Chan Hum Park, Jeong Sook Noh, Jin Pyeong Jeon, Takako Yokozawa
Traditional medicines are recently being focused on to treat diabetes and its complications because of their lack of toxic and/or side effects. This report describes the effects of 7-O-galloyl-D-sedoheptulose (GS), a polyphenolic compound isolated from Corni Fructus, on type 2 diabetic db/db mice with hepatic and pancreatic damage. We examined several biochemical factors and oxidative stress- and inflammation-related markers. In the serum, levels of glucose, leptin, insulin, C-peptide, resistin, tumor necrosis factor-α, and interleukin-6 were down-regulated, while adiponectin was augmented by GS treatment...
May 27, 2023: Drug Discoveries & Therapeutics
Daisuke Miyazawa, Kinari Suzuki, Hikari Sato, Natsumi Katsurayama, Tomoko Tahira, Hideki Mizutani, Naoki Ohara
Docosahexaenoic acid (DHA; 22:6n-3), an n-3 polyunsaturated fatty acid, has various important roles in brain functions. Nitric oxide (NO) produced by neuronal NO synthase (nNOS) and Ca2+ /calmodulindependent protein kinase II (CaMKII) is also involved in brain functions. We investigated the influence of DHA on nNOS and CaMKII protein expression in differentiated NG108-15 cells. NG108-15 cells were seeded in 12-well plates, and after 24 h, the medium was replaced with Dulbecco's modified Eagle's medium containing 1% fetal bovine serum, 0...
May 27, 2023: Drug Discoveries & Therapeutics
Akihiro Matsumoto, Masahiro Murakami
The use of harmful solvents during the preparation of pharmaceutical formulations is restricted to preserve environment and ensure safety of industrial operations. However, harmful solvents must be used to produce certain formulations. For instance, methylene chloride has been used in the fabrication of polylactic acid (PLA) and poly(lactic-co-glycolic) acid (PLGA) microspheres. This review highlights the latest advances in the strategy of PLA or PLGA microsphere production from non-halogenated solvents and describes advantages and limitations of these methods...
May 27, 2023: Drug Discoveries & Therapeutics
Motoki Inoue, Kazuhiko Nakadate, Mami Oosaki, Mikio Shirota, Takeo Yasu
The interruption of anticancer infusion processes in patients undergoing chemotherapy may affect their quality of life and the efficacy and safety of the therapy. We experienced several interruptions of carboplatin infusion in multiple patients receiving paclitaxel-carboplatin combination therapy. Therefore, we investigated the causes of these interruptions. The filter and catheter surfaces were evaluated by scanning electron microscopy. Moreover, using a texture analyzer, the mechanical strengths of catheter-attached syringes were compared pre- and post-administration...
May 23, 2023: Drug Discoveries & Therapeutics
Dianis Wulan Sari, Takeo Minematsu, Mikako Yoshida, Aya Kitamura, Sanai Tomida, Masatoshi Abe, Uswatun Khasanah, Hiromi Sanada
Since itching without rash frequently among older adults' population, study about skin properties of itching without rash is important to develop prevention methods. Therefore, this study explored the skin properties related to itching without rash and the factors associated with them. A correlation, predictive designs study was conducted at Indonesian Long-term Care (LTC) facilities. Skin properties including skin barrier function and skin inflammation were examined by photographs (macroscopic and microscopic), stratum corneum (SC) hydration, skin Potential of Hydrogen (pH), and skin blotting...
May 11, 2023: Drug Discoveries & Therapeutics
Kiyoshi Hotta, Yukihiro Mori, Makoto Aoike, Yukihiro Shigeno, Yuka Aoyama, Mamoru Tanaka, Hana Kozai, Hatsumi Kawamura, Masato Tsurudome, Morihiro Ito
This study aimed to explore the factors influencing subjective health views based on the living conditions and concerns of university students during the coronavirus infection 2019 (COVID-19) pandemic. From March to April 2021, a questionnaire survey was administered to 8,547 Japanese university students, and logistic regression analysis was used to explore factors related to subjective health views. The results showed that satisfaction with quality of sleep (OR = 2.651, 95% Cl 2.370-2.966,p < 0.001), satisfaction with university life (OR = 2...
April 29, 2023: Drug Discoveries & Therapeutics
Yingping Xu, Jia Chen, Yanlin Zhang, Qing Qi, Jing Zhou, Qi Zhou, Danyi Tang, Ling Wang
We aimed to evaluate the effect of serum luteinizing hormone (LH) levels on human chorionic gonadotropin (HCG) injection day (LHHCG ) on outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) patients. It is a retrospective cohort study involving 620 women who had an IVF cycle in Taizhou Hospital Affiliated to Wenzhou Medical University between 2018-2020. The participants were divided into different groups according to LHHCG level and age. The clinical data and outcomes were compared between groups...
April 21, 2023: Drug Discoveries & Therapeutics
Soraya Rodwattanagul, Wutigri Nimlamool, Siriporn Okonogi
Oxidative stress, glycation and inflammation are the main causes of many severe diseases. To date, no single extract has been shown to simultaneously inhibit these three reactions. In this study, the antioxidant, antiglycation and anti-inflammatory activities of ethanol extracts from four edible plants that are commonly used as Thai folk medicine were compared. Among these extracts, Caesalpinia mimosoides extract (CME) showed the highest antioxidant potential with Trolox equivalent antioxidant activity (TEAC) of 5...
April 20, 2023: Drug Discoveries & Therapeutics
Yasuhiko Matsumoto, Hanako Fukano, Harutaka Katano, Yoshihiko Hoshino, Takashi Sugita
Mycobacterium abscessus causes chronic skin infections, lung diseases, and systemic or disseminated infections. Although a silkworm infection model with M. abscessus has been established, pathological analysis of the infected silkworms has not been performed. In this study, we performed hematoxylin-eosin and Ziehl-Neelsen staining of silkworms infected with M. abscessus. Four days after infection with M. abscessus, M. abscessus accumulation was observed in the fat bodies of silkworms. The number of viable M...
April 12, 2023: Drug Discoveries & Therapeutics
Guangbin Chen, Hong-Zhou Lu
Staphylococcus aureus is a common clinical pathogen. Does every S. aureus infection require anti-MRSA drugs? Reported here are three cases of a community-acquired infection with S. aureus. The first case involveds a 45-year-old male who was admitted due to right ankle pain for 1 month; he was diagnosed with chronic suppurative osteomyelitis and an acute soft tissue infection of the ankle. S.aureus was cultured from the pus and was resistant to penicillin and sensitive to oxacillin and vancomycin. After receiving oxacillin, he was cured and discharged 45 days after admission...
April 9, 2023: Drug Discoveries & Therapeutics
Jing Wang, Xinyao Pan, Jing Zhou, Xin Li, Yan Sun, Ling Wang
Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET), increasing cycle cancellation rates and reducing pregnancy rates. Although it is well known that dehydroepiandrosterone (DHEA) can be used as a dietary supplement for age-related diseases, its potential has gradually been shown for many diseases. In this review, we focus on the effects of DHEA on DOR, briefly analysing its clinical benefits and limitations and describing the mechanism of function and the clinical trials conducted...
April 5, 2023: Drug Discoveries & Therapeutics
Jun Zhu, Jiaxi Jin, Qing Qi, Qi Zhou, Jing Zhou, Ling Wang
With the in-depth study of the human genome and the increasing popularity of gene sequencing, it has been gradually confirmed that genetics can play a crucial role in infertility. To provide references for clinical treatment, we have focused on genes and drug therapy for genetic infertility. This review recommends adjuvant therapy and drug substitution. Examples of these therapies include antioxidants (such as folic acid, vitamin D, vitamin E, inositol, coenzyme Q10 etc.), metformin, anticoagulants, levothyroxine, dehydroepiandrosterone, glucocorticoids, and gonadotropins etc...
March 30, 2023: Drug Discoveries & Therapeutics
Qishun Feng, Guoliang Zhang, Hongzhou Lu
Tuberculosis (TB) is a major public health problem that causes millions of deaths in humans around the world, and the bacterial pathogen Mycobacterium tuberculosis (Mtb) is responsible for this disease. Evidence suggested that the inflammasome-pyroptosis pathway is crucial for preventing Mtb infection. Uncertainty exists regarding whether and how these infections can bypass this immune system by Mtb. A recent Science article by Chai et al. (doi: 10.1126/science.abq0132) revealed a novel role by a eukaryotic-like effector called PtpB during Mtb infection...
March 30, 2023: Drug Discoveries & Therapeutics
Satoru Ishii, Moto Kimura, Tohru Miyoshi-Akiyama, Ataru Moriya, Masami Kurokawa, Erina Isaka, Junko Terada-Hirashima, Jin Takasaki, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama
The reverse transcription polymerase chain reaction (RT-PCR) offers high sensitivity, but has some drawbacks, such as the time required for the RNA extraction. Transcription reverse-transcription concerted reaction (TRC) Ready® SARS-CoV-2 i is easy to use and can be performed in about 40 minutes. TRC Ready® SARS-CoV-2 i and real-time one-step RT-PCR using the TaqMan probe tests of cryopreserved nasopharyngeal swab samples from patients diagnosed with COVID-19 were compared. The primary objective was to examine the positive and negative concordance rates...
March 22, 2023: Drug Discoveries & Therapeutics
Akihiro Matsumoto, Takeo Kitazawa, Yuta Hatori, Hiroshi Nakanishi, Chie Watanabe, Tomoya Takashima, Masahiro Murakami
Since nanoparticles are taken up into cells by endocytosis, phagocytosis, or pinocytosis, they have been studied as intracellular drug carriers. Janus particles have an anisotropic structure composed of two or more distinct domains and have been proposed for use in various applications, including use as imaging agents or nanosensors. This study aimed to clarify the influence of the type of nanoparticles on their distribution in a human Caucasian colon adenocarcinoma (Caco-2) cell monolayer. We fabricated Janus and conventional spherical nanoparticles composed of pharmaceutically applicable ingredients...
March 22, 2023: Drug Discoveries & Therapeutics
Mo Zhang, Zhi Wei, Hongbo Zhao, Sai Zhang, Jing Wu, Jing Zhou, Yan Wang, Ling Wang, Yan Du
The majority of cervical cancer cases are contributed to chronic infection with high-risk human papillomavirus (HPV), while only a fraction of infected women finally develop cancer. It is suggested that apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A), a type of mRNA editing enzyme, may be involved in the development and progression of HPV-related tumors. This study aimed to explore the role and potential mechanisms of APOBEC3A in cervical cancer. First, the expression levels, prognostic values and genetic alterations of APOBEC3A in cervical cancer were explored using various bioinformatics tools and databases...
March 9, 2023: Drug Discoveries & Therapeutics
Ryoko Murayama, Mari Abe-Doi, Yosuke Masamoto, Kosuke Kashiwabara, Chieko Komiyama, Hiromi Sanada, Mineo Kurokawa
Intravenous infusion using a peripheral intravenous catheter (PIVC) is often complicated by catheter failure (CF). We hypothesized that catheterization of an upper arm vein instead of a forearm vein may help prevent CF. This study was designed to compare the incidence of CF in patients receiving hyper-stimulant drugs when catheters are placed in the forearm using short PIVCs (SPCs) with that when catheters are placed in the upper arm using the new long PIVCs. Patients admitted to a university hospital in Tokyo, Japan were enrolled in this study and were assigned to the SPC or the new long PIVC group...
February 28, 2023: Drug Discoveries & Therapeutics
M Ismail Hossain, Nusrat U A Saleh, Al Numan, M Mahtab Hossain, M Aftab Uddin, Muktadir S Hossain
Increasing incidences of resistance to antibiotics by pathogenic bacteria is a worldwide concern and isolation of antibiotic-resistant strains of Niallia circulans (formerly known as Bacillus circulans), an opportunistic human pathogen, has been reported. Due to their lack of ethical constraints as well as their cost-effective rearing, invertebrates have been commonly used to study infection by bacteria pathogenic to humans. In this study, we demonstrate that a foodborne strain of N. circulans kills larvae of the silkworm, Bombyx mori within 48 h after hemolymph injection...
February 27, 2023: Drug Discoveries & Therapeutics
Futoshi Kawaura, Takuya Kishi, Tadashi Yamamoto, Shiki Nakayama, Taku Goto, Reimi Tsurusawa, Toshio Katagiri, Kohei Yamanouchi, Ayako Matsuo, Naomi Kobayashi-Watanabe, Tomohiro Imamura, Yoshitaka Hirooka, Kuniyasu Takagi, Tsukuru Umemura, Kazuma Fujimoto, Shinichiro Hayashi, Ayako Takamori
The present retrospective study aimed to examine the real-world data regarding time-dependent changes in the age distribution of patients with coronavirus disease 2019 (COVID-19) as well as the severity and infectivity in a regional core hospital in Japan. Patients with COVID-19 who visited the fever outpatient branch in Takagi Hospital during phase I (May 1 to December 31, 2021), and during phase II (January 1 to April 30, 2022) were evaluated. The age distribution of outpatients and the characteristics of inpatients aged > 75 years were compared between phases I and II...
February 26, 2023: Drug Discoveries & Therapeutics
Saori Yamada-Kanazawa, Shuichi Shimada, Wakana Nakayama, Soichiro Sawamura, Yuki Nishimura, Ikko Kajihara, Katsunari Makino, Jun Aoi, Shinichi Masuguchi, Fukiko Amano, Satoshi Fukushima
We studied 95 patients with infantile hemangioma (IH) treated with propranolol at the Department of Dermatology, Kumamoto University Hospital, from November 2016 to January 2022, based on sex, site, clinical classification, duration of treatment, and residual lesions after treatment. Four of the 95 patients discontinued propranolol due to side effects, and 55 completed follow-ups at our hospital. We observed that 30.1% showed complete resolution of the skin rash, while the remaining 69.8% had erythema or atrophic scarring...
February 25, 2023: Drug Discoveries & Therapeutics
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.