journal
https://read.qxmd.com/read/38536199/the-updated-college-of-american-pathologists-principles-of-analytic-validation-of-immunohistochemical-assays-a-step-forward-for-cytopathology
#1
JOURNAL ARTICLE
Sinchita Roy-Chowdhuri
No abstract text is available yet for this article.
March 27, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38520219/comprehensive-evaluation-of-cytomorphologic-histologic-and-molecular-features-of-dicer1-altered-thyroid-lesions-on-fna-a-multipractice-experience
#2
JOURNAL ARTICLE
Krisztina Lengyel, Daniel J Lubin, Wen-Yu Hsiao, Sam Sirotnikov, Guangju Luo, James W Roberts, Qiuying Shi, Kelly Magliocca, Melinda M Lewis, Donald L Sears, Ghulam Ilyas, Beverly B Rogers, Kartik Viswanathan
BACKGROUND: DICER1 mutations, though infrequent, are encountered on preoperative molecular testing of indeterminate adult and pediatric thyroid fine-needle aspiration (FNA) specimens. Yet, published cytomorphologic features of DICER1-altered thyroid lesions are limited. Cytomorphological features of DICER1-altered thyroid lesions were examined in a multipractice FNA cohort with clinical, radiological, and histologic data. METHODS: The cohort comprised 18 DICER1-altered thyroid FNAs, with 14 having slides available and eight having corresponding surgical resections...
March 23, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38488294/incorporation-of-dna-methylation-profiling-into-the-cytopathology-laboratory
#3
JOURNAL ARTICLE
Gloria H Sura, Leomar Y Ballester
No abstract text is available yet for this article.
March 15, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38451011/interobserver-agreement-in-the-interpretation-of-anal-cytology
#4
JOURNAL ARTICLE
Maria Benevolo, Francesca Rollo, Alessandra Latini, Massimo Giuliani, Amalia Giglio, Eugenia Giuliani, Maria Gabriella Donà
BACKGROUND: Anal cytology represents a tool for anal cancer screening in high-risk populations. In addition to accuracy, the reproducibility of the interpretation is of key importance. The authors evaluated the agreement of anal cytologic interpretation between two cytopathologists. METHODS: Liquid-based cytologic slides from human immunodeficiency virus (HIV)-negative men who have sex with men (MSM) were evaluated by two readers with at least 10 years of expertise in cervical cytology...
March 7, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38450993/improving-diagnostic-yield-of-pancreatic-serous-cystadenoma-with-cyst-fluid-ancillary-testing-adjunct-immunohistochemistry-and-additional-fine-needle-biopsy-sampling
#5
JOURNAL ARTICLE
Xi Wang, Xuchen Zhang, Pei Hui, Guoping Cai
BACKGROUND: Fine-needle aspiration (FNA) diagnosis of pancreatic serous cystadenoma (SCA) remains challenging. This retrospective study aimed to evaluate the roles of cyst fluid ancillary testing and combined fine-needle biopsy (FNB) in improving the diagnostic yield. METHODS: The authors retrospectively reviewed cytology cases that were histologically confirmed SCAs. Clinical features and FNA cyst fluid biochemical and molecular analysis results along FNB findings were reviewed...
March 7, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38427323/leveraging-archival-cerebrospinal-fluid-samples-for-genetic-insights-from-cell-free-dna
#6
EDITORIAL
Alexandra M Miller, Tejus A Bale
No abstract text is available yet for this article.
March 1, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38410851/interobserver-agreement-and-risk-of-malignancy-using-the-international-academy-of-cytology-yokohama-system-for-reporting-breast-fna-biopsy-in-a-liquid-based-exclusive-cohort
#7
JOURNAL ARTICLE
Olawunmi Folarin, David Kim, Hamza N Gokozan, Jonas J Heymann, Jose V Scarpa Carniello, Lucelina Rosado, Momin T Siddiqui, Ami Patel
BACKGROUND: Per the College of American Pathologist's National Breast Fine Needle Aspiration Biopsy (FNAB) Practice Survey, ∼40% of laboratories use liquid-based cytology (LBC) for breast FNAB. The reproducibility of the International Academy of Cytology Yokohama System (YS) for reporting breast FNAB on LBC was explored. DESIGN: Breast FNAB specimens submitted as LBC only (all ThinPrep) between January 2017 and January 2021 were retrieved. Cases without histopathologic follow-up were excluded...
February 27, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38373111/retrospective-analysis-of-cytology-and-high-risk-hpv-testing-in-1067-endocervical-adenocarcinomas-and-precursor-lesions
#8
JOURNAL ARTICLE
Lei Ye, Meifu Gan, Yeli Yao, Bingjian Lu
BACKGROUND: Cytology and high-risk human papilloma virus (hrHPV) cotesting is the mainstay in the detection of cervical carcinoma. METHODS: Endocervical adenocarcinoma (EAC) is divided into HPV-associated adenocarcinoma (HPVA) and HPV-independent adenocarcinoma (HPVI) by the World Health Organization classification (2020). The detection effect of cotesting is suggested to be different among EAC subtypes and precursors, but has not well-documented yet. In this study, the authors retrospectively analyzed cotesting among adenocarcinoma in situ (AIS), HPVA, and HPVI...
February 19, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38373107/detection-of-effusion-tumor-cells-under-different-storage-and-processing-conditions
#9
JOURNAL ARTICLE
Diane M Libert, Yili Zhu, Aihui Wang, Grace M Allard, Alarice Cheng-Yi Lowe
BACKGROUND: Circulating tumor cells (CTCs) shed into blood provide prognostic and/or predictive information. Previously, the authors established an assay to detect carcinoma cells from pleural fluid, termed effusion tumor cells (ETCs), by employing an immunofluorescence-based CTC-identification platform (RareCyte) on air-dried unstained ThinPrep (TP) slides. To facilitate clinical integration, they evaluated different slide processing and storage conditions, hypothesizing that alternative comparable conditions for ETC detection exist...
February 19, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38346148/rapid-on-site-evaluation-of-touch-imprint-cytology-in-navigation-bronchoscopy-for-small-peripheral-pulmonary-nodules
#10
JOURNAL ARTICLE
Stephan E P Kops, Lizanne J W van der Burgt, Shoko Vos, Lia J M van Zuijlen-Manders, Roel L J Verhoeven, Erik H F M van der Heijden
BACKGROUND: Rapid on-site evaluation (ROSE) of cytopathology plays an important role in determining whether representative samples have been taken during navigation bronchoscopy. With touch imprint cytology (TIC), histologic samples can be assessed using ROSE. Although advised by guidelines, there have been almost no studies on the performance of TIC during navigation bronchoscopy. The objective of this study was to evaluate the value of TIC-ROSE (forceps/cryobiopsy) in combination with conventional ROSE (cytology needle/brush)...
February 12, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38329359/urine-cytology-in-the-detection-of-renal-cell-carcinomas-a-territory-wide-multi-institutional-retrospective-review-of-more-than-2-decades
#11
JOURNAL ARTICLE
Joshua J X Li, Joanna K M Ng, Cheuk-Yin Tang, Bryan C H Chan, Sau Yee Chan, Jasmine H N Law, Jeremy Y Teoh, Christopher J VandenBussche, Gary M Tse
INTRODUCTION: Compared with urothelial lesions of the upper urinary tract, the diagnostic performance of urine cytology in detection of renal cell carcinomas is underreported. This study aims to establish the role of urine cytology in the assessment of renal carcinomas by a multi-institute review of urine cytology from nephrectomy confirmed renal cell carcinomas, referenced against renal urothelial and squamous cell carcinomas. METHODS: Records of nephrectomy performed from the 1990s to 2020s at three hospitals were retrieved and matched to urine cytology specimens collected within 1 year prior...
February 8, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38329321/prediction-of-lymph-node-status-in-patients-with-surgically-treated-head-and-neck-squamous-cell-carcinoma-via-neck-lavage-cytology-a-pilot-study
#12
JOURNAL ARTICLE
Hugo Rimbach, Maximilian Linxweiler, Sandrina Körner, Sigrun Smola, Barbara Linxweiler, Stefanie Speicher, Johanna Helfrich, Erich-Franz Solomayer, Mathias Wagner, Bernhard Schick, Jan Philipp Kühn
BACKGROUND: Neck dissection is a standardized surgical procedure for patients with head and neck squamous cell carcinoma (HNSCC) and plays a critical role in the choice of adjuvant treatment based on histopathological findings. Saline irrigation is routinely performed at the end of surgery. However, this irrigant is not used for diagnostic purposes. METHODS: Intraoperative irrigation of the neck dissection wound was performed in 56 patients with HNSCC (N = 93 neck dissections), and the cytological suspension obtained was processed via the liquid-based cytology (LBC) technique, Papanicolaou staining, and immunocytochemical staining...
February 8, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38324231/cell-block-practices-in-european-cytopathology-laboratories
#13
JOURNAL ARTICLE
Irena Srebotnik Kirbis, Ivana Kholova, Heini Huhtala, Massimo Bongiovanni, Margareta Strojan Flezar, Chantell Hodgson, Beatrix Cochand-Priollet
BACKGROUND: There are numerous methods and procedures described for the preparation of cell blocks (CBs) from cytological samples. The objective of this study was to determine current practices and issues with CBs in European laboratories. METHODS: A link to an online survey, with 11 questions about CB practices, was distributed to cytology laboratories via participants of United Kingdom National External Quality Assurance Service for Cellular Pathology Techniques and national representatives in the European Federation of Cytology Societies...
February 7, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38324164/diagnosing-medullary-thyroid-carcinoma-is-facilitated-by-measuring-calcitonin-in-fna-washout-fluids-alea-iacta-est
#14
EDITORIAL
Pierpaolo Trimboli, Anna Crescenzi
No abstract text is available yet for this article.
February 7, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38319805/performance-of-a-multigene-genomic-classifier-and-clinical-parameters-in-predicting-malignancy-in-a-southeast-asian-cohort-of-patients-with-cytologically-indeterminate-thyroid-nodules
#15
JOURNAL ARTICLE
Samantha Peiling Yang, Min En Nga, Manish Mahadeorao Bundele, Simion I Chiosea, Sze Hwa Tan, Jeffrey H Y Lum, Rajeev Parameswaran, Ming Yann Lim, Hao Li, Wei Keat Cheah, Kathleen Su-Yen Sek, Andre Teck Huat Tan, Thomas Kwok Seng Loh, Kee Yuan Ngiam, Wee Boon Tan, Xinyong Huang, Thomas Wai Thong Ho, Keng Hua Lim, Chwee Ming Lim, Reyaz M Singaporewalla, Anil Dinkar Rao, Nandini C L Rao, Dennis Yu Kim Chua, David Chao-Wu Chin, Abigail I Wald, Virginia A LiVolsi, Yuri E Nikiforov, E Shyong Tai
BACKGROUND: Most thyroid nodules are benign. It is important to determine the likelihood of malignancy in such nodules to avoid unnecessary surgery. The primary objective of this study was to characterize the genetic landscape and the performance of a multigene genomic classifier in fine-needle aspiration (FNA) biopsies of cytologically indeterminate thyroid nodules in a Southeast Asian cohort. The secondary objective was to assess the predictive contribution of clinical characteristics to thyroid malignancy...
February 6, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38308613/droplet-digital-polymerase-chain-reaction-detection-of-kras-mutations-in-pancreatic-fna-samples-technical-and-practical-aspects-for-routine-clinical-implementation
#16
JOURNAL ARTICLE
Yara Mansour, Mehdi Boubaddi, Typhaine Odion, Marion Marty, Geneviève Belleannée, Arthur Berger, Clément Subtil, Christophe Laurent, Sandrine Dabernat, Samuel Amintas
BACKGROUND: Pancreatic adenocarcinoma (PDAC) is associated with a 5-year survival rate of less than 6%, and current treatments have limited efficacy. The diagnosis of PDAC is mainly based on a cytologic analysis of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) samples. However, the collected specimens may prove noncontributory in a significant number of cases, delaying patient management and treatment. The combination of EUS-FNA sample examination and KRAS mutation detection can improve the sensitivity for diagnosis...
February 3, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38306309/cytologic-risk-stratification-of-medullary-thyroid-carcinoma-does-it-make-the-grade
#17
JOURNAL ARTICLE
Michiya Nishino
No abstract text is available yet for this article.
February 2, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38294961/implementation-of-the-paris-system-for-reporting-urine-cytology-improves-diagnostic-accuracy-of-selective-upper-urinary-tract-cytology
#18
JOURNAL ARTICLE
Kosuke Miyai, Misaki Nakayama, Shinya Minabe, Sho Ogata, Keiichi Ito, Susumu Matsukuma
BACKGROUND: The Paris System for Reporting Urine Cytology (TPS) recommends diagnostic criteria for urinary tract cytology, focusing primarily on the detection of high-grade urothelial carcinoma (HGUC) in the lower urinary tract. The second edition of TPS (TPS 2.0), published in 2022, extends these recommendations to the upper urinary tract (UUT); however, there is a lack of comprehensive data on this subject. METHODS: In total, 223 consecutive UUT cytology specimens from 137 patients were retrieved and reclassified according to TPS 2...
January 31, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38174804/fine-needle-aspiration%C3%A2-of-amyloidoma-a-critical-analysis
#19
JOURNAL ARTICLE
Nisha S Ramani, Bhuvaneswari Krishnan
BACKGROUND: Amyloid, presenting as a mass, is termed amyloidoma. Among the reported cases, fine-needle aspiration (FNA) of amyloid is often misinterpreted as acellular nondiagnostic material. METHODS: A computer search of all FNAs was performed and cases diagnosed as amyloidoma were identified. RESULTS: Among 11,956 cases and 20,634 FNAs, there were six cases and 12 FNAs of amyloidoma. One case with mucin/myxoid matrix was misinterpreted as amyloid, which on our review was Congo red negative...
January 4, 2024: Cancer Cytopathology
https://read.qxmd.com/read/38450856/growing-threats-of-a-mass-exodus-in-governmental-public-health-recruitment-and-retention-woes-a-lack-of-sustained-investment-and-partisan-harassment-and-attacks-are-creating-a-mounting-crisis-for-public-health-efforts-including-cancer-prevention
#20
journal
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42289
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