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Materials Science & Engineering. C, Materials for Biological Applications

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https://read.qxmd.com/read/30948133/corrigendum-to-mechanochemical-synthesis-of-hydroxyapatite-using-cuttlefish-bone-and-chicken-eggshell-as-calcium-precursors-mater-sci-eng-c-97-2019-124-140
#1
Alberto C Ferro, Mafalda Guedes
No abstract text is available yet for this article.
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948132/optimization-by-design-of-etoposide-loaded-solid-lipid-nanoparticles-for-ocular-delivery-characterization-pharmacokinetic-and-deposition-study
#2
Imran Ahmad, Jayamanti Pandit, Yasmin Sultana, Anil K Mishra, Puja Panwar Hazari, Mohd Aqil
The present study was to develop etoposide loaded solid lipid nanoparticles (SLN) and optimize it for effective ocular delivery to the posterior eye. SLN were prepared by melt-emulsification and ultrasonication technique. Etoposide loaded SLN were optimized by using three-factor three levels Box-Behnken design to establish the functional relationships between variables on responses of particle size, polydispersity index (PDI) and entrapment efficiency (EE). SLN were characterized for size & surface morphology, entrapment efficiency and in vitro release...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948131/simple-and-facile-preparation-of-recombinant-human-bone-morphogenetic-protein-2-immobilized-titanium-implant-via-initiated-chemical-vapor-deposition-technique-to-promote-osteogenesis-for-bone-tissue-engineering-application
#3
Yun Hee Youn, Sang Jin Lee, Go Ro Choi, Hak Rae Lee, Donghyun Lee, Dong Nyong Heo, Byung-Soo Kim, Jae Beum Bang, Yu-Shik Hwang, Vitor M Correlo, Rui L Reis, Sung Gap Im, Il Keun Kwon
Over the past few decades, titanium (Ti) implants have been widely used to repair fractured bones. To promote osteogenesis, immobilization of osteoinductive agents, such as recombinant human bone morphogenic protein-2 (rhBMP2), onto the Ti surface is required. In this study, we prepared rhBMP2 immobilized on glycidyl methacrylate (GMA) deposited Ti surface through initiated chemical vapor deposition (iCVD) technique. After preparation, the bio-functionalized Ti surface was characterized by physicochemical analysis...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948130/a-polysaccharide-based-micelle-hydrogel-synergistic-therapy-system-for-diabetes-and-vascular-diabetes-complications-treatment
#4
Na Wen, Shaoyu Lü, Xiubin Xu, Piao Ning, Zengqiang Wang, Zinan Zhang, Chunmei Gao, Yongqi Liu, Mingzhu Liu
Various glucose-sensitive drug delivery platforms have been developed recently to treat diabetes. However, there is much less work has been reported on treatment of diabetes and vascular diabetes complications simultaneously. In this work, a novel polysaccharide-based micelle-hydrogel synergistic therapy system was fabricated to address this limitation. Zwitterionic dialdehyde starch-based micelles (SB-DAS-VPBA) were synthesized via single electron transfer-living radical polymerization (SET-LRP). Hydrophilic segment sulfobetaine (SB) and hydrophobic segment 4‑vinylphenylboronic acid (VPBA) were grafted to the dialdehyde starch (DAS) backbones...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948129/evaluation-of-human-dental-pulp-stem-cells-behavior-on-a-novel-nanobiocomposite-scaffold-prepared-for-regenerative-endodontics
#5
Reza Moonesi Rad, Deniz Atila, Elif Ece Akgün, Zafer Evis, Dilek Keskin, Ayşen Tezcaner
Dental caries is a dental disease affecting public health, which results in many socio-economic consequences. This disease causes loss of tooth hard tissue and subsequent inflammation and loss of the dental pulp. In this study, it was aimed to develop and characterize boron (B) modified bioactive glass nanoparticles (BG-NPs) containing cellulose acetate/oxidized pullulan/gelatin (CA/ox-PULL/GEL) three dimensional scaffolds with tubular morphology for dentin regeneration. 3D nanobiocomposite structures were prepared by thermally induced phase separation and porogen leaching methods and characterized by in vitro degradation analysis, water absorption (WA) capacity measurement, SEM, in vitro biomineralization analysis, porosity measurement and mechanical tests...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948128/biomimicry-of-oil-infused-layer-on-3d-printed-poly-dimethylsiloxane-non-fouling-antibacterial-and-promoting-infected-wound-healing
#6
Gaoqiang Shi, Yitian Wang, Soroosh Derakhshanfar, Kaige Xu, Wen Zhong, Gaoxing Luo, Tengfei Liu, Ying Wang, Jun Wu, Malcolm Xing
The nepenthes-inspired slippery liquid-infused surface has led to multiple potentials in biomedical devices' design. This study aims to develop a biomimetic, environmentally-friendly slippery layer of oil-infused 3D printed polydimethylsiloxane with anti-bacterial nanosilver (iPDMS/AgNPs) for wound dressing. The engineered 3D printed iPDMS can cater the different requirements of wounds with antifouling, anti-blood staining, and kill bacteria. iPDMS/AgNPs not only exhibits biocompatibility, against adherence and effective antibacterial activity but also effectively promotes neo-epithelial and granulation tissue formation to accelerate wound healing in vivo...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948127/synthesis-characterization-and-utilization-of-a-diallylmethylamine-based-cyclopolymer-for-corrosion-mitigation-in-simulated-acidizing-environment
#7
Saviour A Umoren, Moses M Solomon, Shaikh A Ali, Hatim D M Dafalla
A novel random copolymer 4, containing diallylmethylamine and N1 ,N1 -diallyl-N1 -methyl-N6 ,N6 ,N6 -tripropylhexane-1,6-diammonium dibromide units in a 1:1 ratio (polymer 4) was synthesized via Butler's cyclopolymerization technique. Characterization was accomplished by 1 H NMR, elemental analysis, and Fourier-transform infrared spectroscopy (FTIR). Polymer 4 was tested as corrosion inhibitor for low carbon steel in 15% HCl solution via gravimetric and electrochemical approaches. The analysis of the metal specimen surfaces was done using scanning electron microscope (SEM), atomic force microscopy (AFM), energy dispersive X-ray spectroscopy (EDAX), and X-ray photoelectron spectroscopy (XPS) methods...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948126/antibacterial-and-cytotoxic-assessment-of-poly-methyl-methacrylate-based-hybrid-nanocomposites
#8
S Sathya, P Sriyutha Murthy, V Gayathri Devi, Arindam Das, B Anandkumar, V S Sathyaseelan, M Doble, V P Venugopalan
Poly (methyl methacrylate) (PMMA) is an extensively used implant material in biomedical devices. Biofilm formation creates issues in PMMA-based biomedical implants, while emergence of drug resistant pathogens poses an additional complication. Hence development of surfaces that resist bacterial colonisation is extremely desirable. In this context, nanomaterials are among the potential choices. In the present work, nanocomposites (NCs) were developed by incorporation of chemically synthesized nanoparticles of CuO, cetyl trimethyl ammonium bromide (CTAB) capped CuO and ZnO (singly and in combination) in PMMA...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948125/poly-sodium-4-styrene-sulfonate-modified-hydroxyapatite-nanoparticles-in-zein-based-scaffold-as-a-drug-carrier-for-vancomycin
#9
Melika Babaei, Azadeh Ghaee, Jhamak Nourmohammadi
In order to prepare bone tissue engineered scaffolds, zein, a natural polymer isolated from corn, was used as a starting material. Zein provides ideal properties for tissue engineered scaffolds, and the products derived from its degradation are non-toxic. To enhance the osteogenic properties of the scaffold, hydroxyapatite mineral was used in the form of nanospheres. Hydroxyapatite nanoparticles are designed to carry a drug in addition to the role they play in bone tissue engineering. The surface of the hydroxyapatite nanoparticles was modified with negatively charged poly (sodium 4-styrene sulfonate) polymer, and their surface was then loaded with positively charged Vancomycin as a model drug...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948124/promoting-osteogenic-differentiation-of-bmscs-via-mineralization-of-polylactide-gelatin-composite-fibers-in-cell-culture-medium
#10
Man Cao, Yan Zhou, Jianping Mao, Pengfei Wei, Dafu Chen, Renxian Wang, Qing Cai, Xiaoping Yang
Mineralization capability is an important issue in developing bone repairing biomaterials, while it is not quite clear how this feature would act in the presence of cells and influence cell osteogenic differentiation without adding extra osteoinductive factors such as β‑sodium glycerophosphate and dexamethasone. Poly(l‑lactide) (PLLA) and gelatin composite fibers (PG, 1:1 in weight) were electrospun, treated with CaCl2 solution (PG-Ca), and used for mineralization studies by using cell culture media (αMEM, and αMEM + serum)...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948123/formation-of-enzymatic-redox-switching-nanogates-on-mesoporous-silica-nanoparticles-for-anticancer-drug-delivery
#11
Wei Luo, Xin Xu, Bingjie Zhou, Peixin He, Yulin Li, Changsheng Liu
In this study, we demonstrate a simple approach to developing mesoporous nanohybrids via a process of pre-loading of an anticancer drug (doxorubicin, DOX) into mesoporous silica nanoparticles (MSN), followed by assembly with a kind of naturally-derived polymer (gelatin, cleavable by matrix metalloproteinase 2 overexpressed by tumor). The gelatin shell is then in situ crosslinked by degradable N,N'-bis(acryloyl)cystamine (BAC) to form enzymatic and redox switchable nanogates on the mesoporous nanoparticles. The nanohybrids displayed pH/redox/enzymatic sensitivity in DOX release under conditions mimicking tumor microenvironments...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948122/enhanced-biocompatibility-of-poly-l%C3%A2-lactide%C3%A2-co%C3%A2-epsilon%C3%A2-caprolactone-electrospun-vascular-grafts-via-self-assembly-modification
#12
Haibo Du, Ling Tao, Weizhong Wang, Dinghua Liu, Qianqian Zhang, Ping Sun, Shuguang Yang, Chuanglong He
Thousands of coronary artery bypass surgeries are performed in the world every year. But there is still no alternative to autologous vessel transplantation yet. In the present study, we optimized the weight ratio of chitosan/poly(l‑lactide‑co‑epsilon‑caprolactone) (CS/PLCL) of the electrospun scaffolds, which lead to suitable mechanical properties, such as tensile strength, ultimate strain, elastic modulus and burst pressure. Besides, the scaffolds possessed the structure that mimics the native extracellular matrix...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948121/chlorogenic-acid-peg-based-organic-inorganic-hybrids-a-versatile-sol-gel-synthesis-route-for-new-bioactive-materials
#13
Michelina Catauro, Federico Barrino, Giovanni Dal Poggetto, Francesca Pacifico, Simona Piccolella, Severina Pacifico
New organic-inorganic hybrid materials were synthesized by an acid catalysed sol-gel approach, using silicon alkoxide and low molecular weight polyethylene glycol (PEG400) as inorganic and organic precursor, respectively. Chlorogenic acid (CGA), an antioxidant natural phenol compound, enriched further the organic component. Hybrids synthesized, all identical in terms of their starting materials, but differing in terms of their relative proportions, were characterized by means of Fourier Transform InfraRed (FTIR) measurements, UV-Vis spectroscopy, and UHPLC-HRMS analysis...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948120/graphite-ag-agcl-nanocomposite-as-a-new-and-highly-efficient-electrocatalyst-for-selective-electroxidation-of-oxalic-acid-and-its-assay-in-real-samples
#14
Taher Alizadeh, Sahar Nayeri
Herein, graphite/Ag/AgCl nanocomposite is introduced as a new electrocatalyst material for the electrocatalytic oxidation of oxalic acid. Graphite/Ag/AgCl was synthesized by electroless deposition of nano-sized metallic silver and then silver chloride on graphite powder. The material obtained was characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and Energy-dispersive X-ray spectroscopy. The nanocomposite was mixed with n-eicosane as binder and used as carbon paste electrode for electrocatalytic oxidation of oxalic acid (OA)...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948119/formulation-of-active-packaging-system-using-artemisia-scoparia-for-enhancing-shelf-life-of-fresh-fruits
#15
Javaria Hanif, Nauman Khalid, Rao Sanaullah Khan, Muhammad Faraz Bhatti, Mohammad Qasim Hayat, Muhammad Ismail, Saadia Andleeb, Qaisar Mansoor, Faria Khan, Faheem Amin, Rumeza Hanif, Muhammad Uzair Hashmi, Hussnain Ahmed Janjua
An improved active packaging system was developed for fresh fruits using silver nanoparticles (AgNPs) coupled with calcium alginate (Ca-ALG). For the synthesis of AgNPs aqueous, ethanol and methanol extracts of Artemisia scoparia (AS) were used. These AgNP's were characterized using UV-Vis, SEM, EDS, AFM, FTIR and gel electrophoresis. Ethanol extract of AS (ASE) produced AgNPs with smallest size in comparison to aqueous AS (ASA) and methanol extract of AS (ASM). AgNPs synthesized from ASE had a size range of 12...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948118/characterizations-and-interfacial-reinforcement-mechanisms-of-multicomponent-biopolymer-based-scaffold
#16
REVIEW
Pei Feng, Jiyao He, Shuping Peng, Chengde Gao, Zhenyu Zhao, Shixian Xiong, Cijun Shuai
It is difficult for a single component biopolymer to meet the requirements of scaffold at present. The development of multicomponent biopolymer based scaffold provides an effective method to solve the issue based on the advantages of each kind of the biomaterials. However, the compatibility between different components might be very poor due to the difficulties in forming strong interfacial bonding, and thereby significantly degrading the integrated mechanical properties of the scaffold. In recent years, interface phase introduction, surface modification and in situ growth have been the major strategies for enhancing interfacial bonding...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948117/encapsulated-melatonin-in-polycaprolactone-pcl-microparticles-as-a-promising-graft-material
#17
Esra Bihter Gurler, Necdet Mekki Ergul, Burak Ozbek, Nazmi Ekren, Faik Nuzhet Oktar, Merve Erginer Haskoylu, Ebru Toksoy Oner, Mehmet Sayıp Eroglu, Dilek Ozbeyli, Veysel Korkut, Ahmet Furkan Temiz, Nil Kocanalı, Rosa Juvan Gungordu, Duhan Berkan Kılıckan, Oguzhan Gunduz
Electrospraying assures many advantages with taking less time and costing less relatively to the other conventional particle production methods. In this research, we investigated the encapsulation of melatonin (MEL) hormone in polycaprolactone (PCL) microparticles by using electrospraying method. Morphology analysis of the produced particles completed with Scanning Electron Microscopy (SEM). SEM images demonstrated that micro-particles of 3 wt% PCL solution has the most suitable particle diameter size (2...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948116/pore-size-effect-on-adsorption-and-release-of-metoprolol-tartrate-in-mesoporous-silica-experimental-and-molecular-simulation-studies
#18
Shicheng Luo, Jiakang Hao, Yanmei Gao, Deping Liu, Qing Cai, Xiaoping Yang
Mesoporous silica nanoparticles (MSNs) have been widely studied as drug carriers to get sustained release behaviors, however, their application in sustained release of metoprolol tartrate (MPT) is limited. The possible reason is due to MPT molecule being bulky, while normal type MSNs like MCM-41 and SBA-15 have pore sizes of only 3-6 nm. In this study, two MCF-26 type MSNs were prepared with pore size of 11 or 15 nm, and used to conduct MPT release in comparison with MCM-41 and SBA-15. Both molecular simulation and MPT release experiments were performed to identify the pore size effect on adsorption and diffusion (release) of MPT in these MSNs...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948115/continuous-compression-behaviors-of-selective-laser-melting-ti-6al-4v-alloy-with-cuboctahedron-cellular-structures
#19
J K Chen, M W Wu, T L Cheng, P H Chiang
Cellular structures often show fluctuating stresses in compression stress-strain curves. Such fluctuating stresses correspond to strut fractures. In this study, the cellular Ti-6Al-4V alloy with cuboctahedron structure was prepared by selective laser melting. The cuboctahedron cellular structures showed reduced fluctuations in their compressive stress-strain curves after the initial yielding peak. Their moduli were modulated via the porosity of the structure by changing the strut diameter. A compressive modulus of between 1...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30948114/magnetic-brain-targeting-of-naproxen-loaded-polymeric-micelles-pharmacokinetics-and-biodistribution-study
#20
Zahra Karami, Somayeh Sadighian, Kobra Rostamizadeh, Seyed Hojjat Hosseini, Saeed Rezaee, Mehrdad Hamidi
The blood brain barrier is a major obstacle to the entry of the majority of CNS-active agents. In the present research, the potential of magnetic polymeric micelles (MPMs) for brain-targeting of naproxen was evaluated. The MPMs were made of methoxy poly(ethyleneglycol)-poly (caprolactone) copolymer and super paramagnetic iron oxide nanoparticles (SPIONs). To investigate the impact of particle size on the in vivo biofate of nanoparticles, MPMs with two different sizes were prepared. The prepared magnetic polymeric micelles had diameters of 137 ± 3...
July 2019: Materials Science & Engineering. C, Materials for Biological Applications
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