journal
Journals Nature Reviews. Gastroenterolo...

Nature Reviews. Gastroenterology & Hepatology

https://read.qxmd.com/read/37221319/etrasimod-for-ulcerative-colitis-evaluating-phase-iii-results
#1
JOURNAL ARTICLE
Katsuyoshi Matsuoka, Toshifumi Hibi
No abstract text is available yet for this article.
May 23, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37221318/nanoparticles-in-nafld-therapeutics
#2
JOURNAL ARTICLE
Eleni Kotsiliti
No abstract text is available yet for this article.
May 23, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37208503/fetal-liver-development-and-implications-for-liver-disease-pathogenesis
#3
REVIEW
Jeremy Lotto, Tabea L Stephan, Pamela A Hoodless
The metabolic, digestive and homeostatic roles of the liver are dependent on proper crosstalk and organization of hepatic cell lineages. These hepatic cell lineages are derived from their respective progenitors early in organogenesis in a spatiotemporally controlled manner, contributing to the liver's specialized and diverse microarchitecture. Advances in genomics, lineage tracing and microscopy have led to seminal discoveries in the past decade that have elucidated liver cell lineage hierarchies. In particular, single-cell genomics has enabled researchers to explore diversity within the liver, especially early in development when the application of bulk genomics was previously constrained due to the organ's small scale, resulting in low cell numbers...
May 19, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37193833/microbial-cues-stimulate-linear-growth-in-undernourished-mice
#4
JOURNAL ARTICLE
Chioma Moneme, Sean R Moore
No abstract text is available yet for this article.
May 16, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37173571/elucidating-the-link-between-clonal-haematopoiesis-and-chronic-liver-disease
#5
JOURNAL ARTICLE
Jordan Hindson
No abstract text is available yet for this article.
May 12, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37138044/gastrointestinal-health-and-the-environment-a-bidirectional-relationship
#6
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
May 3, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37130952/current-status-of-colon-capsule-endoscopy-in-clinical-practice
#7
JOURNAL ARTICLE
Anastasios Koulaouzidis, Gunnar Baatrup
No abstract text is available yet for this article.
May 2, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37186118/paracellular-permeability-and-tight-junction-regulation-in-gut-health-and-disease
#8
REVIEW
Arie Horowitz, Sandra D Chanez-Paredes, Xenia Haest, Jerrold R Turner
Epithelial tight junctions define the paracellular permeability of the intestinal barrier. Molecules can cross the tight junctions via two distinct size-selective and charge-selective paracellular pathways: the pore pathway and the leak pathway. These can be distinguished by their selectivities and differential regulation by immune cells. However, permeability increases measured in most studies are secondary to epithelial damage, which allows non-selective flux via the unrestricted pathway. Restoration of increased unrestricted pathway permeability requires mucosal healing...
April 25, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37085618/combination-therapy-with-methotrexate-in-paediatric-crohn-s-disease
#9
JOURNAL ARTICLE
Eleni Kotsiliti
No abstract text is available yet for this article.
April 21, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37085617/nafld-incidence-is-increasing
#10
JOURNAL ARTICLE
Eleni Kotsiliti
No abstract text is available yet for this article.
April 21, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37085616/zolbetuximab-treatment-in-metastatic-gastric-cancer
#11
JOURNAL ARTICLE
Eleni Kotsiliti
No abstract text is available yet for this article.
April 21, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37085615/air-pollution-and-oesophageal-cancer-risk
#12
JOURNAL ARTICLE
Eleni Kotsiliti
No abstract text is available yet for this article.
April 21, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37085614/gut-liver-axis-barriers-and-functional-circuits
#13
REVIEW
Oliver Pabst, Mathias W Hornef, Frank G Schaap, Vuk Cerovic, Thomas Clavel, Tony Bruns
The gut and the liver are characterized by mutual interactions between both organs, the microbiome, diet and other environmental factors. The sum of these interactions is conceptualized as the gut-liver axis. In this Review we discuss the gut-liver axis, concentrating on the barriers formed by the enterohepatic tissues to restrict gut-derived microorganisms, microbial stimuli and dietary constituents. In addition, we discuss the establishment of barriers in the gut and liver during development and their cooperative function in the adult host...
April 21, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37081213/the-appendix-and-ulcerative-colitis-an-unsolved-connection
#14
REVIEW
Manasi Agrawal, Kristine H Allin, Saurabh Mehandru, Jeremiah Faith, Tine Jess, Jean-Frederic Colombel
The appendix is thought to have a role in the pathogenesis of ulcerative colitis, but the nature and basis of this association remains unclear. In this Perspective, we consider the biology of the appendix with respect to its immunological function and the microbiome, and how this relates to evidence that supports the involvement of the appendix in ulcerative colitis. In experimental models, removal of the inflamed appendix prevents colitis, and in human observational studies, appendectomy is associated with protection against ulcerative colitis...
April 20, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37069322/liver-fibrosis-with-methotrexate-an-overestimated-risk
#15
JOURNAL ARTICLE
Raul J Andrade, Einar S Björnsson
No abstract text is available yet for this article.
April 17, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37069321/il-12-and-il-23-pathway-inhibition-in-inflammatory-bowel-disease
#16
REVIEW
Bram Verstockt, Azucena Salas, Bruce E Sands, Clara Abraham, Haim Leibovitzh, Markus F Neurath, Niels Vande Casteele
Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in the pathogenesis of inflammatory bowel disease. Upon their secretion by antigen-presenting cells, they exert both pro-inflammatory and anti-inflammatory receptor-mediated effects. An increased understanding of these biological effects, particularly the pro-inflammatory effects mediated by IL-12 and IL-23, has led to the development of monoclonal antibodies that target a subunit common to IL-12 and IL-23 (p40; targeted by ustekinumab and briakinumab), or the IL-23-specific subunit (p19; targeted by risankizumab, guselkumab, brazikumab and mirikizumab)...
April 17, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37069320/macrophages-in-intestinal-homeostasis-and-inflammatory-bowel-disease
#17
REVIEW
Lizi M Hegarty, Gareth-Rhys Jones, Calum C Bain
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be drivers of inflammation in the context of inflammatory bowel disease (IBD). How these peacekeepers become powerful aggressors in IBD is still unclear, but technological advances have revolutionized our understanding of many facets of their biology. In this Review, we discuss the progress made in understanding the heterogeneity of intestinal macrophages, the functions they perform in gut health and how the environment and origin can control the differentiation and longevity of these cells...
April 17, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37046097/elucidating-the-transmission-landscape-of-the-human-microbiome
#18
JOURNAL ARTICLE
Amira Metwaly, Dirk Haller
No abstract text is available yet for this article.
April 12, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37041321/screening-for-barrett-oesophagus-a-call-for-collaboration-between-gastroenterology-and-primary-care
#19
JOURNAL ARTICLE
Arvind J Trindade, Nicholas J Shaheen
No abstract text is available yet for this article.
April 11, 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37024566/global-burden-of-hepatitis-b-virus-current-status-missed-opportunities-and-a-call-for-action
#20
REVIEW
Yao-Chun Hsu, Daniel Q Huang, Mindie H Nguyen
Chronic hepatitis B virus (HBV) infection affects about 296 million people worldwide and is the leading aetiology of cirrhosis and liver cancer globally. Major medical complications also include acute flares and extrahepatic manifestations. In addition, people living with HBV infection also experience stigma. HBV-related cirrhosis resulted in an estimated 331,000 deaths in 2019, and it is estimated that the number of deaths from HBV-related liver cancer in 2019 was 192,000, an increase from 156,000 in 2010...
April 6, 2023: Nature Reviews. Gastroenterology & Hepatology
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