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American Journal of Rhinology & Allergy

Luan V Tran, Ngoc H Ngo, Alkis J Psaltis
BACKGROUND: To date, there are numerous studies documenting the prevalence of frontal recess cells, but only 1 study using the newly developed International Frontal Sinus Anatomical Classification (IFAC) system. The identification of the frontal cells and their influence on the frontal drainage pathway plays an important role in endoscopic frontal sinus surgery. OBJECTIVE: The aim of this study is to document the radiological prevalence of various types of frontal cells, as classified by IFAC and the most common frontal sinus drainage pathways based on its anatomic relationships with these cells...
February 13, 2019: American Journal of Rhinology & Allergy
David W Jang, Cecily Abraham, Derek D Cyr, Kristine Schulz, Ralph Abi Hachem, David L Witsell
BACKGROUND: In-office balloon sinus dilation (BSD) has recently gained popularity as a surgical treatment option for chronic rhinosinusitis (CRS). However, utilization, indications, and practice patterns surrounding in-office BSD remain unclear. OBJECTIVE: The purpose of this study was to use a large national administrative database to assess preoperative management of CRS prior to in-office BSD. METHODS: Patients undergoing standalone in-office BSD from 2011 to 2014 were identified on MarketScan and compared to a control group undergoing functional endoscopic sinus surgery (FESS)...
February 7, 2019: American Journal of Rhinology & Allergy
Xi Chen, Wei-Jie Guan, Shi-Xue Sun, Pei-Yan Zheng, Li-Hong Sun, De-Hui Chen, Dan-Dan Wang, Chang Chen, Bao-Qing Sun, Xiao-Hua Douglas Zhang
BACKGROUND: Perennial allergic rhinitis (PAR) often coexists in asthmatic patients. Intranasal cellulose powder (ICP) was reportedly effective in ameliorating PAR. OBJECTIVE: We investigated whether ICP is equally effective compared with intranasal corticosteroids in improving asthma control as well as nasal symptoms among children with PAR and allergic asthma (AA). METHODS: Between July 2015 and September 2016, we did a single-center, randomized, placebo-controlled trial...
February 1, 2019: American Journal of Rhinology & Allergy
Benjamin N Hunter, Brandon Cardon, Gretchen M Oakley, Arun Sharma, Dana L Crosby
BACKGROUND: Nonattendance to clinical appointments is a global problem appreciated by clinicians with an ambulatory presence. There are few reports of nonattendance in otolaryngology clinics, and no reports on nonattendance for a single otolaryngology subspecialty. OBJECTIVE: To describe the no-show population in rhinology clinics. METHODS: A retrospective chart review was performed involving rhinology clinics from 2 academic medical centers in the United States...
January 29, 2019: American Journal of Rhinology & Allergy
Zachary H Griggs, Amy M Williams, John R Craig
BACKGROUND: Certain head positions can optimize topical irrigation distribution to specific sinuses. No studies have assessed whether patients attain these positions when irrigating. OBJECTIVE: The purpose of this study was to assess head and bottle angles achieved when patients irrigate based on instructions from an irrigation device or from a Rhinologist. METHODS: Study approval was obtained from Henry Ford Health System's Institutional Review Board (10604)...
January 24, 2019: American Journal of Rhinology & Allergy
Nicholas R Rowan, Tyler A Janz, Rodney J Schlosser, Zachary M Soler
BACKGROUND: Allergic fungal rhinosinusitis (AFRS) is characterized by higher revision endoscopic sinus surgery (ESS) rates and unique radiographic features when compared to chronic rhinosinusitis with nasal polyposis (CRSwNP) or chronic rhinosinusitis without nasal polyposis (CRSsNP). OBJECTIVE: We hypothesized that an increased frequency of concha bullosa in AFRS or other radiographic nuances might allow for accumulation of allergic mucin and contribute to increased ESS revision rates...
January 24, 2019: American Journal of Rhinology & Allergy
Sabrina A Brody-Camp, Dane A Weinert, Edward D McCoul
BACKGROUND: Despite a proliferation of technological advances in sinonasal surgery, "cold steel" instruments still comprise the core of the sinus surgeon's tools of the trade. Many of these implements retain eponyms that recall the legacies of prominent surgeons of the past. OBJECTIVE: This review aims to familiarize the reader with the lives of 10 men who designed and popularized some of the most recognizable sinus instruments, without which the practice of rhinologic surgery would be unrecognizable...
January 23, 2019: American Journal of Rhinology & Allergy
Shin Kariya, Mitsuhiro Okano, Takaya Higaki, Tomoyasu Tachibana, Toru Rikimaru, Kazunori Nishizaki
BACKGROUND: A remarkable relationship between upper airway conditions and lung diseases has been reported. At the same time, sinonasal findings in chronic cough patients have not been fully examined. OBJECTIVE: The purpose of this study is to show paranasal sinus findings and lung function in chronic cough patients without asthma and chest X-ray abnormalities. METHODS: A total of 1412 patients with persistent cough were enrolled in this study...
January 18, 2019: American Journal of Rhinology & Allergy
Aneeza W Hamizan, Janet Rimmer, Raquel Alvarado, William A Sewell, Jessica Tatersall, Henry P Barham, Larry Kalish, Richard J Harvey
BACKGROUND: Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis. OBJECTIVE: The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients. METHODS: A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions...
January 18, 2019: American Journal of Rhinology & Allergy
Ashkan Pirayesh, Shaghayegh Shahsavan, Omid Zargari Samani, Hedayatollah Shirzad, Soroush Amani, Mohamad Ali Zamani, Loghman Salimzadeh, Nader Bageri, Mandana Moghni, Fatemeh Deris
BACKGROUND AND AIMS: The roles of Fas in immune system are multifaceted, and the interaction between Fas receptor and Fas ligand is essential for maintaining the immune tolerance. We aimed to assess the level of the expression of Fas receptor on nasal inferior turbinate mucosa in patients with mild persistent allergic rhinitis (M PAR) and moderate to severe (M/S) PAR and determined the relationship between disease severity and production of Fas. METHODS: A total of 70 patients with M/S PAR, 70 patients with M PAR, and 70 healthy individuals were enrolled in this study...
January 16, 2019: American Journal of Rhinology & Allergy
Zhenxiao Huang, Nathalia Velasquez, Alan Nguyen, Ting Ye, Wei Le, Dawn T Bravo, Peter H Hwang, Bing Zhou, Jayakar V Nayak
BACKGROUND: Topical corticosteroids are currently employed to reduce established airway inflammation; their prophylactic use might help limit cellular damage against harmful stimuli. OBJECTIVES: To determine the effects of a prophylactic topical application of budesonide (BD) on an in vivo nasal epithelium injury model induced by trichloroacetic acid (TCA). METHODS: C57Bl/6 mice were exposed to intranasal TCA topical application. Three groups received topical intranasal BD, saline solution, or no intervention prior to a single topical exposure to TCA...
January 14, 2019: American Journal of Rhinology & Allergy
Giuseppe Riva, Pierfrancesco Franco, Erica Provenzano, Francesca Arcadipane, Claudia Bartoli, Paolo Lava, Umberto Ricardi, Giancarlo Pecorari
BACKGROUND: Oral mucositis is a well-known adverse event of radiotherapy (RT) for head and neck cancer (HNC). Its nasal counterpart, the radiation-induced rhinitis, is poorly studied and considered in clinical practice. OBJECTIVE: The aim of this observational study was to evaluate acute cytological and olfactory alterations during RT and their correlation with RT doses. METHODS: Ten patients who underwent RT for HNC, excluding tumors of the nasal cavities, were evaluated with nasal scraping for cytological examination, Sniffin' Sticks test for olfactory assessment, and Nasal Obstruction Symptom Evaluation scale...
January 11, 2019: American Journal of Rhinology & Allergy
Ian Churnin, Jamiluddin Qazi, Cyrelle R Fermin, James H Wilson, Spencer C Payne, Jose L Mattos
BACKGROUND: The association between olfactory dysfunction (OD) and cognitive decline is becoming apparent in the emerging literature. However, the literature demonstrating a similar effect between gustatory dysfunction (GD) and cognition is not well established. OBJECTIVE: To determine whether OD and GD are independently associated with cognitive impairment. METHODS: The 2013-2014 National Health and Nutrition Examination Survey was queried for 1376 older adults, corresponding to a weighted population sample of 50 816 529, to assess olfactory and gustatory status and cognition using univariate and multivariate regression analyses...
January 11, 2019: American Journal of Rhinology & Allergy
Xiaoling Liu, Yu Ren, Xiaolei Sun, Haiyun Huang, Xiaojia Liu
OBJECTIVE: As the most prevalent type of rhinitis, allergic rhinitis is consisted of seasonal allergic rhinitis (SAR) and perennial allergic rhinitis. This study is carried out for revealing the mechanisms of SAR. METHODS: Microarray data set GSE43523 (including 7 SAR nasal epithelial cells and 5 nonallergic control nasal epithelial cells) was extracted from Gene Expression Omnibus database. Based on limma package, differential expression analysis for the 2 groups was performed to obtain differentially expressed genes (DEGs)...
January 8, 2019: American Journal of Rhinology & Allergy
Sean Setzen, Michael Platt
BACKGROUND: Sneezing is an almost universal daily phenomenon as a reflex to evacuate irritants from the nasal cavities. An autonomic-controlled buildup of intrathoracic pressure against a closed glottis followed by sudden release results in a burst of 1 kPa of air through the upper airway. Active intervention to limit a sneeze can be deleterious. Closure of the airway during a sneeze can result in over 20 times the airway pressures resulting in a variety of untoward events. This review summarizes all reported injuries that occurred as the result of a sneeze...
January 8, 2019: American Journal of Rhinology & Allergy
Kevin Hur, Paul Zhang, Alison Yu, Natalie Kim-Orden, Lynn Kysh, Bozena Wrobel
BACKGROUND: Open resection (OR) of sinonasal mucosal melanoma (SNM) traditionally has been the gold standard for treatment. However, endoscopic resection (ER) has recently become a surgical alternative. The aim of this study was to compare survival outcomes between OR and ER of SNM. METHODS: A literature search encompassing PubMed, Embase, Cochrane Library, Web of Science,, and Google Scholar was performed. Two reviewers independently screened for original studies comparing survival outcomes between OR and ER for SNM...
January 7, 2019: American Journal of Rhinology & Allergy
Alison G Kartush, Jane K Schumacher, Rachna Shah, Monica O Patadia
BACKGROUND: Chronic rhinosinusitis with nasal polyposis is a complex inflammatory disorder, which is often recalcitrant to medical and surgical management. Recently, biologic agents have been studied as an adjunct treatment for this patient population. OBJECTIVE: The purpose of this study is to examine the role of biologic agents for chronic rhinosinusitis patients by reviewing literature and clinical trials. METHODS: A comprehensive review of literature and clinical trials-both recently completed and ongoing-was undertaken to examine up-to-date evidence of current biologic therapy and its role in chronic rhinosinusitis patients-including anti-IgE, anti-IL-4, anti-IL-5, anti-IL-13, and GATA-3 DNAzyme...
December 27, 2018: American Journal of Rhinology & Allergy
Do-Yeon Cho, Dong Jin Lim, Calvin Mackey, Daniel Skinner, Shaoyan Zhang, Justin McCormick, Bradford A Woodworth
BACKGROUND: Methods to improve the clinical efficacy of currently available antibiotics against multidrug resistant bacteria in cystic fibrosis (CF) chronic rhinosinusitis (CRS) are greatly needed. Ivacaftor, a cystic fibrosis transmembrane conductance regulator potentiator, was recently identified as having potentially beneficial off-target effects as a weak inhibitor of bacterial DNA gyrase and topoisomerase IV. The objective of the current study is to evaluate whether ivacaftor enhances the antimicrobial activity of ciprofloxacin against Pseudomonas aeruginosa...
December 25, 2018: American Journal of Rhinology & Allergy
Sevan R Komshian, Michael B Cohen, Christopher Brook, Jessica R Levi
BACKGROUND: Historically, there has been uncertainty in the treatment of inferior turbinate hypertrophy (ITH) in children. Although management always begins with medical therapy, the decision to offer surgery in resistant cases is becoming more widely practiced. In the pediatric population, turbinate reduction can be achieved with turbinectomy, electrocautery, lasers, submucous microdebridement, and radiofrequency volumetric tissue reduction (RVTR). However, there remains a lack of consensus on the preferred approach to treatment...
December 17, 2018: American Journal of Rhinology & Allergy
Suhyla Alam, Chengyu Li, Kathryn H Bradburn, Kai Zhao, Thomas S Lee
BACKGROUND: The impact of middle turbinate resection (MTR) on olfaction remains a point of debate in the current literature. Few studies have objectively evaluated olfactory cleft airflow following MTR; thus, the mechanism by which MTR may impact olfaction is poorly understood. It is not known whether the postsurgical changes in airway volume, flow, and resistance increase odorant transport or disrupt the patterns of normal airflow. Computational fluid dynamics can be used to study the nasal airway and predict responses to surgical intervention...
December 13, 2018: American Journal of Rhinology & Allergy
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