journal
https://read.qxmd.com/read/37286759/rheumatic-diseases-on-the-rise
#1
JOURNAL ARTICLE
Sarah Onuora
No abstract text is available yet for this article.
June 7, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37286758/notch-signalling-mediates-oa-pain-in-mice
#2
JOURNAL ARTICLE
Jessica McHugh
No abstract text is available yet for this article.
June 7, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37286757/cognitive-functional-therapy-improves-low-back-pain
#3
JOURNAL ARTICLE
Jessica McHugh
No abstract text is available yet for this article.
June 7, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37280256/bone-forming-properties-of-an-ascorbic-acid-derivative
#4
JOURNAL ARTICLE
Robert Phillips
No abstract text is available yet for this article.
June 6, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37258663/reprogramming-autologous-cells-to-treat-oa
#5
JOURNAL ARTICLE
Robert Phillips
No abstract text is available yet for this article.
May 31, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37231248/shared-inflammatory-pathways-of-rheumatoid-arthritis-and-atherosclerotic-cardiovascular-disease
#6
REVIEW
Brittany N Weber, Jon T Giles, Katherine P Liao
The association between chronic inflammation and increased risk of cardiovascular disease in rheumatoid arthritis (RA) is well established. In the general population, inflammation is an established independent risk factor for cardiovascular disease, and much interest is placed on controlling inflammation to reduce cardiovascular events. As inflammation encompasses numerous pathways, the development of targeted therapies in RA provides an opportunity to understand the downstream effect of inhibiting specific pathways on cardiovascular risk...
May 25, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37225964/bone-marrow-lesions-plugging-the-holes-in-our-knowledge-using-animal-models
#7
REVIEW
Rebecca T Hansen, Chantal Chenu, Nidhi Sofat, Andrew A Pitsillides
Bone marrow lesions (BMLs), which are early signs of osteoarthritis (OA) that are associated with the presence, onset and severity of pain, represent an emerging imaging biomarker and clinical target. Little is known, however, regarding their early spatial and temporal development, structural relationships or aetiopathogenesis, because of the sparsity of human early OA imaging and paucity of relevant tissue samples. The use of animal models is a logical approach to fill the gaps in our knowledge, and it can be informed by appraising models in which BMLs and closely related subchondral cysts have already been reported, including in spontaneous OA and pain models...
May 24, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37217611/pjp-prophylaxis-with-rituximab
#8
JOURNAL ARTICLE
Sarah Onuora
No abstract text is available yet for this article.
May 22, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37217610/which-dmard-for-ici-associated-arthritis
#9
JOURNAL ARTICLE
Sarah Onuora
No abstract text is available yet for this article.
May 22, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37188756/juvenile-idiopathic-inflammatory-myositis-an-update-on-pathophysiology-and-clinical-care
#10
REVIEW
Charalampia Papadopoulou, Christine Chew, Meredyth G Ll Wilkinson, Liza McCann, Lucy R Wedderburn
The childhood-onset or juvenile idiopathic inflammatory myopathies (JIIMs) are a heterogenous group of rare and serious autoimmune diseases of children and young people that predominantly affect the muscles and skin but can also involve other organs, including the lungs, gut, joints, heart and central nervous system. Different myositis-specific autoantibodies have been identified that are associated with different muscle biopsy features, as well as with different clinical characteristics, prognoses and treatment responses...
May 15, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37165088/targeting-kdm2-7-histone-demethylases-could-protect-against-oa
#11
JOURNAL ARTICLE
Sarah Onuora
No abstract text is available yet for this article.
May 10, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37165087/antibodies-cross-reactive-with-dnase1l3-and-dsdna-discovered
#12
JOURNAL ARTICLE
Sarah Onuora
No abstract text is available yet for this article.
May 10, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37161086/gut-metabolite-mediates-neoantigen-generation-in-as
#13
JOURNAL ARTICLE
Jessica McHugh
No abstract text is available yet for this article.
May 9, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37161085/g-csf-implicated-as-therapeutic-target-in-aplaid
#14
JOURNAL ARTICLE
Jessica McHugh
No abstract text is available yet for this article.
May 9, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37161084/evidence-based-guideline-for-the-diagnosis-and-management-of-eosinophilic-granulomatosis-with-polyangiitis
#15
REVIEW
Giacomo Emmi, Alessandra Bettiol, Elena Gelain, Ingeborg M Bajema, Alvise Berti, Stella Burns, Maria C Cid, Jan W Cohen Tervaert, Vincent Cottin, Eugenia Durante, Julia U Holle, Alfred D Mahr, Marcos Martinez Del Pero, Chiara Marvisi, John Mills, Sergey Moiseev, Frank Moosig, Chetan Mukhtyar, Thomas Neumann, Iacopo Olivotto, Carlo Salvarani, Benjamin Seeliger, Renato A Sinico, Camille Taillé, Benjamin Terrier, Nils Venhoff, George Bertsias, Loïc Guillevin, David R W Jayne, Augusto Vaglio
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, characterized by asthma, eosinophilia and granulomatous or vasculitic involvement of several organs. The diagnosis and management of EGPA are often challenging and require an integrated, multidisciplinary approach. Current practice relies on recommendations and guidelines addressing the management of ANCA-associated vasculitis and not specifically developed for EGPA. Here, we present evidence-based, cross-discipline guidelines for the diagnosis and management of EGPA that reflect the substantial advances that have been made in the past few years in understanding the pathogenesis, clinical subphenotypes and differential diagnosis of the disease, as well as the availability of new treatment options...
May 9, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37161083/matrix-metalloproteinases-in-arthritis-towards-precision-medicine
#16
REVIEW
Bernard Grillet, Rafaela Vaz Sousa Pereira, Jo Van Damme, Ahmed Abu El-Asrar, Paul Proost, Ghislain Opdenakker
Proteolysis of structural molecules of the extracellular matrix (ECM) is an irreversible post-translational modification in all arthropathies. Common joint disorders, including osteoarthritis and rheumatoid arthritis, have been associated with increased levels of matrix remodelling enzymes, including matrix metalloproteinases (MMPs). MMPs, in concert with other host proteinases and glycanases, destroy proteoglycans, collagens and other ECM molecules. MMPs may also control joint remodelling indirectly by signalling through cell-surface receptors or by proteolysis of cytokines and receptor molecules...
May 9, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37147460/down-syndrome-insights-into-autoimmune-mechanisms
#17
JOURNAL ARTICLE
Bernard Khor, Jane H Buckner
No abstract text is available yet for this article.
May 5, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37142866/osteoarthritis-research-is-failing-to-reach-consumers
#18
JOURNAL ARTICLE
Vicky Duong, David J Hunter
No abstract text is available yet for this article.
May 4, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37118507/chimeric-receptors-broaden-the-therapeutic-landscape-for-autoimmune-disease
#19
JOURNAL ARTICLE
Terri H Finkel, Marko Radic
No abstract text is available yet for this article.
April 28, 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37059913/real-world-data-provide-insights-into-psa-treatment-patterns
#20
JOURNAL ARTICLE
Helena Marzo-Ortega, Stephanie R Harrison
No abstract text is available yet for this article.
April 14, 2023: Nature Reviews. Rheumatology
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