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Nature Reviews. Cardiology

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https://read.qxmd.com/read/30770894/t-cell-co-stimulation-and-co-inhibition-in-cardiovascular-disease-a-double-edged-sword
#1
REVIEW
Karin H Simons, Alwin de Jong, J Wouter Jukema, Margreet R de Vries, Ramon Arens, Paul H A Quax
The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and contribute to the onset and progression of CVD. T cell activation is modulated by T cell co-stimulation and co-inhibition pathways. Immune checkpoint inhibitors (ICIs) targeting T cell inhibition pathways have revolutionized cancer treatment and improved survival in patients with cancer. However, ICIs might induce cardiovascular toxicity via T cell re-invigoration...
February 15, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30755739/modulating-myosin-function-to-treat-hypertrophic-cardiomyopathy
#2
Irene Fernández-Ruiz
No abstract text is available yet for this article.
February 12, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30728471/mobilizing-regulatory-t-cells-to-promote-myocardial-repair
#3
Gregory B Lim
No abstract text is available yet for this article.
February 6, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30710151/a-new-organoid-model-to-study-diabetic-vasculopathy
#4
Alexandra Le Bras
No abstract text is available yet for this article.
February 1, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30700861/midkine-promotes-netosis-in-myocarditis
#5
Gregory B Lim
No abstract text is available yet for this article.
January 30, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30700860/what-is-ldl-cholesterol
#6
Michael V Holmes, Mika Ala-Korpela
No abstract text is available yet for this article.
January 30, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30696979/poor-sleep-linked-to-atherosclerosis
#7
Alexandra Le Bras
No abstract text is available yet for this article.
January 29, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30692657/ketone-body-utilization-in-myocardial-ischaemia
#8
Gregory B Lim
No abstract text is available yet for this article.
January 28, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30692656/income-volatility-and-increased-risk-of-cvd
#9
Gregory Lim
No abstract text is available yet for this article.
January 28, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30692655/adding-rivaroxaban-to-aspirin-after-cabg-surgery
#10
Gregory B Lim
No abstract text is available yet for this article.
January 28, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30683889/mechanical-regulation-of-gene-expression-in-cardiac-myocytes-and-fibroblasts
#11
REVIEW
Jeffrey J Saucerman, Philip M Tan, Kyle S Buchholz, Andrew D McCulloch, Jeffrey H Omens
The intact heart undergoes complex and multiscale remodelling processes in response to altered mechanical cues. Remodelling of the myocardium is regulated by a combination of myocyte and non-myocyte responses to mechanosensitive pathways, which can alter gene expression and therefore function in these cells. Cellular mechanotransduction and its downstream effects on gene expression are initially compensatory mechanisms during adaptations to the altered mechanical environment, but under prolonged and abnormal loading conditions, they can become maladaptive, leading to impaired function and cardiac pathologies...
January 25, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30683888/artificial-intelligence-to-improve-the-diagnosis-of-cardiovascular-diseases
#12
Irene Fernández-Ruiz
No abstract text is available yet for this article.
January 25, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30675027/oxidized-phospholipids-as-a-unifying-theory-for-lipoprotein-a-and-cardiovascular-disease
#13
REVIEW
Michael B Boffa, Marlys L Koschinsky
Epidemiological and clinical studies over the past decade have firmly established that elevated plasma concentrations of lipoprotein(a) (Lp(a)) are an important, independent and probably causal risk factor for the development of cardiovascular diseases. Whereas a link between Lp(a) levels and atherosclerotic cardiovascular disease (ASCVD) has been appreciated for decades, the role of Lp(a) in calcific aortic valve disease (CAVD) and aortic stenosis has come into focus only in the past 5 years. ASCVD and CAVD are aetiologically distinct but have several risk factors in common and similar pathological processes at the cellular and molecular levels...
January 23, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30664669/transient-receptor-potential-channels-in-cardiac-health-and-disease
#14
REVIEW
Thomas Hof, Sébastien Chaigne, Alice Récalde, Laurent Sallé, Fabien Brette, Romain Guinamard
Transient receptor potential (TRP) channels are nonselective cationic channels that are generally Ca2+ permeable and have a heterogeneous expression in the heart. In the myocardium, TRP channels participate in several physiological functions, such as modulation of action potential waveform, pacemaking, conduction, inotropy, lusitropy, Ca2+ and Mg2+ handling, store-operated Ca2+ entry, embryonic development, mitochondrial function and adaptive remodelling. Moreover, TRP channels are also involved in various pathological mechanisms, such as arrhythmias, ischaemia-reperfusion injuries, Ca2+ -handling defects, fibrosis, maladaptive remodelling, inherited cardiopathies and cell death...
January 21, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30659248/percutaneous-management-of-paravalvular-leaks
#15
REVIEW
Joel P Giblett, Bushra S Rana, Leonard M Shapiro, Patrick A Calvert
Paravalvular leak (PVL) is a complication that occurs in 5-17% of patients after surgical prosthetic valve implantation. Whereas PVLs can be benign, some PVLs are associated with substantial morbidity and mortality. Percutaneous closure using occluders specifically designed to improve closure and reduce procedural complications has now become the first-line treatment for PVL. In this Review, we first detail the frequency and clinical consequences of PVL closure. The role of cardiac imaging in the assessment and management of PVL, including echocardiographic imaging and adjunctive techniques such as CT, is then discussed, together with important considerations for the percutaneous closure of PVL, such as access site and device selection...
January 18, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30643301/clonal-haematopoiesis-predicts-poor-prognosis-in-heart-failure
#16
Gregory B Lim
No abstract text is available yet for this article.
January 14, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30607010/the-lncrna-chrome-regulates-cholesterol-homeostasis
#17
Alexandra Le Bras
No abstract text is available yet for this article.
January 3, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30607009/breakthrough-in-heart-xenotransplantation
#18
Irene Fernández-Ruiz
No abstract text is available yet for this article.
January 3, 2019: Nature Reviews. Cardiology
https://read.qxmd.com/read/30575807/decoding-a-major-cad-risk-locus
#19
Irene Fernández-Ruiz
No abstract text is available yet for this article.
December 21, 2018: Nature Reviews. Cardiology
https://read.qxmd.com/read/30573761/nutrient-supplementation-no-substitute-for-healthy-diets
#20
Frank B Hu
No abstract text is available yet for this article.
December 20, 2018: Nature Reviews. Cardiology
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