Regie Lyn P Santos-Cortez, Kimberly Mae C Ong, Angeli Carlos-Hiceta, Ma Leah C Tantoco, Talitha Karisse L Yarza, Ma Luz San Agustin, Melquiadesa Pedro, Teresa Luisa G Cruz, Eva Maria Cutiongco-de la Paz, Generoso T Abes, Erasmo Gonzalo D V Llanes, Abner L Chan, Charlotte M Chiong, Maria Rina T Reyes-Quintos
Background: Many indigenous peoples are at elevated risk for otitis media, however there is limited information on hearing loss due to OM in these communities. An Indigenous Filipino community that has previously been described with an elevated prevalence of OM that is due to rare A2ML1 variants and a common FUT2 variant underwent additional phenological testing. In this study, we describe the audiologic profiles in A2ML1 - and FUT2 -related otitis media and the validity of otoscopy and genotyping for A2ML1 and FUT2 variants in screening for otitis media and hearing loss...
January 2023: Genetic Testing and Molecular Biomarkers