journal
https://read.qxmd.com/read/37735215/the-role-of-complement-in-kidney-disease
#1
REVIEW
Vojtech Petr, Joshua M Thurman
The complement cascade comprises soluble and cell surface proteins and is an important arm of the innate immune system. Once activated, the complement system rapidly generates large quantities of protein fragments that are potent mediators of inflammatory, vasoactive and metabolic responses. Although complement is crucial to host defence and homeostasis, its inappropriate or uncontrolled activation can also drive tissue injury. For example, the complement system has been known for more than 50 years to be activated by glomerular immune complexes and to contribute to autoimmune kidney disease...
September 21, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37735214/use-of-kidneys-from-sars-cov-2-infected-donors
#2
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
September 21, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37714934/lymph-vessels-na-and-the-teleological-science-of-hypertension
#3
JOURNAL ARTICLE
Jens M Titze
No abstract text is available yet for this article.
September 15, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37684523/sex-differences-in-renal-transporters-assessment-and-functional-consequences
#4
REVIEW
Alicia A McDonough, Autumn N Harris, Lingyun Ivy Xiong, Anita T Layton
Mammalian kidneys are specialized to maintain fluid and electrolyte homeostasis. The epithelial transport processes along the renal tubule that match output to input have long been the subject of experimental and theoretical study. However, emerging data have identified a new dimension of investigation: sex. Like most tissues, the structure and function of the kidney is regulated by sex hormones and chromosomes. Available data demonstrate sex differences in the abundance of kidney solute and electrolyte transporters, establishing that renal tubular organization and operation are distinctly different in females and males...
September 8, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37667082/author-correction-regulatory-t-cells-in-autoimmune-kidney-diseases-and-transplantation
#5
Norihisa Mikami, Shimon Sakaguchi
No abstract text is available yet for this article.
September 4, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37667081/interorgan-communication-networks-in-the-kidney-lung-axis
#6
REVIEW
Yohei Komaru, Yun Zhu Bai, Daniel Kreisel, Andreas Herrlich
The homeostasis and health of an organism depend on the coordinated interaction of specialized organs, which is regulated by interorgan communication networks of circulating soluble molecules and neuronal connections. Many diseases that seemingly affect one primary organ are really multiorgan diseases, with substantial secondary remote organ complications that underlie a large part of their morbidity and mortality. Acute kidney injury (AKI) frequently occurs in critically ill patients with multiorgan failure and is associated with high mortality, particularly when it occurs together with respiratory failure...
September 4, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37653237/designing-acute-kidney-injury-clinical-trials
#7
REVIEW
Alexander Zarbock, Lui G Forni, Marlies Ostermann, Claudio Ronco, Sean M Bagshaw, Ravindra L Mehta, Rinaldo Bellomo, John A Kellum
Acute kidney injury (AKI) is a common clinical condition with various causes and is associated with increased mortality. Despite advances in supportive care, AKI increases not only the risk of premature death compared with the general population but also the risk of developing chronic kidney disease and progressing towards kidney failure. Currently, no specific therapy exists for preventing or treating AKI other than mitigating further injury and supportive care. To address this unmet need, novel therapeutic interventions targeting the underlying pathophysiology must be developed...
August 31, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37626271/digital-determinants-of-health-opportunities-and-risks-amidst-health-inequities
#8
JOURNAL ARTICLE
Jack Gallifant, Leo Anthony Celi, Robin L Pierce
No abstract text is available yet for this article.
August 25, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37612381/diagnosis-of-cardiovascular-disease-in-patients-with-chronic-kidney-disease
#9
REVIEW
Carmine Zoccali, Patrick B Mark, Pantelis Sarafidis, Rajiv Agarwal, Marcin Adamczak, Rodrigo Bueno de Oliveira, Ziad A Massy, Peter Kotanko, Charles J Ferro, Christoph Wanner, Michel Burnier, Raymond Vanholder, Francesca Mallamaci, Andrzej Wiecek
Patients with chronic kidney disease (CKD) are at high risk of cardiovascular disease (CVD) and cardiovascular death. Identifying and monitoring cardiovascular complications and hypertension is important for managing patients with CKD or kidney failure and transplant recipients. Biomarkers of myocardial ischaemia, such as troponins and electrocardiography (ECG), have limited utility for diagnosing cardiac ischaemia in patients with advanced CKD. Dobutamine stress echocardiography, myocardial perfusion scintigraphy and dipyridamole stress testing can be used to detect coronary disease in these patients...
August 23, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37612380/primary-aldosteronism-molecular-medicine-meets-public-health
#10
REVIEW
Elena A B Azizan, William M Drake, Morris J Brown
Primary aldosteronism is the most common single cause of hypertension and is potentially curable when only one adrenal gland is the culprit. The importance of primary aldosteronism to public health derives from its high prevalence but huge under-diagnosis (estimated to be <1% of all affected individuals), despite the consequences of poor blood pressure control by conventional therapy and enhanced cardiovascular risk. This state of affairs is attributable to the fact that the tools used for diagnosis or treatment are still those that originated in the 1970-1990s...
August 23, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37612379/rna-interference-for-treatment-of-hypertension
#11
JOURNAL ARTICLE
Ellen F Carney
No abstract text is available yet for this article.
August 23, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37608184/role-of-perivascular-cells-in-kidney-homeostasis-inflammation-repair-and-fibrosis
#12
REVIEW
Shinji Tanaka, Didier Portilla, Mark D Okusa
Perivascular niches in the kidney comprise heterogeneous cell populations, including pericytes and fibroblasts, with distinct functions. These perivascular cells have crucial roles in preserving kidney homeostasis as they maintain microvascular networks by stabilizing the vasculature and regulating capillary constriction. A subset of kidney perivascular cells can also produce and secrete erythropoietin; this ability can be enhanced with hypoxia-inducible factor-prolyl hydroxylase inhibitors, which are used to treat anaemia in chronic kidney disease...
August 22, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37608183/targeting-il-1ra-to-attenuate-fungal-infection
#13
JOURNAL ARTICLE
Monica Wang
No abstract text is available yet for this article.
August 22, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37596389/the-realities-of-diagnosing-and-managing-glomerular-disease-in-low-income-countries
#14
JOURNAL ARTICLE
Robert Kalyesubula
No abstract text is available yet for this article.
August 18, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37587370/impact-of-persistent-conflict-and-destabilizing-events-on-dialysis-care
#15
JOURNAL ARTICLE
Sami Alasfar, Ephrem Berhe, Sabine Karam, Valerie Luyckx
No abstract text is available yet for this article.
August 16, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37582933/propagation-of-acute-kidney-injury
#16
JOURNAL ARTICLE
Susan J Allison
No abstract text is available yet for this article.
August 15, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37580571/inequities-in-kidney-health-and-kidney-care
#17
REVIEW
Raymond Vanholder, Lieven Annemans, Marion Braks, Edwina A Brown, Priya Pais, Tanjala S Purnell, Simon Sawhney, Nicole Scholes-Robertson, Bénédicte Stengel, Elliot K Tannor, Vladimir Tesar, Arjan van der Tol, Valérie A Luyckx
Health inequity refers to the existence of unnecessary and unfair differences in the ability of an individual or community to achieve optimal health and access appropriate care. Kidney diseases, including acute kidney injury and chronic kidney disease, are the epitome of health inequity. Kidney disease risk and outcomes are strongly associated with inequities that occur across the entire clinical course of disease. Insufficient investment across the spectrum of kidney health and kidney care is a fundamental source of inequity...
August 14, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37580570/digital-health-and-acute-kidney-injury-consensus-report-of-the-27th-acute-disease-quality-initiative-workgroup
#18
REVIEW
Kianoush B Kashani, Linda Awdishu, Sean M Bagshaw, Erin F Barreto, Rolando Claure-Del Granado, Barbara J Evans, Lui G Forni, Erina Ghosh, Stuart L Goldstein, Sandra L Kane-Gill, Jejo Koola, Jay L Koyner, Mei Liu, Raghavan Murugan, Girish N Nadkarni, Javier A Neyra, Jacob Ninan, Marlies Ostermann, Neesh Pannu, Parisa Rashidi, Claudio Ronco, Mitchell H Rosner, Nicholas M Selby, Benjamin Shickel, Karandeep Singh, Danielle E Soranno, Scott M Sutherland, Azra Bihorac, Ravindra L Mehta
Acute kidney injury (AKI), which is a common complication of acute illnesses, affects the health of individuals in community, acute care and post-acute care settings. Although the recognition, prevention and management of AKI has advanced over the past decades, its incidence and related morbidity, mortality and health care burden remain overwhelming. The rapid growth of digital technologies has provided a new platform to improve patient care, and reports show demonstrable benefits in care processes and, in some instances, in patient outcomes...
August 14, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37550563/increasing-diversity-and-inclusion-in-nephrology-clinical-trials
#19
JOURNAL ARTICLE
Bessie A Young, Sylvia E Rosas
No abstract text is available yet for this article.
August 7, 2023: Nature Reviews. Nephrology
https://read.qxmd.com/read/37528186/reducing-preventable-acute-kidney-injury-in-a-hospital-setting
#20
JOURNAL ARTICLE
Rolando Claure-Del Granado
No abstract text is available yet for this article.
August 1, 2023: Nature Reviews. Nephrology
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