Korean Journal of Anesthesiology

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BACKGROUND: Among the various diaphragm-sparing alternatives to interscalene blocks, costoclavicular block (CCB) demonstrated a low hemidiaphragmatic paresis (HDP) occurrence but an inconsistent analgesic effect in arthroscopic shoulder surgery. We hypothesized that a larger volume of local anesthetic for CCB could provide sufficient analgesia by achieving sufficient supraclavicular spreading. METHODS: Sixty patients scheduled for arthroscopic rotator cuff repair were randomly assigned to receive CCB using one of two volumes of local anesthetic (CCB20, 0...

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Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that has been used for several decades to reduce blood loss during surgery and after trauma. TXA was traditionally used to reduce bleeding in various clinical settings such as menorrhagia, hemophilia, or other bleeding disorder . Numerous studies have demonstrated the efficacy of TXA in reducing blood loss and the need for transfusions. Interest in the potential applications of TXA beyond its traditional use has been growing recently, with studies investigating the use of TXA in postpartum hemorrhage, cardiac surgery, trauma, neurosurgery, and orthopedic surgery...

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No abstract text is available yet for this article.

BACKGROUND: Liver transplantation (LT) surgery increase the workload on the heart and vessels in patients with cirrhotic cardiomyopathy. While the interaction of the left ventricle (LV) with the arterial system (ventricular-arterial coupling, VAC) is a key determinant of cardiovascular performance, little has been known about the changes in VAC after LT. Therefore, we evaluated the relationship between the VAC after LT and cardiovascular outcomes. METHODS: A total of 344 consecutive patients received echocardiographic assessments before and within one month after LT...

BACKGROUND: We investigated the impacts of sevoflurane exposure on matrix metalloproteinase (MMP) expression, natural killer group 2, member D (NKG2D) ligands (UL16-binding proteins [ULBP] 1-3, and major histocompatibility complex class I chain-related molecules [MIC] A/B) expression and ablation, and natural killer (NK) cell-mediated cytotoxicity in breast cancer cells. METHODS: Three human breast cancer cell lines (MCF-7, MDA-MB-453, and HCC-70) were incubated with 0 (control), 600 (S6), or 1200 μM (S12) sevoflurane for 4 h...

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BACKGROUND: Laparoscopic and robotic prostatectomy allows a higher precision and a magnified view of the surgical field but it did not show to be characterized by a lower pain compared to open surgery so the management of postoperative pain still remains an important issue. METHODS: We enrolled 60 patients randomized in 1:1:1 ratio into three groups: group SUB: treated with a lumbar subarachnoid injection of 10.5 mg ropivacaine, 30 μg clonidine, 2 μg/kg morphine, and 0...

Background Although programmed intermittent epidural bolus (PIEB) is effective for labor analgesia, appropriate flow rate has not established. Thus, we investigated the analgesic effect according to the epidural injection flow rate. Methods Nulliparous women scheduled for spontaneous labor were enrolled in this randomized trial. After injection of intrathecal 0.2% ropivacaine 3 mg with fentanyl 20 mcg, participants were randomized to three study groups. Patient-controlled epidural analgesia at 10 mL/hour was given as follows (0...

BACKGROUND: A combination of opioids with adjunctive drugs can be used for intravenous patient-controlled analgesia (PCA) to minimize opioid-related side effects. Herein, we investigated whether two different analgesics administered separately via a dual-chamber PCA may have fewer side effects with adequate analgesia than single fentanyl PCA in gynecologic patients undergoing pelviscopic surgery. METHODS: This prospective, double-blinded, randomized and controlled study included 68 patients who underwent pelviscopic gynecological surgery...

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BACKGROUND: A precise anatomical understanding of the adductor canal (AC) and its neural components is essential for discerning the action mechanism of the AC block. We therefore aimed to clarify the detailed anatomy of the AC using micro-computed tomography (micro-CT), histological evaluation, and immunofluorescence (IF) assays. METHODS: Gross dissections of 39 thighs provided morphometric data relevant to injection landmarks. Serial sectional images of the AC were defined using micro-CT and ultrasonography...

BACKGROUND: We compared the effect of general anesthetics on postoperative quality of recovery between propofol-based total intravenous anesthesia (TIVA) and inhalation anesthesia. METHODS: In this randomized trial, 150 patients undergoing robot-assisted or laparoscopic nephrectomy for renal cancer were randomly allocated to either the TIVA or desflurane anesthesia (DES) group. Postoperative recovery was evaluated using the Korean version of the Quality of Recovery-15 questionnaire (QoR-15K) at 24 h, 48 h, and 72 h postoperatively...

BACKGROUND: Early postoperative neurocognitive disorders (ePND) include emergence delirium, defined as a very early onset postoperative delirium, and emergence agitation, defined as motor arousal. These ways of anesthesia emergence are poorly investigated although they are probably associated with unfavorable outcomes. This meta-analysis aimed to assess the impact of ePND on clinically relevant outcomes. METHODS: A systematic search of studies published over the past 20 years was carried out in Medline, PubMed, Google Scholar and Cochrane Library...

BACKGROUND: Acute kidney injury (AKI) is a serious pathology, causing dysfunction of urination and concentration due to damage to kidneys, resulting with blood pressure dysregulation and increased toxic metabolites. Dexpanthenol (DEX), a pantothenic acid analog, has anti-inflammatory and anti-apoptotic properties in various tissues. This study aimed to investigate the protective effects of DEX in systemic inflammation induced AKI. METHODS: Thirty-two female rats were randomly assigned as control, lipopolysaccharide (LPS), LPS+DEX and DEX groups...

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