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Cancer Cytopathology

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https://read.qxmd.com/read/30768868/incidence-and-malignancy-rates-of-indeterminate-pediatric-thyroid-nodules
#1
Huiying Wang, Mitra Mehrad, Kim A Ely, Jiancong Liang, Carmen C Solórzano, Wallace W Neblett, Alice C Coogan, Vivian L Weiss
BACKGROUND: The American Thyroid Association guidelines task force currently recommends definitive thyroidectomy or lobectomy after an indeterminate thyroid biopsy in children. This recommendation is based on evidence of a greater incidence and a higher risk of malignancy compared with adults in earlier pediatric studies. Such management may lead to overtreatment and unnecessary surgery for many children in the United States. METHODS: The objective of the current study was to re-evaluate pediatric thyroid nodules and assess the overall percentages and malignancy rates for indeterminate thyroid biopsies in children...
February 15, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30720925/nkx2-2-immunohistochemistry-in-the-distinction-of-ewing-sarcoma-from-cytomorphologic-mimics-diagnostic-utility-and-pitfalls-comment-on-russell-goldman-et-al
#2
LETTER
https://read.qxmd.com/read/30707506/sustainable-cytopathology-in-the-precision-medicine-era-exploring-new-sources-for-molecular-testing-in-thyroid-cytology-specimens
#3
EDITORIAL
Michiya Nishino
No abstract text is available yet for this article.
February 1, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30702803/automating-the-paris-system-for-urine-cytopathology-a-hybrid-deep-learning-and-morphometric-approach
#4
Louis J Vaickus, Arief A Suriawinata, Jason W Wei, Xiaoying Liu
BACKGROUND: The Paris System for Urine Cytopathology (the Paris System) has succeeded in making the analysis of liquid-based urine preparations more reproducible. Any algorithm seeking to automate this system must accurately estimate the nuclear-to-cytoplasmic (N:C) ratio and produce a qualitative "atypia score." The authors propose a hybrid deep-learning and morphometric model that reliably automates the Paris System. METHODS: Whole-slide images (WSI) of liquid-based urine cytology specimens were extracted from 51 negative, 60 atypical, 52 suspicious, and 54 positive cases...
January 31, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30690877/new-entities-new-technologies-new-findings-a-review-of-the-cytologic-features-of-recently-established-subtypes-of-renal-cell-carcinoma
#5
REVIEW
Valentina Robila, Adele O Kraft, Steven Christopher Smith
Several new renal tumor types with distinctive pathologic, epidemiologic, and genetic signatures have recently been adopted in the fourth edition of the World Health Organization classification. In succeeding years, the cytologic features of most of these new types have been described, adding to the trend of increasing diagnostic accuracy for most common renal cell carcinoma subtypes and the important diagnostic role of cytologic sampling in the management and personalization of therapy. The current article reviews the cytologic findings from these recently established renal cell carcinoma subtypes...
January 28, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30689294/targeting-specimen-misprocessing-safety-events-with-failure-modes-and-effects-analysis
#6
Pamela E Stravitz, Edmund S Cibas, Yael K Heher
No abstract text is available yet for this article.
January 28, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30668897/the-prevalence-and-surgical-outcomes-of-hurthle-cell-lesions-in-fnas-of-the-thyroid-a-multi-institutional-study-in-6-asian-countries
#7
Shipra Agarwal, Andrey Bychkov, Chan Kwon Jung, Mitsuyoshi Hirokawa, Chiung-Ru Lai, SoonWon Hong, Hyeong Ju Kwon, Samreung Rangdaeng, Zhiyan Liu, Peng Su, Kennichi Kakudo, Deepali Jain
BACKGROUND: Hurthle cell-rich nodules (HCNs) encompass non-neoplastic to malignant lesions. There is paucity of literature on the frequency distribution of HCNs among Bethesda categories, histologic follow-up, risk of malignancy (ROM), and risk of neoplasia (RON). The objective of this retrospective, multi-institutional study was to determine the prevalence of the cytologic diagnostic category and surgical outcomes of patients with HCN. METHODS: Nine tertiary health centers representing 6 Asian countries participated...
January 22, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30668891/negative-predictive-value-and-sensitivity-of-urine-cytology-prior-to-implementation-of-the-paris-system-for-reporting-urinary-cytology
#8
Patrick J McIntire, Reema Khan, Hamad Hussain, Stefan E Pambuccian, Eva M Wojcik, Güliz A Barkan
BACKGROUND: Urinary tract cytology (UTCy) is used for screening urothelial carcinoma (UC) and it must have a high negative predictive value (NPV) to be an effective test. To the authors' knowledge, the literature regarding the NPV of UTCy provides little information regarding the risk of malignancy, especially for patients with high-grade urothelial carcinoma (HGUC). METHODS: Patients with negative UTCy specimens were identified in the pathology files at the study institution for the years 2012 through 2013...
January 22, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30668886/the-value-of-cytology-in-the-management-of-patients-with-pancreatic-cysts
#9
Matthew John Weiss
No abstract text is available yet for this article.
January 22, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30620446/centrifuged-supernatants-from-fna-provide-a-liquid-biopsy-option-for-clinical-next-generation-sequencing-of-thyroid-nodules
#10
Wenrui Ye, Brette Hannigan, Stephanie Zalles, Meenakshi Mehrotra, Bedia A Barkoh, Michelle D Williams, Maria E Cabanillas, Beth Edeiken-Monroe, Peter Hu, Dzifa Duose, Ignacio I Wistuba, L Jeffrey Medeiros, John Stewart, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri
BACKGROUND: Molecular testing is recommended as an adjunct to improve the preoperative diagnosis of fine-needle aspiration (FNA) of thyroid nodules. Centrifuged supernatants from FNA samples, which are typically discarded, have recently emerged as a novel liquid-based biopsy for molecular testing. This study evaluates the use of thyroid FNA supernatants for detecting clinically relevant mutations. METHODS: Supernatants from thyroid FNA samples (n = 156) were evaluated...
January 8, 2019: Cancer Cytopathology
https://read.qxmd.com/read/30561909/adequacy-criteria-for-voided-urine-cytology-using-cytospin-preparations
#11
Andrew A Renshaw, Edwin W Gould
BACKGROUND: Previous studies have suggested that urine cytology adequacy may be related to both specimen volume and cellularity. METHODS: The authors reviewed cytospin preparations from 314 urine specimens (162 voided and 152 instrumented specimens) found to have high-grade urothelial carcinoma on biopsy. RESULTS: The sensitivity of instrumented urine cytology was significantly higher than that of voided cytology (82% vs 25%; P < .001)...
December 18, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30561907/benign-call-rate-and-molecular-test-result-distribution-of-thyroseq-v3
#12
N Paul Ohori, Michael S Landau, Sally E Carty, Linwah Yip, Shane O LeBeau, Pooja Manroa, Raja R Seethala, Karen E Schoedel, Marina N Nikiforova, Yuri E Nikiforov
BACKGROUND: The benign call rate (BCR) is the percentage of cytomorphologically indeterminate cases with subsequent benign or negative molecular results. For rule-out tests, the BCR is an important parameter because these molecular "negative" cases may be managed similarly to those with a benign cytology diagnosis. Although earlier versions of ThyroSeq molecular tests were less effective in excluding malignancy, the extensively expanded v3 version with a high negative predictive value is considered to represent a rule-out test...
December 18, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30512242/the-role-of-cytology-in-molecular-testing-and-personalized-medicine-in-lung-cancer-a-clinical-perspective
#13
Kelvin Young, Gilda da Cunha Santos, Paul Card, Natasha Leighl
No abstract text is available yet for this article.
December 4, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30501010/teaching-fna-techniques-and-ultrasound-guided-fna
#14
Susan D Rollins
No abstract text is available yet for this article.
November 30, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30500997/expression-of-programmed-cell-death-ligand-1-in-non-small-cell-lung-cancer-comparison-between-cytologic-smears-core-biopsies-and-whole-sections-using-the-sp263-assay
#15
Enrico Munari, Giuseppe Zamboni, Giorgia Sighele, Marcella Marconi, Marco Sommaggio, Gianluigi Lunardi, Giulio Rossi, Alberto Cavazza, Francesca Moretta, Eliana Gilioli, Anna Caliò, George J Netto, Mohammad O Hoque, Guido Martignoni, Matteo Brunelli, Paola Vacca, Lorenzo Moretta, Giuseppe Bogina
BACKGROUND: Evaluation of programmed cell death ligand 1 (PD-L1) expression can be made on both resection specimens and diagnostic biopsies; however, more than 30% of patients with advanced non-small cell lung cancer (NSCLC) do not have adequate histologic material to perform PD-L1 assays and require additional biopsies. In addition, in our practice, more than 16% of cases have cytological smears as the only available material. Our aim was to validate the PD-L1 immunocytochemistry assay on cytological smears and compare its accuracy with the results obtained from tissue cores and whole tumor sections using the clinically relevant cutoff of 50%...
November 30, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30489699/communicating-communication-to-pathology-residents-and-fellows
#16
Benjamin L Witt
No abstract text is available yet for this article.
November 29, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30485690/advances-in-the-cytologic-diagnosis-of-gastroenteropancreatic-neuroendocrine-neoplasms
#17
REVIEW
Carlie S Sigel
Two-thirds of neuroendocrine neoplasms arising in the human body originate from the gastrointestinal system or pancreas. Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous, comprising both well differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The clinical presentation, molecular characteristics, and behavior are distinct for NETs and NECs. Fine-needle aspiration is an important modality for the primary diagnosis and staging of these neoplasms and can provide information of prognostic and therapeutic significance...
November 28, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30475447/hpv-associated-neuroendocrine-carcinomas-of-the-head-and-neck-in-fna-biopsies-clinicopathologic-features-of-a-rare-entity
#18
Vickie Y Jo, Jeffrey F Krane, Liron Pantanowitz, Sara E Monaco
BACKGROUND: The majority of human papillomavirus (HPV)-associated oropharyngeal carcinomas are squamous cell carcinomas; however, there are rare reports of HPV-associated neuroendocrine carcinomas (HPV-NECs) in the upper aerodigestive tract. The aim of this study was to characterize the diagnostic features of fine-needle aspiration (FNA) cases of head and neck HPV-NEC. METHODS: Cytology cases of HPV-NEC were identified over a 3-year period from 2 institutions. Clinical, cytomorphologic, and ancillary test results were evaluated...
November 26, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30468701/cytopathologic-characteristics-of-hpv-related-small-cell-carcinoma-of-the-oropharynx
#19
Derek B Allison, Lisa M Rooper, Sara Mustafa, Zahra Maleki, Paul E Wakely, Syed Z Ali
BACKGROUND: Human papillomavirus (HPV)-related squamous cell carcinoma (SqCC) of the oropharynx is an epidemiologically and clinically distinct form of SqCC that is associated with an improved prognosis. However, HPV-related small cell carcinoma of the oropharynx is a rare and newly described variant that is associated with aggressive clinical behavior and poor outcomes. To date, fewer than 2 dozen reports of this entity exist in the literature, and there is no discussion of cytopathologic features...
November 23, 2018: Cancer Cytopathology
https://read.qxmd.com/read/30762975/seeing-the-signs-of-cancer-s-metabolic-changes-more-and-more-researchers-are-visualizing-metabolic-markers-to-provide-details-regarding-how-cancer-cells-react-to-changing-conditions-and-treatments
#20
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