journal
Journals Materials Science & Engineerin...

Materials Science & Engineering. C, Materials for Biological Applications

https://read.qxmd.com/read/35589470/osteogenic-and-anti-inflammatory-potential-of-oligochitosan-nanoparticles-in-treating-osteomyelitis
#1
JOURNAL ARTICLE
Shixiong Zhang, Guo Chen, Mohong Wang, Bingyan Lin, Xueqin Gao, Jiaxing Hu, Bin Chen, Chao Zhang
Osteomyelitis is commonly developed via hematogenous spreading or direct inoculation of bacteria from orthopedics trauma. Pathogens-induced bone destruction impedes the penetration of antibiotics to the infection site, and the severe inflammation further compromises the traditional treatment outcome. In this work, vancomycin-loaded oligochitosan nanoparticles (Van-NPs) with antibacterial, antibiofilm, antioxidant as well as bone regenerative properties are prepared using sodium tripolyphosphate (TPP) as a crosslinker, and employed for the treatment of osteomyelitis...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581090/a-loofah-inspired-scaffold-with-enhanced-mimicking-mechanics-and-tumor-cells-distribution-for-in-vitro-tumor-cell-culture-platform
#2
JOURNAL ARTICLE
Xingxing Liu, Sijia Fu, Yongjie Jiao, Mengbo Hu, Chaojing Li, Fujun Wang, Lu Wang
Tumor cells cultured in a physiologically related three-dimensional (3D) matrix can replicate many basic characteristics of tumor tissue. Tumor tissues are harder than normal, so when using hydrogels for 3D tumor cell culture, attempts have been made to prepare hydrogel scaffolds that mimic the hardness of tumor tissues without reducing the porosity. In this study, a new 3D loofah-inspired scaffold was developed for prostate cancer cell culture. Since the loofah sponge structure of the spacer fabric, the composite scaffolds had a compression modulus similar to that of natural prostate tumor tissue at a lower hydrogel concentration (0...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581086/silk-inspired-fiber-implant-with-multi-cues-enhanced-bionic-microenvironment-for-promoting-peripheral-nerve-repair
#3
JOURNAL ARTICLE
Xiaoli Chen, Xiaoxuan Tang, Yaling Wang, Xinyi Gu, Tingting Huang, Yumin Yang, Jue Ling
Successful repair and desirable functional recovery of large-gap nerve injuries using artificial nerve implants remains a significant clinical challenge. The beneficial bionic microenvironment within scaffolds can significantly promote the outgrowth of newborn nerve tissues after implantation. Herein, we developed an aligned silk-inspired fiber scaffold (RGD@ASFFs) with a synergistic effect of an extracellular matrix mimicking physical cues and RGD (Arg-Gly-Asp) signals to provide an enhanced cell-friendly microenvironment for repairing large-gap peripheral nerve injuries...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581080/micro-textured-silicone-based-implant-fabrication-using-electrospun-fibers-as-a-sacrificial-template-to-suppress-fibrous-capsule-formation
#4
JOURNAL ARTICLE
Juhwan Choi, Byung Ho Shin, Taehyeon Kim, Jae Sang Lee, Semin Kim, Young Bin Choy, Chan Yeong Heo, Won-Gun Koh
Conventionally, macro-textured surfaces comprising several hundred micrometer-sized patterns are used to minimize silicone-based breast implant complications, including capsular contracture. However, because of the recent cases of breast implant-associated anaplastic large cell lymphoma from macro-textured implants, there is a strong demand for nano- or micro-textured silicone implants with dimensions smaller than sub-micrometers. Herein, we propose a simple and cost-effective topographical surface modification strategy for silicone-based implants...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581077/electrochemical-aptamer-based-nanobiosensors-for-diagnosing-alzheimer-s-disease-a-review
#5
REVIEW
Masoud Negahdary, Lúcio Angnes
Diagnosis and prognosis of Alzheimer's disease by electrochemical nanoaptasensors have recently received abundant attention. In this review, all recent nanomaterial-based electrochemical aptasensors developed to diagnose or prognosis Alzheimer's disease have been collected, categorized, and reviewed. Analytes in these aptasensors were specific biomarkers, including amyloid-β (Aβ) and tau protein, as well as other nonspecific markers (microRNAs (miRNAs), dopamine, thrombin, adenosine triphosphate (ATP), interleukin-6, α-1 antitrypsin, α-synuclein, target DNA (tDNA), and glycated albumin)...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581070/bioactive-and-degradable-hydrogel-based-on-human-platelet-rich-plasma-fibrin-matrix-combined-with-oxidized-alginate-in-a-diabetic-mice-wound-healing-model
#6
JOURNAL ARTICLE
Itxaso Garcia-Orue, Edorta Santos-Vizcaino, Pello Sanchez, Francisco Borja Gutierrez, Jose Javier Aguirre, Rosa Maria Hernandez, Manoli Igartua
In the present study we developed an injectable, bioactive and degradable hydrogel composed of alginate at 2.5% oxidation degree and calcium-activated platelet rich plasma (PRP) for wound healing applications (PRP-HG-2.5%). The alginate gives mechanical support to the hydrogel while the activated PRP provides growth factors that enhance wound healing and fibrin which creates an adequate microenvironment for cell migration and proliferation. The rheological and mechanical properties of the hydrogel were characterized...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581060/the-effect-of-the-surface-coating-of-human-adipose-derived-stem-cells-by-various-gags-on-the-biodistribution-of-them-upon-intravenous-administration
#7
JOURNAL ARTICLE
Jong Chul Kim, Kiyoon Min, Giyoong Tae
Glycosaminoglycans (GAGs) are essential for cell-cell and cell-ECM interactions. Unique structures of GAGs provide high affinities to specific cell receptors. Especially, hyaluronic acid (HA), chondroitin sulfate (CS), and heparin are known to have affinities to the liver sinusoidal endothelial cells (LSECs), so they have been utilized as a ligand for liver targeting nanoparticle systems. In this study, we compared different GAGs as a targeted cell delivery ligand by using lipid-conjugated GAGs. Conjugated lipids of GAGs could provide a stable coating over 2 days on the surface of human adipose-derived stem cells (hADSCs) by physical insertion...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35577688/construction-of-novel-antiplatelet-modified-polyethersulfone-membrane-and-study-into-its-blood-compatibility
#8
JOURNAL ARTICLE
Xiao Fu, Ting Lei, Shu-Jun Li, Yan-Feng Liu, Jie Peng, Jian-Ping Ning
Blood purification therapy is widely used in patients with renal insufficiency and severe infections, where membrane-associated thrombosis is a side effect. How to improve the hemocompatibility of dialysis membranes and reduce thrombosis is a focus of current research, in which platelets play a key role. However, few dialysis membranes that directly inhibit platelets have been developed to date. In this study, a polyethersulfone (PES) membrane was modified with ticagrelor, a platelet P2Y12 receptor inhibitor, and detailed characterization was performed...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35577687/an-in-vitro-and-in-vivo-study-of-pcl-chitosan-electrospun-mat-on-polyurethane-propolis-foam-as-a-bilayer-wound-dressing
#9
JOURNAL ARTICLE
Mohsen Shie Karizmeh, Seyed Ali Poursamar, Amirhosein Kefayat, Zohreh Farahbakhsh, Mohammad Rafienia
In the current study, we fabricated a bilayer wound dressing consisting of an electrospun poly-ε-caprolactone/chitosan (PCL/CS) fibrous mat as the sublayer and a polyurethane (PU) foam coated with ethanolic extract of propolis (EEP) as the top layer. By blending the solutions of PCL and CS, we fabricated an electrospun mat consisting of bead-free and uniform nanofibers with enhanced hydrophilicity, swelling ratio, and degradation properties. To further enhance the mechanical and antibacterial properties, we electrospun the PCL/CS solution on a PU foam coated with EEP to fabricate the PCL/CS-PU/EEP bilayer wound dressing...
April 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35589472/challenges-and-opportunities-on-vegetable-oils-derived-systems-for-biomedical-applications
#10
REVIEW
Ana R Ribeiro, Simone S Silva, Rui L Reis
Vegetable oils have been suggested in polymer science as an environmentally friendly feedstock existing in abundance in nature, with worldwide availability and low cost. Although they have been widely explored as building blocks for polymers synthesis, their functional roles as owners of potent biomolecules are less unexplored. Their ancient biomolecules support natural biological roles such as antioxidant, antibacterial, anti-inflammatory, and anti-tumor properties, which are considered a great promise for biomedical proposes...
February 23, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35474147/silk-sericin-plga-electrospun-scaffolds-with-anti-inflammatory-drug-eluting-properties-for-periodontal-tissue-engineering
#11
JOURNAL ARTICLE
Konstantina Chachlioutaki, Christina Karavasili, Elisavet Adamoudi, Nikolaos Bouropoulos, Dimitrios Tzetzis, Athina Bakopoulou, Dimitrios G Fatouros
Periodontal disease is associated with chronic inflammation and destruction of the soft and hard tissues in the periodontium. Scaffolds that would enable cell attachment and proliferation while at the same time providing a local sustained anti-inflammatory action would be beneficial in restoring or reversing disease progression. In the current study, silk sericin, a natural protein derived from the silkworm cocoons, was electrospun with poly lactide-co-glycolic acid (PLGA) and ketoprofen, and the composite scaffolds were assessed for their physicochemical and mechanical properties, as well as their biocompatibility and in vitro anti-inflammatory action...
February 19, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35584980/mechanical-properties-degradation-behavior-and-cytocompatibility-of-biodegradable-3vol-x-x-mgo-zno-and-cuo-zn-matrix-composites-with-excellent-dispersion-property-fabricated-by-graphene-oxide-assisted-hetero-aggregation
#12
JOURNAL ARTICLE
Xiaohao Sun, Xiao Yu, Wei Li, Minfang Chen, Debao Liu
Metal matrix composites have been recognized as a feasible approach to obtain a new generation of biodegradable Zn-based material. Nevertheless, there is a great challenge in achieving good dispersion properties of the bioactive reinforcements within zinc matrix. A novel and facile approach, namely graphene oxide (GO)-assisted hetero-aggregation, were developed to achieve uniformly dispersed nanoceramics in the Zn matrix, by using very low-content (0.03 vol%) GO as a linker between the Zn matrix and reinforcement...
February 18, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581068/melanin-gelatin-nanoparticles-with-both-epr-effect-and-renal-clearance-for-pa-mri-dual-modal-imaging-of-tumors
#13
JOURNAL ARTICLE
Tingting Li, Yilin Yang, Wenyu Jing, Zirui Yan, Jiaying Che, Huijie Xu, Xiaoqin Hu, Ruiping Zhang
As cancer nanotherapeutics, the ideal multifunctional nanoparticles not only have the processing ability to accumulate effectively in tumors, but also can be excreted rapidly from the body via renal clearance after effective treatment. Melanin is an endogenous biological material, and gelatin has natural biocompatibility and biodegradability. Such materials are more promising in the development of diagnostic and therapeutic nanoplatform for future clinical translation. In this study, we have developed a kind of size-shrinkable PA/MRI theranostic agent based on gelatin fabricated ultrasmall melanin nanoparticles (MNPs-GNP)...
February 18, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581078/ph-responsive-release-of-curcumin-from-photocrosslinked-pectin-gelatin-hydrogel-wound-dressings
#14
JOURNAL ARTICLE
Nazlı Seray Bostancı, Senem Büyüksungur, Nesrin Hasirci, Ayşen Tezcaner
The aim of this study was to develop hydrogel wound dressings made of photocrosslinkable pectin and gelatin with pH dependent release of curcumin, an antimicrobial agent. Methacrylated forms of pectin and gelatin (PeMA and GelMA, respectively) were synthesized, and hydrogels were prepared with different compositions (1:1, 1:2 and 1:3 v/v ratios of PeMA and GelMA) by UV exposure. Pure GelMA was used as control group. Average pore diameter of hydrogels with the highest PeMA content (P1:G1) was 43 μm. All hydrogels showed about 90% swelling...
February 17, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581069/coassembling-functionalized-glycopolypeptides-to-prepare-ph-responsive-self-indicating-nanocomplexes-to-manipulate-self-assembly-drug-delivery-and-visualize-intracellular-drug-release
#15
JOURNAL ARTICLE
Junyang Zhong, Yusi Quan, Xiaoya Zhao, Suifei Li, Ziqing He, Guodong Ye, Mingna Sun, Yingling Miao, Chunping Ma, Huikang Yang, Xing Chen, Yugang Huang
The pH-responsive polymeric micelles (PMs) have been widely used as smart nano drug delivery systems to treat tumors. However, synchronously manipulating these PMs' self-assembly properties, drug release dynamics and tracing their pH-dependent intracellular fate remain challenges. Herein, we have first synthesized hyaluronic acid (HA) based glycopolypeptides modified by tetraphenylethylene (TPE) and a pH-sensitive doxorubicin (DOX) prodrug through Diels-Alder reaction, respectively. Then, the pH-responsive nanocomplexes (NCs) were prepared by coassembling the two obtained glycopolypeptides with different formulations...
February 14, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35599098/injectable-recombinant-human-collagen-derived-material-with-high-cell-adhesion-activity-limits-adverse-remodelling-and-improves-pelvic-floor-function-in-pelvic-floor-dysfunction-rats
#16
JOURNAL ARTICLE
Hu Li, Shuang You, Xia Yang, Shuaibin Liu, Lina Hu
Female pelvic floor dysfunction (FPFD) is a life-changing condition that severely affects women's physical and mental health. Despite the effectiveness of current treatments for FPFD, there is a high rate of short-term recurrence. Here, we introduced an injectable recombinant human collagen (rhCOL)-derived material with high cell adhesion activity to achieve pelvic floor repair and extracellular matrix (ECM) assembly. In our study, rhCOL promoted human uterosacral ligament fibroblast (HULF) adhesion, migration, and collagen I and III expression and regulated the metabolism of HULFs in vitro...
February 12, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581094/inhibitory-potential-of-irgd-peptide-conjugated-garcinol-loaded-biodegradable-nanoparticles-in-rat-colorectal-carcinoma
#17
JOURNAL ARTICLE
Brahamacharry Paul, Raghuvir H Gaonkar, Debasmita Dutta, Rajesh Dasi, Biswajit Mukherjee, Shantanu Ganguly, Sujoy K Das
Targeted drug delivery has become attention in chemotherapy during the last decade. The principle of chemotherapy seeks maximum effect to the desired site and the minimum impact to other undesired sites of action. The nanoparticulated drug delivery system progressed a lot in this aspect in the last twenty years. Plant-derived natural products and their semisynthetic analogues boosted chemotherapy through their excellent mechanistic approach to killing cancer cells. Keeping in mind the available molecular targets in colorectal carcinoma (CRC), in this article, we proposed a peptide conjugated novel polymeric nanoparticle to deliver garcinol against colorectal carcinoma...
February 12, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581066/silver-substituted-hydroxyapatite-inhibits-pseudomonas-aeruginosa-outer-membrane-protein-f-a-potential-antibacterial-mechanism
#18
JOURNAL ARTICLE
Yun Zhao, Chien Yi Wee, Haozhe Zhang, Zhijie Yang, Wilson Ee Jen Wang, Eng San Thian
Bone fractures are one of the most common injuries, and they have a big effect on population health worldwide. Traumatic bone injuries can be partially treated with implanting bone-graft substitutes, for example, hydroxyapatite (HA), a bioceramic that is similar materially to natural bones with good bioactivity and osteoconductivity. It could, however, be vulnerable to infections because of the way an HA-based bone graft is put in, which could be a weakness in the host's defense. This study incorporated silver (Ag) into hydroxyapatite (Ag-HA) and silicon-containing hydroxyapatite (AgSi-HA) discs to combat this implant-triggered infection...
February 12, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581089/balancing-the-biocompatibility-and-bacterial-resistance-of-polypyrrole-by-optimized-silver-incorporation
#19
JOURNAL ARTICLE
Yuzheng Wu, Qingdong Ruan, Chao Huang, Qing Liao, Liangliang Liu, Pei Liu, Shi Mo, Guomin Wang, Huaiyu Wang, Paul K Chu
Polypyrrole (PPy) which is a conductive polymer with excellent biocompatibility has enormous potential in implantable electronics. However, pristine PPy does not have sufficient bacterial resistance and hence, bacterial infection poses serious threats in vivo. Silver is an excellent antibacterial agent but the optimal concentration is critical because excessive silver is detrimental to human health. In this study, electrochemical polymerization is carried out to fabricate PPy coatings and silver ions (Ag) are introduced by plasma immersion ion implantation (PIII)...
February 8, 2022: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/35581073/surface-modification-of-carbon-dots-with-tetraalkylammonium-moieties-for-fine-tuning-their-antibacterial-activity
#20
JOURNAL ARTICLE
Elizaveta Sviridova, Alexandre Barras, Ahmed Addad, Evgenii Plotnikov, Antonio Di Martino, Dominique Deresmes, Ksenia Nikiforova, Marina Trusova, Sabine Szunerits, Olga Guselnikova, Pavel Postnikov, Rabah Boukherroub
The widespread of bacterial infections including biofilms drives the never-ending quest for new antimicrobial agents. Among the great variety of nanomaterials, carbon dots (CDs) are the most promising antibacterial material, but still require the adjustment of their surface properties for enhanced activity. In this contribution, we report a facile functionalization method of carbon dots (CDs) by tetraalkylammonium moieties using diazonium chemistry to improve their antibacterial activity against Gram-positive and Gram-negative bacteria...
February 8, 2022: Materials Science & Engineering. C, Materials for Biological Applications
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