Lin Yang, Yan Shen, Wenxiao Li, Bingbing Zha, Wenjun Xu, Heyuan Ding
BACKGROUND: Diabetic kidney disease (DKD) is the most frequent complication in patients with type 2 diabetes mellitus (T2DM). It causes a chronic and progressive decline in kidney function, and ultimately patients require renal replacement therapy. To date, an increasing number of clinical studies have been conducted to explore the potential and novel biomarkers, which can advance the diagnosis, estimate the prognosis, and optimize the therapeutic strategies at the early stage of DKD...
November 30, 2023: Journal of Diabetes
Yuying Yang, Jianmin Liu, Stavroula Kousteni
The skeleton is traditionally known for its structural support, organ protection, movement, and maintenance of mineral homeostasis. Over the last 10 years, bone has emerged as an endocrine organ with diverse physiological functions. The two key molecules in this context are fibroblast growth factor 23 (FGF23), secreted by osteocytes, and osteocalcin, a hormone produced by osteoblasts. FGF23 affects mineral homeostasis through its actions on the kidneys, and osteocalcin has beneficial effects in improving glucose homeostasis, muscle function, brain development, cognition, and male fertility...
November 30, 2023: Journal of Diabetes
Xiaoyu Chen, Qingquan Liu, Niyao Chen, Jiangxin Ma, Xiaohong Wu, Haibin Zhang, Liying Yu, Huibin Huang
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 diabetes mellitus (T2DM), which frequently results in disabling neuropathic pain and lower-limb amputation. The identification of noninvasive biomarkers for DPN may help early detection and individualized treatment of DPN. METHODS: In this study, we identified differentially expressed genes (DEGs) between DPN and the control based on blood-source (GSE95849) and tissue-source gene expression profiles (GSE143979) from the Gene Expression Omnibus (GEO) database using limma, edgeR, and DESeq2 approaches...
November 29, 2023: Journal of Diabetes
Minmin Wang, Jingyi Liu, Jia Wang, Yinzi Jin, Zhi-Jie Zheng
BACKGROUND: Tracheal, bronchus, and lung (TBL) cancer is the third most common and lethal type of cancer worldwide. Glucose metabolism disorders, as represented by high fasting plasma glucose (HFPG), increase the risk of development and worsen the prognosis of TBL cancer. This study aimed to evaluate the global disease burden of TBL cancer attributable to HFPG. METHODS: The TBL cancer burden attributable to HFPG was estimated based on a modeling strategy using the Global Burden of Disease Study 2019...
November 27, 2023: Journal of Diabetes
Lingyan Chen, Li Wu, Qian Li, Hui Ma, Ting Liu, Jing Li, Baisheng Pan, Yu Hu, Huandong Lin, Xin Gao
INTRODUCTION: Elevated urinary albumin-to-creatinine ratio (UACR) was associated with increased mortality in general population and diabetic patients. However, whether the association remains similar in the subjects with different status of glucose metabolism was unclear. Tthe optimal level of UACR in predicting mortality also remained unknown. This study aims to investigate the relationship between UACR with all-cause and cardiovascular mortality in population with different status of glucose metabolism and explore the predictive cutoff point of UACR...
November 20, 2023: Journal of Diabetes
Juliana N M Lui, Eric S H Lau, Aimin Yang, Hongjiang Wu, Amy Fu, Vanessa Lau, Kitman Loo, Theresa Yeung, Rebecca Yue, Ronald C W Ma, Alice P S Kong, Risa Ozaki, Andrea O Y Luk, Elaine Y K Chow, Juliana C N Chan
BACKGROUND: Patients with type 2 diabetes (T2D) are at high risk of developing multiple complications, affecting their health-related quality of life (HRQoL). Existing studies only considered impact of complication on HRQoL in the year of occurrence but not its residual impacts in subsequent years. We investigated temporal impacts of diabetes-related complications on HRQoL in a 12-year prospective cohort of ambulatory Chinese patients with T2D enrolled in the clinic-based Joint Asia Diabetes Evaluation (JADE) Register...
November 20, 2023: Journal of Diabetes
Yufang Liu, Sanbao Chai, Xiaomei Zhang
OBJECTIVE: To investigate the effects of metabolic associated fatty liver disease (MAFLD) on chronic kidney disease (CKD) and abnormal albuminuria and the interaction between MAFLD and diabetes on abnormal albuminuria. METHODS: Data of participants in the American 2017-2018 National Health and Nutrition Examination Survey were analyzed. Hepatic steatosis was defined as median controlled attenuation parameter ≥248 dB/m, which was measured by ultrasound transient elastography...
November 16, 2023: Journal of Diabetes
Joseph Henson, Melanie J Davies, Emer M Brady, Charlotte L Edwardson, Andrew P Hall, Kamlesh Khunti, Emma Redman, Alex V Rowlands, Jack Sargeant, Thomas Yates
Highlights Our analysis indicates a potential blunting effect of metformin and/or statin therapy on physical activity-induced associations with HbA1c. The benefit of daily physical activity on glycemic control in people with type 2 diabetes is potentially more apparent in those prescribed neither metformin nor statin therapy. As physical activity is rarely prescribed in isolation of other background medications used to manage type 2 diabetes, the results of this analysis may help to maximize interventions delivered through routine clinical care, while allowing for personalization in prescribed physical activity and pharmacotherapy...
November 14, 2023: Journal of Diabetes
Wenjing Dong, Shiju Yan, Han Chen, Jian Zhao, Zengqiang Zhang, Weijun Gu
BACKGROUND: With the increasing incidence of diabetes worldwide, patients diagnosed with diabetes has been getting younger. Previous studies have shown that high remnant cholesterol (RC) level leads to an increased risk of cardiovascular disease events. However, the relationship between RC levels and newly diagnosed early-onset type 2 diabetes mellitus (T2DM) is unknown. This study aimed to explore the association between RC and newly diagnosed early-onset T2DM. METHODS: A total of 606 patients newly diagnosed with early-onset T2DM and 619 gender-matched subjects with normal blood glucose levels were retrospectively enrolled in this study...
November 14, 2023: Journal of Diabetes
Marcelo Maia Pinheiro, Felipe Moura Maia Pinheiro
No abstract text is available yet for this article.
November 13, 2023: Journal of Diabetes
Fei Chen, Liping Yu, Shuo Xie, Zhaoqing Li, Ruifen Deng, Xian Jin, Yifan He, Zhaojun Yang, Yao Wang, Wenying Yang, Bo Zhang
BACKGROUND: This study investigated the effects of early-onset type 2 diabetes (EOD) vs late-onset type 2 diabetes (LOD) on nonfatal cardiovascular diseases (CVD) in China. METHODS: We conducted a cross-sectional survey of 46 239 participants from 14 provinces in China from 2007 to 2008, selecting 4949 participants with type 2 diabetes for analysis. Participants were categorized as EOD (<40 years) or LOD (≥40 years) based on age at diabetes diagnosis...
November 6, 2023: Journal of Diabetes
Chenye Jin, Yaxin Lai, Yongze Li, Di Teng, Wenying Yang, Weiping Teng, Zhongyan Shan
INTRODUCTION: To examine changes in the prevalence of diabetes and the control of risk factors for diabetes over 10 years among adults in China. METHODS: Two population-based cross-sectional surveys were used to obtain a nationally representative sample of adults aged 20 years and older in mainland China in 2007 (n = 46 239) and 2017 (n = 73 340). Changes in the prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and prediabetes, as diagnosed by the World Health Organization criteria, were assessed over time...
November 5, 2023: Journal of Diabetes
Zachary Bloomgarden
No abstract text is available yet for this article.
November 5, 2023: Journal of Diabetes
Liam Mc Morrow, Frauke Becker, Ruth L Coleman, Hertzel C Gerstein, Lars Rydén, Stefan Schöder, Alastair M Gray, Jose Leal, Rury R Holman
BACKGROUND: The Acarbose Cardiovascular Evaluation (ACE) trial (ISRCTN91899513) evaluated the alpha-glucosidase inhibitor acarbose, compared with placebo, in 6522 patients with coronary heart disease and impaired glucose tolerance in China and showed a reduced incidence of diabetes. We assessed the within-trial medical resource use and costs, and quality-adjusted life years (QALYs). METHODS: Resource use data were collected prospectively within the ACE trial. Hospitalizations, medications, and outpatient visits were valued using Chinese unit costs...
November 1, 2023: Journal of Diabetes
Qian Yi, Jing Wu, Yaojia Shen, Yunying Zhu, Yiyang Zhou, He Bai, Jiajun Hao, Peige Song
BACKGROUND: Evidence has shown that early-life famine exposure and obesity in adulthood are independently associated with the risk of type 2 diabetes mellitus (T2DM). However, few studies had revealed the combined effect of these risk factors. METHODS: Two sets of groups from the China Health and Retirement Longitudinal Study (CHARLS) were selected. The fetal-exposure group born in 1959-1961 from 2011 wave (N = 958) and nonexposure group born in 1963-1965 from 2015 wave (N = 1540) were selected as Comparison 1...
October 26, 2023: Journal of Diabetes
Xiangyang Liu, Wenjuan Yang, Jianrong Liu, Xinxi Huang, Yujie Fang, Jie Ming, Jingbo Lai, Jianfang Fu, Qiuhe Ji, Li Wang
BACKGROUND: To compare glycemic control in Chinese patients with type 2 diabetes mellitus (T2DM) whose blood glucose levels were inadequately controlled with oral antidiabetic drugs after beinaglutide alone or combined with insulin glargine (IGlar). METHODS: In this 16-week multicenter, randomized clinical trial, 68 participants randomly received beinaglutide or IGlar for 8 weeks, then the two drugs in combination for 8 weeks. The primary outcomes were the proportion of individuals achieving their glycemic target and the change in glucose variability as measured with a continuous glucose monitoring system from baseline to 8 and 16 weeks...
October 20, 2023: Journal of Diabetes
Ram Weiss
No abstract text is available yet for this article.
October 19, 2023: Journal of Diabetes
Takafumi Masuda, Naoto Katakami, Hirotaka Watanabe, Naohiro Taya, Kazuyuki Miyashita, Mitsuyoshi Takahara, Ken Kato, Akio Kuroda, Munehide Matsuhisa, Iichiro Shimomura
BACKGROUND: This study aimed to evaluate the changes in glycemic control and diabetic complications over time in Japanese patients with juvenile-onset type 1 diabetes mellitus and to clarify the factors associated with the progression of diabetic complications. METHODS: We tracked 129 patients with type 1 diabetes mellitus (21.8 ± 4.1 years old [mean ± SD] with a diabetes duration of 12.6 ± 5.7 years) for up to 19 years and analyzed data on glycated hemoglobin (HbA1c) and indicators related to the severity of diabetic complications (estimated glomerular filtration rate [eGFR], urinary albumin excretion rate [UAE], carotid intima-media thickness [CIMT], and brachial-ankle pulse wave velocity [baPWV]) using linear mixed model and decision tree analysis...
October 18, 2023: Journal of Diabetes
Zhiqiang Ning, Guoqiang Ai, Bo Chen, He Yao, Haixiang Cao, Desi Pan, Xianping Lu
BACKGROUND: To evaluate the glycemic control effects of vhiglitazar (carfloglitazar), a novel peroxisome proliferator-activated receptor pan-agonist, in patients with type 2 diabetes mellitus (T2DM) with metabolic syndrome (MetS) or insulin resistance (IR) using pooled data analysis of two phase III clinical trials. METHODS: Data were collected from two randomized phase III clinical trials in China, comparing chiglitazar to placebo or sitagliptin in T2DM patients...
October 18, 2023: Journal of Diabetes
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