journal
https://read.qxmd.com/read/38789686/sleep-disorders-in-chronic-kidney-disease
#1
REVIEW
Owen D Lyons
Sleep disorders are highly prevalent in chronic kidney disease (CKD) but are often under-recognized. Restless legs syndrome, which is common in CKD owing to issues with dopamine metabolism and is exacerbated by iron deficiency and uraemia, can lead to poor sleep quality and increased daytime fatigue. Insomnia is also prevalent in CKD, particularly in patients requiring dialysis, with increased sleep latency and sleep fragmentation being reported. The cause of insomnia in CKD is multifactorial - poor sleep habits and frequent napping during dialysis, uraemia, medications and mood disorders have all been suggested as potential contributing factors...
May 24, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38760475/kidney-health-within-the-broader-non-communicable-disease-agenda
#2
JOURNAL ARTICLE
Slim Slama, Valerie A Luyckx, Bianca Hemmingsen
No abstract text is available yet for this article.
May 17, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38724717/podocyte-targeted-therapies-progress-and-future-directions
#3
REVIEW
Kristin Meliambro, John C He, Kirk N Campbell
Podocytes are the key target cells for injury across the spectrum of primary and secondary proteinuric kidney disorders, which account for up to 90% of cases of kidney failure worldwide. Seminal experimental and clinical studies have established a causative link between podocyte depletion and the magnitude of proteinuria in progressive glomerular disease. However, no substantial advances have been made in glomerular disease therapies, and the standard of care for podocytopathies relies on repurposed immunosuppressive drugs...
May 9, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38719971/spatial-transcriptomics-in-health-and-disease
#4
REVIEW
Sanjay Jain, Michael T Eadon
The ability to localize hundreds of macromolecules to discrete locations, structures and cell types in a tissue is a powerful approach to understand the cellular and spatial organization of an organ. Spatially resolved transcriptomic technologies enable mapping of transcripts at single-cell or near single-cell resolution in a multiplex manner. The rapid development of spatial transcriptomic technologies has accelerated the pace of discovery in several fields, including nephrology. Its application to preclinical models and human samples has provided spatial information about new cell types discovered by single-cell sequencing and new insights into the cell-cell interactions within neighbourhoods, and has improved our understanding of the changes that occur in response to injury...
May 8, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38714805/a-patient-perspective-on-kidney-disease-in-the-public-health-agenda
#5
JOURNAL ARTICLE
Daniel Gallego
No abstract text is available yet for this article.
May 7, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38684790/role-of-the-gut-microbiota-in-the-pathogenesis-of-iga-nephropathy
#6
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
April 29, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38671191/progression-and-outcomes-of-rare-kidney-diseases
#7
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
April 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38671190/applications-of-sglt2-inhibitors-beyond-glycaemic-control
#8
REVIEW
Daniel V O'Hara, Carolyn S P Lam, John J V McMurray, Tae Won Yi, Samantha Hocking, Jessica Dawson, Smriti Raichand, Andrzej S Januszewski, Meg J Jardine
Sodium-glucose cotransporter 2 (SGLT2) inhibitors were initially developed for their glucose-lowering effects and have shown a modest glycaemic benefit in people with type 2 diabetes mellitus (T2DM). In the past decade, a series of large, robust clinical trials of these therapies have demonstrated striking beneficial effects for various care goals, transforming the chronic disease therapeutic landscape. Cardiovascular safety studies in people with T2DM demonstrated that SGLT2 inhibitors reduce cardiovascular death and hospitalization for heart failure...
April 26, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38664592/post-translational-modifications-in-kidney-diseases-and-associated-cardiovascular-risk
#9
REVIEW
Heidi Noels, Vera Jankowski, Stefan J Schunk, Raymond Vanholder, Sahir Kalim, Joachim Jankowski
Patients with chronic kidney disease (CKD) are at an increased cardiovascular risk compared with the general population, which is driven, at least in part, by mechanisms that are uniquely associated with kidney disease. In CKD, increased levels of oxidative stress and uraemic retention solutes, including urea and advanced glycation end products, enhance non-enzymatic post-translational modification events, such as protein oxidation, glycation, carbamylation and guanidinylation. Alterations in enzymatic post-translational modifications such as glycosylation, ubiquitination, acetylation and methylation are also detected in CKD...
April 25, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38658670/not-every-organ-ticks-the-same
#10
JOURNAL ARTICLE
Khaoula Talbi, Anette Melk
No abstract text is available yet for this article.
April 24, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38658669/immune-mechanisms-in-the-pathophysiology-of-hypertension
#11
REVIEW
Bianca A Nguyen, Matthew R Alexander, David G Harrison
Hypertension is a leading risk factor for morbidity and mortality worldwide. Despite current anti-hypertensive therapies, most individuals with hypertension fail to achieve adequate blood pressure control. Moreover, even with adequate control, a residual risk of cardiovascular events and associated organ damage remains. These findings suggest that current treatment modalities are not addressing a key element of the underlying pathology. Emerging evidence implicates immune cells as key mediators in the development and progression of hypertension...
April 24, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38654119/considerations-of-sex-as-a-binary-variable-in-clinical-algorithms
#12
JOURNAL ARTICLE
Dinushika Mohottige, Samira Farouk, Tonia Poteat, Asa Radix, Selma Feldman Witchel
No abstract text is available yet for this article.
April 23, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38641658/calcium-signalling-and-transport-in-the-kidney
#13
REVIEW
Alexander Staruschenko, R Todd Alexander, Michael J Caplan, Daria V Ilatovskaya
The kidney plays a pivotal role in regulating calcium levels within the body. Approximately 98% of the filtered calcium is reabsorbed in the nephron, and this process is tightly controlled to maintain calcium homeostasis, which is required to facilitate optimal bone mineralization, preserve serum calcium levels within a narrow range, and support intracellular signalling mechanisms. The maintenance of these functions is attributed to a delicate balance achieved by various calcium channels, transporters, and calcium-binding proteins in renal cells...
April 19, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38632382/thiazides-in-kidney-transplant-recipients-skin-in-the-game
#14
JOURNAL ARTICLE
Steven Van Laecke
No abstract text is available yet for this article.
April 17, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38632381/epithelial-cell-states-associated-with-kidney-and-allograft-injury
#15
REVIEW
Christian Hinze, Svjetlana Lovric, Philip F Halloran, Jonathan Barasch, Kai M Schmidt-Ott
The kidney epithelium, with its intricate arrangement of highly specialized cell types, constitutes the functional core of the organ. Loss of kidney epithelium is linked to the loss of functional nephrons and a subsequent decline in kidney function. In kidney transplantation, epithelial injury signatures observed during post-transplantation surveillance are strong predictors of adverse kidney allograft outcomes. However, epithelial injury is currently neither monitored clinically nor addressed therapeutically after kidney transplantation...
April 17, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38575770/a-new-era-in-the-science-and-care-of-kidney-diseases
#16
REVIEW
Carmine Zoccali, Francesca Mallamaci, Liz Lightstone, Vivek Jha, Carol Pollock, Katherine Tuttle, Peter Kotanko, Andrzej Wiecek, Hans Joachim Anders, Giuseppe Remuzzi, Kamyar Kalantar-Zadeh, Adeera Levin, Raymond Vanholder
Notable progress in basic, translational and clinical nephrology research has been made over the past five decades. Nonetheless, many challenges remain, including obstacles to the early detection of kidney disease, disparities in access to care and variability in responses to existing and emerging therapies. Innovations in drug development, research technologies, tissue engineering and regenerative medicine have the potential to improve patient outcomes. Exciting prospects include the availability of new drugs to slow or halt the progression of chronic kidney disease, the development of bioartificial kidneys that mimic healthy kidney functions, and tissue engineering techniques that could enable transplantable kidneys to be created from the cells of the recipient, removing the risk of rejection...
April 4, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38570632/combination-therapy-for-kidney-disease-in-people-with-diabetes-mellitus
#17
REVIEW
Daniƫl H van Raalte, Petter Bjornstad, David Z I Cherney, Ian H de Boer, Paola Fioretto, Daniel Gordin, Frederik Persson, Sylvia E Rosas, Peter Rossing, Jennifer A Schaub, Katherine Tuttle, Sushrut S Waikar, Hiddo J L Heerspink
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear causes of kidney injury, occurs in approximately 20-40% of patients with diabetes mellitus. As the global prevalence of diabetes has increased, DKD has become highly prevalent and a leading cause of kidney failure, accelerated cardiovascular disease, premature mortality and global health care expenditure. Multiple pathophysiological mechanisms contribute to DKD, and single lifestyle or pharmacological interventions have shown limited efficacy at preserving kidney function...
April 3, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38570631/chronic-kidney-disease-and-the-global-public-health-agenda-an-international-consensus
#18
REVIEW
Anna Francis, Meera N Harhay, Albert C M Ong, Sri Lekha Tummalapalli, Alberto Ortiz, Agnes B Fogo, Danilo Fliser, Prabir Roy-Chaudhury, Monica Fontana, Masaomi Nangaku, Christoph Wanner, Charu Malik, Anne Hradsky, Dwomoa Adu, Sunita Bavanandan, Ana Cusumano, Laura Sola, Ifeoma Ulasi, Vivekanand Jha
Early detection is a key strategy to prevent kidney disease, its progression and related complications, but numerous studies show that awareness of kidney disease at the population level is low. Therefore, increasing knowledge and implementing sustainable solutions for early detection of kidney disease are public health priorities. Economic and epidemiological data underscore why kidney disease should be placed on the global public health agenda - kidney disease prevalence is increasing globally and it is now the seventh leading risk factor for mortality worldwide...
April 3, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38570630/kidney-disease-a-global-health-priority
#19
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 3, 2024: Nature Reviews. Nephrology
https://read.qxmd.com/read/38565773/the-global-landscape-of-kidney-registries-immense-challenges-and-unique-opportunities
#20
JOURNAL ARTICLE
Christopher H Grant, Fergus J Caskey, M Razeen Davids, Manisha Sahay, Aminu K Bello, Dorothea Nitsch, Samira Bell
No abstract text is available yet for this article.
April 2, 2024: Nature Reviews. Nephrology
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