journal
https://read.qxmd.com/read/38382942/monoclonal-antibody-therapy-for-alzheimer-s-disease-focusing-on-intracerebral-targets
#1
JOURNAL ARTICLE
Xiaolei Gu, Long Qi, Qing Qi, Jing Zhou, Song Chen, Ling Wang
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Due to the complexity of the disorder and the presence of the blood-brain barrier (BBB), its drug discovery and development are facing enormous challenges, especially after several failures of monoclonal antibody (mAb) trials. Nevertheless, the Food and Drug Administration's approval of the mAb aducanumab has ushered in a new day. As we better understand the disease's pathogenesis and identify novel intracerebral therapeutic targets, antibody-based therapies have advanced over the past few years...
February 21, 2024: Bioscience Trends
https://read.qxmd.com/read/38382930/neoadjuvant-therapies-in-resectable-hepatocellular-carcinoma-exploring-strategies-to-improve-prognosis
#2
JOURNAL ARTICLE
Ya-Nan Ma, Xuemei Jiang, Peipei Song, Wei Tang
Hepatocellular carcinoma (HCC), a challenging malignancy, often necessitates surgical intervention, notably liver resection. However, the high recurrence rate, reaching 70% within 5 years post-resection, significantly impacts patient outcomes. Neoadjuvant therapies aim to preoperatively address this challenge, reducing lesion size, improving surgical resection rates, deactivating potential micro-metastases, and ultimately lowering postoperative recurrence rates. This review concentrates on advances in research on and clinical use of neoadjuvant therapies for HCC, with particular attention to the use of immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)...
February 20, 2024: Bioscience Trends
https://read.qxmd.com/read/38382929/predictive-deep-learning-models-for-cognitive-risk-using-accessible-data
#3
JOURNAL ARTICLE
Kenji Karako
The early detection of mild cognitive impairment (MCI) is crucial to preventing the progression of dementia. However, it necessitates that patients voluntarily undergo cognitive function tests, which may be too late if symptoms are only recognized once they become apparent. Recent advances in deep learning have improved model performance, leading to applied research in various predictive problems. Studies attempting to estimate dementia and the risk of MCI based on readily available data are being conducted, with the hope of facilitating the early detection of MCI...
February 20, 2024: Bioscience Trends
https://read.qxmd.com/read/38325825/socioeconomic-disparities-in-education-placement-for-children-of-primary-school-age-with-autism-spectrum-disorder-in-china
#4
JOURNAL ARTICLE
Yanan Zhao, Rong Zhang, Xiaoying Zheng
Relatively little is known about education placements for children with autism spectrum disorder (ASD) in China. While disparities in ASD diagnoses and services for the population broadly are often documented, the presence and determinants of differences in the educational placement of ASD children are less studied and understood. By identifying who is likely to be in segregated settings, we can discern how to best support them and facilitate a possible transition to a less restrictive setting. This study describes four placements (regular schools, special schools, institutions, homes) and their influencing factors retrospectively in a large sample (n = 2,190) of Chinese primary school-aged children (6-12 years old)...
February 8, 2024: Bioscience Trends
https://read.qxmd.com/read/38325824/roadmap-for-ending-tb-in-china-by-2035-the-challenges-and-strategies
#5
JOURNAL ARTICLE
Qishun Feng, Guoliang Zhang, Liang Chen, Huizhong Wu, Yingzhou Yang, Qian Gao, Tetsuya Asakawa, Yanlin Zhao, Shuihua Lu, Lin Zhou, Hongzhou Lu
Tuberculosis (TB) is one of the top ten causes of death worldwide, taking the lives of over a million people annually. In addition to being a serious health issue, TB is also closely linked to eradicating poverty according to the Sustainable Development Goals (SDGs) of the United Nations (UN). All UN members have committed to ending the TB epidemic by 2030. China has one of the highest TB loads worldwide, ranking third in the world on many TB burden indices. The national strategy for TB control is aimed at creating a collaborative network and integrating TB treatment into the medical system...
February 8, 2024: Bioscience Trends
https://read.qxmd.com/read/38325823/effect-of-transcatheter-arterial-chemoembolization-combined-with-lenvatinib-plus-anti-pd-1-antibodies-in-patients-with-unresectable-hepatocellular-carcinoma-a-treatment-with-chinese-characteristics
#6
JOURNAL ARTICLE
Jiayi Wu, Junyi Wu, Shuqun Li, Mengchao Luo, Zhenxin Zeng, Yinan Li, Yangkai Fu, Han Li, Deyi Liu, Xiangye Ou, Zhongtai Lin, Shaoming Wei, Maolin Yan
Therapies for patients with unresectable hepatocellular carcinoma (uHCC) are currently popular. Current first-line standard-of-care treatments for uHCC are systematic therapies. However, treatments that combine locoregional therapy with systemic therapy are widely accepted in China and have demonstrated high rates of tumor response and conversion to resection with manageable toxicity. A literature review was performed by searching published literature in PubMed and Web of Science up to December 2023 for relevant articles on the use of triple therapy (transarterial chemoembolization combined with lenvatinib and anti-PD-1 antibodies) in uHCC...
February 8, 2024: Bioscience Trends
https://read.qxmd.com/read/38325822/new-mechanisms-from-lactate-to-lactylation-to-rescue-heart-failure
#7
JOURNAL ARTICLE
Linfeng Yi, Dan Tang, Xing Xiang, Chungang Xiao, Huifang Tang, Hong Huang
Lactylation of α-myosin heavy chain (α-MHC) has recently been reported to preserve sarcomeric structure and function and attenuate the development of heart failure. Specifically, lactylation enhanced the interaction of α-MHC with the sarcomeric protein Titin, thereby maintaining normal sarcomeric structure and myocardial contractile function. Furthermore, the administration of lactate or inhibition of lactate efflux potentially treats heart failure by restoring lactylation of α-MHC and the interaction of α-MHC with Titin...
February 8, 2024: Bioscience Trends
https://read.qxmd.com/read/38325821/diabetes-mellitus-glycemic-traits-sglt2-inhibition-and-risk-of-pulmonary-arterial-hypertension-a-mendelian-randomization-study
#8
JOURNAL ARTICLE
Jiang-Shan Tan, Yanmin Yang, Jingyang Wang, Yimeng Wang, Tingting Lv, Yuyuan Shu, Wei Xu, Lingtao Chong
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of gene expression and hemoglobin A1c...
February 8, 2024: Bioscience Trends
https://read.qxmd.com/read/38143081/an-update-on-diagnosis-and-treatment-of-hepatoblastoma
#9
JOURNAL ARTICLE
Yinbiao Cao, Shurui Wu, Haowen Tang
Hepatoblastoma (HB) remains the most common paediatric liver tumour and survival in children with hepatoblastoma has improved considerably since the advent of sequential surgical regimens of chemotherapy based on platinum-based chemotherapeutic agents in the 1980s. With the advent of modern diagnostic imaging and pathology techniques, new preoperative chemotherapy regimens and the maturation of surgical techniques, new diagnostic and treatment options for patients with hepatoblastoma have emerged and international collaborations are investigating the latest diagnostic approaches, chemotherapy drug combinations and surgical strategies...
December 23, 2023: Bioscience Trends
https://read.qxmd.com/read/38143080/conversion-therapy-for-initially-unresectable-hepatocellular-carcinoma-current-status-and-prospects
#10
JOURNAL ARTICLE
Ya-Nan Ma, Xuemei Jiang, Hui Liu, Peipei Song, Wei Tang
Research has shown that locoregional and/or systemic treatments can reduce the tumor stage, enabling radical surgical resection in patients with initially unresectable hepatocellular carcinoma. This is referred to as conversion therapy. Patients who undergo conversion therapy followed by curative surgery experience a significant survival benefit compared to those who receive chemotherapy alone, those who are successfully downstaged with conversion therapy but not treated with surgery, or those who are treated with upfront surgery...
December 23, 2023: Bioscience Trends
https://read.qxmd.com/read/38123336/risk-factors-for-postoperative-recurrence-of-pt2-3n0m0-esophageal-squamous-cell-carcinoma-and-patterns-of-its-recurrence
#11
JOURNAL ARTICLE
Li Niu, Bo Hu, Li Zhang, Mei Kang
This study aimed to explore the patterns of postoperative recurrence in patients with pT2-3N0M0 esophageal squamous cell carcinoma (ESCC) and to identify the risk factors for the recurrence. Patients with pT2-3N0M0 ESCC who were treated at our hospital from January 2010 to August 2019 were divided into three categories: those with anastomotic recurrence, those with lymph node recurrence, and those with hematogenous metastasis. The sites of initial recurrence and metastasis were counted and potential risk factors were analyzed using univariate and multivariate Cox proportional hazard regression...
December 20, 2023: Bioscience Trends
https://read.qxmd.com/read/38104979/the-effect-of-the-female-genital-tract-and-gut-microbiome-on-reproductive-dysfunction
#12
JOURNAL ARTICLE
Wenli Cao, Xiayan Fu, Jing Zhou, Qing Qi, Feijun Ye, Lisha Li, Ling Wang
Microorganisms are ubiquitous in the human body; they are present in various areas including the gut, mouth, skin, respiratory tract, and reproductive tract. The interaction between the microbiome and reproductive health has become an increasingly compelling area of study. Disruption of the female genital tract microbiome can significantly impact the metabolism of amino acids, carbohydrates, and lipids, increasing susceptibility to reproductive tract diseases such as vaginitis, chronic endometritis, endometrial polyps, endometriosis, and polycystic ovary syndrome...
December 17, 2023: Bioscience Trends
https://read.qxmd.com/read/38092390/feasibility-of-novel-intraoperative-navigation-for-anatomical-liver-resection-using-real-time-virtual-sonography-combined-with-indocyanine-green-fluorescent-imaging-technology
#13
JOURNAL ARTICLE
Changsheng Pu, Tiantian Wu, Qiang Wang, Yinmo Yang, Keming Zhang
To analyze the feasibility and clinical effect of novel intraoperative navigation of real-time virtual sonography (RVS) combined with indocyanine green (ICG) fluorescent imaging technology in anatomical liver resection (ALR) for hepatocellular carcinoma. The clinical data of 41 patients who underwent ALR using RVS intraoperative navigation combined with ICG fluorescent imaging technology in the Department of Hepatobiliary Surgery of Peking University International Hospital from January 2020 to May 2022 were retrospectively analyzed...
December 13, 2023: Bioscience Trends
https://read.qxmd.com/read/38072447/pal-power-demonstration-of-the-functional-association-of-the-helicobacter-pylori-flagellar-motor-with-peptidoglycan-associated-lipoprotein-pal-and-its-preliminary-crystallographic-analysis
#14
JOURNAL ARTICLE
Xiaotian Zhou, Mohammad M Rahman, Sharmin Q Bonny, Yue Xin, Nikki Liddelow, Mohammad F Khan, Alexandra Tikhomirova, Jihane Homman-Ludiye, Anna Roujeinikova
The bacterial flagellar motor is a molecular nanomachine, the assembly and regulation of which requires many accessory proteins. Their identity, structure and function are often discovered through characterisation of mutants with impaired motility. Here, we demonstrate the functional association of the Helicobacter pylori peptidoglycan-associated lipoprotein (HpPal) with the flagellar motor by analysing the motility phenotype of the ∆pal mutant, and present the results of the preliminary X-ray crystallographic analysis of its globular C-terminal domain HpPal-C...
December 8, 2023: Bioscience Trends
https://read.qxmd.com/read/38072446/development-of-a-novel-cholesterol-tag-based-system-for-trans-membrane-transport-of-protein-drugs
#15
JOURNAL ARTICLE
Pengfei Zhao, Shuo Song, Zhuojun He, Guiqin Dai, Deliang Liu, Jiayin Shen, Tetsuya Asakawa, Mingbin Zheng, Hongzhou Lu
The main technological difficulties of developing an intracellular (transmembrane) transport system for protein drugs lie in two points: i) overcoming the barriers in the cellular membrane, and ii) loading enough protein drugs, and particularly high-dose proteins, into particles. To address these two technological problems, we recently developed a novel cholesterol tag (C-Tag)-based transmembrane transport system. This pilot study found that the C-Tag dramatically improved the cellular uptake of Fab (902-fold, vs...
December 8, 2023: Bioscience Trends
https://read.qxmd.com/read/38072445/immunity-debt-hospitals-need-to-be-prepared-in-advance-for-multiple-respiratory-diseases-that-tend-to-co-occur
#16
JOURNAL ARTICLE
Ting Li, Cordia Chu, Biying Wei, Hongzhou Lu
As SARS-CoV-2 transitions from a pandemic to an endemic presence, a significant rise in respiratory diseases such as influenza and Mycoplasma pneumonia is challenging healthcare systems weakened by the impact of COVID-19. This commentary examines the global resurgence of respiratory pathogens, heightened by the post-pandemic "immunity debt", through an analysis of WHO surveillance data and national health reports. Findings reveal a substantial increase in respiratory illnesses, notably among children, compounded by a shortage of pediatricians and growing antimicrobial resistance...
December 8, 2023: Bioscience Trends
https://read.qxmd.com/read/37981319/the-immune-response-of-hepatocellular-carcinoma-after-locoregional-and-systemic-therapies-the-available-combination-option-for-immunotherapy
#17
JOURNAL ARTICLE
Yuxin Duan, Hua Zhang, Tao Tan, Wentao Ye, Kunli Yin, Yanxi Yu, Meiqing Kang, Jian Yang, Rui Liao
Hepatocellular carcinoma (HCC) is associated with a highly heterogeneous immune environment that produces an immune response to various locoregional treatments (LRTs), which in turn affects the effectiveness of immunotherapy. Although LRTs still dominate HCC therapies, 50-60% of patients will ultimately be treated with systemic therapies and might receive those treatments for the rest of their life. TACE, SIRT, and thermal ablation can dramatically increase the immunosuppressive state of HCC, a condition that can be addressed by combination with immunotherapy to restore the activity of lymphocytes and the secretion of cellular immune factors...
November 19, 2023: Bioscience Trends
https://read.qxmd.com/read/37866883/the-function-and-immune-role-of-cuproptosis-associated-hub-gene-in-barrett-s-esophagus-and-esophageal-adenocarcinoma
#18
JOURNAL ARTICLE
Kailin Lin, Ke Hu, Qiwen Chen, Jiangchun Wu
Barrett's esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EAC), with approximately 3-5% of patients developing EAC. Cuproptosis is a kind of programmed cell death phenomenon discovered in recent years, which is related to the occurrence and development of many diseases. However, its role in BE and EAC is not fully understood. We used single sample Gene Set Enrichment Analysis (ssGSEA) for differential analysis of BE in the database, followed by enrichment analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO) and GSEA, Protein-Protein Interaction (PPI), Weighted Gene Co-expression Network Analysis (WGCNA), Receiver Operating Characteristic Curve (ROC) and finally Quantitative Real Time Polymerase Chain Reaction (qRT-PCR) and immunohistochemistry (IHC) of clinical tissues...
October 21, 2023: Bioscience Trends
https://read.qxmd.com/read/37866882/sarcopenia-and-risk-of-cardio-cerebrovascular-disease-a-two-sample-mendelian-randomization-study
#19
JOURNAL ARTICLE
Qifeng Ou, Ding Pan
Based on the association between sarcopenia and the risk of developing cardio-cerebrovascular disease (CCVD) established by a meta-analysis by Fang et al.(Biosci Trends. 2023; 17:293-301), we have used Mendelian randomization (MR) analysis to test the authenticity and accuracy of such an association. In this MR study, appendicular lean mass, handgrip strength, and walking pace were used as sarcopenia-related traits, with cardiovascular diseases and stroke set as outcomes of CCVD. MR analysis was performed using inverse-variance weighting, the MR Egger, weighted median, simple mode, and weighted mode...
October 21, 2023: Bioscience Trends
https://read.qxmd.com/read/37839890/improving-the-accessibility-of-health-care-for-internal-migrants-in-china-achieving-the-aim-of-equalization
#20
JOURNAL ARTICLE
Dan Zhao, Chengchao Zhou
Although equitable access to healthcare is considered key to the health of internal migrants, more concerted efforts are needed to improve the accessibility of healthcare in low- and middle-income countries. The software CiteSpace was used to analyze scientific literature on healthcare utilization among internal migrants in China since 2000. We focused on factors influencing access to healthcare, including geographical, economic, sociocultural, and institutional aspects. The government is urged to play a role in ensuring equal access to healthcare through policies, resource distribution, and information technology...
October 14, 2023: Bioscience Trends
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