journal
https://read.qxmd.com/read/38591920/multi-strain-probiotics-during-pregnancy-in-women-with-obesity-influence-infant-gut-microbiome-development-results-from-a-randomized-double-blind-placebo-controlled-study
#1
RANDOMIZED CONTROLLED TRIAL
Sofie Ingdam Halkjær, Malene Refslund Danielsen, Victoria E de Knegt, Lee O'Brien Andersen, Christen Rune Stensvold, Henrik Vedel Nielsen, Hengameh Chloé Mirsepasi-Lauridsen, Karen Angeliki Krogfelt, Dina Cortes, Andreas Munk Petersen
Probiotics have been described to influence host health and prevent the risk of obesity by gut microbiome (GM) modulation. In a randomized double-blinded placebo-controlled feasibility study, we investigated whether Vivomixx® multi-strain probiotics administered to 50 women with obesity during pregnancy altered the GM composition and perinatal health outcomes of their infants up to 9 months after birth. The mothers and infants were followed up with four visits after birth: at 3 d, and at 3, 6, and 9 months after delivery...
2024: Gut Microbes
https://read.qxmd.com/read/38591915/new-treatment-approaches-for-clostridioides-difficile-infections-alternatives-to-antibiotics-and-fecal-microbiota-transplantation
#2
REVIEW
Tomaž Bratkovič, Abida Zahirović, Maruša Bizjak, Maja Rupnik, Borut Štrukelj, Aleš Berlec
Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It is particularly problematic as a hospital-acquired infection, causing significant costs to the health care system. Antibiotics, such as vancomycin and fidaxomicin, are still the drugs of choice for C. difficile infections, but their effectiveness is limited, and microbial interventions are emerging as a new treatment option. This paper focuses on alternative treatment approaches, which are currently in various stages of development and can be divided into four therapeutic strategies...
2024: Gut Microbes
https://read.qxmd.com/read/38591914/cognitive-behavioral-and-mindfulness-with-daily-exercise-intervention-is-associated-with-changes-in-intestinal-microbial-taxa-and-systemic-inflammation-in-patients-with-crohn-s-disease
#3
JOURNAL ARTICLE
Ilan K, Motro Y, Nemirovsky A, Schwartz D, Goren G, Sergienko R, Greenberg D, Slonim-Nevo V, Sarid O, Friger M, Regev S, Odes S, Moran-Gilad J, Monsonego A
Crohn's disease (CD) is a chronic inflammatory bowel disease associated with psychological distress and intestinal microbial changes. Here, we examined whether a 3-month period of Cognitive Behavioral and Mindfulness with Daily Exercise (COBMINDEX) intervention, which improves the wellbeing and inflammatory state of CD patients, may also affect their gut microbiome. Gut microbiota, circulating inflammatory markers and hormones were analyzed in 24 CD patients before (T1) and after 3 months of COBMINDEX (T2), and in 25 age- and sex-matched wait-list control patients at the corresponding time-points...
2024: Gut Microbes
https://read.qxmd.com/read/38563680/gastrointestinal-microbiota-and-metabolites-possibly-contribute-to-distinct-pathogenicity-of-sars-cov-2-proto-or-its-variants-in-rhesus-monkeys
#4
JOURNAL ARTICLE
Hongyu Chen, Junbin Wang, Kaiyun Ding, Jingwen Xu, Yun Yang, Cong Tang, Yanan Zhou, Wenhai Yu, Haixuan Wang, Qing Huang, Bai Li, Dexuan Kuang, Daoju Wu, Zhiwu Luo, Jiahong Gao, Yuan Zhao, Jiansheng Liu, Xiaozhong Peng, Shuaiyao Lu, Hongqi Liu
Gastrointestinal (GI) infection is evidenced with involvement in COVID-19 pathogenesis caused by SARS-CoV-2. However, the correlation between GI microbiota and the distinct pathogenicity of SARS-CoV-2 Proto and its emerging variants remains unclear. In this study, we aimed to determine if GI microbiota impacted COVID-19 pathogenesis and if the effect varied between SARS-CoV-2 Proto and its variants. We performed an integrative analysis of histopathology, microbiomics, and transcriptomics on the GI tract fragments from rhesus monkeys infected with SARS-CoV-2 proto or its variants...
2024: Gut Microbes
https://read.qxmd.com/read/38563656/integrative-analysis-with-microbial-modelling-and-machine-learning-uncovers-potential-alleviators-for-ulcerative-colitis
#5
JOURNAL ARTICLE
Jinlin Zhu, Jialin Yin, Jing Chen, Mingyi Hu, Wenwei Lu, Hongchao Wang, Hao Zhang, Wei Chen
Ulcerative colitis (UC) is a challenging form of inflammatory bowel disease, and its etiology is intricately linked to disturbances in the gut microbiome. To identify the potential alleviators of UC, we employed an integrative analysis combining microbial community modeling with advanced machine learning techniques. Using metagenomics data sourced from the Integrated Human Microbiome Project, we constructed individualized microbiome community models for each participant. Our analysis highlighted a significant decline in both α and β-diversity of strain-level microbial populations in UC subjects compared to controls...
2024: Gut Microbes
https://read.qxmd.com/read/38561312/pathogen-specific-alterations-in-intestinal-microbiota-precede-urinary-tract-infections-in-preterm-infants-a-longitudinal-case-control-study
#6
JOURNAL ARTICLE
Luyang Hong, Yihuang Huang, Junyan Han, Shujuan Li, Lan Zhang, Qi Zhou, Xincheng Cao, Weiyin Yu, Xinhui Guo, Yi Yang, Yufeng Zhou, Weili Yan, Shangyu Hong, Siyuan Jiang, Yun Cao
Urinary tract infections (UTIs) are among the most common late-onset infections in preterm infants, characterized by nonspecific symptoms and a pathogenic spectrum that diverges from that of term infants and older children, which present unique diagnostic and therapeutic challenges. Existing data on the role of gut microbiota in UTI pathogenesis in this demographic are limited. This study aims to investigate alterations in gut microbiota and fecal calprotectin levels and their association with the development of UTIs in hospitalized preterm infants...
2024: Gut Microbes
https://read.qxmd.com/read/38555499/the-effects-of-antibiotic-exposures-on-the-gut-resistome-during-hematopoietic-cell-transplantation-in-children
#7
JOURNAL ARTICLE
Sarah M Heston, Rebecca R Young, Kirsten Jenkins, Paul L Martin, Andre Stokhuyzen, Doyle V Ward, Shakti K Bhattarai, Vanni Bucci, Mehreen Arshad, Nelson J Chao, Patrick C Seed, Matthew S Kelly
Antibiotic resistance is a global threat driven primarily by antibiotic use. We evaluated the effects of antibiotic exposures on the gut microbiomes and resistomes of children at high risk of colonization by antibiotic-resistant bacteria. We performed shotgun metagenomic sequencing of 691 serially collected fecal samples from 80 children (<18 years) undergoing hematopoietic cell transplantation. We evaluated the effects of aerobic (cefepime, vancomycin, fluoroquinolones, aminoglycosides, macrolides, and trimethoprim-sulfamethoxazole) and anaerobic (piperacillin-tazobactam, carbapenems, metronidazole, and clindamycin) antibiotic exposures on the diversity and composition of the gut microbiome and resistome...
2024: Gut Microbes
https://read.qxmd.com/read/38549437/gastrointestinal-signals-in-supplemented-media-reveal-a-role-in-adherence-for-the-shigella-flexneri-sap-autotransporter-gene
#8
JOURNAL ARTICLE
Yrvin León, Raphael Honigsberg, David A Rasko, Christina S Faherty
Shigella flexneri causes severe diarrheal disease worldwide. While many aspects of pathogenesis have been elucidated, significant knowledge gaps remain regarding the role of putative chromosomally-encoded virulence genes. The uncharacterized sap gene encoded on the chromosome has significant nucleotide sequence identity to the fluffy ( flu ) antigen 43 autotransporter gene in pathogenic Escherichia coli . Here, we constructed a Δ sap mutant in S. flexneri strain 2457T and examined the effects of this mutation on bacterial cell aggregation, biofilm formation, and adherence to colonic epithelial cells...
2024: Gut Microbes
https://read.qxmd.com/read/38548676/integrated-analysis-of-gut-metabolome-microbiome-and-brain-function-reveal-the-role-of-gut-brain-axis-in-longevity
#9
JOURNAL ARTICLE
Bin Jiao, Ziyu Ouyang, Qianqian Liu, Tianyan Xu, Meidan Wan, Guangrong Ma, Lu Zhou, Jifeng Guo, Junling Wang, Beisha Tang, Zhixiang Zhao, Lu Shen
The role of microbiota-gut-brain axis in modulating longevity remains undetermined. Here, we performed a multiomics analysis of gut metagenomics, gut metabolomics, and brain functional near-infrared spectroscopy (fNIRS) in a cohort of 164 participants, including 83 nonagenarians (NAs) and 81 non-nonagenarians (NNAs) matched with their spouses and offspring. We found that 438 metabolites were significantly different between the two groups; among them, neuroactive compounds and anti-inflammatory substances were enriched in NAs...
2024: Gut Microbes
https://read.qxmd.com/read/38545880/oral-pathobiont-klebsiella-chaperon-usher-pili-provide-site-specific-adaptation-for-the-inflamed-gut-mucosa
#10
JOURNAL ARTICLE
Yijie Guo, Sho Kitamoto, Gustavo Caballero-Flores, Yeji Kim, Daisuke Watanabe, Kohei Sugihara, Gabriel Núñez, Christopher J Alteri, Naohiro Inohara, Nobuhiko Kamada
The ectopic gut colonization by orally derived pathobionts has been implicated in the pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease (IBD). For example, gut colonization by orally derived Klebsiella spp. has been linked to IBD in mice and humans. However, the mechanisms whereby oral pathobionts colonize extra-oral niches, such as the gut mucosa, remain largely unknown. Here, we performed a high-density transposon (Tn) screening to identify genes required for the adaptation of an oral Klebsiella strain to different mucosal sites - the oral and gut mucosae - at the steady state and during inflammation...
2024: Gut Microbes
https://read.qxmd.com/read/38536705/from-animal-models-to-gut-on-chip-the-challenging-journey-to-capture-inter-individual-variability-in-chronic-digestive-disorders
#11
JOURNAL ARTICLE
Aicha Kriaa, Vincent Mariaule, Charlotte De Rudder, Amin Jablaoui, Harry Sokol, Paul Wilmes, Emmanuelle Maguin, Moez Rhimi
Chronic digestive disorders are of increasing incidence worldwide with expensive treatments and no available cure. Available therapeutic schemes mainly rely on symptom relief, with large degrees of variability in patients' response to such treatments, underlining the need for new therapeutic strategies. There are strong indications that the gut microbiota's contribution seems to be a key modulator of disease activity and patients' treatment responses. Hence, efforts have been devoted to understanding host-microbe interactions and the mechanisms underpinning such variability...
2024: Gut Microbes
https://read.qxmd.com/read/38533575/intestinal-microbiota-modulates-neuroinflammatory-response-and-brain-injury-after-neonatal-hypoxia-ischemia
#12
JOURNAL ARTICLE
Alexander Drobyshevsky, Sylvia Synowiec, Ivan Goussakov, Rafael Fabres, Jing Lu, Michael Caplan
Premature infants lack a normal intestinal microbial community and also at risk of perinatal hypoxic-ischemic (HI) brain injury, which is considered to be one of the major factors for motor, sensory, and cognitive deficits. We hypothesized that neonatal gut microbiota composition modulated the immune reaction and severity of neonatal H-I brain injury. Neonatal C57BL/6J mouse pups were exposed to H-I protocol consisting of permanent left carotid artery ligation, followed by 8% hypoxia for 60 min. Microbial manipulation groups included 1) antibiotic treatment, E18 (maternal) to P5; 2) antibiotic treatment E18 to P5 + E...
2024: Gut Microbes
https://read.qxmd.com/read/38533566/-fusobacterium-nucleatum-induces-chemoresistance-in-colorectal-cancer-by-inhibiting-pyroptosis-via-the-hippo-pathway
#13
JOURNAL ARTICLE
Ni Wang, Lu Zhang, Xiao-Xu Leng, Yi-Le Xie, Zi-Ran Kang, Li-Cong Zhao, Lin-Hong Song, Cheng-Bei Zhou, Jing-Yuan Fang
Chemotherapy resistance is one of the main reasons for the poor prognosis of colorectal cancer (CRC). Moreover, dysbiosis of gut bacteria was found to be a specific environmental risk factor. In this study, enrichment of F. nucleatum was elucidated to be significantly associated with CRC recurrence after chemotherapy. Functional experiments showed that F. nucleatum could inhibit pyroptosis induced by chemotherapy drugs, thereby inducing chemoresistance. Furthermore, mechanistic investigation demonstrated that F...
2024: Gut Microbes
https://read.qxmd.com/read/38532703/transplant-of-microbiota-from-crohn-s-disease-patients-to-germ-free-mice-results-in-colitis
#14
JOURNAL ARTICLE
Irshad Ali Sheikh, Jared Bianchi-Smak, Daniel Laubitz, Gabriele Schiro, Monica T Midura-Kiela, David G Besselsen, Gayatri Vedantam, Sara Jarmakiewicz, Rafał Filip, Fayez K Ghishan, Nan Gao, Pawel R Kiela
Although the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been limited to reports of promoting the disease in genetically susceptible mice or in chemically induced colitis. We aimed to further test the host response to fecal microbiome transplantation (FMT) from Crohn's disease patients on mucosal homeostasis in ex-germ-free (xGF) mice. We characterized and transferred fecal microbiota from healthy patients and patients with defined Crohn's ileocolitis (CD_L3) to germ-free mice and analyzed the resulting microbial and mucosal homeostasis by 16S profiling, shotgun metagenomics, histology, immunofluorescence (IF) and RNAseq analysis...
2024: Gut Microbes
https://read.qxmd.com/read/38528729/indole-3-acetic-acid-alleviates-dss-induced-colitis-by-promoting-the-production-of-r-equol-from-bifidobacterium-pseudolongum
#15
JOURNAL ARTICLE
Miaomiao Li, Xue Han, Lijun Sun, Xinjuan Liu, Weizhen Zhang, Jianyu Hao
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence of IBD is driven by the complex interactions of multiple factors. The objective of this study was to evaluate the therapeutic effects of IAA in colitis. METHOD: C57/BL6 mice were administered 2.5% DSS in drinking water to induce colitis. IAA, Bifidobacterium pseudolongum, and R-equol were administered by oral gavage and fed a regular diet...
2024: Gut Microbes
https://read.qxmd.com/read/38517357/using-a-human-colonoid-derived-monolayer-to-study-bacteriophage-translocation
#16
JOURNAL ARTICLE
Huu Thanh Le, Alicia Fajardo Lubian, Bethany Bowring, David van der Poorten, Jonathan Iredell, Jacob George, Carola Venturini, Golo Ahlenstiel, Scott Read
Bacteriophages (phages) are estimated to be the most abundant microorganisms on Earth. Their presence in human blood suggests that they can translocate from non-sterile sites such as the gastrointestinal tract where they are concentrated. To examine phage translocation ex vivo , we adapted a primary colonoid monolayer model possessing cell diversity and architecture, and a thick layer of mucus akin to the colonic environment in vivo . We show that the colonoid monolayer is superior to the Caco-2 cell-line model, possessing intact and organized tight junctions and generating a physiologically relevant mucus layer...
2024: Gut Microbes
https://read.qxmd.com/read/38512768/mnfe-microbiome-network-flow-entropy-for-detecting-pre-disease-states-of-type-1-diabetes
#17
JOURNAL ARTICLE
Rong Gao, Peiluan Li, Yueqiong Ni, Xueqing Peng, Jing Ren, Luonan Chen
In the development of Type 1 diabetes (T1D), there are critical states just before drastic changes, and identifying these pre-disease states may predict T1D or provide crucial early-warning signals. Unlike gene expression data, gut microbiome data can be collected noninvasively from stool samples. Gut microbiome sequencing data contain different levels of phylogenetic information that can be utilized to detect the tipping point or critical state in a reliable manner, thereby providing accurate and effective early-warning signals...
2024: Gut Microbes
https://read.qxmd.com/read/38512763/breaking-the-barriers-the-role-of-gut-homeostasis-in-metabolic-associated-steatotic-liver-disease-masld
#18
REVIEW
Raquel Benedé-Ubieto, Francisco Javier Cubero, Yulia A Nevzorova
Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), a growing health concern. The complex progression of MASLD extends beyond the liver, driven by "gut-liver axis," where diet, genetics, and gut-liver interactions influence disease development. The pathophysiology of MASLD involves excessive liver fat accumulation, hepatocyte dysfunction, inflammation, and fibrosis, with subsequent risk of hepatocellular carcinoma (HCC)...
2024: Gut Microbes
https://read.qxmd.com/read/38502202/cobb-mediated-deacetylation-of-the-chaperone-cesa-regulates-escherichia-coli-o157-h7-virulence
#19
JOURNAL ARTICLE
Linxing Li, Bin Yang, Jing Wang, Yi Wei, Binbin Xiang, Yutao Liu, Pan Wu, Wanwu Li, Yanling Wang, Xinyu Zhao, Jingliang Qin, Miaomiao Liu, Ruiying Liu, Guozhen Ma, Tian Fu, Min Wang, Bin Liu
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a common food-borne pathogen that can cause acute diseases. Lysine acetylation is a post-translational modification (PTM) that occurs in various prokaryotes and is regulated by CobB, the only deacetylase found in bacteria. Here, we demonstrated that CobB plays an important role in the virulence of EHEC O157:H7 and that deletion of cobB significantly decreased the intestinal colonization ability of bacteria. Using acetylation proteomic studies, we systematically identified several proteins that could be regulated by CobB in EHEC O157:H7...
2024: Gut Microbes
https://read.qxmd.com/read/38488630/stress-in-the-microbiome-immune-crosstalk
#20
REVIEW
Eléonore Beurel
The gut microbiota exerts a mutualistic interaction with the host in a fragile ecosystem and the host intestinal, neural, and immune cells. Perturbations of the gastrointestinal track composition after stress have profound consequences on the central nervous system and the immune system. Reciprocally, brain signals after stress affect the gut microbiota highlighting the bidirectional communication between the brain and the gut. Here, we focus on the potential role of inflammation in mediating stress-induced gut-brain changes and discuss the impact of several immune cells and inflammatory molecules of the gut-brain dialogue after stress...
2024: Gut Microbes
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