journal
Journals Progress in Molecular Biology ...

Progress in Molecular Biology and Translational Science

https://read.qxmd.com/read/38360000/computational-tools-supporting-known-mirna-identification
#21
JOURNAL ARTICLE
Van-Quy Do, Chuc Hoang-Thi, Thanh-Truong Pham, Nhat-Le Bui, Dinh-Thai Kim, Dinh-Toi Chu
The study of small RNAs is a field that is expanding quickly. Other functional short RNA molecules other than microRNAs, and gene expression regulators, have been found in animals and plants. MicroRNAs play a significant role in host-microbe interactions, and parasite microRNAs may affect the host's innate immunity. Furthermore, short RNAs are intriguing non-invasive biomarker possibilities because they can be found in physiological fluids. These trends suggest that for many researchers, quick and simple techniques for expression profiling and subsequent downstream analysis of miRNA-seq data are crucial...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38359999/rna-therapeutics-in-cancer-treatment
#22
JOURNAL ARTICLE
Minh Nam Nguyen, Van Thai Than
RNA therapeutics are a class of drugs that use RNA molecules to treat diseases, including cancer. RNA therapeutics work by targeting specific genes or proteins involved in the disease process, with the aim of blocking or altering their activity to ultimately halt or reverse the disease progression. The use of RNA therapeutics in cancer treatment has shown great potential, as they offer the ability to specifically target cancer cells while leaving healthy cells intact. This is in contrast to traditional chemotherapy and radiation treatments, which can damage healthy cells and cause unpleasant side effects...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38359998/rna-therapeutics-for-metabolic-disorders
#23
JOURNAL ARTICLE
Thuy-Duong Vu, Sheng-Che Lin, Chia-Ching Wu, Dinh-Toi Chu
The prevalence of metabolic disorders is increasing exponentially and has recently reached epidemic levels. Over the decades, a large number of therapeutic options have been proposed to manage these diseases but still show several limitations. In this circumstance, RNA therapeutics have rapidly emerged as a new hope for patients with metabolic diseases. 57 years have elapsed from the discovery of mRNA, a large number of RNA-based drug candidates have been evaluated for their therapeutic effectiveness and clinical safety under clinical studies...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38359997/rna-therapeutics-for-neurological-disease
#24
JOURNAL ARTICLE
Lien Nguyen
Neurological disorders are the group of diseases that primarily affect the center nervous system, which could lead to a significant negative impact on the ability of learning new skills, speaking, breathing, walking, judging, making decision, and other essential living skills. In the last decade, neurological disorders have significantly increased their impact to our community and become the one of leading causes of disability and death. The World Health Organization has identified neurological disorders including Alzheimer's disease and other dementia as the health crisis for the modern life...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38359996/advantages-and-disadvantages-of-rna-therapeutics
#25
JOURNAL ARTICLE
Binh Le Huy, Hai Bui Thi Phuong, Huy Luong Xuan
RNA therapeutics is an innovative and rapidly evolving field at the forefront of medical research and biotechnology. Recently, many studies have shown that diverse RNA types play important roles in cells. Besides the protein translation coding, they also express and regulate a variety of cellular pathways. Indeed, along with the research and studies, many drugs and vaccines were developed from RNAs, including both coding and non-coding RNA. Some cases were approved to be medicines or under clinical trial. After years of use and application, they have shown a bright opportunity to prevent and treat many fatal and rare diseases with many strong points, such as fast production and long-term effects...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38359995/the-development-and-technologies-of-rna-therapeutics
#26
JOURNAL ARTICLE
Huong Lan Vuong, Chu Thanh Lan, Hien Thi Thu Le
Since it was discovered for over 20 years ago, the potentiality of siRNAs in gene silencing in vitro and in vivo models has been recognized. Several studies in the new generation, molecular mechanisms, target attachment, and purification of RNA have supported the development of RNA therapeutics for a variety of applications. RNA therapeutics are growing rapidly with various platforms contributing to the standard of personalized medicine and rare disease treatment. Therefore, understanding the development and technologies of RNA therapeutics becomes a crucial point for new drug generation...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38359994/recent-applications-of-rna-therapeutic-in-clinics
#27
JOURNAL ARTICLE
Huyen Trang Ha Thi, Van Thai Than
Ribonucleic acid (RNA) therapy has been extensively researched for several decades and has garnered significant attention in recent years owing to its potential in treating a broad spectrum of diseases. It falls under the domain of gene therapy, leveraging RNA molecules as a therapeutic approach in medicine. RNA can be targeted using small-molecule drugs, or RNA molecules themselves can serve as drugs by interacting with proteins or other RNA molecules. While several RNA drugs have been granted clinical approval, numerous RNA-based therapeutics are presently undergoing clinical investigation or testing for various conditions, including genetic disorders, viral infections, and diverse forms of cancer...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38359993/an-introduction-to-rna-therapeutics-and-their-potentials
#28
JOURNAL ARTICLE
Nhat-Le Bui, Dinh-Toi Chu
RNA therapeutics is a biological term regarding the usage of RNA-based molecules for medical purposes. Thanks to the success of mRNA-vaccine production against COVID-19, RNA therapeutics has gained more and more attention and investigation from worldwide scientists. It is considered as one of the promising alternatives for conventional drugs. In this first chapter, we presented an overview of the history and perspectives of RNA therapeutics' development. This chapter also explained the underlying mechanisms of different RNA-based molecules, including antisense oligonucleotide, interfering RNA (iRNA), aptamer, and mRNA, from degrading mRNA to inactivating targeted protein...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237991/covid-19-pathogenesis
#29
JOURNAL ARTICLE
Asiya Kamber Zaidi, Rohan Bir Singh, Syed A A Rizvi, Puya Dehgani-Mobaraki, Nicola Palladino
The pathogenesis of COVID-19 involves a complex interplay between host factors and the SARS-CoV-2 virus, leading to a multitude of clinical manifestations beyond the respiratory system. This chapter provides an overview of the risk factors, genetic predisposition, and multisystem manifestations of COVID-19, shedding light on the underlying mechanisms that contribute to extrapulmonary manifestations. The chapter discusses the direct invasion of SARS-CoV-2 into various organs as well as the indirect mechanisms such as dysregulation of the renin-angiotensin-aldosterone system (RAAS), immune response dysfunctions within the innate and adaptive immune systems, endothelial damage, and immunothrombosis...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237990/sars-cov-2-variant-biology-and-immune-evasion
#30
JOURNAL ARTICLE
Asiya Kamber Zaidi, Rohan Bir Singh
This chapter discusses the SARS-CoV-2 variants and their immune evasion strategies, shedding light on the dynamic nature of the COVID-19 pandemic. The ecological dynamics and viral evolution of SARS-CoV-2 are explored, considering carriers of infection, individual immunity profiles, and human movement as key factors in the emergence and dissemination of variants. The chapter discusses SARS-CoV-2 mutation, including mutation rate, substitution rate, and recombination, influencing genetic diversity and evolution...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237989/structural-biology-of-sars-cov-2
#31
JOURNAL ARTICLE
Asiya Kamber Zaidi, Sunny Dawoodi
This chapter provides a comprehensive overview of the techniques employed to unravel the structural biology of SARS-CoV-2, facilitating a deeper understanding of the virus for developing future therapeutic strategies. Various techniques such as Electron microscopy (EM) for capturing high-resolution images of the virus and X-ray crystallography used for determining atomic-level structures of viral proteins are discussed. Cryo-electron microscopy (cryo-EM) imaging is also examined as a powerful tool for visualizing the virus's structure in its native state...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237988/epidemiology-of-covid-19
#32
JOURNAL ARTICLE
Asiya Kamber Zaidi, Rohan Bir Singh
This chapter provides a detailed exploration of the epidemiology of COVID-19, focusing on several key aspects that offer valuable insights into the disease progression. A comprehensive comparison is made between the three related coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2, elucidating their similarities and differences in terms of transmission dynamics, clinical presentation, laboratory and radiological findings, infection mechanisms, and mortality rates. The concept of herd immunity is then discussed, exploring its relevance and potential implications for controlling the spread of COVID-19...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237987/future-insights
#33
JOURNAL ARTICLE
Asiya Kamber Zaidi
This chapter explores two significant aspects of the ongoing COVID-19 pandemic: the realistic prediction of its end and the status of long-term COVID in 2023. While the World Health Organization (WHO) declared an end to COVID-19 as a public health emergency, the possibility of future waves caused by variants remains. Widespread vaccination and prior infections provide substantial protection, but the virus is expected to persist, necessitating continued monitoring and potential reimplementation of control measures...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237986/t-cell-responses-to-sars-cov-2
#34
JOURNAL ARTICLE
Laiqha Khadri, Mohammad Hossein Ziraksaz, Ahmad Bashir Barekzai, Baber Ghauri
This chapter provides a comprehensive analysis of T cell responses in COVID-19, focusing on T cell differentiation, specificity, and functional characteristics during SARS-CoV-2 infection. The differentiation of T cells in COVID-19 is explored, highlighting the key factors that influence T cell fate and effector functions. The immunology of the spike protein, a critical component of SARS-CoV-2, is discussed in detail, emphasizing its role in driving T-cell responses. The cellular immune responses against SARS-CoV-2 during acute infection are examined, including the specificity, phenotype, and functional attributes of SARS-CoV-2-specific T-cell responses...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237985/b-cell-responses-to-sars-cov-2
#35
JOURNAL ARTICLE
Asiya Kamber Zaidi, Sanchit Bajpai, Puya Dehgani-Mobaraki
This chapter provides an overview of B cell responses in COVID-19, highlighting the structure of SARS-CoV-2 and its impact on B cell immunity. It explores the production and maturation of SARS-CoV-2-specific B cells, with a focus on the two distinct phases of the humoral immune response: the extrafollicular (EF) phase and the germinal center (GC) phase. Furthermore, the interplay between B cells, follicular T helper cells, CD4+ T cells, and plasma cells is discussed, emphasizing their collaborative role in mounting an effective humoral immune response against SARS-CoV-2...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237984/innate-immune-responses-to-sars-cov-2
#36
JOURNAL ARTICLE
Sunny Dawoodi, Syed A A Rizvi, Asiya Kamber Zaidi
This chapter provides an overview of the innate immune response to SARS-CoV-2, focusing on the recognition, activation, and evasion strategies employed by the virus. The innate immune system plays a crucial role in the early defense against viral infections, and understanding its response to SARS-CoV-2 is essential for developing effective therapeutic approaches. The chapter begins by explaining the basics of the innate immune system, including its components and salient features. It discusses the various pattern recognition receptors involved in recognizing SARS-CoV-2, such as toll-like receptors, RIG-I-like receptors, NOD-like receptors, and other cytosolic sensors...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237983/long-covid
#37
JOURNAL ARTICLE
Asiya Kamber Zaidi, Puya Dehgani-Mobaraki
Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to a constellation of persistent symptoms and health issues that continue beyond the acute phase of COVID-19. This chapter provides an overview of the pathogenesis, risk factors, manifestations, major findings, and diagnosis and treatment strategies associated with Long COVID. Hypotheses regarding the pathogenesis of Long COVID are discussed, encompassing various factors such as persistent viral reservoirs, immune dysregulation with or without reactivation of herpesviruses (e...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38237982/sars-cov-2-virus-structure-and-life-cycle
#38
JOURNAL ARTICLE
Sameer Saleem Tebha, Aimen Tameezuddin, Sanchit Bajpai, Asiya Kamber Zaidi
This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses, the SARS-CoV-2 structure including the structural as well as nonstructural proteins in detail, and the viral replication mechanisms. The chapter then delves into the characteristics and diversity of coronaviruses, particularly SARS-CoV-2, highlighting its similarities with other beta-coronaviruses...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/37770177/phage-therapy-in-gut-microbiome
#39
JOURNAL ARTICLE
Xingyao Chen, Beatriz G Mendes, Bruno Secchi Alves, Yi Duan
Phage therapy, the use of bacteriophage viruses for bacterial infection treatment, has been around for almost a century, but with the increase in antibiotic use, its importance has declined rapidly. There has been renewed interest in revisiting this practice due to the general decline in the effectiveness of antibiotics, combined with improved understanding of human microbiota and advances in sequencing technologies. Phage therapy has been proposed as a clinical alternative to restore the gut microbiota in the absence of an effective treatment...
2023: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/37770176/phages-for-the-treatment-of-mycobacterium-species
#40
JOURNAL ARTICLE
Christoffel Johannes Opperman, Justyna Wojno, Wynand Goosen, Rob Warren
Highly drug-resistant strains are not uncommon among the Mycobacterium genus, with patients requiring lengthy antibiotic treatment regimens with multiple drugs and harmful side effects. This alarming increase in antibiotic resistance globally has renewed the interest in mycobacteriophage therapy for both Mycobacterium tuberculosis complex and non-tuberculosis mycobacteria. With the increasing number of genetically well-characterized mycobacteriophages and robust engineering tools to convert temperate phages to obligate lytic phages, the phage cache against extensive drug-resistant mycobacteria is constantly expanding...
2023: Progress in Molecular Biology and Translational Science
journal
journal
42275
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.