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Journal of Evidence-based Medicine

Chang Xu, Lehana Thabane, Tongzu Liu, Asm Borhan, Xin Sun
OBJECTIVES: Dose-response meta-analysis (DRMA) is widely employed in establishing the potential dose-response relationship between continuous exposures and disease outcomes. However, there is no valid DRMA method readily for discrete exposures, especially when the possible dose-response trend not likely to be linear. We proposed a piecewise linear DRMA model as a solution to this issue. METHODS: We illustrated the methodology of piecewise linear model in both one-stage DRMA approach and two-stage DRMA approach...
February 5, 2019: Journal of Evidence-based Medicine
Junxiang Li, Jing Chen, Wenfu Tang
Acute pancreatitis (AP) is one of the most common acute abdominal diseases. The digestive disease committee, Chinese Association of Integrative Medicine, released Integrated traditional Chinese and Western medicine for diagnosis and treatment of acute pancreatitis in 2010.1 Since then, further studies and great progress have been made by domestic and foreign counterparts from the perspective of both Chinese and Western medicine in AP, including the classification, fluid resuscitation, organ function maintenance, surgery intervention, enteral nutrition (EN), and syndrome differentiation and treatment...
February 2019: Journal of Evidence-based Medicine
Robert L Grant
AIM: Bayesian statistical methods can allow for more complete and accurate incorporation of evidence in meta-analyses. However, these methods remain under-utilized. METHODS: A scoping review was conducted to examine the proportion of biomedical meta-analyses that used Bayesian methods in the period 2005-2016. The review also examined the reproducibility of the work, the cited sources, the reasons for it, its success or failure, the type of model and prior distributions, and whether a mixture of Bayesian and frequentist methods were employed...
February 2019: Journal of Evidence-based Medicine
Wisit Kaewput, Charat Thongprayoon, Mathirut Mungthin, Sarawut Jindarat, Narittaya Varothai, Picha Suwannahitatorn, Ram Rangsin, Michael A Mao, Wisit Cheungpasitporn
BACKGROUND: This study aimed to assess the nationwide trends in optimal diabetic care and complications of elderly type 2 diabetes mellitus (T2DM) patients over a 6-year period in Thailand. METHODS: T2DM patients aged 65 years or older who received medical care at public hospitals in Thailand from 2010 to 2015 were included. The optimal T2DM care in elderly patients was defined as (1) blood pressure (BP) < 140/90, (2) hemoglobin A1C (HbA1c) < 7%, (3) low-density lipoprotein cholesterol (LDL-C) < 100 mg/dL, (4) use of antiplatelet medications, and (5) use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) in hypertensive patients...
February 2019: Journal of Evidence-based Medicine
Mohammadreza Yeganeh, Hamid Yekta, Rabiollah Farmanbar, Malahat Khalili, Tahereh Khaleghdoost, Zahra Atrkar Roushan
OBJECTIVE: The purpose of this study was to assess the intensive care unit nurses' knowledge of evidence-based guidelines for ventilator-associated pneumonia (VAP) prevention at Guilan University of Medical Sciences (GUMS) hospitals, Guilan Province, northern Iran. METHODS: This cross-sectional study included 219 nurses working in 14 intensive care units at 11 Guilan hospitals. The questionnaire consisted of three parts of demographic information, nurses' knowledge of evidence-based guidelines for the prevention of VAP, and the barrier for the implementation of these guidelines...
February 2019: Journal of Evidence-based Medicine
Frank Peinemann, Alexander Labeit
BACKGROUND: Since January 2011, the Federal Joint Committee (FJC) conducts early benefit assessments (EBA) of newly approved pharmaceutical drugs compared to appropriate standard therapies. The FJC commissions the Institute for Quality and Efficiency in Healthcare (IQEH) to prepare preliminary reports. We aimed to evaluate the extent, impact, and reason for different judgments on added benefit of both institutions. METHODS: We searched EBA data on the FJC website and included completed procedures from 2011 to 2017...
January 30, 2019: Journal of Evidence-based Medicine
Boonphiphop Boonpheng, Charat Thongprayoon, Michael A Mao, Karn Wijarnpreecha, Tarun Bathini, Wisit Kaewput, Patompong Ungprasert, Wisit Cheungpasitporn
BACKGROUND: Bone and mineral metabolism disorders are common among end-stage renal disease (ESRD) patients, which could lead to hip fracture. It is unclear whether the hip fracture risk is different among patients on hemodialysis (HD) versus peritoneal dialysis (PD). This meta-analysis was conducted to evaluate the hip fracture risk in ESRD patients on HD, when compared to PD. METHODS: A literature review was conducted in EMBASE, MEDLINE, and Cochrane databases through January 31, 2018 to identify studies that appraised the rate or risk of hip fracture among patients on HD, when compared to PD...
January 30, 2019: Journal of Evidence-based Medicine
Elizabeth Gargon
No abstract text is available yet for this article.
January 2019: Journal of Evidence-based Medicine
Qiaozhi Hu, Bin Wu, Mei Zhan, Weiguo Jia, Yimei Huang, Ting Xu
OBJECTIVES: The purpose of this study was to describe the level, preventability and categories of adverse events (AEs) in Chinese geriatric patients identified by medical record review using the Global Trigger Tool. The applicability of the GTT was also assessed to explore possible modifications for trigger tools. METHODS: The study was conducted at a 4300-bed tertiary teaching hospital. Twenty randomly-selected medical records for patients over 60 were reviewed every 2 weeks from January 1 2015 to December 31st, 2015...
December 3, 2018: Journal of Evidence-based Medicine
Daniel Simancas-Racines, Nadia Montero-Oleas, Robin W M Vernooij, Ingrid Arevalo-Rodriguez, Paulina Fuentes, Ignasi Gich, Ricardo Hidalgo, Maria José Martinez-Zapata, Xavier Bonfill, Pablo Alonso-Coello
BACKGROUND: Red blood cell (RBC) transfusions are essential in health care. The quality of recommendations included in clinical practice guidelines (CPG), regarding this intervention, has not been systematically evaluated. This paper systematically assessed CPGs for RBC-transfusion, to appraise their methodological quality, to explore changes in quality over time, and to assess the consistency of the hemoglobin threshold (HT) recommendations. METHODS: We searched for CPGs that included recommendations of RBC-transfusion in generic databases, compiler entities, registries, clearinghouses and guideline developers...
December 3, 2018: Journal of Evidence-based Medicine
Aryono Hendarto, Mikhael Yosia, Sudigdo Sastroasmoro
OBJECTIVE: To determine the quality of reports of the randomized controlled trial (RCT) in the field of pediatrics conducted by Indonesian investigators. METHODS: All pediatric RCTs conducted by Indonesian researchers were sourced from international and national (local) publications. The assessment was done using both the Consolidated Standards of Reporting Trial (CONSORT) 2010 statement and Jadad Scale. Overall scores from each assessment are reported with a comparison of overall scores between studies in international and local publications...
December 3, 2018: Journal of Evidence-based Medicine
Lorena Marques da Nóbrega, Ítalo de Macedo Bernardino, Paula Miliana Leal, Carolina de Castro Martins, Ana Flávia Granville-Garcia, Sérgio d'Avila
AIM: This study aimed to evaluate the scientific evidence regarding the risk factors for maxillofacial injuries among victims of traffic accidents. METHOD: A systematic review of articles published until February 2017 was carried out in the following databases: PubMed, Web of Science, Scopus, and Cochrane Library. Studies were selected by two independent reviewers (ϰ = 0.841). The risk of bias in the selected studies was assessed using an adapted version of the Newcastle-Ottawa Scale for observational studies...
December 2, 2018: Journal of Evidence-based Medicine
Reza Jannati, Mahdi Afshari, Mahmood Moosazadeh, Seyedeh Zahra Allahgholipour, Milad Eidy, Mojtaba Hajihoseini
OBJECTIVE: During the last years, different prevalences of dental pulps had been reported from different parts of the world. Combining these original estimates will provide useful information for policymaking in the field of health, treatment and research. This study aims to estimate the global prevalence of pulp stones. METHODS: Electronic databanks such as PubMed, Scopus, Science direct, Cochrane, and also Google scholar motor engine were searched by 2 researchers using related keywords...
November 20, 2018: Journal of Evidence-based Medicine
Frank Peinemann, Alexander Labeit
BACKGROUND: Negative pressure wound therapy (NPWT) proposes to provide better wound healing than standard wound management. Evidence quality of randomized controlled trials (RCTs) varies. METHODS: We included participants with any kind of wounds and commercial as well as the homemade NPWT system. Comparators were any other wound dressing including variant NPWTs. We included RCTs randomizing patients or wounds in parallel or crossover designs. We searched PubMed and Cochrane Library on January 03, 2018...
November 20, 2018: Journal of Evidence-based Medicine
Pouran Mokhtari Zanjani, Elahe Ahmadnia, Roghieh Kharaghani
OBJECTIVE: There are some studies on the prevalence of ectopic pregnancy (EP) in a different population of Iranian women. This study aimed to estimate the ectopic pregnancy prevalence in obstetrical clients and infertile patients treated by assisted reproductive technologies in Iran. METHODS: International and national databases including PubMed, Web of Science, Ovid, Scopus, ScienceDirect, Magiran, Iran doc, and Iran Medex were searched up to January 2016. Also, conference databases were searched...
November 13, 2018: Journal of Evidence-based Medicine
Arsenio Paez
The role of expertise in evidence-based medicine (EBM) and practice (EBP) has long been debated. In the early years of the EBP movement, the role of expertise and experience were diminished in clinical decision-making. However, the concepts of EBP are evolving. A more nuanced view of the value of clinician expertise, based on experience and clinical judgement, has emerged. This article proposes that clinical expertise does not belong within the evidence hierarchy's decision-making pyramid as the lowest form of evidence, but rather alongside it, representing a complementary source of knowledge that supports the processes of EBP...
November 2018: Journal of Evidence-based Medicine
Ronpichai Chokesuwattanaskul, Tarun Bathini, Charat Thongprayoon, Somchai Preechawat, Oisin A O'Corragain, Pavida Pachariyanon, Patompong Ungprasert, Wisit Cheungpasitporn
OBJECTIVE: Previous studies have suggested a high incidence of atrial fibrillation (AF) in heart transplant recipients. However, incidence trends of AF in heart transplant recipients remain unclear. The study's aims were (1) to investigate the pooled incidence/incidence trends of AF following heart transplantation and (2) to assess the mortality risk of heart transplant recipients with AF. METHODS: A literature search for studies that reported the incidence of AF following heart transplantation was conducted using MEDLINE, EMBASE, and The Cochrane Database from inception through March 2018...
November 2018: Journal of Evidence-based Medicine
Jingsi Dong, Bingjie Li, Qinghua Zhou, Depei Huang
Tumor immunotherapy is praised as "green therapy," which can attack tumor by mobilizing immune system. By removing the inhibition of immune cells, checkpoint inhibitors help T cells to identify and kill tumor cells. In recent years, more and more attention has been paid to its effectiveness as a tumor therapy with a large number of clinical data. Currently, inhibitors of 2 checkpoints, CTLA-4 and PD-1/PD-L1, have been approved to be listed. In particular, the latter has achieved breakthrough progress in non-small cell lung cancer in recent years, bringing about changes in the therapeutic strategy of lung cancer, as well as challenges to the evaluation criteria...
November 2018: Journal of Evidence-based Medicine
Udaya K Ranawaka, Ashwini de Abrew, Manujasri Wimalachandra, Chandanie A Wanigatunge, Lalani C Rajapakse, Colvin Goonaratna
AIM: Prospective registration in a freely accessible public platform is a key step in the ethical conduct of clinical trials. Little is known of the awareness of clinical trial registration among the scientific community. This study aimed to assess awareness of clinical trial registration among participants attending a medical congress in Sri Lanka. METHODS: Knowledge of trial registration was assessed using a self-administered questionnaire, which spanned domains such as involvement in research, and knowledge and perceptions regarding trial registration...
November 2018: Journal of Evidence-based Medicine
Farzaneh Barzkar, Hamid Reza Baradaran, Jalil Koohpayehzadeh
AIM: To assess knowledge, attitude, and practice of graduate physicians toward evidence-based medicine (EBM) and the barriers to the implementation of EBM worldwide. METHODS: Relevant databases were searched systematically with appropriate search terms up to September 2017. References of the articles detected by the search were screened for any new articles. Risk of bias was assessed by two independent reviewers. Data were extracted from the full-text articles based on the study summary measures and were collected in a data table...
November 2018: Journal of Evidence-based Medicine
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