journal
https://read.qxmd.com/read/36964228/pharmacogenomics-in-the-clinic
#1
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
March 24, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36964227/phosphate-sensing-via-ptc-glycolysis
#2
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
March 24, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36964226/blockchain-in-nephrology
#3
JOURNAL ARTICLE
Tamas Szili-Torok, Daan Kremer, Stephan J L Bakker, Uwe J F Tietge, Martin H de Borst
No abstract text is available yet for this article.
March 24, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36959481/regulated-cell-death-pathways-in-kidney-disease
#4
REVIEW
Ana B Sanz, Maria Dolores Sanchez-Niño, Adrian M Ramos, Alberto Ortiz
Disorders of cell number that result from an imbalance between the death of parenchymal cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis of kidney disease. Acute kidney injury can result from an acute loss of kidney epithelial cells. In chronic kidney disease, loss of kidney epithelial cells leads to glomerulosclerosis and tubular atrophy, whereas interstitial inflammation and fibrosis result from an excess of leukocytes and myofibroblasts. Other conditions, such as acquired cystic disease and kidney cancer, are characterized by excess numbers of cyst wall and malignant cells, respectively...
March 23, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36949339/intradialytic-acute-brain-injury
#5
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
March 22, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36922653/ferroptotic-mechanisms-and-therapeutic-targeting-of-iron-metabolism-and-lipid-peroxidation-in-the-kidney
#6
REVIEW
Hülya Bayır, Scott J Dixon, Yulia Y Tyurina, John A Kellum, Valerian E Kagan
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can be inhibited by glutathione peroxidase 4. Morphologically, it is characterized by cellular, organelle and cytoplasmic swelling and the loss of plasma membrane integrity, with the release of intracellular components. Ferroptosis is triggered in cells with dysregulated iron and thiol redox metabolism, whereby the initial robust but selective accumulation of hydroperoxy polyunsaturated fatty acid-containing phospholipids is further propagated through enzymatic and non-enzymatic secondary mechanisms, leading to formation of oxidatively truncated electrophilic species and their adducts with proteins...
March 15, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36914889/the-cilia-mechanosensation-debate-gets-bio-physical
#7
JOURNAL ARTICLE
Dagmar Wachten, Pleasantine Mill
No abstract text is available yet for this article.
March 13, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36894628/the-role-of-lysosomes-in-metabolic-and-autoimmune-diseases
#8
REVIEW
Frédéric Gros, Sylviane Muller
Lysosomes are catabolic organelles that contribute to the degradation of intracellular constituents through autophagy and of extracellular components through endocytosis, phagocytosis and macropinocytosis. They also have roles in secretory mechanisms, the generation of extracellular vesicles and certain cell death pathways. These functions make lysosomes central organelles in cell homeostasis, metabolic regulation and responses to environment changes including nutrient stresses, endoplasmic reticulum stress and defects in proteostasis...
March 9, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36849741/mechanism-of-b-cell-survival-in-lupus-nephritis
#9
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
February 27, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36849740/sglt2-inhibitors-attenuate-alterations-of-kidney-metabolic-pathways-in-youth-onset-t2dm
#10
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
February 27, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36849739/experimental-evidence-for-a-pathogenic%C3%A2-role-of-anti-pla-2-r1-antibodies-in-membranous-nephropathy
#11
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
February 27, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36823169/targeting-iron-uptake-to-correct-t-cell-dysfunction
#12
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
February 23, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36823168/sepsis-associated-acute-kidney-injury-consensus-report-of-the-28th-acute-disease-quality-initiative-workgroup
#13
REVIEW
Alexander Zarbock, Mitra K Nadim, Peter Pickkers, Hernando Gomez, Samira Bell, Michael Joannidis, Kianoush Kashani, Jay L Koyner, Neesh Pannu, Melanie Meersch, Thiago Reis, Thomas Rimmelé, Sean M Bagshaw, Rinaldo Bellomo, Vicenzo Cantaluppi, Akash Deep, Silvia De Rosa, Xose Perez-Fernandez, Faeq Husain-Syed, Sandra L Kane-Gill, Yvelynne Kelly, Ravindra L Mehta, Patrick T Murray, Marlies Ostermann, John Prowle, Zaccaria Ricci, Emily J See, Antoine Schneider, Danielle E Soranno, Ashita Tolwani, Gianluca Villa, Claudio Ronco, Lui G Forni
Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and is strongly associated with adverse outcomes, including an increased risk of chronic kidney disease, cardiovascular events and death. The pathophysiology of SA-AKI remains elusive, although microcirculatory dysfunction, cellular metabolic reprogramming and dysregulated inflammatory responses have been implicated in preclinical studies. SA-AKI is best defined as the occurrence of AKI within 7 days of sepsis onset (diagnosed according to Kidney Disease Improving Global Outcome criteria and Sepsis 3 criteria, respectively)...
February 23, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36806372/use-of-convalescent-plasma-in-the-treatment-of-covid-19
#14
LETTER
Michael J Joyner, Nigel Paneth, Arturo Casadevall
No abstract text is available yet for this article.
February 17, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36806371/reply-to-use-of-convalescent-plasma-in-the-treatment-of-covid-19
#15
LETTER
Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R Lawler, Meghan Sise, David E Leaf
No abstract text is available yet for this article.
February 17, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36806370/bridging-the-gap-of-referral-to-nephrology-care
#16
JOURNAL ARTICLE
Nestor Oliva-Damaso, Navdeep Tangri, Pierre Delanaye, Richard J Glassock
No abstract text is available yet for this article.
February 17, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36747084/author-correction-therapeutic-advances-in-covid-19
#17
Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R Lawler, Meghan E Sise, David E Leaf
No abstract text is available yet for this article.
February 6, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36702905/pathological-consequences-of-dna-damage-in-the-kidney
#18
REVIEW
Juan I Garaycoechea, Catherine Quinlan, Martijn S Luijsterburg
DNA lesions that evade repair can lead to mutations that drive the development of cancer, and cellular responses to DNA damage can trigger senescence and cell death, which are associated with ageing. In the kidney, DNA damage has been implicated in both acute and chronic kidney injury, and in renal cell carcinoma. The susceptibility of the kidney to chemotherapeutic agents that damage DNA is well established, but an unexpected link between kidney ciliopathies and the DNA damage response has also been reported...
January 26, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36694057/targeting-glutamine-use-in-rcc
#19
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
January 24, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/36694056/vps34-functions-in-the-proximal-tubule
#20
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
January 24, 2023: Nature Reviews. Nephrology
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