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Nature Reviews. Gastroenterology & Hepatology

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https://read.qxmd.com/read/30778141/cancer-associated-fibroblasts-in-gastrointestinal-cancer
#1
REVIEW
Hiroki Kobayashi, Atsushi Enomoto, Susan L Woods, Alastair D Burt, Masahide Takahashi, Daniel L Worthley
The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme, includes fibroblasts, immune cells, blood vessels and the extracellular matrix and substantially influences the initiation, growth and dissemination of gastrointestinal cancer. Cancer-associated fibroblasts (CAFs) are one of the critical components of the tumour mesenchyme and not only provide physical support for epithelial cells but also are key functional regulators in cancer, promoting and retarding tumorigenesis in a context-dependent manner...
February 18, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30733608/bacterial-strains-modulate-cd8-t-cell-function-and-cancer-immunity
#2
Hugh Thomas
No abstract text is available yet for this article.
February 7, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30723265/aclf-monocyte-dysfunction
#3
Clemens Thoma
No abstract text is available yet for this article.
February 5, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30718832/molecular-subtypes-of-pancreatic-cancer
#4
REVIEW
Eric A Collisson, Peter Bailey, David K Chang, Andrew V Biankin
Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indistinguishable cancers substantially impact the clinical characteristics of the disease. Molecular subtypes now guide preclinical and clinical therapeutic development and treatment in many cancer types. The ability to predict optimal therapeutic strategies ahead of treatment improves overall patient outcomes, minimizing treatment-related morbidity and cost...
February 4, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30705396/mutation-and-clonal-selection-in-the-ageing-oesophagus
#5
Hugh Thomas
No abstract text is available yet for this article.
January 31, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30705395/gut-microbiota-mediated-liver-inflammation-in-psc
#6
Iain Dickson
No abstract text is available yet for this article.
January 31, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30692658/risk-assessment-of-probiotics-use-requires-clinical-parameters
#7
Philippe Langella, Jean-Marc Chatel
No abstract text is available yet for this article.
January 28, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30675026/reduction-of-visceral-adipose-tissue-mass-requires-il-6-signalling
#8
Clemens Thoma
No abstract text is available yet for this article.
January 23, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30675025/panel-of-10-serum-metabolites-shows-promise-in-the-non-invasive-detection-of-advanced-fibrosis
#9
Clemens Thoma
No abstract text is available yet for this article.
January 23, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30675024/modified-folfirinox-superior-to-gemcitabine-in-resected-pancreatic-ductal-adenocarcinoma
#10
Clemens Thoma
No abstract text is available yet for this article.
January 23, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30659247/big-data-in-ibd-a-look-into-the-future
#11
REVIEW
Pablo Olivera, Silvio Danese, Nicolas Jay, Gioacchino Natoli, Laurent Peyrin-Biroulet
Big data methodologies, made possible with the increasing generation and availability of digital data and enhanced analytical capabilities, have produced new insights to improve outcomes in many disciplines. Application of big data in the health-care sector is in its early stages, although the potential for leveraging underutilized data to gain a better understanding of disease and improve quality of care is enormous. Owing to the intrinsic characteristics of inflammatory bowel disease (IBD) and the management dilemmas that it imposes, the implementation of big data research strategies not only can complement current research efforts but also could represent the only way to disentangle the complexity of the disease...
January 18, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30655632/better-end-points-needed-in-primary-sclerosing-cholangitis-trials
#12
Alessio Gerussi, Pietro Invernizzi
No abstract text is available yet for this article.
January 17, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30644454/precision-dietary-supplementation-based-on-personal-gut-microbiota
#13
Yu-Jui Yvonne Wan, Prasant Kumar Jena
No abstract text is available yet for this article.
January 15, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30643227/alcohol-liver-disease-and-the-gut-microbiota
#14
REVIEW
Jasmohan S Bajaj
Alcoholic liver disease, which ranges from mild disease to alcoholic hepatitis and cirrhosis, is a leading cause of morbidity and mortality worldwide. Alcohol intake can lead to changes in gut microbiota composition, even before liver disease development. These alterations worsen with advancing disease and could be complicit in disease progression. Microbial function, especially related to bile acid metabolism, can modulate alcohol-associated injury even in the presence of cirrhosis and alcoholic hepatitis...
January 14, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30643226/preventing-brain-damage-in-necrotizing-enterocolitis
#15
Clemens Thoma
No abstract text is available yet for this article.
January 14, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30643225/prucalopride-before-surgery-alleviates-postoperative-ileus
#16
Hugh Thomas
No abstract text is available yet for this article.
January 14, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30626900/fungal-dysbiosis-associated-with-colorectal-cancer
#17
Iain Dickson
No abstract text is available yet for this article.
January 9, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30626899/probiotics-fail-to-improve-preschool-gastroenteritis
#18
Iain Dickson
No abstract text is available yet for this article.
January 9, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30617296/host-pathogen-interactions-in-chronic-hbv-infection-and-transplantation-of-hcv-positive-organs
#19
Jordan J Feld, Adam J Gehring
No abstract text is available yet for this article.
January 7, 2019: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/30568278/hepatic-microcirculation-and-mechanisms-of-portal-hypertension
#20
REVIEW
Jordi Gracia-Sancho, Giusi Marrone, Anabel Fernández-Iglesias
The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells (LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in liver homeostasis, including in preserving hepatocyte function, regulating the vascular tone and controlling inflammation. Liver microcirculatory dysfunction is one of the key mechanisms that promotes the progression of chronic liver disease (also termed cirrhosis) and the development of its major clinical complication, portal hypertension...
December 19, 2018: Nature Reviews. Gastroenterology & Hepatology
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