Andjela R Petrovic, Ivan P Jovanovic, Milena M Jurisevic, Marina Z Jovanovic, Marina M Jovanovic, Sladjana P Pavlovic, Nebojsa N Arsenijevic, Gordana M Supic, Danilo V Vojvodic, Milan M Jovanovic, Nevena M Gajovic
OBJECTIVES: Metformin, an oral anti-diabetic drug, is known to possess a powerful antitumor effect by modulating the tumor-immune interaction. The precise influence of metformin on natural killer (NK) cells, a crucial innate immunity player, is not completely understood. In our study, analyses of the effect of metformin on the NK cell functional phenotype were performed, and the potential mechanisms underlying it were investigated. METHODS: BALB/C wild type mice were treated with metformin, and the functional phenotype of splenocytes and potential underlying mechanisms were investigated...
2023: American Journal of Translational Research