Samantha Peiling Yang, Min En Nga, Manish Mahadeorao Bundele, Simion I Chiosea, Sze Hwa Tan, Jeffrey H Y Lum, Rajeev Parameswaran, Ming Yann Lim, Hao Li, Wei Keat Cheah, Kathleen Su-Yen Sek, Andre Teck Huat Tan, Thomas Kwok Seng Loh, Kee Yuan Ngiam, Wee Boon Tan, Xinyong Huang, Thomas Wai Thong Ho, Keng Hua Lim, Chwee Ming Lim, Reyaz M Singaporewalla, Anil Dinkar Rao, Nandini C L Rao, Dennis Yu Kim Chua, David Chao-Wu Chin, Abigail I Wald, Virginia A LiVolsi, Yuri E Nikiforov, E Shyong Tai
BACKGROUND: Most thyroid nodules are benign. It is important to determine the likelihood of malignancy in such nodules to avoid unnecessary surgery. The primary objective of this study was to characterize the genetic landscape and the performance of a multigene genomic classifier in fine-needle aspiration (FNA) biopsies of cytologically indeterminate thyroid nodules in a Southeast Asian cohort. The secondary objective was to assess the predictive contribution of clinical characteristics to thyroid malignancy...
February 6, 2024: Cancer Cytopathology