journal
https://read.qxmd.com/read/38613789/diagnostic-accuracy-of-international-system-for-reporting-serous-fluid-cytopathology-a-systematic-review-and-meta-analysis-in-malignancy-diagnosis
#1
REVIEW
Sana Ahuja, Rhea Ahuja, Shivam Pandey, Sufian Zaheer
This study conducts the first meta-analysis to assess the aggregated risk of malignancy associated with each category of the International System for Reporting Serous Fluid Cytopathology (ISRSFC) for reporting serous effusion cytology, while also evaluating diagnostic accuracy. PubMed/MEDLINE and Embase were systematically searched using the keywords "(pleural, peritoneal, and pericardial effusions) AND (serous effusion cytology) OR (International System for Reporting Serous Fluid Cytopathology)". Articles underwent risk of bias assessment using the QUADAS-2 tool...
April 13, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38613788/atypical-squamous-cells-in-urine-cytology-are-associated-with-a-significant-risk-of-high-grade-malignancy
#2
JOURNAL ARTICLE
Linh Ho, Tarik M Elsheikh
BACKGROUND: Atypical squamous cells (ASC) in urine cytology are rarely found, and their clinical significance is not well studied. Previous studies were limited by a small number of cases and a lack of objective grading of ASC and/or their correlation with accompanying urothelial cell abnormality (UCA). METHODS: The institutional database was searched over 10 years for urine cytology reports containing ASC or from patients who had a concurrent diagnoses of high-grade (HG) urothelial carcinoma with squamous differentiation or squamous carcinoma...
April 13, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38605557/spotlight-rising-stars-in-cytology
#3
JOURNAL ARTICLE
Pasquale Pisapia
No abstract text is available yet for this article.
April 11, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38594206/spotlight-rising-stars-in-cytology
#4
JOURNAL ARTICLE
Jaylou M Velez Torres
No abstract text is available yet for this article.
April 9, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38594192/atypia-of-undetermined-significance-and-thyroseq-v3-positive-call-rates-as-quality-control-metrics-for-cytology-laboratory-performance
#5
JOURNAL ARTICLE
Odille Mejia-Mejia, Andres Bravo-Gonzalez, Monica Sanchez-Avila, Youley Tjendra, Rodrigo Santoscoy, Katherine Drews-Elger, Yiqin Zuo, Camilo Arias-Abad, Carmen Gomez, Monica Garcia-Buitrago, Mehrdad Nadji, Merce Jorda, Jaylou M Velez-Torres, Roberto Ruiz-Cordero
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) recommends an upper limit of 10% for atypia of undetermined significance (AUS). Recent data suggest that this category might be overused when the rate of cases with molecular positive results is low. As a quality metric, the AUS and positive call rates for this facility's cytology laboratory and each cytopathologist (CP) were calculated. METHODS: A retrospective analysis of all thyroid cytology cases in a 4...
April 9, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38594180/exploring-the-atypia-of-undetermined-significance-malignant-ratio-thyroseq-v3-positive-call-rate-molecular-derived-risk-of-malignancy-and-risk-of-malignancy-as-possible-quality-metric-tools-in-thyroid-cytology
#6
JOURNAL ARTICLE
Jaylou M Velez Torres, Porshya M Curnow, Youley Tjendra, Merce Jorda, Carmen Gomez Fernandez, Monica Garcia Buitrago, Yiqin Zuo, Roberto Ruiz Cordero
BACKGROUND: The atypia of undetermined significance (AUS) category is heterogeneous, leading to variations in its use. To prevent excessive usage, the AUS rate should be ≤10%. Although this recommendation aims to maintain diagnostic quality, it lacks supporting data. The AUS:Malignant (AUS:M) ratio has been proposed as a metric tool to evaluate AUS use. Furthermore, integrating ThyroSeq v3 (TSV3) positive call rate (PCR) and the molecular-derived risk of malignancy (MDROM) have been put forward as performance improvement tools...
April 9, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38594082/how-the-milan-system-for-reporting-salivary-gland-cytopathology-works-in-cytopathology-practice-meta-analysis-of-prospective-studies-and-comparison-with-retrospective-studies
#7
JOURNAL ARTICLE
Henri Lagerstam, David Kalfert, Zahra Maleki, Ivana Kholová
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is widely accepted and endorsed by professional societies. Although several studies focusing on the MSRSGC have been published, few have been prospective studies. The objective of this study was to evaluate the effectiveness of the MSRSGC in cytopathology practice. METHODS: A comprehensive literature search was conducted to identify all prospective studies on the MSRSGC. The risk of malignancy (ROM), risk of neoplasm, and diagnostic accuracy for each diagnostic category were calculated...
April 9, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38563876/molecular-analysis-using-salvglanddx-improves-risk-of-malignancy-estimation-and-diagnosis-of-salivary-gland-cytopathology-an-exploratory-multicenter-study
#8
JOURNAL ARTICLE
Sandra N Freiberger, Kristian Ikenberg, Demi van Egmond, Sofie Claerhout, Tom van Wezel, Isabelle Vanden Bempt, Jeroen N van Rossem, Simon A Mueller, Paul M Clement, Vincent Vander Poorten, Danielle Cohen, Esther Hauben, Niels J Rupp
BACKGROUND: Diagnosis of salivary gland neoplasms is challenging, especially on cytological specimens acquired by fine-needle aspiration. The recently implemented standardized Milan system for reporting salivary gland cytopathology provides an estimated risk of malignancy (ROM); yet, for two of the categories, the diagnosis of the lesion remains unclear. However, a precise diagnosis is desirable for optimal patient management, including planning of surgery and imaging procedures. METHODS: Cytological specimens (n = 106) were subjected to molecular analysis using the SalvGlandDx panel...
April 2, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38563725/papillae-psammoma-bodies-and-or-many-nuclear-pseudoinclusions-are-helpful-criteria-but-should-not-be-required-for-a-definitive-cytologic-diagnosis-of-papillary-thyroid-carcinoma-an-institutional-experience-of-207-cases-with-surgical-follow-up
#9
JOURNAL ARTICLE
Tarik M Elsheikh, Matthew Thomas, Jennifer Brainard, Jessica Di Marco, Erica Manosky, Bridgette Springer, Dawn Underwood, Deborah J Chute
BACKGROUND: Noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP) was introduced in 2016 replacing noninvasive follicular variant of papillary thyroid carcinoma, with recommendations to label them "noncancer." To avoid reducing risk of malignancy (ROM) and overdiagnosing NIFTP as malignant, some authors required restricted cytologic criteria (RC) for a definitive diagnosis of papillary thyroid carcinoma (PTC), including papillae, psammoma bodies. or ≥3 nuclear pseudoinclusions...
April 2, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38558329/thyroid-nodules-with-dicer1-mutation-or-pten-alteration-a-comparative-cytologic-clinical-and-molecular-study-of-117-fna-cases
#10
JOURNAL ARTICLE
Tikamporn Jitpasutham, Stefen Andrianus, Maria Gubbiotti, Vania Nosé, Zubair W Baloch, Emilio Madrigal, William C Faquin
BACKGROUND: DICER1 mutations and PTEN alterations are increasingly detected by thyroid fine-needle aspiration (FNA). Both are associated with nodular thyroid disease and cancer. The authors analyzed a large comparative thyroid FNA cohort with DICER1 mutation or PTEN alteration. METHODS: A total of 117 thyroid FNAs with DICER1 or PTEN alterations were retrieved from the databases of two academic medical institutions. Demographic, clinical, and radiologic data were collected; FNA slides were analyzed for 29 cytomorphologic features...
April 1, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38552002/risks-of-malignancy-in-the-major-nongynecologic-cytopathology-reporting-systems-critiques-and-discussions
#11
REVIEW
Marc P Pusztaszeri, Mauro Saieg, Zubair W Baloch
The ever-increasing popularity of standardized systems for reporting cytopathology has led in part to much attention to and importance of the risk stratification schemes, especially the risks of malignancy (ROMs), which are associated with the different diagnostic categories and upon which recommendations for clinical management are based. However, it is well known that the ROM calculations are based on retrospective reviews of the existing literature, representing a heterogeneous patient population, and are plagued by significant biases and variations...
March 29, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38536199/the-updated-college-of-american-pathologists-principles-of-analytic-validation-of-immunohistochemical-assays-a-step-forward-for-cytopathology
#12
JOURNAL ARTICLE
Sinchita Roy-Chowdhuri
No abstract text is available yet for this article.
March 27, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38520219/comprehensive-evaluation-of-cytomorphologic-histologic-and-molecular-features-of-dicer1-altered-thyroid-lesions-on-fna-a-multipractice-experience
#13
JOURNAL ARTICLE
Krisztina Lengyel, Daniel J Lubin, Wen-Yu Hsiao, Sam Sirotnikov, Guangju Luo, James W Roberts, Qiuying Shi, Kelly Magliocca, Melinda M Lewis, Donald L Sears, Ghulam Ilyas, Beverly B Rogers, Kartik Viswanathan
BACKGROUND: DICER1 mutations, though infrequent, are encountered on preoperative molecular testing of indeterminate adult and pediatric thyroid fine-needle aspiration (FNA) specimens. Yet, published cytomorphologic features of DICER1-altered thyroid lesions are limited. Cytomorphological features of DICER1-altered thyroid lesions were examined in a multipractice FNA cohort with clinical, radiological, and histologic data. METHODS: The cohort comprised 18 DICER1-altered thyroid FNAs, with 14 having slides available and eight having corresponding surgical resections...
March 23, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38488294/incorporation-of-dna-methylation-profiling-into-the-cytopathology-laboratory
#14
JOURNAL ARTICLE
Gloria H Sura, Leomar Y Ballester
No abstract text is available yet for this article.
March 15, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38451011/interobserver-agreement-in-the-interpretation-of-anal-cytology
#15
JOURNAL ARTICLE
Maria Benevolo, Francesca Rollo, Alessandra Latini, Massimo Giuliani, Amalia Giglio, Eugenia Giuliani, Maria Gabriella Donà
BACKGROUND: Anal cytology represents a tool for anal cancer screening in high-risk populations. In addition to accuracy, the reproducibility of the interpretation is of key importance. The authors evaluated the agreement of anal cytologic interpretation between two cytopathologists. METHODS: Liquid-based cytologic slides from human immunodeficiency virus (HIV)-negative men who have sex with men (MSM) were evaluated by two readers with at least 10 years of expertise in cervical cytology...
March 7, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38450993/improving-diagnostic-yield-of-pancreatic-serous-cystadenoma-with-cyst-fluid-ancillary-testing-adjunct-immunohistochemistry-and-additional-fine-needle-biopsy-sampling
#16
JOURNAL ARTICLE
Xi Wang, Xuchen Zhang, Pei Hui, Guoping Cai
BACKGROUND: Fine-needle aspiration (FNA) diagnosis of pancreatic serous cystadenoma (SCA) remains challenging. This retrospective study aimed to evaluate the roles of cyst fluid ancillary testing and combined fine-needle biopsy (FNB) in improving the diagnostic yield. METHODS: The authors retrospectively reviewed cytology cases that were histologically confirmed SCAs. Clinical features and FNA cyst fluid biochemical and molecular analysis results along FNB findings were reviewed...
March 7, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38427323/leveraging-archival-cerebrospinal-fluid-samples-for-genetic-insights-from-cell-free-dna
#17
EDITORIAL
Alexandra M Miller, Tejus A Bale
No abstract text is available yet for this article.
March 1, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38410851/interobserver-agreement-and-risk-of-malignancy-using-the-international-academy-of-cytology-yokohama-system-for-reporting-breast-fna-biopsy-in-a-liquid-based-exclusive-cohort
#18
JOURNAL ARTICLE
Olawunmi Folarin, David Kim, Hamza N Gokozan, Jonas J Heymann, Jose V Scarpa Carniello, Lucelina Rosado, Momin T Siddiqui, Ami Patel
BACKGROUND: Per the College of American Pathologist's National Breast Fine Needle Aspiration Biopsy (FNAB) Practice Survey, ∼40% of laboratories use liquid-based cytology (LBC) for breast FNAB. The reproducibility of the International Academy of Cytology Yokohama System (YS) for reporting breast FNAB on LBC was explored. DESIGN: Breast FNAB specimens submitted as LBC only (all ThinPrep) between January 2017 and January 2021 were retrieved. Cases without histopathologic follow-up were excluded...
February 27, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38373111/retrospective-analysis-of-cytology-and-high-risk-hpv-testing-in-1067-endocervical-adenocarcinomas-and-precursor-lesions
#19
JOURNAL ARTICLE
Lei Ye, Meifu Gan, Yeli Yao, Bingjian Lu
BACKGROUND: Cytology and high-risk human papilloma virus (hrHPV) cotesting is the mainstay in the detection of cervical carcinoma. METHODS: Endocervical adenocarcinoma (EAC) is divided into HPV-associated adenocarcinoma (HPVA) and HPV-independent adenocarcinoma (HPVI) by the World Health Organization classification (2020). The detection effect of cotesting is suggested to be different among EAC subtypes and precursors, but has not well-documented yet. In this study, the authors retrospectively analyzed cotesting among adenocarcinoma in situ (AIS), HPVA, and HPVI...
February 19, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38373107/detection-of-effusion-tumor-cells-under-different-storage-and-processing-conditions
#20
JOURNAL ARTICLE
Diane M Libert, Yili Zhu, Aihui Wang, Grace M Allard, Alarice Cheng-Yi Lowe
BACKGROUND: Circulating tumor cells (CTCs) shed into blood provide prognostic and/or predictive information. Previously, the authors established an assay to detect carcinoma cells from pleural fluid, termed effusion tumor cells (ETCs), by employing an immunofluorescence-based CTC-identification platform (RareCyte) on air-dried unstained ThinPrep (TP) slides. To facilitate clinical integration, they evaluated different slide processing and storage conditions, hypothesizing that alternative comparable conditions for ETC detection exist...
February 19, 2024: Cancer Cytopathology
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