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Nature Reviews. Nephrology

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https://read.qxmd.com/read/30778152/modelling-diabetic-vasculopathy-with-human-vessel-organoids
#1
Ryuji Morizane
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30778151/growing-mouse-kidneys-in-rats
#2
Katharine H Wrighton
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30778150/fluid-flow-enhances-vascularization-and-maturation-of-kidney-organoids
#3
Susan J Allison
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30770906/cyclin-g1-drives-maladaptive-renal-repair
#4
Monica Wang
No abstract text is available yet for this article.
February 15, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30765852/albuminuria-a-target-for-clinical-trials-in-kidney-disease
#5
Richard J Glassock
No abstract text is available yet for this article.
February 14, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30737496/some-nephron-progenitors-fail-to-commit
#6
Ellen F Carney
No abstract text is available yet for this article.
February 8, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30733609/cellular-signalling-by-primary-cilia-in-development-organ-function-and-disease
#7
REVIEW
Zeinab Anvarian, Kirk Mykytyn, Saikat Mukhopadhyay, Lotte Bang Pedersen, Søren Tvorup Christensen
Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect and transmit extracellular cues to regulate diverse cellular processes during development and to maintain tissue homeostasis. The sensory capacity of primary cilia relies on the coordinated trafficking and temporal localization of specific receptors and associated signal transduction modules in the cilium. The canonical Hedgehog (HH) pathway, for example, is a bona fide ciliary signalling system that regulates cell fate and self-renewal in development and tissue homeostasis...
February 7, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30728454/uraemic-syndrome-of-chronic-kidney-disease-altered-remote-sensing-and-signalling
#8
REVIEW
Sanjay K Nigam, Kevin T Bush
Uraemic syndrome (also known as uremic syndrome) in patients with advanced chronic kidney disease involves the accumulation in plasma of small-molecule uraemic solutes and uraemic toxins (also known as uremic toxins), dysfunction of multiple organs and dysbiosis of the gut microbiota. As such, uraemic syndrome can be viewed as a disease of perturbed inter-organ and inter-organism (host-microbiota) communication. Multiple biological pathways are affected, including those controlled by solute carrier (SLC) and ATP-binding cassette (ABC) transporters and drug-metabolizing enzymes, many of which are also involved in drug absorption, distribution, metabolism and elimination (ADME)...
February 6, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30723305/kidney-disease-in-the-global-burden-of-disease-study-2017
#9
Simon D S Fraser, Paul J Roderick
No abstract text is available yet for this article.
February 5, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30705419/the-genetic-changes-of-wilms-tumour
#10
REVIEW
Taryn Dora Treger, Tanzina Chowdhury, Kathy Pritchard-Jones, Sam Behjati
Wilms tumour is the most common renal malignancy of childhood. The disease is curable in the majority of cases, albeit at considerable cost in terms of late treatment-related effects in some children. However, one in ten children with Wilms tumour will die of their disease despite modern treatment approaches. The genetic changes that underpin Wilms tumour have been defined by studies of familial cases and by unbiased DNA sequencing of tumour genomes. Together, these approaches have defined the landscape of cancer genes that are operative in Wilms tumour, many of which are intricately linked to the control of fetal nephrogenesis...
January 31, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30692665/macrophages-versatile-players-in-renal-inflammation-and-fibrosis
#11
REVIEW
Patrick Ming-Kuen Tang, David J Nikolic-Paterson, Hui-Yao Lan
Macrophages have important roles in immune surveillance and in the maintenance of kidney homeostasis; their response to renal injury varies enormously depending on the nature and duration of the insult. Macrophages can adopt a variety of phenotypes: at one extreme, M1 pro-inflammatory cells contribute to infection clearance but can also promote renal injury; at the other extreme, M2 anti-inflammatory cells have a reparative phenotype and can contribute to the resolution phase of the response to injury. In addition, bone marrow monocytes can differentiate into myeloid-derived suppressor cells that can regulate T cell immunity in the kidney...
January 28, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30692664/c3-glomerulopathy-understanding-a-rare-complement-driven-renal-disease
#12
REVIEW
Richard J H Smith, Gerald B Appel, Anna M Blom, H Terence Cook, Vivette D D'Agati, Fadi Fakhouri, Véronique Fremeaux-Bacchi, Mihály Józsi, David Kavanagh, John D Lambris, Marina Noris, Matthew C Pickering, Giuseppe Remuzzi, Santiago Rodriguez de Córdoba, Sanjeev Sethi, Johan Van der Vlag, Peter F Zipfel, Carla M Nester
The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples. The two major subgroups of C3 glomerulopathy - dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) - have overlapping clinical and pathological features suggestive of a disease continuum. Dysregulation of the complement alternative pathway is fundamental to the manifestations of C3 glomerulopathy, although terminal pathway dysregulation is also common...
January 28, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30679811/nitric-oxide-protects-against-aki-by-reprogramming-metabolism
#13
Pierre-Yves Martin, Sophie de Seigneux
No abstract text is available yet for this article.
January 24, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30670871/the-genetic-architecture-of-blood-pressure
#14
Ellen F Carney
No abstract text is available yet for this article.
January 22, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30670870/dna-methylation-links-intrauterine-stress-with-abnormal-nephrogenesis
#15
Samir S El-Dahr
No abstract text is available yet for this article.
January 22, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30664682/cnvs-in-cakut
#16
Susan J Allison
No abstract text is available yet for this article.
January 21, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30664681/evolving-concepts-in-the-pathogenesis-of-uraemic-cardiomyopathy
#17
REVIEW
Xiaoliang Wang, Joseph I Shapiro
The term uraemic cardiomyopathy refers to the cardiac abnormalities that are seen in patients with chronic kidney disease (CKD). Historically, this term was used to describe a severe cardiomyopathy that was associated with end-stage renal disease and characterized by severe functional abnormalities that could be reversed following renal transplantation. In a modern context, uraemic cardiomyopathy describes the clinical phenotype of cardiac disease that accompanies CKD and is perhaps best characterized as diastolic dysfunction seen in conjunction with left ventricular hypertrophy and fibrosis...
January 21, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30651611/epigenetic-regulation-in-aki-and-kidney-repair-mechanisms-and-therapeutic-implications
#18
REVIEW
Chunyuan Guo, Guie Dong, Xinling Liang, Zheng Dong
Acute kidney injury (AKI) is a major public health concern associated with high morbidity and mortality. Despite decades of research, the pathogenesis of AKI remains incompletely understood and effective therapies are lacking. An increasing body of evidence suggests a role for epigenetic regulation in the process of AKI and kidney repair, involving remarkable changes in histone modifications, DNA methylation and the expression of various non-coding RNAs. For instance, increases in levels of histone acetylation seem to protect kidneys from AKI and promote kidney repair...
January 16, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30617290/local-solutions-save-young-lives
#19
Simon J Davies
No abstract text is available yet for this article.
January 7, 2019: Nature Reviews. Nephrology
https://read.qxmd.com/read/30607032/endothelium-structure-and-function-in-kidney-health-and-disease
#20
REVIEW
Noemie Jourde-Chiche, Fadi Fakhouri, Laetitia Dou, Jeremy Bellien, Stéphane Burtey, Marie Frimat, Pierre-André Jarrot, Gilles Kaplanski, Moglie Le Quintrec, Vincent Pernin, Claire Rigothier, Marion Sallée, Veronique Fremeaux-Bacchi, Dominique Guerrot, Lubka T Roumenina
The kidney harbours different types of endothelia, each with specific structural and functional characteristics. The glomerular endothelium, which is highly fenestrated and covered by a rich glycocalyx, participates in the sieving properties of the glomerular filtration barrier and in the maintenance of podocyte structure. The microvascular endothelium in peritubular capillaries, which is also fenestrated, transports reabsorbed components and participates in epithelial cell function. The endothelium of large and small vessels supports the renal vasculature...
January 3, 2019: Nature Reviews. Nephrology
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