M Lisa Zhang
No abstract text is available yet for this article.
March 1, 2023: Cancer Cytopathology
Jesse Suben, Abha Goyal, Rema Rao, Simon Sung
BACKGROUND: Pancreatic and/or biliary (PB) brushing is commonly used to rule out malignant strictures. Many studies have attempted to characterize cytomorphologic characteristics of brushing and stent cytology. However, scant literature exists on the diagnostic implication (DI) of thick extracellular mucin (ECM) indicative of neoplasm in these samples. This study was aimed at reviewing the DI of thick ECM in PB brushing and stent cytology. METHODS: A retrospective search of consecutive cytologic samples of PB brushings/stents with corresponding surgical pathology or relevant clinical information over a 1-year period was performed...
February 18, 2023: Cancer Cytopathology
Samuel E Harvey, Christopher J VandenBussche
BACKGROUND: The Paris System for Reporting Urine Cytology defines objective (elevated nuclear/cytoplasmic ratio ≥0.7) and subjective (nuclear membrane irregularity, hyperchromicity, and coarse chromatin) cytomorphologic criteria to identify conventional high-grade urothelial carcinoma (HGUC) cells. Digital image analysis allows quantitative and objective measurement of these subjective criteria. In this study, digital image analysis was used to quantitate nuclear membrane irregularity in HGUC cells...
February 16, 2023: Cancer Cytopathology
Jiao Dai, Heng Zheng, Ju Jin, Ye Cheng, Haimiao Xu
BACKGROUND: Zolbetuximab (IMAB362) is under investigation for treating advanced gastrointestinal tumors because it targets Claudin18.2 (CLDN18.2). CLDN18.2 is a promising molecule along with the presence of human epidermal growth factor receptor 2 in gastric cancer. This study evaluated cell block (CB) preparations of serous cavity effusions for the feasibility for CLDN18.2 protein expression and compared the results with those of biopsy or resection specimens. The association of CLDN18...
February 15, 2023: Cancer Cytopathology
Elizabeth A Hall, Pamela Hartzband, Paul A VanderLaan, Michiya Nishino
BACKGROUND: Evidence guiding the management of cytologically indeterminate thyroid nodules with nondiagnostic (ND) or benign cytology on repeat fine-needle aspiration (FNA) is limited. This study evaluates the utility of molecular testing and estimates the risk of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and cancer among such nodules. METHODS: This was a retrospective single-institution review of thyroid nodules from adults that were classified as atypia of undetermined significance (AUS) or follicular neoplasm (FN) on initial FNA and underwent repeat FNA for cytology and Afirma testing (June 2013-July 2021)...
February 15, 2023: Cancer Cytopathology
Paul E Wakely
INTRODUCTION: Benign peripheral nerve tumors (BPNTs) are a heterogenous group of soft tissue tumors that include a variety of nerve sheath tumors, granular cell tumor (GCT), and ganglioneuroma. Only a few large studies exist on cytopathology and diagnostic accuracy using fine-needle aspiration (FNA) biopsy for this set of neoplasms. MATERIALS AND METHODS: Both surgical and cytopathology files were searched for cases of BPNT. FNA biopsy was performed using standard techniques...
January 17, 2023: Cancer Cytopathology
Carlie Sigel, Xiao-Jun Wei, Narasimhan Agaram, Keith Sigel, Roshan Raza, Rebecca Andrade, Rema Rao, Pari Shah, Kevin Soares, Abha Goyal
BACKGROUND: Pancreatic cyst cytology evaluates for neoplastic mucin and epithelial grade. This study describes cytological features of low- and high-grade mucinous neoplasms (MNs) using gastrointestinal contaminants for comparison. METHODS: Histologically confirmed pancreatic cystic neoplasms were reviewed by a panel of cytopathologists to identify which, among 26 selected cytologic features, correlate significantly with low- and high-grade MN. A test for greater than or equal to four of eight high-grade features (three-dimensional architecture, high nuclear:cytoplasmic ratio, moderate nuclear membrane abnormalities, loss of nuclear polarity, hyperchromasia, >4:1 nuclear size variation in one cluster, karyorrhexis, and necrosis) was assessed for identifying a high-grade neoplasms...
January 17, 2023: Cancer Cytopathology
Michal Marczyk, Chunxiao Fu, Rosanna Lau, Lili Du, Alexander J Trevarton, Bruno V Sinn, Rebekah E Gould, Lajos Pusztai, Christos Hatzis, William Fraser Symmans
BACKGROUND: Rather than surgical resection, cytologic specimens are often used as first-line clinical diagnostic procedures due to higher safety, speed, and cost-effectiveness. Archival diagnostic cytology slides containing cancer can be equivalent to tissue biopsies for DNA mutation testing, but the accuracy of transcriptomic profiling by RNA sequencing (RNA-seq) is less understood. METHODS: This study compares the results from whole transcriptome RNA-seq and a targeted RNA-seq assay of stained cytology smears (CS) versus matched tumor tissue samples preserved fresh-frozen (FF) and processed as formalin-fixed paraffin-embedded (FFPE) sections...
January 17, 2023: Cancer Cytopathology
Maria Benevolo, Alessandra Latini, Francesca Rollo, Massimo Giuliani, Amalia Giglio, Eugenia Giuliani, Antonio Cristaudo, Aldo Morrone, Maria Gabriella Donà
INTRODUCTION: Anal cytology is used in the prevention of anal cancer, which disproportionally affects men who have sex with men (MSM). Data on the incidence of cytologic abnormalities in these individuals are scant. METHODS: MSM with baseline negative anal cytology and at least one further adequate cytology were included. Incidence rate for positive atypical squamous cells of undetermined significance (ASC-US+) was calculated. Kaplan-Meier curves were compared by log-rank test according to HIV status, baseline high-risk human papillomavirus (HPV) (high-risk HPV-negative, HPV16-positive, other high-risk HPV-positive [non-HPV16]) and high-risk HPV persistence (positive from baseline to the first ASC-US+ or last visit for those who remained cytologically negative)...
December 29, 2022: Cancer Cytopathology
Edward J Gutmann
No abstract text is available yet for this article.
December 27, 2022: Cancer Cytopathology
Marc Pusztaszeri, Daniel Deschler, William C Faquin Md PhD
No abstract text is available yet for this article.
December 27, 2022: Cancer Cytopathology
Anjelica Hodgson, Veronica Kim, Rajmohan Murali
BACKGROUND: In this study, the authors sought to describe the cytologic features of primary gynecologic germ cell tumors and carcinomas exhibiting germ cell differentiation because little information currently exists. METHODS: An institutional database search was performed to identify histologically confirmed gynecologic germ cell tumors and carcinomas with germ cell tumor differentiation. Available cytologic material was reviewed by three observers, and morphologic features were recorded in addition to patient age at original diagnosis, primary tumor site, site(s) from which the examined cytologic material was obtained, and the type of examined cytologic preparations...
December 27, 2022: Cancer Cytopathology
Judith Jebastin Thangaiah, Kelsey E McHugh, Lisi Yuan, Jordan P Reynolds, Michael W Cruise, Maria Luisa C Policarpio-Nicolas
BACKGROUND: Autoimmune pancreatitis (AIP) is a known mimicker of pancreatic ductal adenocarcinoma both clinically and radiologically. In this study, the authors present their institutional experience in diagnosing AIP on cytology and correlate results with the histologic findings. METHODS: A 14-year computerized search for patients who had histologically confirmed AIP with concurrent or prior cytology was performed. Clinical data, cytology findings, and surgical pathology results were reviewed for analysis...
December 27, 2022: Cancer Cytopathology
Megan J Fitzpatrick, Vandana Sundaram, Amy Ly, Jeremy S Abramson, Ronald Balassanian, Matthew C Cheung, Stephen L Cook, Lorenzo Falchi, Annabel K Frank, Srishti Gupta, Robert P Hasserjian, Oscar Lin, Steven R Long, Joshua R Menke, Eric Mou, Daniel R Reed, Roberto Ruiz-Cordero, Ashley K Volaric, Linlin Wang, Kwun Wah Wen, Yi Xie, Sara L Zadeh, Dita Gratzinger
BACKGROUND: Few studies have evaluated diagnostic yield of small volume biopsies (SVB) for the diagnosis and management of follicular lymphoma (FL). METHODS: The authors performed a multi-institutional retrospective analysis of SVBs including fine-needle aspiration (FNA) and needle core biopsy (NCB) for initial FL diagnosis and suspected recurrence or transformation of FL. A total of 676 workups beginning with SVB were assessed for the mean number of biopsies per workup, the proportion of workups requiring multiple biopsies, and the proportion with a complete diagnosis including grade, on initial biopsy...
December 27, 2022: Cancer Cytopathology
Kenji Amemiya, Yosuke Hirotsu, Hitoshi Mochizuki, Rumi Higuchi, Takahiro Nakagomi, Taichiro Goto, Toshio Oyama, Tetsuo Kondo, Masao Omata
BACKGROUND: Genomic profiling in lung cancer is essential for precision medicine. Cytological specimens provide an alternative to formalin-fixed paraffin-embedded (FFPE) samples for comprehensive genomic analysis. However, this approach remains challenging when a limited number of tumor cells are available. We applied whole genome amplification (WGA) to cytology specimens to overcome this limitation. METHODS: Using a lung cancer panel targeting 58 genes, we performed next-generation sequencing of whole genome-amplified DNA extracted from cytological specimens containing 10-20 tumor cells (cyto-WGA) and DNA from corresponding FFPE tumor tissue...
January 2023: Cancer Cytopathology
Mitsuyoshi Hirokawa, Hirohiko Niioka, Ayana Suzuki, Masatoshi Abe, Yusuke Arai, Hajime Nagahara, Akira Miyauchi, Takashi Akamizu
BACKGROUND: Several studies have used artificial intelligence (AI) to analyze cytology images, but AI has yet to be adopted in clinical practice. The objective of this study was to demonstrate the accuracy of AI-based image analysis for thyroid fine-needle aspiration cytology (FNAC) and to propose its application in clinical practice. METHODS: In total, 148,395 microscopic images of FNAC were obtained from 393 thyroid nodules to train and validate the data, and EfficientNetV2-L was used as the image-classification model...
December 16, 2022: Cancer Cytopathology
Saleh Najjar, Qiong Gan, John Stewart, Nour Sneige
BACKGROUND: Claudin-4 is a sensitive and specific marker for carcinoma in effusion cytology. The authors examined the diagnostic use of claudin-4 versus MOC-31 and Ber-EP4 by comparing their sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) in differentiating carcinoma from mesothelioma and benign/mesothelial hyperplasia in effusion specimens. METHODS: This retrospective study comprised a cohort of 229 cytology specimens, including 211 effusion fluid and 18 fine-needle aspiration specimens...
December 15, 2022: Cancer Cytopathology
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