journal
https://read.qxmd.com/read/38532004/clonal-haematopoiesis-and-aki
#21
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
March 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38532003/switching-off-sox9-for-epithelial-recovery-after-aki
#22
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
March 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38491222/drug-stewardship-in-chronic-kidney-disease-to-achieve-effective-and-safe-medication-use
#23
REVIEW
Rasheeda K Hall, Rümeyza Kazancıoğlu, Teerawat Thanachayanont, Germaine Wong, Dharshana Sabanayagam, Marisa Battistella, Sofia B Ahmed, Lesley A Inker, Erin F Barreto, Edouard L Fu, Catherine M Clase, Juan J Carrero
People living with chronic kidney disease (CKD) often experience multimorbidity and require polypharmacy. Kidney dysfunction can also alter the pharmacokinetics and pharmacodynamics of medications, which can modify their risks and benefits; the extent of these changes is not well understood for all situations or medications. The principle of drug stewardship is aimed at maximizing medication safety and effectiveness in a population of patients through a variety of processes including medication reconciliation, medication selection, dose adjustment, monitoring for effectiveness and safety, and discontinuation (deprescribing) when no longer necessary...
March 15, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38443711/role-of-biophysics-and-mechanobiology-in-podocyte-physiology
#24
REVIEW
Jonathan Haydak, Evren U Azeloglu
Podocytes form the backbone of the glomerular filtration barrier and are exposed to various mechanical forces throughout the lifetime of an individual. The highly dynamic biomechanical environment of the glomerular capillaries greatly influences the cell biology of podocytes and their pathophysiology. Throughout the past two decades, a holistic picture of podocyte cell biology has emerged, highlighting mechanobiological signalling pathways, cytoskeletal dynamics and cellular adhesion as key determinants of biomechanical resilience in podocytes...
March 5, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38443710/clinical-practice-recommendations-for-kidney-involvement-in-tuberous-sclerosis-complex-a-consensus-statement-by-the-erknet-working-group-for-autosomal-dominant-structural-kidney-disorders-and-the-era-genes-kidney-working-group
#25
REVIEW
Djalila Mekahli, Roman-Ulrich Müller, Matko Marlais, Tanja Wlodkowski, Stefanie Haeberle, Marta López de Argumedo, Carsten Bergmann, Luc Breysem, Carla Fladrowski, Elizabeth P Henske, Peter Janssens, François Jouret, John Christopher Kingswood, Jean-Baptiste Lattouf, Marc Lilien, Geert Maleux, Micaela Rozenberg, Stefan Siemer, Olivier Devuyst, Franz Schaefer, David J Kwiatkowski, Olivier Rouvière, John Bissler
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the presence of proliferative lesions throughout the body. Management of TSC is challenging because patients have a multifaceted systemic illness with prominent neurological and developmental impact as well as potentially severe kidney, heart and lung phenotypes; however, every organ system can be involved. Adequate care for patients with TSC requires a coordinated effort involving a multidisciplinary team of clinicians and support staff...
March 5, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38438536/innovating-dialysis-through-computational-modelling-of-hollow-fibre-haemodialysers
#26
JOURNAL ARTICLE
Ruhit Sinha, Michael V Rocco, Pirouz Daeihagh, Anne E Staples
No abstract text is available yet for this article.
March 4, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38424242/the-renal-glucagon-receptor-is-essential-to-kidney-metabolic-and-homeostatic-functions
#27
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
February 29, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38418898/a-caar-nk-cell-approach-to-eliminate-pathogenic-autoantibody-secreting-cells
#28
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
February 28, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409369/physiological-principles-underlying-the-kidney-targeting-of-renal-nanomedicines
#29
REVIEW
Yingyu Huang, Xuhui Ning, Samira Ahrari, Qi Cai, Nilum Rajora, Ramesh Saxena, Mengxiao Yu, Jie Zheng
Kidney disease affects more than 10% of the global population and is associated with considerable morbidity and mortality, highlighting a need for new therapeutic options. Engineered nanoparticles for the treatment of kidney diseases (renal nanomedicines) represent one such option, enabling the delivery of targeted therapeutics to specific regions of the kidney. Although they are underdeveloped compared with nanomedicines for diseases such as cancer, findings from preclinical studies suggest that renal nanomedicines may hold promise...
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409368/organ-trafficking-a-continuing-challenge
#30
JOURNAL ARTICLE
Thomas F Mueller, Sanjay Nagral
No abstract text is available yet for this article.
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409367/pericyte-stem-cell-crosstalk-in-ccrcc
#31
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409366/long-term-health-outcomes-associated-with-hydration-status
#32
REVIEW
Natalia I Dmitrieva, Manfred Boehm, Paul H Yancey, Sofia Enhörning
Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular and intracellular fluids. Water balance is maintained by multiple mechanisms that continuously match water losses through urine, the skin, the gastrointestinal tract and respiration with water gains achieved through drinking, eating and metabolic water production. Hydration status is determined by the state of the water balance. Underhydration occurs when a decrease in body water availability, due to high losses or low gains, stimulates adaptive responses within the water balance network that are aimed at decreasing losses and increasing gains...
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38273026/the-changing-landscape-of-hiv-associated-kidney-disease
#33
REVIEW
Nina E Diana, Saraladevi Naicker
The HIV epidemic has devastated millions of people globally, with approximately 40 million deaths since its start. The availability of antiretroviral therapy (ART) has transformed the prognosis of millions of individuals infected with HIV such that a diagnosis of HIV infection no longer automatically confers death. However, morbidity and mortality remain substantial among people living with HIV. HIV can directly infect the kidney to cause HIV-associated nephropathy (HIVAN) - a disease characterized by podocyte and tubular damage and associated with an increased risk of kidney failure...
May 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38168662/translating-b%C3%A2-cell-immunology-to-the-treatment-of-antibody-mediated-allograft-rejection
#34
REVIEW
Peter S Heeger, Maria Carrera Haro, Stanley Jordan
Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes ~50% of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective therapeutics for the management of AMR, to date, none has obtained FDA approval, thereby highlighting an urgent unmet medical need. Discoveries over the past decade from basic, translational and clinical studies of transplant recipients have provided a foundation for developing novel therapeutic approaches to preventing and treating AMR and cAMR...
April 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/37758939/acute-kidney-injury-in-patients-with-burns
#35
REVIEW
Matthieu Legrand, Audra T Clark, Javier A Neyra, Marlies Ostermann
Burn injury is associated with a high risk of acute kidney injury (AKI) with a prevalence of AKI among patients with burns of 9-50%. Despite an improvement in burn injury survival in the past decade, AKI in patients with burns is associated with an extremely poor short-term and long-term prognosis, with a mortality of >80% among those with severe AKI. Factors that contribute to the development of AKI in patients with burns include haemodynamic alterations, burn-induced systemic inflammation and apoptosis, haemolysis, rhabdomyolysis, smoke inhalation injury, drug nephrotoxicity and sepsis...
March 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38321168/sirtuins-in-kidney-health-and-disease
#36
REVIEW
Luca Perico, Giuseppe Remuzzi, Ariela Benigni
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including mitochondrial metabolism, oxidative stress, autophagy, DNA repair and inflammation...
February 6, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38302585/macrophages-clean-out-the-tubules
#37
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
February 1, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38097776/new-evidence-of-the-impact-of-mitochondria-on-kidney-health-and-disease
#38
JOURNAL ARTICLE
Thomas Verissimo, Sophie de Seigneux
No abstract text is available yet for this article.
February 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38097775/the-dawn-of-multimodal-artificial-intelligence-in-nephrology
#39
JOURNAL ARTICLE
Benjamin Shickel, Azra Bihorac
No abstract text is available yet for this article.
February 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38040863/targeted-identification-of-risk-and-treatment-of-diabetic-kidney-disease
#40
JOURNAL ARTICLE
Sarah J Glastras, Carol A Pollock
No abstract text is available yet for this article.
February 2024: Nature Reviews. Nephrology
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