Yumi Ohba, Hiroshi Hayashi, Maki Kanda, Chieko Nagano, Souichi Yoshikawa, Takayuki Nakajima, Yoko Matsushima, Hiroshi Koike, Momoka Hayashi, Tomoko Yokoyama, Takeo Sasamoto
The simultaneous determination of five carbapenems (biapenem, doripenem, ertapenem, imipenem, and meropenem) in raw and pasteurised bovine milk samples using LC-MS/MS was achieved and validated. Chromatographic separation was conducted on an InertSustain® AQ-C18 column using 0.1% formic acid in water and acetonitrile as the mobile phase. Target compounds were extracted using acetonitrile/water (20:80, v/v). After the removal of lipids with acetonitrile-saturated hexane, the dissolved protein was denatured with acetic acid...
January 22, 2024: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment