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Nature Reviews. Neurology

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https://read.qxmd.com/read/30778210/long-term-outcomes-of-deep-brain-stimulation-in-parkinson-disease
#1
REVIEW
Patricia Limousin, Tom Foltynie
The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically discuss the evidence on the long-term outcomes of DBS and consider the clinical implications. Although many patients are lost to follow-up, the evidence indicates that subthalamic nucleus DBS improves motor function for up to 10 years, although the magnitude of improvement tends to decline over time. Functional scores recorded during on-medication periods worsen more quickly than those recorded in off periods, consistent with the degeneration of non-dopaminergic pathways...
February 18, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30778209/exploring-vascular-a%C3%AE-pathology-using-microvessel-extracts-from-frozen-human-brain-samples
#2
Rebecca Kelsey
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30778208/iron-deposition-in-periaqueductal-grey-matter-as-a-biomarker-of-chronic-migraine
#3
Rebecca Kelsey
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30778207/prodromal-symptoms-might-vary-between-multiple-sclerosis-subtypes
#4
Rebecca Kelsey
No abstract text is available yet for this article.
February 18, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30755723/oligodendrocyte-studies-reveal-limits-on-remyelination
#5
Ian Fyfe
No abstract text is available yet for this article.
February 12, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30742037/author-correction-protecting-the-ischaemic-penumbra-as-an-adjunct-to-thrombectomy-for-acute-stroke
#6
Jean-Claude Baron
The originally published article contained an error in Table 1, whereby the RESCUE trial appeared on the "Transient descending aortic balloon occlusion (TAO)" line instead of the "Remote ischaemic perconditioning (RIPerC)" line. This has been corrected in the HTML and PDF versions of the manuscript.
February 11, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30733618/dementia-in-down-syndrome-unique-insights-for-alzheimer-disease-research
#7
REVIEW
Ira T Lott, Elizabeth Head
Virtually all adults with Down syndrome (DS) show the neuropathological changes of Alzheimer disease (AD) by the age of 40 years. This association is partially due to overexpression of amyloid precursor protein, encoded by APP, as a result of the location of this gene on chromosome 21. Amyloid-β accumulates in the brain across the lifespan of people with DS, which provides a unique opportunity to understand the temporal progression of AD and the epigenetic factors that contribute to the age of dementia onset...
February 7, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30733617/defects-in-adenosine-metabolism-identified-in-als
#8
Heather Wood
No abstract text is available yet for this article.
February 7, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30718825/lifestyle-factors-and-progression-of-pd
#9
Rebecca Kelsey
No abstract text is available yet for this article.
February 4, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30718824/gene-editing-shows-promise-in-lca10
#10
Rebecca Kelsey
No abstract text is available yet for this article.
February 4, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30718823/prolonging-the-integrated-stress-response-could-be-beneficial-in-multiple-sclerosis
#11
Rebecca Kelsey
No abstract text is available yet for this article.
February 4, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30710130/cgrp-antibodies-for-migraine-prevention-new-kids-on-the-block
#12
Hans-Christoph Diener
No abstract text is available yet for this article.
February 1, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30710129/stroke-trial-drug-is-effective-in-alzheimer-disease-mouse-model
#13
Ian Fyfe
No abstract text is available yet for this article.
February 1, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30700825/the-role-of-sensory-information-in-the-pathophysiology-of-focal-dystonias
#14
REVIEW
Antonella Conte, Giovanni Defazio, Mark Hallett, Giovanni Fabbrini, Alfredo Berardelli
Over the past few decades, abnormalities in sensory functions, such as tactile, proprioceptive and nociceptive processing, have been increasingly recognized in patients with focal dystonias. In this Review, we ask whether sensory system abnormalities are specific to particular types of dystonia, whether a causal link exists between sensory alterations and dystonic motor activity and how mechanisms underlying the sensory abnormalities fit in with the proposed 'network model' of dystonia. We suggest that alterations in the various sensory modalities participate at three different levels in the pathophysiological cascade that leads to dystonia: a background level that predisposes individuals to dystonia, a disease-related level that is evident only when dystonia becomes manifest and a causative level that triggers dystonia...
January 30, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30700824/exosomes-beyond-stem-cells-for-restorative-therapy-in-stroke-and-neurological-injury
#15
REVIEW
Zheng Gang Zhang, Benjamin Buller, Michael Chopp
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and their families, but currently no drugs on the market promote neurological recovery. Limited spontaneous recovery of function as a result of brain remodelling after stroke or injury does occur, and cell-based therapies have been used to promote these endogenous processes. Increasing evidence is demonstrating that the positive effects of such cell-based therapy are mediated by exosomes released from the administered cells and that the microRNA cargo in these exosomes is largely responsible for the therapeutic effects...
January 30, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30700823/decreased-nrem-sleep-linked-with-tauopathy
#16
Rebecca Kelsey
No abstract text is available yet for this article.
January 30, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30696951/concussion-and-risk-of-suicide-who-when-and-under-what-circumstances
#17
Lisa A Brenner, Nazanin H Bahraini
No abstract text is available yet for this article.
January 29, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30683913/deep-brain-stimulation-current-challenges-and-future-directions
#18
REVIEW
Andres M Lozano, Nir Lipsman, Hagai Bergman, Peter Brown, Stephan Chabardes, Jin Woo Chang, Keith Matthews, Cameron C McIntyre, Thomas E Schlaepfer, Michael Schulder, Yasin Temel, Jens Volkmann, Joachim K Krauss
The clinical use of deep brain stimulation (DBS) is among the most important advances in the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly measure pathological brain activity and can deliver adjustable stimulation for therapeutic effect in neurological and psychiatric disorders correlated with dysfunctional circuitry. The development of DBS has opened new opportunities to access and interrogate malfunctioning brain circuits and to test the therapeutic potential of regulating the output of these circuits in a broad range of disorders...
January 25, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30664683/chronic-traumatic-encephalopathy-confusion-and-controversies
#19
REVIEW
Douglas H Smith, Victoria E Johnson, John Q Trojanowski, William Stewart
The term chronic traumatic encephalopathy (CTE) has recently entered public consciousness via media reports and even a Hollywood movie. However, in contrast to general impressions, the incidence of CTE is unknown, the clinical diagnostic criteria have not been agreed upon and the current neuropathological characterization of CTE is acknowledged as preliminary. Additionally, few studies have compared the pathologies of CTE with those of other neurodegenerative disorders or of age-matched controls. Consequently, disagreement continues about the neuropathological aspects that make CTE unique...
January 21, 2019: Nature Reviews. Neurology
https://read.qxmd.com/read/30655610/getting-closer-to-a-cure-for-migraine
#20
Cristina Tassorelli, Roberto De Icco
No abstract text is available yet for this article.
January 17, 2019: Nature Reviews. Neurology
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