 diabetes. METHODS: 219 type 2 diabetes patients were recruited from January 2017 to May 2018. Subjects were classified into no CAN (NCAN), early CAN (ECAN), definite CAN (DCAN) or advanced CAN (ACAN) according to cardiovascular autonomic reflex tests (CARTs)...
February 15, 2019: Journal of Diabetes
Xia Li, Jin Cheng, Gan Huang, Shuoming Luo, Zhiguang Zhou
OBJECTIVE: This study aimed to investigate the natural progression of beta cell function in Chinese autoimmune type 1 diabetic patients and clarify its possible influencing factors. METHODS: The natural progression of beta cell function of 325 newly diagnosed Chinese autoimmune T1D patients were assessed by fasting C-peptide (FCP) and postprandial C-peptide (PCP) levels. Beta cell function failure was defined by FCP<50 pmol/L and PCP<100 pmol/L, while preserved beta cell function was defined as FCP>200 pmol/L or PCP>400 pmol/L...
February 14, 2019: Journal of Diabetes
Yan Guo, Chao-Qian Liu, Guo-Ping Liu, Zhi-Ping Huang, Da-Jin Zou
BACKGROUND: Postoperative modulation of the gut microbiome has been suggested to contribute to the metabolic benefits after metabolic surgery; however, the mechanistic contributions of these metabolic benefits remain undefined. We previously reported that Roux-en-Y gastric bypass (RYGB) surgery in Zucker diabetic fatty (ZDF) rats increased the abundance of Proteobacteria/Gammaproteobacteria. However, theoretically, these Gram-negative bacteria may elevate lipopolysaccharide (LPS) levels...
February 3, 2019: Journal of Diabetes
Louise J Maple-Brown, Greta Lindenmayer, Federica Barzi, Cherie Whitbread, Christine Connors, Elizabeth Moore, Jaqueline Boyle, Marie Kirkwood, I-Lynn Lee, Danielle Longmore, Paula Van Dokkum, Mary Wicks, Michelle Dowden, Chrissie Inglis, Margaret Cotter, Renae Kirkham, Sumaria Corpus, Sridhar Chitturi, Sujatha Thomas, Kerin O'dea, Paul Zimmet, Jeremy Oats, Harold D McIntyre, Alex Brown, Jonathan E Shaw
BACKGROUND: In Australia's Northern Territory, Indigenous mothers account for 33% of births and have high rates of hyperglycaemia in pregnancy. Prevalence of type 2 diabetes in pregnancy is up to 10 times higher in Indigenous than non-Indigenous Australian mothers, and the use of metformin is common. We assessed birth outcomes in relation to metformin use during pregnancy from a clinical register. METHODS: Women with gestational diabetes (GDM), newly diagnosed diabetes in pregnancy (DIP), or pre-existing type 2 diabetes (T2DM) from 2012 to 2016 were included...
January 25, 2019: Journal of Diabetes
Rui Du, Xueyan Wu, Kui Peng, Lin Lin, Mian Li, Yu Xu, Min Xu, Yuhong Chen, Donghui Li, Jieli Lu, Yufang Bi, Weiqing Wang, Ning Guang
BACKGROUND: Serum apoB has been associated with increased risk of atherosclerotic cardiovascular diseases. But findings on the association between apoB and risk of metabolic syndrome (MetS) are inconsistent. The purpose of the study is to investigate the association between serum apoB and MetS risk in Chinese. METHODS: Baseline survey was conducted in a population-based cohort of 10,340 adults aged ≥40 years in Shanghai, China in 2010. A follow-up visit was conducted to assess incident diabetes in 2015...
January 16, 2019: Journal of Diabetes
Jia Li, Tong Li, Haibin Wang, Wenhua Yan, Yiming Mu
No abstract text is available yet for this article.
January 13, 2019: Journal of Diabetes
Ashu Rastogi, Abhishek Hajela, Mahesh Prakash, Niranjan Khandelwal, Rajender Kumar, Anish Bhattacharya, B R Mittal, Anil Bhansali, David G Armstrong
BACKGROUND: Charcot neuroarthropathy of foot is associated with demineralization of foot bones causing fractures and deformities. Currently, there is no consensus for the medical treatment of chronic charcot foot except for effective off-loading. As tarsal bones are predominantly trabecular, teriparatide may improve the foot bones' macroarchitecture in chronic charcot neuroarthropathy. METHODS: People with diabetes and chronic charcot neuroarthropathy were randomized to receive 20 mcg teriparatide, or placebo subcutaneous daily for 12 months...
January 10, 2019: Journal of Diabetes
Martin J Kurian, Peter J Rentzepis, Ann M Carracher, Kelly L Close
No abstract text is available yet for this article.
January 8, 2019: Journal of Diabetes
Wenjia Yang, Xiao Ling Cai, Haiya Wu, Linong Ji
BACKGROUND: Metformin is the first line therapy for patients with diabetes. However, it may lower vitamin B12 (B12) level which could have hematological or neurological implications. The current study aimed to perform meta-analyses of all available studies on associations between metformin use and B12 level, anemia and neuropathy in diabetic patients. METHODS: The PubMed, Web of Knowledge, Cochrane Library and Embase were searched to identify all relevant studies published in English prior to March 2018...
January 7, 2019: Journal of Diabetes
Neeraj Kumar, Narinder K Mehra, Uma Kanga, Gurvinder Kaur, Nikhil Tandon, Neihenuo Chuzho, Gunja Mishra, Shekhar C Neolia
BACKGROUND: Type 1 Diabetes (T1D) is a complex disease with the involvement of various susceptibility genes. Human Leukocyte Antigen (HLA) on chromosome 6p21 is the major susceptibility region. This study examined the genetic association of HLA genes with T1D. METHODS: The study recruited 259 T1D patients and 706 controls from North India. Genomic DNA was extracted from EDTA blood. HLA class I and II typing was carried out by polymerase chain reaction-sequence specific primers (PCR-SSP) and LiPA (Line Probe Assay)...
January 7, 2019: Journal of Diabetes
Shuying Li, Yaxing Hou, Xinxin Yan, Yuwen Wang, Chen Shi, Xiaoyan Wu, Huihuan Liu, Liwen Zhang, Xumei Zhang, Juan Liu, Ming Zhang, Qiang Zhang, Naijun Tang
BACKGROUND: The purpose of this study was to examine whether folate and vitamin B12 imbalance is associated with gestational diabetes mellitus (GDM) and to explore the interaction effects between B-vitamin imbalance and maternal risk factors for GDM. METHODS: A cross-sectional study with 406 participants was performed in a Chinese population. Serum folate, vitamin B12, and blood glucose levels were measured at 24 to 28 weeks' gestation during GDM screening. GDM was diagnosed according to the criteria of the International Association of Diabetes and Pregnancy Study Groups (fasting plasma glucose ≥ 5...
January 7, 2019: Journal of Diabetes
Cagatay Emir Onder, Koray Gursoy, Serife Mehlika Kuskonmaz, Ugur Kocer, Cavit Culha
No abstract text is available yet for this article.
January 2, 2019: Journal of Diabetes
Zachary Bloomgarden, Daniel Einhorn, Yehuda Handelsman, George Grunberger
No abstract text is available yet for this article.
January 2, 2019: Journal of Diabetes
Shumei Miao, Xiao Dong, Xin Zhang, Shenqi Jing, Xiaoliang Zhang, Tingyu Xu, Li Wang, Xianglin Du, Hua Xu, Yun Liu
BACKGROUND: Pioglitazone may have a protective effect on cardiovascular disease risk among type 2 diabetes patients but evidence from China is lacking. Our study aimed to investigate the association using massive electronic health records data from a Chinese cohort of type 2 diabetes patients. METHODS: All T2DM patients from the First Affiliated Hospital of Nanjing Medical University in China who were prescribed at least one oral antidiabetic drug and aged >=18 between July 1, 2005 and June 30, 2017 were eligible for the study (n=71,783)...
December 30, 2018: Journal of Diabetes
Junichi Okada, Eijiro Yamada, Yawara Niijima, Shuichi Okada, Masanobu Yamada
No abstract is available for this article. This article is protected by copyright. All rights reserved.
December 30, 2018: Journal of Diabetes
Omran Bakoush, Loay Lubbad, Carl M Öberg, Fayez Hammad
BACKGROUND: Following reversal of short periods of ureteral obstruction (UO), glomerular and tubular renal dysfunction recovers with time. Diabetes mellitus (DM) affects glomerular functions; thus, it is possible that the ability of diabetic kidneys to recover from UO is impaired. We investigated the impact of long-term DM on the recovery pattern of glomerular and tubular functions and the permeability function of glomerular filtration barrier (GFB) post-unilateral UO (UUO) reversal. METHODS: DM was induced in Wistar rats by intraperitoneal streptozotocin...
December 28, 2018: Journal of Diabetes
Qi You, DongMei He, GuoFang Shu, Bo Cao, YongQuan Xia, Yun Xing, Min Ni, JiFang Chen, ShuLi Shi, Harvest F Gu, Yu Liu, Jie Wu
BACKGROUND: The aims of this study were to investigate the association of formation of neutrophil extracellular traps (NETs) with gut leakage not only in type 1 diabetes (T1D) but also in type 2 diabetes (T2D). METHODS: A total of 105 subjects, including 56 T1D and 49 T2D, were involved in the study. Eight biomarkers of NETs formation and gut leakage, including Protein-arginine deiminase type 4 (PAD4), Neutrophil elastase (NE), Proteinase 3 (PR3), Complement 5a (C5a), Alpha-1-antitrypsin (AAT), Deoxyribonuclease I (DNase I), Zonulin and Lipopolysaccharide (LPS) in serum samples were measured with enzyme-linked immunosorbent assay (ELISA)...
December 28, 2018: Journal of Diabetes
Tali Zitman-Gal, Yael Einbinder, Meital Ohana, Aviva Katzav, Amany Kartawy, Sydney Benchetrit
BACKGROUND: Emerging evidence demonstrates the involvement of Janus kinase/signal transducer and transcription activator (JAK/STAT) proteins in the pathophysiology of diabetic kidney disease (DKD). The JAK/STAT pathway is involved in the inflammatory response and endothelial cell dysfunction observed in DKD. The GLP-1 analogue, liraglutide, is an effective treatment for type 2 diabetes mellitus, as it improved the inflammatory changes observed in experimental models of DKD. This study used db/db mice and endothelial cells (EC) to determine the effect of diabetic environment on the JAK-STAT pathway and to assess the potential effect of liraglutide in both models...
December 21, 2018: Journal of Diabetes
Jennifer Morone
BACKGROUND: The increasing incidence of Type 1 diabetes (T1D) in youth < 20 years old in the U.S. is a mounting public health concern. Specific sociodemographic characteristics-racial/ethnic minority, low SES, single parent home and underinsured-have been associated with increased risk for poor glycemic control and poor self-management in adolescents with T1D. METHODS: Sample demographic and cultural responsiveness methods in psychosocial and behavioral interventions focused on improving self-management and glycemic control in adolescents with T1D were systematically evaluated, to identify if studies were targeting these high risk groups...
December 18, 2018: Journal of Diabetes
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