journal
Journals Genetic Testing and Molecular ...

Genetic Testing and Molecular Biomarkers

https://read.qxmd.com/read/37768331/could-aneurysm-and-atherosclerosis-associated-micrornas-mir-24-1-5p-mir-34a-5p-mir-126-5p-mir-143-5p-mir-145-5p-also-be-associated-with-coronary-artery-ectasia
#41
JOURNAL ARTICLE
Zafer Yalım, Serap Tutgun Onrat, Ibrahim Etem Dural, Ersel Onrat
Background: Coronary artery ectasia (CAE), known for localized or diffuse excessive dilatation of the coronary artery, has an unknown etiology, but it has been reported that the underlying cause may be atherosclerosis and genetic changes that may affect the arterial lumen. MicroRNAs have been shown to have an effect in aneurysm diseases and are known to contribute to vascular development and atherosclerosis. The purpose of this study was to investigate whether they are also associated with CAE. Methods: This cross-sectional study consisted of 25 patients with CAE and 25 subjects with normal coronary arteries...
September 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37768330/clinical-characteristics-and-genotyping-of-pediatric-adenovirus-pneumonia-disease-and-coinfection-in-southeast-china
#42
JOURNAL ARTICLE
Dongyi Pan, Jingyang Zheng, Qionghua Chen, Li-E Zeng, Chunyan Lin, Yuting You, Jieru Lin
Introduction: Human adenovirus (HAdV) is a common pathogen that can cause acute respiratory infections (ARIs) in children. Adenovirus pneumonia is the most severe respiratory disease associated with HAdV. Objective: We aimed to investigate the clinical characteristics of children hospitalized with adenovirus pneumonia in Quanzhou, China, in 2019. We also sought to determine the viral genotype in these cases and explore cases associated with severe adenovirus pneumonia. Methods: We collected oropharyngeal swabs from 99 children who were hospitalized with pneumonia in Quanzhou Women and Children's Hospital, these samples were tested for the presence of HAdV...
September 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37768329/allergic-rhinitis-and-cancer-risk-a-two-sample-mendelian-randomization-study
#43
JOURNAL ARTICLE
Fang Zhang, Jing Luo, Yang Tian, Bingjie Tang, Hailing Lv, Hai Liu, Jianhui Zhang
Background: There is increasing evidence that allergic rhinitis (AR) is associated with cancer. However, these results are inconsistent. Because of common risk factors, there may be reverse causality and confounding factors that affect our understanding of the relationship between AR and cancer. We aimed to explore the role of AR in cancer development using Mendelian randomization (MR) analysis. Materials and Methods: We performed a two-sample MR analysis using summary data from genome-wide association studies (GWAS)...
September 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37768328/association-of-apolipoprotein-a5-gene-variants-with-hyperlipidemic-acute-pancreatitis-in-southeastern-china
#44
JOURNAL ARTICLE
Yingyi Li, Hehui Cai, Yancheng Lin, Zhipeng Huang, Apei Zhou, Tianhao Huang, Yue-E Zeng, Meizhen Ye, Guiyuan Guo, Zicheng Huang
Background: Apolipoprotein A5 (APOA5) is involved in serum triglyceride (TG) regulation. Several studies have reported that the rs651821 locus in the APOA5 gene is associated with serum TG levels in the Chinese population. However, no research has been performed regarding the association between the variants of rs651821 and the risk of hyperlipidemic acute pancreatitis (HLAP). Methods: A case-control study was conducted and is reported following the STROBE guidelines. We enrolled a total of 88 participants in this study (60 HLAP patients and 28 controls)...
September 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37643326/linc00891-attenuates-the-proliferation-and-metastasis-of-osteosarcoma-cells-via-mir-27a-3p-tet1-axis
#45
JOURNAL ARTICLE
Shufang Zhang, Rongchun Chen
Objective: There is currently no adequate treatment for osteosarcoma, a bone malignancy that poses a serious threat to adolescents and children. The dysregulation of long noncoding RNAs is associated with many cancers, including osteosarcoma. LINC00891 expression is aberrant in endometrial cancer, lung cancer, and thyroid cancer, and likely regulate the malignant behavior of cancer. However, the potential function and mechanisms of LINC00891 in osteosarcoma progression remain unclear. Materials and Methods: LINC00891, miR-27a-3p, and TET1 mRNA expression in osteosarcoma cells were analyzed using quantitative reverse transcription-polymerase chain reaction...
August 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37643325/the-ratio-of-mir-122-to-mir-20a-mir-122-mir-20a-is-a-useful-minimally-invasive-biomarker-for-non-alcoholic-fatty-liver-disease-detection
#46
JOURNAL ARTICLE
Yuji Hattori, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Yoshitaka Ando, Mirai Yamazaki, Genki Mizuno, Yoshiki Tsuboi, Yuya Ishihara, Naohiro Ichino, Keiko Sugimoto, Keisuke Osakabe, Hiroaki Ishikawa, Koji Ohashi, Koji Suzuki
Background: The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) has become a global health problem. NAFLD has few initial symptoms and may be difficult to detect early, so there is need for a minimally invasive early detection marker. We hypothesized that miR-122 and miR-20a levels combined, as the miR-122/miR-20a ratio might detect NAFLD more sensitively. Methods: This study involved 167 participants with low alcohol intake. Those who had an increase in echogenicity of the liver parenchyma and hepato-renal contrast on ultrasonography were classified as the NAFLD group ( n  = 44), which was further classified into mild ( n  = 26) and severe ( n  = 18) groups based on echogenic intensity and hepatic vessel and diaphragm visualization...
August 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37643324/circulating-plasma-mir-122-and-mir-583-levels-are-involved-in-chronic-hepatitis-b-virus-pathogenesis-and-serve-as-novel-diagnostic-biomarkers
#47
JOURNAL ARTICLE
Fedra Mokhtari, Hami Kaboosi, Seyed Reza Mohebbi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
Background: MicroRNAs regulate many biological processes and are involved in the pathogenesis of many diseases including chronic hepatitis B (CHB). Moreover, besides investigation of their roles in hepatitis B virus (HBV) infection, a noninvasive, sensitive, and specific biomarker is essential in the diagnosis of liver diseases. This study was designed to evaluate the role of miR-122, miR-583, and miR-24 in the pathogenesis of CHB both in active chronic hepatitis (ACH) patients and in inactive carriers (IC)...
August 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37643323/a-novel-pair-of-compound-heterozygous-mutation-of-eys-in-a-han-chinese-family-with-retinitis-pigmentosa
#48
JOURNAL ARTICLE
Chao Dai, Weiming Ren, Yao Wei, Chunbao Xie, Suyang Duan, Qi Li, Lingxi Jiang, Yi Shi
Background: Retinitis pigmentosa (RP) is a complex inherited and progressive degenerative retinal disease. The eyes shut homolog ( EYS ) is frequently associated with RP is surprisingly high. Exploring the function of EYS is quite difficult due to the unique gene size and species specificity. Gene therapy may provide a breakthrough to treat this disease. Therefore, exploring and clarifying pathogenic mutations of EYS -associated RP has important guiding significance for clinical treatment. Methods: Clinical and molecular genetic data for EYS -associated RP were retrospectively analyzed...
August 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37643322/diagnose-quickly-and-effectively-now
#49
JOURNAL ARTICLE
Dawn Barry, Sharon F Terry
No abstract text is available yet for this article.
August 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37471205/the-application-of-artificial-intelligence-in-the-diagnosis-of-cancer-and-rare-genetic-diseases
#50
JOURNAL ARTICLE
Danielle Donadio, Sharon F Terry
No abstract text is available yet for this article.
July 20, 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37522794/otitis-media-in-children-with-down-syndrome-is-associated-with-shifts-in-the-nasopharyngeal-and-middle-ear-microbiotas
#51
JOURNAL ARTICLE
Christina L Elling, Salina H Goff, Scott D Hirsch, Kaitlyn Tholen, Jennifer M Kofonow, Danielle Curtis, Charles E Robertson, Jeremy D Prager, Patricia J Yoon, Todd M Wine, Kenny H Chan, Melissa A Scholes, Norman R Friedman, Daniel N Frank, Brian W Herrmann, Regie Lyn P Santos-Cortez
Background: Otitis media (OM) is defined as middle ear (ME) inflammation that is usually due to infection. Globally, OM is a leading cause of hearing loss and is the most frequently diagnosed disease in young children. For OM, pediatric patients with Down syndrome (DS) demonstrate higher incidence rates, greater severity, and poorer outcomes. However, to date, no studies have investigated the bacterial profiles of children with DS and OM. Method: We aimed to determine if there are differences in composition of bacterial profiles or the relative abundance of individual taxa within the ME and nasopharyngeal (NP) microbiotas of pediatric OM patients with DS ( n  = 11) compared with those without DS ( n  = 84)...
July 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37522793/association-of-rad51-xrcc1-xrcc2-and-xrcc3-polymorphisms-with-risk-of-breast-cancer
#52
JOURNAL ARTICLE
Priyanka Gupta, Vasudha Sambyal, Kamlesh Guleria, Manjit Singh Uppal, Meena Sudan
Background: DNA repair genes are among the low-penetrance genes implicated in breast cancer. However variants of DNA repair genes may alter their protein function thus leading to carcinogenesis. Breast cancer is the most common cancer among women in India. The aim of the present study was to identify association, if any, of single nucleotide polymorphisms (SNP's) in four genes involved in DNA repair pathways including, RAD51 rs1801320, XRCC1 rs25487, XRCC2 rs3218536, and XRCC3 rs861539 with the risk of breast cancer...
July 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37522792/evaluating-the-clinical-application-of-automatic-chromosome-harvesting-for-prenatal-karyotype-analysis
#53
JOURNAL ARTICLE
Yunmeng Wang, Yifan Feng, Chanchan Ma, Jing Zhao, Shiying Sun
Objective: The clinical value of an automatic chromosome harvester was evaluated, which included a comparison between the manual and automatic harvesting for the isolation of amniotic fluid cell chromosomes. Methods: Amniotic fluid samples from 96 high-risk gravida cases identified at 17-25 weeks treated at the Prenatal Diagnostic and Reproductive Center from June to July 2022 were collected. These samples underwent both manual and automatic chromosome collection, and their harvest time and number of amniotic cells were compared...
July 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37382908/role-of-genetic-polymorphism-and-expression-of-angiopoietin-2-in-patients-with-primary-liver-cancer-among-the-southeastern-chinese-hans-population
#54
JOURNAL ARTICLE
Bin Wang, Yunxiao Lv, Shenjian Ye, Jin Zhao, Xinling Pan
Background: Angiopoietin-2 ( Ang2)-mediated angiogenesis plays a crucial role in the pathogenesis of vascular-rich cancers. However, the genetic polymorphism and expression level of Ang2 in patients with primary liver cancer remain unknown. Methods: This study included 234 primary liver cancer patients and 199 healthy controls. The expression levels of Ang2 in liver cancer tissues and plasma were determined. Peripheral blood samples were collected to test five ANGPT2 single nucleotide polymorphisms (rs2442598, rs734701, rs1823375, rs11137037, and rs12674822)...
June 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37382907/the-applicability-of-polygenic-risk-scores-in-under-represented-populations
#55
JOURNAL ARTICLE
Katie Riefski, Sharon F Terry
No abstract text is available yet for this article.
June 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37382906/impact-of-piwil1-single-nucleotide-polymorphisms-on-gastric-cancer-risk-in-a-chinese-population
#56
JOURNAL ARTICLE
Dan Hu, Laicheng Wang, Xin Chen, Yunchai Lin, Shunpeng Zhang, Zongcheng Fan, Feng Peng
Background: PIWI-like proteins contribute to the onset and progression of carcinogenesis. Whether single nucleotide polymorphisms (SNPs) in the PIWI-like 1 (PIWIL1) gene affect the morbidity and mortality of gastric cancer (GC) remains unclear. To investigate the efficacy of PIWIL1 SNPs genotype on the morbidity and mortality of GC and its interaction within PIWIL1 gene SNPs variation and between elevated plasma glucose. Materials and Methods: We conducted a case-control study that contained 216 GC patients and 204 cancer-free controls to compare differential expression of PIWIL1 SNPs...
June 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37382905/creating-a-path-for-gene-and-cell-therapies-to-be-accessible-to-patients
#57
Helen Albert
No abstract text is available yet for this article.
June 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37204320/association-of-brca2-gene-functional-polymorphisms-with-nonsyndromic-cleft-lip-with-or-without-cleft-palate-in-a-chinese-population
#58
JOURNAL ARTICLE
Siyuan Guo, Zuo Zhou, Tingting Guo, Yi Xu, Xintao Yang, Yupei Wang, Renji Chen
Background: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex congenital disease affected by gene and environmental factors. Hereditary factors play an important role; however, its specific pathogenic genes and regulatory mechanisms remain unclear. In this study, we aimed to study the association between eight potentially functional single nucleotide polymorphisms (SNPs) of BRCA2 and MGMT genes and NSCL/P in a Chinese population through a case-control study. Materials and Methods: To investigate the relationship between potentially functional SNPs of the BRCA2 and MGMT genes and NSCL/P, we selected 200 affected patients and 200 unrelated normal controls in a Chinese population...
May 18, 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37158849/-correction-to-identifying-mitochondrial-transcription-factor-a-as-a-potential-biomarker-for-the-carcinogenesis-and-prognosis-of-prostate-cancer-by-yaqiong-tian-et-al-genet-test-mol-biomarkers-2023-vol-27-no-1-5-11-doi-10-1089-gtmb-2022-0141
#59
https://read.qxmd.com/read/37257183/association-between-the-slc2a2-gene-rs1499821-polymorphism-and-caries-susceptibility
#60
JOURNAL ARTICLE
Li Liu, Fei Ma, Qiulin Liu, Xueting Yu, Xiaojuan Zeng
Objectives: This study was designed to analyze the association between the SLC2A2 rs1499821 polymorphism and caries susceptibility in the Chinese Han, Zhuang, and Baikuyao populations. Materials and Methods: The present case-control study included 1067 12-year-old children: 481 with caries (142 Han, 166 Zhuang and 173 Baikuyao) and 586 who were caries-free (135 Han, 178 Zhuang and 273 Baikuyao). Questionnaires about diet and oral habits were obtained from all subjects. All of the children received dental examinations and DNA collection...
May 2023: Genetic Testing and Molecular Biomarkers
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