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Nature Reviews. Rheumatology

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https://read.qxmd.com/read/31092910/hla-associations-in-inflammatory-arthritis-emerging-mechanisms-and-clinical-implications
#1
REVIEW
Robert Busch, Simon Kollnberger, Elizabeth D Mellins
Our understanding of the mechanisms underlying HLA associations with inflammatory arthritis continues to evolve. Disease associations have been refined, and interactions of HLA genotype with other genes and environmental risk factors in determining disease risk have been identified. This Review provides basic information on the genetics and molecular function of HLA molecules, as well as general features of HLA associations with disease. Evidence is discussed regarding the various peptide-dependent and peptide-independent mechanisms by which HLA alleles might contribute to the pathogenesis of three types of inflammatory arthritis: rheumatoid arthritis, spondyloarthritis and systemic juvenile idiopathic arthritis...
May 15, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31073217/should-18-f-fdg-pet-imaging-be-used-in-the-diagnosis-of-gca
#2
Dario Camellino, Christian Dejaco
No abstract text is available yet for this article.
May 9, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31068673/therapeutic-options-for-targeting-inflammatory-osteoarthritis-pain
#3
REVIEW
Philip G Conaghan, Andrew D Cook, John A Hamilton, Paul P Tak
Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to manage this disease. However, the current standard of care does not provide satisfactory pain relief for many patients. The pathophysiology of OA is complex, and its presentation as a clinical syndrome is associated with pathologies of multiple joint tissues. Inflammation is associated with both OA pain and disease outcome and is therefore a major treatment target for OA and OA pain. Unlike TNF inhibitors and IL-1 inhibitors, established drugs such as glucocorticoids and methotrexate can reduce OA pain...
May 8, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31065108/single-cell-technologies-studying-rheumatic-diseases-one-cell-at-a-time
#4
REVIEW
Peggie Cheung, Purvesh Khatri, Paul J Utz, Alex J Kuo
Cells, the basic units of life, have striking differences at transcriptomic, proteomic and epigenomic levels across tissues, organs, organ systems and organisms. The coordination of individual immune cells is essential for the generation of effective immune responses to pathogens while immune tolerance is maintained to protect the host. In rheumatic diseases, when immune responses are dysregulated, pathologically important cells might represent only a small fraction of the immune system. Interrogation of the contributions of individual immune cells to pathogenesis and disease progression should therefore reveal important insights into the complicated aetiology of rheumatic diseases...
May 7, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31053833/fra1-in-macrophages-promotes-arthritis
#5
Jessica McHugh
No abstract text is available yet for this article.
May 3, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31053832/preventing-netosis-to-reduce-thrombosis
#6
Joanna Collison
No abstract text is available yet for this article.
May 3, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31048784/choline-uptake-is-vital-for-il-1%C3%AE-driven-inflammation
#7
Isobel Leake
No abstract text is available yet for this article.
May 2, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31048783/burden-of-musculoskeletal-diseases-increasing
#8
Sarah Onuora
No abstract text is available yet for this article.
May 2, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31048782/namilumab-improves-ra-symptoms
#9
Sarah Onuora
No abstract text is available yet for this article.
May 2, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31048781/tigit-ig-shows-therapeutic-potential-in-sle
#10
Sarah Onuora
No abstract text is available yet for this article.
May 2, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31048780/daily-atorvastatin-safe-for-patients-with-ra
#11
Sarah Onuora
No abstract text is available yet for this article.
May 2, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31048779/amyloid-pet-a-new-tool-for-diagnosing-ibm
#12
Iago Pinal-Fernandez, Andrew L Mammen
No abstract text is available yet for this article.
May 2, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31043693/controlling-chondrocyte-senescence
#13
Nicholas J Bernard
No abstract text is available yet for this article.
May 1, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31040441/can-personalized-use-of-nsaids-be-a-reality-in-the-clinic
#14
Michael T Nurmohamed
No abstract text is available yet for this article.
April 30, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31040440/x-chromosome-inactivation-altered-in-sle
#15
Joanna Collison
No abstract text is available yet for this article.
April 30, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31028371/soluble-cd83-a-proresolving-mediator-in-inflammatory-arthritis
#16
Jessica McHugh
No abstract text is available yet for this article.
April 26, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31000790/insights-into-rheumatic-diseases-from-next-generation-sequencing
#17
REVIEW
Laura T Donlin, Sung-Ho Park, Eugenia Giannopoulou, Aleksandra Ivovic, Kyung-Hyun Park-Min, Richard M Siegel, Lionel B Ivashkiv
Rheumatic diseases have complex aetiologies that are not fully understood, which makes the study of pathogenic mechanisms in these diseases a challenge for researchers. Next-generation sequencing (NGS) and related omics technologies, such as transcriptomics, epigenomics and genomics, provide an unprecedented genome-wide view of gene expression, environmentally responsive epigenetic changes and genetic variation. The integrated application of NGS technologies to samples from carefully phenotyped clinical cohorts of patients has the potential to solve remaining mysteries in the pathogenesis of several rheumatic diseases, to identify new therapeutic targets and to underpin a precision medicine approach to the diagnosis and treatment of rheumatic diseases...
April 18, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/31000789/has-lupus-anticoagulant-testing-had-its-day
#18
Yuichiro Fujieda, Tatsuya Atsumi
No abstract text is available yet for this article.
April 18, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/30967621/b-cell-checkpoints-in-autoimmune-rheumatic-diseases
#19
REVIEW
Samuel J S Rubin, Michelle S Bloom, William H Robinson
B cells have important functions in the pathogenesis of autoimmune diseases, including autoimmune rheumatic diseases. In addition to producing autoantibodies, B cells contribute to autoimmunity by serving as professional antigen-presenting cells (APCs), producing cytokines, and through additional mechanisms. B cell activation and effector functions are regulated by immune checkpoints, including both activating and inhibitory checkpoint receptors that contribute to the regulation of B cell tolerance, activation, antigen presentation, T cell help, class switching, antibody production and cytokine production...
April 9, 2019: Nature Reviews. Rheumatology
https://read.qxmd.com/read/30953037/involvement-of-the-myeloid-cell-compartment-in-fibrogenesis-and-systemic-sclerosis
#20
REVIEW
Gabriela Kania, Michal Rudnik, Oliver Distler
Systemic sclerosis (SSc) is an autoimmune fibrotic disease of unknown aetiology that is characterized by vascular changes in the skin and visceral organs. Autologous haematopoietic stem cell transplantation can improve skin and organ fibrosis in patients with progressive disease and a high risk of organ failure, indicating that cells originating in the bone marrow are important contributors to the pathogenesis of SSc. Animal studies also indicate a pivotal function of myeloid cells in the development of fibrosis leading to changes in the tissue architecture and dysfunction in multiple organs such as the heart, lungs, liver and kidney...
April 5, 2019: Nature Reviews. Rheumatology
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