journal
https://read.qxmd.com/read/38622282/neuronal-activity-drives-glymphatic-waste-clearance
#1
JOURNAL ARTICLE
Lisa Kiani
No abstract text is available yet for this article.
April 15, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38609644/neurofilaments-as-biomarkers-in-neurological-disorders-towards-clinical-application
#2
REVIEW
Michael Khalil, Charlotte E Teunissen, Sylvain Lehmann, Markus Otto, Fredrik Piehl, Tjalf Ziemssen, Stefan Bittner, Maria Pia Sormani, Thomas Gattringer, Samir Abu-Rumeileh, Simon Thebault, Ahmed Abdelhak, Ari Green, Pascal Benkert, Ludwig Kappos, Manuel Comabella, Hayrettin Tumani, Mark S Freedman, Axel Petzold, Kaj Blennow, Henrik Zetterberg, David Leppert, Jens Kuhle
Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-axonal injury. The advent of highly sensitive analytical platforms that enable reliable quantification of neurofilaments in blood samples and simplify longitudinal follow-up has paved the way for the development of neurofilaments as a biomarker in clinical practice. Potential applications include assessment of disease activity, monitoring of treatment responses, and determining prognosis in many acute and chronic neurological disorders as well as their use as an outcome measure in trials of novel therapies...
April 12, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38609643/addressing-disparities-in-neurology-by-identifying-gaps-in-hospital-care
#3
Lisa Kiani
No abstract text is available yet for this article.
April 12, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38594557/btk-inhibitor-falters-in-multiple-sclerosis-trials
#4
JOURNAL ARTICLE
Heather Wood
No abstract text is available yet for this article.
April 10, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38594556/ebv-specific-t-cells-in-multiple-sclerosis
#5
JOURNAL ARTICLE
Heather Wood
No abstract text is available yet for this article.
April 10, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38580849/support-for-network-theories-of-schizophrenia
#6
JOURNAL ARTICLE
Martijn P van den Heuvel, Sara L Seoane
No abstract text is available yet for this article.
April 5, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38570705/neurostimulation-for-treatment-of-post-stroke-impairments
#7
REVIEW
Jesse Dawson, Azmil H Abdul-Rahim, Teresa J Kimberley
Neurostimulation, the use of electrical stimulation to modulate the activity of the nervous system, is now commonly used for the treatment of chronic pain, movement disorders and epilepsy. Many neurostimulation techniques have now shown promise for the treatment of physical impairments in people with stroke. In 2021, vagus nerve stimulation was approved by the FDA as an adjunct to intensive rehabilitation therapy for the treatment of chronic upper extremity deficits after ischaemic stroke. In 2024, pharyngeal electrical stimulation was conditionally approved by the UK National Institute for Health and Care Excellence for neurogenic dysphagia in people with stroke who have a tracheostomy...
April 3, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38570704/insights-into-epileptogenesis-from-post-traumatic-epilepsy
#8
REVIEW
Matthew Pease, Kunal Gupta, Solomon L Moshé, Daniel J Correa, Aristea S Galanopoulou, David O Okonkwo, Jorge Gonzalez-Martinez, Lori Shutter, Ramon Diaz-Arrastia, James F Castellano
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after traumatic brain injury (TBI) depends on the severity of injury, approaching one in three in groups with the most severe injuries. The repeated seizures that characterize PTE impair neurological recovery and increase the risk of poor outcomes after TBI. Given this high risk of recurrent seizures and the relatively short latency period for their development after injury, PTE serves as a model disease to understand human epileptogenesis and trial novel anti-epileptogenic therapies...
April 3, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38570703/approval-of-omaveloxolone-for-friedreich-ataxia
#9
JOURNAL ARTICLE
Sylvia Boesch, Elisabetta Indelicato
No abstract text is available yet for this article.
April 3, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38499761/neurological-care-for-lgbt-people
#10
REVIEW
Salvatore Giovanni Volpe, Joya Ahmad, Roshni Abee Patel, Nicole Rosendale
Sexual and gender minority (LGBT+) people face unique health disparities that must be considered by health-care providers to ensure equitable and inclusive care. Although traditionally LGBT+ health has not been integrated into neurology training, sexual orientation and gender identity have direct relevance to neurological health, driven by both systemic and interpersonal factors. In this Review, we summarize the evidence for associations between sexual orientation and gender identity with the prevalence and outcomes of various neurological conditions, including neurodegenerative diseases, epilepsy, stroke and neurodevelopmental disorders, among others...
March 18, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38454092/towards-the-era-of-biological-biomarkers-for-parkinson-disease
#11
JOURNAL ARTICLE
Nobutaka Hattori
No abstract text is available yet for this article.
March 7, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38443479/%C3%AE-synuclein-seeds-in-amyotrophic-lateral-sclerosis
#12
JOURNAL ARTICLE
Ian Fyfe
No abstract text is available yet for this article.
March 5, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38443477/marker-provides-10-year-warning-of-dementia
#13
JOURNAL ARTICLE
Ian Fyfe
No abstract text is available yet for this article.
March 5, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38443476/metabolic-changes-in-status-epilepticus
#14
JOURNAL ARTICLE
Ian Fyfe
No abstract text is available yet for this article.
March 5, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38443475/parkinson-disease-pathology-in-inflammatory-bowel-disease
#15
JOURNAL ARTICLE
Heather Wood
No abstract text is available yet for this article.
March 5, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38429551/biomarker-based-staging-of-alzheimer-disease-rationale-and-clinical-applications
#16
REVIEW
Joseph Therriault, Suzanne E Schindler, Gemma Salvadó, Tharick A Pascoal, Andréa Lessa Benedet, Nicholas J Ashton, Thomas K Karikari, Liana Apostolova, Melissa E Murray, Inge Verberk, Jacob W Vogel, Renaud La Joie, Serge Gauthier, Charlotte Teunissen, Gil D Rabinovici, Henrik Zetterberg, Randall J Bateman, Philip Scheltens, Kaj Blennow, Reisa Sperling, Oskar Hansson, Clifford R Jack, Pedro Rosa-Neto
Disease staging, whereby the spatial extent and load of brain pathology are used to estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard neuropathological diagnosis of AD. Current in vivo diagnostic frameworks for AD are based on abnormal concentrations of amyloid-β and tau in the cerebrospinal fluid or on PET scans, and breakthroughs in molecular imaging have opened up the possibility of in vivo staging of AD. Focusing on the key principles of disease staging shared across several areas of medicine, this Review highlights the potential for in vivo staging of AD to transform our understanding of preclinical AD, refine enrolment criteria for trials of disease-modifying therapies and aid clinical decision-making in the era of anti-amyloid therapeutics...
March 1, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38424454/is-alzheimer-disease-a-disease
#17
REVIEW
Amos D Korczyn, Lea T Grinberg
Dementia, a prevalent condition among older individuals, has profound societal implications. Extensive research has resulted in no cure for what is perceived as the most common dementing illness: Alzheimer disease (AD). AD is defined by specific brain abnormalities - amyloid-β plaques and tau protein neurofibrillary tangles - that are proposed to actively influence the neurodegenerative process. However, conclusive evidence of amyloid-β toxicity is lacking, the mechanisms leading to the accumulation of plaques and tangles are unknown, and removing amyloid-β has not halted neurodegeneration...
February 29, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38378999/ultrasound-and-antibodies-a-potentially-powerful-combination-for-alzheimer-disease-therapy
#18
JOURNAL ARTICLE
Jürgen Götz, Pranesh Padmanabhan
No abstract text is available yet for this article.
February 20, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38356056/epilepsy-and-epileptiform-activity-in-late-onset-alzheimer-disease-clinical-and-pathophysiological-advances-gaps-and-conundrums
#19
REVIEW
Anita Kamondi, Madeleine Grigg-Damberger, Wolfgang Löscher, Heikki Tanila, Andras Attila Horvath
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in AD by years, and its presence has been shown to predict a faster disease course. In animal models of AD, amyloid and tau pathology are linked to cortical network hyperexcitability that precedes the first signs of memory decline. Thus, detection of epileptiform activity in AD has substantial clinical importance as a potential novel modifiable risk factor for dementia...
February 14, 2024: Nature Reviews. Neurology
https://read.qxmd.com/read/38336911/reply-to-questioning-the-cycad-theory-of-kii-als-pdc-causation
#20
LETTER
Katerina Menšíková, Raymond Rosales, Carlo Colosimo, Peter Spencer, Annie Lannuzel, Yoshikazu Ugawa, Ryogen Sasaki, Santiago Giménez-Roldán, Radoslav Matej, Lucie Tuckova, Dominik Hrabos, Kristyna Kolarikova, Radek Vodicka, Radek Vrtel, Miroslav Strnad, Petr Hlustik, Pavel Otruba, Martin Prochazka, Martin Bares, Susana Boluda, Luc Buee, Gerhard Ransmayr, Petr Kaňovský
No abstract text is available yet for this article.
February 9, 2024: Nature Reviews. Neurology
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