Journals American Journal of Rhinology ...

American Journal of Rhinology & Allergy
Yasuhiro Tsunemi, Tsuguhisa Nakayama, Takashi Kashiwagi, Makoto Akutsu, Shota Saito, Shinichi Haruna
BACKGROUND: Eosinophilic chronic rhinosinusitis (eCRS) is a type 2 inflammatory disease that frequently recurs after surgery. In recent years, dupilumab has been available for the treatment of refractory chronic rhinosinusitis since 2020 in Japan. Although there are some reports of its usefulness, there are not enough reports of its clinical efficacy for longer than 1 year, especially for olfactory recovery. METHODS: Twenty patients with eCRS who had recurrence after surgery and had been receiving dupilumab were enrolled retrospectively...
September 26, 2023: American Journal of Rhinology & Allergy
Tyler B Merrill, Vijay A Patel, Christopher Pool, John L Dornhoffer, Robert A Saadi
BACKGROUND: Eustachian tube balloon dilation (ETBD) has been Food and Drug Administration (FDA) approved for refractory Eustachian tube dysfunction since 2016. While ETBD is generally seen as safe, the complication profile has not been well defined. OBJECTIVE: The objective of this study was to utilize the FDA manufacturer and user facility device experience (MAUDE) database to better assess adverse events (AE) related to ETBD. METHODS: This is a study of a multiinstitutional database maintained by the U...
August 27, 2023: American Journal of Rhinology & Allergy
Tripti Brar, Saurabh Baheti, Michael J Marino, Hirohito Kita, Devyani Lal
BACKGROUND: Epigenetics studies mechanisms such as DNA methylation, histone modifications, non-coding RNAs, and alternative polyadenylation that can modify gene activity without changing the underlying DNA nucleotide base-pair structure. Because these changes are reversible, they have potential in developing novel therapeutics. Currently, seven pharmaceutical agents targeting epigenetic changes are FDA approved and commercially available for treatment of certain cancers. However, studies investigating epigenetics in chronic rhinosinusitis (CRS) have not been undertaken previously in the United States...
August 16, 2023: American Journal of Rhinology & Allergy
Dijiang Ma, Qiling Zheng, Jianing Sun, Shenjun Tang, Wudan He
OBJECTIVE: Sublingual immunotherapy (SLIT) has been widely applied to treat patients with allergic rhinitis (AR). However, meta-analyses on the efficacy of SLIT in AR patients with asthma are still limited. METHODS: Literature without language limitation published before October 28, 2022, were retrieved from PubMed, EMBASE, and Cochrane Library. STATA 16.0 software was used for the meta-analysis of the extracted data. The results reported were symptom scores, drug scores, adverse effects rates, and cost of treatment...
August 9, 2023: American Journal of Rhinology & Allergy
Xu Liang, Peng Jin, Changcui Zhan, Li Zhao, Xiaoxue Zi, Lili Zhi, Kena Yu
BACKGROUND: Evidence has shown that glucocorticoid-induced transcript 1 (GLCCI1) single nucleotide polymorphism (SNP) rs37937 is associated with asthma. OBJECTIVES: The objective of this study was to investigate whether the GLCCI1 SNP rs37937 is a risk factor for allergic rhinitis (AR) in a Chinese Han population. METHODS: A total of 220 individuals including 109 AR patients and 111 healthy subjects were included. The genotyping of GLCCI1 rs37973 was performed by the SNaPshot method...
August 8, 2023: American Journal of Rhinology & Allergy
Vikram Vasan, Jonathan T Dullea, Alex Devarajan, Devarshi Vasa, Muhammad Ali, Noah Nichols, Philip Henson, Christian Porras, Christine Lopez, Diego Luna, Lathan Liou, Alfred Marc Iloreta, Satish Govindaraj, Joshua Bederson, Raj K Shrivastava
OBJECTIVE: In this nationwide retrospective study, the authors aimed to identify demographic, clinical, and baseline health risk factors predictive of a prolonged length of stay (PLOS) for patients with pituitary adenomas (PAs). METHODS: The National Inpatient Sample dataset from 2016 to 2019 was utilized to identify all included hospitalizations for PA resection as identified by the appropriate diagnosis-related group code. Comorbidities were classified based on the Charlson Comorbidity Index mapping of ICD-10 codes, and PLOS was identified as any stay longer than 3 days...
August 7, 2023: American Journal of Rhinology & Allergy
Hong Wei Yu, Wei Wei Wang, Qian Jing, Yong Liang Pan
BACKGROUND: Airway remodeling is demonstrated in Asian patients with allergic rhinitis (AR). The epithelial-mesenchymal transition (EMT) is one of the key mechanisms underlying airway remodeling. Thymic stromal lymphopoietin (TSLP) is an important contributor to airway remodeling. Although increased TSLP is found in AR, little is known about whether TSLP is involved in airway remodeling through induction of the EMT. OBJECTIVE: We investigated the effect of TSLP on the EMT in human nasal epithelial cells (HNECs) from AR patients...
August 3, 2023: American Journal of Rhinology & Allergy
Hong Wang, Jing Wu, Ruxin Zhang
BACKGROUND: Neurokinin-1 receptor (NK-1R) and normal T cell expressed and secreted (RANTES) have been shown to play important roles in allergic rhinitis (AR). However, whether the regulating effect of NK-1R in AR is achieved via RANTES remains unknown. METHODS: In the present study, Sprague-Dawley rats were sensitized and challenged with ovalbumin to make AR models. During the challenge period, the rats were treated intranasally with NK-1R-specific small interfering RNA (siRNA) for NKR group, negative siRNA for NCS group, rats in NSAR group and NS group were given saline...
July 31, 2023: American Journal of Rhinology & Allergy
Shyam A Gokani, Andreas Espehana, Ana C Pratas, Louis Luke, Ekta Sharma, Jennifer Mattock, Jelena Gavrilovic, Allan Clark, Tom Wileman, Carl M Philpott
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous condition characterized by differing inflammatory endotypes. The identification of suitable biomarkers could enable personalized approaches to treatment selection. OBJECTIVE: This study aimed to identify and summarize clinical studies of biomarkers in adults with CRS in order to inform future research into CRS endotypes. METHODS: We conducted systematic searches of MEDLINE and Web of Science from inception to January 30, 2022 and included all clinical studies of adult CRS patients and healthy controls measuring biomarkers using enzyme-linked immunosorbent assays or Luminex immunoassays...
July 25, 2023: American Journal of Rhinology & Allergy
Yousif Alammar, Simon Rousseau, Martin Desrosiers, Marc A Tewfik
BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease with no known single cause, but it is thought that bacteria play a role in the disease process. OBJECTIVE: This pilot study aims to assess the longitudinal effect of corticosteroid therapy on sinus microbiota in chronic rhinosinusitis patients with nasal polyposis (CRSwNP). METHODS: A longitudinal prospective case-control study was done on patients with CRSwNP and healthy controls...
July 20, 2023: American Journal of Rhinology & Allergy
Ju Guo, Xuan Meng, Yao-Ming Zheng, Shan-Kun Zhao, Chen Qiang, Li-Bo Zhou
BACKGROUND: Extensive data suggest that exposure to cigarette smoke can induce pulmonary epithelial barrier dysfunction. However, the effects of cigarette smoke on the nasal epithelial barrier are still unclear. Here, we investigated the consequence and mechanism of cigarette smoke on the nasal epithelial barrier. METHODS: Sprague Dawley rats were exposed to cigarette smoke for 3 or 6 months, and changes in inflammatory markers and nasal barrier function were evaluated...
July 9, 2023: American Journal of Rhinology & Allergy
Xu Xiaodong, Li Tao, Liu Jianmin, Zhou Jing, Zhong Bing, Du Jintao, Claus Bachert, Ba Luo
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is subdivided into type 1 and type 2 inflammatory responses according to the mucosal inflammatory patterns. Crocin can reduce the level of T-helper type 2 cell (Th2) cytokines, such as interleukin-4 (IL-4), and inhibit the nuclear factor kappa-B (NF-κB) signaling pathway. OBJECTIVE: This study aimed to investigate the role of group 2 innate lymphoid cells (ILC2s) in type 2 inflammation in eosinophilic nasal polyps and the inhibitory effect of crocin on this inflammation...
July 9, 2023: American Journal of Rhinology & Allergy
Tripti Brar, Adam Brown, Amar Miglani, Devyani Lal, Michael J Marino
BACKGROUND: Mometasone-eluting poly-L-lactide-coglycolide (MPLG) is available commercially for frontal sinus ostium (FSO) stenting. An alternative chitosan polymer-based drug delivery microsponge is also available at a lower cost per unit. OBJECTIVE: To compare the outcomes of MPLG stents versus triamcinolone-impregnated chitosan polymer (TICP) microsponge in frontal sinus surgery. METHODS: Patients who underwent endoscopic sinus surgery from December 2018 to February 2022 were reviewed to identify those with the intraoperative placement of TICP microsponge or MPLG stent in the FSO...
July 5, 2023: American Journal of Rhinology & Allergy
Hossam Elsayed El-Sisi, Mohammed Etman, Hisham Atef Ebada
BACKGROUND: Variable surgical options are available for turbinate reduction. These options include total turbinectomy, partial turbinectomy, submucosal resection, laser surgery, cryosurgery, electrocautery, radiofrequency ablation, and turbinate out-fracture. However, there remains a lack of consensus for the preferred technique. OBJECTIVES: The aim of this study was to describe the use of coblation for medial flap turbinoplasty procedure. Furthermore, the outcomes of this technique were compared to submucous resection in terms of improvement of patients' symptoms, postoperative bleeding, crusting, and pain scores...
July 5, 2023: American Journal of Rhinology & Allergy
Sarita U Patil
No abstract text is available yet for this article.
September 2023: American Journal of Rhinology & Allergy
David K Lerner, Katherine L Garvey, Annie Arrighi-Allisan, Evan Kominsky, Andrey Filimonov, Abdurrahman Al-Awady, Peter Filip, Katherine Liu, Sen Ninan, Todd Spock, Benjamin Tweel, Maaike van Gerwen, Madeleine Schaberg, Patrick Colley, Anthony Del Signore, Satish Govindaraj, Alfred Marc Iloreta
OBJECTIVE: To evaluate the efficacy of omega-3 fatty acid (O3FA) supplementation in the treatment of COVID-related olfactory dysfunction (OD). METHODS: Patients with laboratory-confirmed or clinically-suspected COVID-19 infection and new-onset OD from August 2020 to November 2021 were prospectively recruited. Patients with quantitative OD, defined as a brief smell identification test (BSIT) score of 9 or less, were eligible for study inclusion. The experimental group received 2 g of O3FA supplementation, while the control group received an identical placebo to be taken daily for 6 weeks...
September 2023: American Journal of Rhinology & Allergy
David El-Adem, Nathan Yang, David A Gudis
BACKGROUND: Positron emission tomography (PET) scan is a valuable imaging modality widely used in the management of cancers. Its usage is well defined for most head and neck malignancies. However, there is a lack of consensus regarding the utility of PET scan for sinonasal malignancies. This is highlighted by the latest international consensus statement on endoscopic skull base surgery. OBJECTIVE: This systematic review aims to clarify the role of PET scan in the management of sinonasal malignancies...
September 2023: American Journal of Rhinology & Allergy
Hannah J Brown, Ali M Baird, Sarah Khalife, Pedro Escobedo, Peter Filip, Peter Papagiannopoulos, Paolo Gattuso, Pete Batra, Bobby A Tajudeen
BACKGROUND: Adult and elderly patients with chronic rhinosinusitis (CRS) undergo similar therapeutic management. Few studies have undertaken sinonasal tissue-level comparisons of these groups. This study examines histopathological differences between adults (>18, <65 years) and the elderly (≥65 years) with CRS, with the goal of optimizing medical management. METHODS: In a retrospective cohort analysis, demographic factors, comorbidities, and a structured histopathological report of 13 variables were compared across adult and elderly patients with CRS who underwent functional endoscopic sinus surgery...
September 2023: American Journal of Rhinology & Allergy
Sanjeet V Rangarajan
No abstract text is available yet for this article.
July 2023: American Journal of Rhinology & Allergy
Neal R Godse, Satyan B Sreenath, Firas Sbeih, Troy D Woodard, Varun R Kshettry, Pablo F Recinos, Raj Sindwani
BACKGROUND: Multiple methods exist for skull base reconstruction of defects created by expanded endonasal approaches. While the nasoseptal flap (NSF) has been well established as the workhorse of mucosal reconstruction in complex skull base defects in multi-layered closures, a variety of options exist for the inner layer of multilayer reconstruction, including fascia lata (FL). OBJECTIVE: To present our experience and outcomes in utilizing FL in multiple ways to reconstruct a wide variety of complex skull base defects...
July 2023: American Journal of Rhinology & Allergy
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