journal
https://read.qxmd.com/read/38491222/drug-stewardship-in-chronic-kidney-disease-to-achieve-effective-and-safe-medication-use
#1
REVIEW
Rasheeda K Hall, Rümeyza Kazancıoğlu, Teerawat Thanachayanont, Germaine Wong, Dharshana Sabanayagam, Marisa Battistella, Sofia B Ahmed, Lesley A Inker, Erin F Barreto, Edouard L Fu, Catherine M Clase, Juan J Carrero
People living with chronic kidney disease (CKD) often experience multimorbidity and require polypharmacy. Kidney dysfunction can also alter the pharmacokinetics and pharmacodynamics of medications, which can modify their risks and benefits; the extent of these changes is not well understood for all situations or medications. The principle of drug stewardship is aimed at maximizing medication safety and effectiveness in a population of patients through a variety of processes including medication reconciliation, medication selection, dose adjustment, monitoring for effectiveness and safety, and discontinuation (deprescribing) when no longer necessary...
March 15, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38443711/role-of-biophysics-and-mechanobiology-in-podocyte-physiology
#2
REVIEW
Jonathan Haydak, Evren U Azeloglu
Podocytes form the backbone of the glomerular filtration barrier and are exposed to various mechanical forces throughout the lifetime of an individual. The highly dynamic biomechanical environment of the glomerular capillaries greatly influences the cell biology of podocytes and their pathophysiology. Throughout the past two decades, a holistic picture of podocyte cell biology has emerged, highlighting mechanobiological signalling pathways, cytoskeletal dynamics and cellular adhesion as key determinants of biomechanical resilience in podocytes...
March 5, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38443710/clinical-practice-recommendations-for-kidney-involvement-in-tuberous-sclerosis-complex-a-consensus-statement-by-the-erknet-working-group-for-autosomal-dominant-structural-kidney-disorders-and-the-era-genes-kidney-working-group
#3
REVIEW
Djalila Mekahli, Roman-Ulrich Müller, Matko Marlais, Tanja Wlodkowski, Stefanie Haeberle, Marta López de Argumedo, Carsten Bergmann, Luc Breysem, Carla Fladrowski, Elizabeth P Henske, Peter Janssens, François Jouret, John Christopher Kingswood, Jean-Baptiste Lattouf, Marc Lilien, Geert Maleux, Micaela Rozenberg, Stefan Siemer, Olivier Devuyst, Franz Schaefer, David J Kwiatkowski, Olivier Rouvière, John Bissler
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the presence of proliferative lesions throughout the body. Management of TSC is challenging because patients have a multifaceted systemic illness with prominent neurological and developmental impact as well as potentially severe kidney, heart and lung phenotypes; however, every organ system can be involved. Adequate care for patients with TSC requires a coordinated effort involving a multidisciplinary team of clinicians and support staff...
March 5, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38438536/innovating-dialysis-through-computational-modelling-of-hollow-fibre-haemodialysers
#4
JOURNAL ARTICLE
Ruhit Sinha, Michael V Rocco, Pirouz Daeihagh, Anne E Staples
No abstract text is available yet for this article.
March 4, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38424242/the-renal-glucagon-receptor-is-essential-to-kidney-metabolic-and-homeostatic-functions
#5
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
February 29, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38418898/a-caar-nk-cell-approach-to-eliminate-pathogenic-autoantibody-secreting-cells
#6
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
February 28, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409369/physiological-principles-underlying-the-kidney-targeting-of-renal-nanomedicines
#7
REVIEW
Yingyu Huang, Xuhui Ning, Samira Ahrari, Qi Cai, Nilum Rajora, Ramesh Saxena, Mengxiao Yu, Jie Zheng
Kidney disease affects more than 10% of the global population and is associated with considerable morbidity and mortality, highlighting a need for new therapeutic options. Engineered nanoparticles for the treatment of kidney diseases (renal nanomedicines) represent one such option, enabling the delivery of targeted therapeutics to specific regions of the kidney. Although they are underdeveloped compared with nanomedicines for diseases such as cancer, findings from preclinical studies suggest that renal nanomedicines may hold promise...
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409368/organ-trafficking-a-continuing-challenge
#8
JOURNAL ARTICLE
Thomas F Mueller, Sanjay Nagral
No abstract text is available yet for this article.
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409367/pericyte-stem-cell-crosstalk-in-ccrcc
#9
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38409366/long-term-health-outcomes-associated-with-hydration-status
#10
REVIEW
Natalia I Dmitrieva, Manfred Boehm, Paul H Yancey, Sofia Enhörning
Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular and intracellular fluids. Water balance is maintained by multiple mechanisms that continuously match water losses through urine, the skin, the gastrointestinal tract and respiration with water gains achieved through drinking, eating and metabolic water production. Hydration status is determined by the state of the water balance. Underhydration occurs when a decrease in body water availability, due to high losses or low gains, stimulates adaptive responses within the water balance network that are aimed at decreasing losses and increasing gains...
February 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38321168/sirtuins-in-kidney-health-and-disease
#11
REVIEW
Luca Perico, Giuseppe Remuzzi, Ariela Benigni
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including mitochondrial metabolism, oxidative stress, autophagy, DNA repair and inflammation...
February 6, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38302585/macrophages-clean-out-the-tubules
#12
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
February 1, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38291107/effects-of-sglt2-inhibitors-on-the-metabolic-environment-and-uraemic-toxins
#13
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
January 30, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38291106/design-of-a-renal-sparing-antifungal
#14
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
January 30, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38287135/a-united-vision-for-cardiovascular-kidney-metabolic-health
#15
JOURNAL ARTICLE
Susan E Quaggin, Benjamin Magod
No abstract text is available yet for this article.
January 29, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38287134/the-multifaceted-links-between-hearing-loss-and-chronic-kidney-disease
#16
REVIEW
Dina Greenberg, Norman D Rosenblum, Marcello Tonelli
Hearing loss affects nearly 1.6 billion people and is the third-leading cause of disability worldwide. Chronic kidney disease (CKD) is also a common condition that is associated with adverse clinical outcomes and high health-care costs. From a developmental perspective, the structures responsible for hearing have a common morphogenetic origin with the kidney, and genetic abnormalities that cause familial forms of hearing loss can also lead to kidney disease. On a cellular level, normal kidney and cochlea function both depend on cilial activities at the apical surface, and kidney tubular cells and sensory epithelial cells of the inner ear use similar transport mechanisms to modify luminal fluid...
January 29, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38273026/the-changing-landscape-of-hiv-associated-kidney-disease
#17
REVIEW
Nina E Diana, Saraladevi Naicker
The HIV epidemic has devastated millions of people globally, with approximately 40 million deaths since its start. The availability of antiretroviral therapy (ART) has transformed the prognosis of millions of individuals infected with HIV such that a diagnosis of HIV infection no longer automatically confers death. However, morbidity and mortality remain substantial among people living with HIV. HIV can directly infect the kidney to cause HIV-associated nephropathy (HIVAN) - a disease characterized by podocyte and tubular damage and associated with an increased risk of kidney failure...
January 25, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38253811/metabolic-alterations-in-hereditary-and-sporadic-renal-cell-carcinoma
#18
REVIEW
Nathan J Coffey, M Celeste Simon
Kidney cancer is the seventh leading cause of cancer in the world, and its incidence is on the rise. Renal cell carcinoma (RCC) is the most common form and is a heterogeneous disease comprising three major subtypes that vary in their histology, clinical course and driver mutations. These subtypes include clear cell RCC, papillary RCC and chromophobe RCC. Molecular analyses of hereditary and sporadic forms of RCC have revealed that this complex and deadly disease is characterized by metabolic pathway alterations in cancer cells that lead to deregulated oxygen and nutrient sensing, as well as impaired tricarboxylic acid cycle activity...
January 22, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38253810/amplifying-the-voices-of-patients-with-kidney-disease
#19
JOURNAL ARTICLE
Miranda Scanlon
No abstract text is available yet for this article.
January 22, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38238532/health-policy-for-universal-sustainable-and-equitable-kidney-care
#20
JOURNAL ARTICLE
Ricardo Silvariño, Laura Solá
No abstract text is available yet for this article.
January 18, 2024: Nature Reviews. Nephrology
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