Read by QxMD icon Read

Korean Journal of Hematology

Pasquale Niscola, Massimiliano Palombi, Stefano Fratoni, Malgorzata Monika Trawinska, Laura Scaramucci, Andrea Tendas, Marco Giovannini, Alessio Perrotti, Paolo de Fabritiis
No abstract text is available yet for this article.
December 2012: Korean Journal of Hematology
Min Jin Kim, John Jeongseok Yang, Claus Meyer, Rolf Marschalek, Tae Sung Park
No abstract text is available yet for this article.
December 2012: Korean Journal of Hematology
Sun Mi Jin, Moon Ju Jang, Ji Young Huh, Myoung Hee Park, Eun Young Song, Doyeun Oh
Transfusion-related acute lung injury (TRALI) is a noncardiogenic pulmonary edema that occurs during or within 6 hours after transfusion. Risk factors for TRALI, which is relatively common in critically ill patients, include recent surgery, hematologic malignancy, and sepsis. Here, we report a case of TRALI induced by anti-human leukocyte antigen (anti-HLA) class II antibodies (HLA-DR) occurring after transfusion of platelet concentrates in a patient with acute leukemia. Although most patients with TRALI show improvement within 48-96 hours, our patient's condition rapidly worsened, and he did not respond to supportive treatment...
December 2012: Korean Journal of Hematology
Jay S Raval, Jonathan H Waters, Darrell J Triulzi, Mark H Yazer
Plasma is used to correct coagulopathies, but not all coagulation abnormalities are clinically significant enough to require correction before an invasive procedure. We report an 82 year old female who, in response to a mildly prolonged INR of unknown etiology, was unnecessarily transfused with plasma in advance of elective surgery. The patient suffered a moderately severe transfusion reaction, including hives and voice hoarseness, which caused a 4-week delay in her surgery. This delay and adverse reaction could have been avoided had the principles of evidence based plasma therapy, which we herein review, been followed and if the etiology of the mildly elevated INR been investigated before the day of her surgery...
December 2012: Korean Journal of Hematology
Masashi Ohe, Satoshi Hashino, Atsuo Hattori
We report a case of diffuse large B-cell lymphoma (DLBCL) treated successfully with clarithromycin (CAM) and prednisolone (PSL). A 71-year-old woman presented with fever and cervical pain. DLBCL was diagnosed based on histological results from lymph node biopsy. Cervical pain was thought to be caused by the invasion of lymphoma cells into the cervical vertebrae. She initially received radiotherapy for the cervical lesion. She did not receive conventional chemotherapy because of the risk of recurrent non-tuberculous mycobacteria infection; therefore, she was treated with 20 mg/day PSL and 800 mg/day CAM to induce apoptosis in lymphoma cells...
December 2012: Korean Journal of Hematology
Hyoung Soo Choi, Sang Hoon Song, Jae Hee Lee, Hee-Jin Kim, Hye Ran Yang
BACKGROUND: Iron deficiency (ID) and iron deficiency anemia (IDA) are common nutritional disorders in children. Hepcidin, a peptide hormone produced in the liver, is a central regulator of systemic iron metabolism. We evaluated whether serum hepcidin levels can diagnose ID in children. METHODS: Sera from 59 children (23 males and 36 females; 5 months to 17 years) were analyzed for hepcidin-25 by ELISA. Patients were classified according to hemoglobin level and iron parameters as: IDA, (N=17), ID (N=18), and control (N=24)...
December 2012: Korean Journal of Hematology
Shin-Hee Kim, Young Shil Park, Kee-Hwan Kwon, Jae Hoon Lee, Kwang Chul Kim, Myung Chul Yoo
BACKGROUND: Congenital factor VII (FVII) deficiency is a rare hemorrhagic disorder that can cause excessive bleeding during and after surgery in affected patients. The recombinant form of activated factor VII (rFVIIa, NovoSeven® from Novo Nordisk, Bagsvaerd, Denmark), which was developed as a second-generation bypassing agent, has recently been used in the management of bleeding for patients with congenital FVII deficiency. METHODS: We reviewed the results of 8 surgical procedures in 5 patients with congenital FVII deficiency at the Kyung Hee University Hospital, Gangdong, Seoul, Korea, between January 2008 and June 2010...
December 2012: Korean Journal of Hematology
Myung-Mi Kim, Mi-Sun Yum, Hae-Won Choi, Tae-Sung Ko, Ho Joon Im, Jong-Jin Seo, Kyung-Nam Koh
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder that frequently involves the central nervous system (CNS). We compared the clinical characteristics, treatment, and prognosis of patients with HLH according to the degree of CNS involvement. METHODS: The clinical manifestations, initial laboratory data, treatment, and outcomes for 50 patients diagnosed with HLH and treated at Asan Medical Center between January 1995 and August 2011 were retrospectively reviewed and analyzed...
December 2012: Korean Journal of Hematology
Jong-Jin Seo, Taeshik Cho, Sun-Young Kim, Ibrahim Nassour, Hee-Jin Kim, Yeon-Jung Lim, Kyung-Nam Koh, Ho-Joon Im
BACKGROUND: Gelsolin and matrix metalloproteinase 12 (MMP12) expression has been reported in Langerhans cell histiocytosis (LCH), but the clinical significance of this expression is unknown. We investigated the associations of these proteins with clinical manifestations in patients diagnosed with LCH. METHODS: We performed a retrospective analysis of clinical data from patients diagnosed with LCH and followed up between 1998 and 2008. Available formalin-fixed, paraffin-embedded specimens were used for gelsolin and MMP12 immunohistochemical staining...
December 2012: Korean Journal of Hematology
Tae-Dong Jeong, Chan-Jeoung Park, Hyoeun Shim, Seongsoo Jang, Hyun-Sook Chi, Dok Hyun Yoon, Dae-Young Kim, Jung-Hee Lee, Je-Hwan Lee, Cheolwon Suh, Kyoo Hyung Lee
BACKGROUND: Flow cytometric immunophenotyping has been used to identify neoplastic plasma cell populations in patients with multiple myeloma (MM). Previous reports have described the use of several antigens, including CD38, CD138, CD56, CD117, CD52, CD19 and CD45, to distinguish distinct populations of plasma cells. The aim of this study was to evaluate a simplified immunophenotyping panel for MM analysis. METHODS: A total of 70 patients were enrolled in the study, 62 of which were newly diagnosed with MM (untreated), whereas the remaining 8 were undergoing bone marrow assessment as part of follow-up after treatment (treated)...
December 2012: Korean Journal of Hematology
Ji Yean Lee, Chul Won Jung, Kihyun Kim, Jun Ho Jang
BACKGROUND: Invasive pulmonary aspergillosis (IPA) is one of the major complications encountered by patients receiving chemotherapy for hematologic malignancies. The prolonged period of intense immunosuppression following allogeneic hematopoietic stem cell transplantation (HSCT) may increase the risk of IPA recurrence in patients with a history of IPA. We evaluated the impact of a history of IPA on allogeneic HSCT outcome, and examined the incidence of IPA after HSCT. METHODS: This retrospective study included 22 patients with a history of IPA prior to receiving allogeneic HSCT at the Samsung Medical Center from 1995 to 2007...
December 2012: Korean Journal of Hematology
Dario Campana, Elaine Coustan-Smith
Measuring response to chemotherapy is a backbone of the clinical management of patients with acute leukemia. This task has historically relied on the ability to identify leukemic cells among normal bone marrow cells by their morphology. However, more accurate ways to identify leukemic cells have been developed, which allow their detection even when they are present in small numbers that would be impossible to be recognized by microscopic inspection. The levels of such minimal residual disease (MRD) are now widely used as parameters for risk assignment in acute lymphoblastic leukemia (ALL) and increasingly so in acute myeloid leukemia (AML)...
December 2012: Korean Journal of Hematology
Misung Kim, Jooryung Huh
No abstract text is available yet for this article.
December 2012: Korean Journal of Hematology
Jai Hyang Go, Joowon Park
No abstract text is available yet for this article.
December 2012: Korean Journal of Hematology
Chul Won Jung
No abstract text is available yet for this article.
December 2012: Korean Journal of Hematology
Mina Hur
No abstract text is available yet for this article.
December 2012: Korean Journal of Hematology
Tae-Dong Jeong, Seongsoo Jang, Chan-Jeoung Park, Hyun-Sook Chi
No abstract text is available yet for this article.
September 2012: Korean Journal of Hematology
Hea-Lin Oh, Hae-Ryong Kang, Seok-Cheol Jeon, Young-Ho Lee
We describe 2 cases in which radiographic evidence of thromboembolic events was obtained during germ cell tumor diagnosis. There was no evidence of coagulation factor abnormalities or contributory procedures or drugs in either patient. We used anticoagulation therapy for thrombolysis in one patient, but in the other, the thromboembolism resolved spontaneously.
September 2012: Korean Journal of Hematology
Anshu Palta, Pratibha Dhiman, Sanjay D Cruz
A 23-year-old male presented with pulmonary tuberculosis and swelling of both lower limbs. He was put on antitubercular treatment. Hemogram showed mild anemia and Pseudo Pelger-huet cells. The bone marrow (BM) examination showed 52% promyelocytes with regular round to oval nuclei, few granules and were positive for CD13 and CD33, and negative for HLA-DR. Cytogenetic analysis of the BM aspirate revealed an apparently balanced t(11;17)(q23;q21). Final diagnosis rendered was acute promyelocytic leukemia (APL) with t(11;17)(q23;q21); ZBTB16/RARA...
September 2012: Korean Journal of Hematology
Ji Hun Jeong, Jeong Yeal Ahn, Soon Ho Park, Mi Jung Park, Kyung Hee Kim, Jun Shik Hong
Radioiodine is regularly used in the treatment of thyroid cancer to eliminate residual malignant tissue after thyroidectomy and to treat metastasis. Because of the low dose of radioiodine used to treat thyroid cancer patients, leukemia is an uncommon complication of exposure to radioiodine. Here, we present a patient who developed therapy-related acute myeloid leukemia with inv(16)(p13.1q22);CBFβ-MYH11, eosinophilia, and K-ras mutation and who had been treated with very low-dose radioiodine following total thyroidectomy...
September 2012: Korean Journal of Hematology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"