Bo-Shih Huang, Chih-Ta Chen, Chao-Chi Yeh, Ting-Yu Fan, Fang-Yun Chen, Jyh-Ming Liou, Chia-Tung Shun, Ming-Shiang Wu, Lu-Ping Chow
Helicobacte r pylori ( H. pylori ) infection affects cell survival pathways, including apoptosis and proliferation in host cells, and disruption of this balance is the key event in the development of H. pylori -induced gastric cancer (HPGC). H. pylori infection induces alterations in microRNAs expression that may be involved in GC development. Bioinformatic analysis showed that microRNA-21 (miR-21) is significantly upregulated in HPGC. Furthermore, quantitative proteomics and in silico prediction were employed to identify potential targets of miR-21...
2023: Journal of Oncology