Journals Journal of Neurodevelopmental ...

Journal of Neurodevelopmental Disorders
Joni N Saby, Sarika U Peters, Timothy A Benke, Shannon M Standridge, Lindsay C Swanson, David N Lieberman, Heather E Olson, Alexandra P Key, Alan K Percy, Jeffrey L Neul, Charles A Nelson, Timothy P L Roberts, Eric D Marsh
BACKGROUND: Developing biomarkers is a priority for drug development for all conditions, but vital in the rare neurodevelopmental disorders where sensitive outcome measures are lacking. We have previously demonstrated the feasibility and tracking of evoked potentials to disease severity in Rett syndrome and CDKL5 deficiency disorder. The aim of the current study is to characterize evoked potentials in two related developmental encephalopathies, MECP2 duplication syndrome and FOXG1 syndrome, and compare across all four groups to better understand the potential of these measures to serve as biomarkers of clinical severity for the developmental encephalopathies...
March 4, 2023: Journal of Neurodevelopmental Disorders
Noemi A Spinazzi, Jonathan D Santoro, Katherine Pawlowski, Gabriel Anzueto, Yamini J Howe, Lina R Patel, Nicole T Baumer
BACKGROUND: Down syndrome (DS) is one of the most common genetic causes of intellectual disability, and it is associated with an increased incidence of numerous co-occurring conditions. Autism spectrum disorder (ASD) is common in persons with DS, with rates reported as high as 39%. However, little is known regarding co-occurring conditions in children with both DS and ASD. METHODS: A single-center retrospective review of prospective longitudinally collected clinical data was performed...
March 2, 2023: Journal of Neurodevelopmental Disorders
Armin Raznahan, Srishti Rau, Luke Schaffer, Siyuan Liu, Ari M Fish, Catherine Mankiw, Anastasia Xenophontos, Liv S Clasen, Lisa Joseph, Audrey Thurm, Jonathan D Blumenthal, Dani S Bassett, Erin N Torres
BACKGROUND: Recurrent gene dosage disorders impart substantial risk for psychopathology. Yet, understanding that risk is hampered by complex presentations that challenge classical diagnostic systems. Here, we present a suite of generalizable analytic approaches for parsing this clinical complexity, which we illustrate through application to XYY syndrome. METHOD: We gathered high-dimensional measures of psychopathology in 64 XYY individuals and 60 XY controls, plus additional interviewer-based diagnostic data in the XYY group...
February 20, 2023: Journal of Neurodevelopmental Disorders
Xiaonan Du, Lei Wei, Baofeng Yang, Shasha Long, Ji Wang, Aiqi Sun, Yonghui Jiang, Zhongwei Qiao, He Wang, Yi Wang
BACKGROUND: Angelman syndrome (AS) is a neurodevelopmental disorder with serious seizures. We aim to explore the brain morphometry of patients with AS and figure out whether the seizure is associated with brain development. METHODS: Seventy-three patients and 26 healthy controls (HC) underwent high-resolution structural brain MRI. Group differences between the HC group and the AS group and also between AS patients with seizure (AS-Se) and age-matched AS patients with non-seizure (AS-NSe) were compared...
February 14, 2023: Journal of Neurodevelopmental Disorders
Di Wu, Jiansheng Zhu, Lianghui You, Jingyu Wang, Sufen Zhang, Zhonghui Liu, Qu Xu, Xiaojie Yuan, Lei Yang, Wei Wang, Meiling Tong, Qin Hong, Xia Chi
BACKGROUND: Neurodevelopmental disorders (NDDs) are a group of disorders induced by abnormal brain developmental processes. The prefrontal cortex (PFC) plays an essential role in executive function, and its role in NDDs has been reported. NDDs are associated with high-risk gene mutations and share partially overlapping genetic abnormalities. METHODS: Neurexins (NRXNs) are related to autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD)...
February 3, 2023: Journal of Neurodevelopmental Disorders
Jaclyn Gunderson, Emma Worthley, Breanne Byiers, Frank Symons, Jason Wolff
BACKGROUND: Unusual responses to sensory stimuli are considered a diagnostic symptom of autism spectrum disorder with mounting research efforts put towards understanding, characterizing, and treating such symptoms. METHODS: This paper examines self and caregiver report tools used to measure sensory features in ASD through a systematic review of the psychometric evidence for their use. A total of 31 empirical papers were reviewed across 20 assessment tools. Substantial differences were identified in the specific sensory features defined across assessment tools...
January 25, 2023: Journal of Neurodevelopmental Disorders
Cristan Farmer, Audrey Thurm, Jesse D Troy, Aaron J Kaat
BACKGROUND: For genetic conditions associated with neurodevelopmental disorder (GCAND), developmental domains such as motor ability, thinking and learning, social abilities, and communication are potential intervention targets. Performance on measures of developmental concepts can be expressed using several types of scores. Norm-referenced scores are intended for the diagnostic context, allowing for the identification of impairment relative to age-based expectations, and can exhibit dramatic floor effects when used in individuals with more significant limitations...
January 17, 2023: Journal of Neurodevelopmental Disorders
Robyn M Busch, Thomas W Frazier Ii, Claire Sonneborn, Olivia Hogue, Patricia Klaas, Siddharth Srivastava, Antonio Y Hardan, Julian A Martinez-Agosto, Mustafa Sahin, Charis Eng
BACKGROUND: Individuals with PTEN hamartoma tumor syndrome (PHTS) demonstrate a distinct neurobehavioral profile suggesting primary disruption of frontal lobe symptoms, with more severe cognitive deficits in those with associated autism spectrum disorder (ASD) that extend to other areas of neurobehavioral function as well (e.g., adaptive behavior, sensory deficits). The current study sought to characterize longitudinal neurobehavioral profiles in individuals with PHTS who completed serial assessments (2-3 evaluations) over a 2-year time period...
January 14, 2023: Journal of Neurodevelopmental Disorders
Daifeng Wang, John R Pruett
No abstract text is available yet for this article.
January 12, 2023: Journal of Neurodevelopmental Disorders
Joseph M Palumbo, Brian F Thomas, Dejan Budimirovic, Steven Siegel, Flora Tassone, Randi Hagerman, Christopher Faulk, Stephen O'Quinn, Terri Sebree
Multiple lines of evidence suggest a central role for the endocannabinoid system (ECS) in the neuronal development and cognitive function and in the pathogenesis of fragile X syndrome (FXS). This review describes the ECS, its role in the central nervous system, how it is dysregulated in FXS, and the potential role of cannabidiol as a treatment for FXS. FXS is caused by deficiency or absence of the fragile X messenger ribonucleoprotein 1 (FMR1) protein, FMRP, typically due to the presence of >200 cytosine, guanine, guanine sequence repeats leading to methylation of the FMR1 gene promoter...
January 9, 2023: Journal of Neurodevelopmental Disorders
Blake A Gimbel, Mary E Anthony, Abigail M Ernst, Donovan J Roediger, Erik de Water, Judith K Eckerle, Christopher J Boys, Joshua P Radke, Bryon A Mueller, Anita J Fuglestad, Steven H Zeisel, Michael K Georgieff, Jeffrey R Wozniak
BACKGROUND: Fetal alcohol spectrum disorder (FASD) is a lifelong condition. Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age during childhood. We present a long-term follow-up study evaluating the neurodevelopmental effects of early choline supplementation in children with FASD approximately 7 years on average after an initial efficacy trial...
December 16, 2022: Journal of Neurodevelopmental Disorders
Claire Weichselbaum, Nicole Hendrix, Jordan Albright, Joseph D Dougherty, Kelly N Botteron, John N Constantino, Natasha Marrus
BACKGROUND: A central challenge in preclinical research investigating the biology of autism spectrum disorder (ASD) is the translation of ASD-related social phenotypes across humans and animal models. Social orienting, an observable, evolutionarily conserved behavior, represents a promising cross-species ASD phenotype given that disrupted social orienting is an early-emerging ASD feature with evidence for predicting familial recurrence. Here, we adapt a competing-stimulus social orienting task from domesticated dogs to naturalistic play behavior in human toddlers and test whether this approach indexes decreased social orienting in ASD...
December 14, 2022: Journal of Neurodevelopmental Disorders
Isha Jalnapurkar, Jean A Frazier, Mark Roth, David M Cochran, Ann Foley, Taylor Merk, Lauren Venuti, Lucienne Ronco, Shane Raines, Diego Cadavid
BACKGROUND: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability in males and the most common single gene cause of autism. This X-linked disorder is caused by an expansion of a trinucleotide CGG repeat (> 200 base pairs) on the promotor region of the fragile X messenger ribonucleoprotein 1 gene (FMR1). This leads to the deficiency or absence of the encoded protein, fragile X messenger ribonucleoprotein 1 (FMRP). FMRP has a central role in the translation of mRNAs involved in synaptic connections and plasticity...
December 9, 2022: Journal of Neurodevelopmental Disorders
Elizabeth Berry-Kravis, Randi Hagerman, Dejan Budimirovic, Craig Erickson, Helen Heussler, Nicole Tartaglia, Jonathan Cohen, Flora Tassone, Thomas Dobbins, Elizabeth Merikle, Terri Sebree, Nancy Tich, Joseph M Palumbo, Stephen O'Quinn
BACKGROUND: Fragile X syndrome (FXS) is associated with dysregulated endocannabinoid signaling and may therefore respond to cannabidiol therapy. DESIGN: CONNECT-FX was a double-blind, randomized phase 3 trial assessing efficacy and safety of ZYN002, transdermal cannabidiol gel, for the treatment of behavioral symptoms in children and adolescents with FXS. METHODS: Patients were randomized to 12 weeks of ZYN002 (250 mg or 500 mg daily [weight-based]) or placebo, as add-on to standard of care...
November 25, 2022: Journal of Neurodevelopmental Disorders
Prany Wantzen, Patrice Clochon, Franck Doidy, Fabrice Wallois, Mahdi Mahmoudzadeh, Pierre Desaunay, Christian Mille, Jean-Marc Guilé, Fabian Guénolé, Francis Eustache, Jean-Marc Baleyte, Bérengère Guillery-Girard
No abstract text is available yet for this article.
October 16, 2022: Journal of Neurodevelopmental Disorders
Laura Groves, Joanna Moss, Chris Oliver, Rachel Royston, Jane Waite, Hayley Crawford
BACKGROUND: Anxiety symptomatology is common in individuals with intellectual disability (ID). Symptomatology includes both traditional Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) anxiety disorders and autism spectrum disorder (ASD)-related anxiety traits. Some genetic disorders such as Cornelia de Lange (CdLS) and fragile X syndromes (FXS) are at very high risk of anxiety and afford the opportunity to examine prevalence, profiles and associated person characteristics...
October 5, 2022: Journal of Neurodevelopmental Disorders
Scott S Hall, Arlette Bujanda Rodriguez, Booil Jo, Joy S Pollard
BACKGROUND: A significant proportion of boys with fragile X syndrome (FXS), the most common known genetic cause of intellectual disability, exhibit challenging behaviors such as aggression and self-injury that can cause significant distress to families. Recent evidence suggests that coaching caregivers to implement functional communication training (FCT) with their child via telehealth can help to ameliorate these behaviors in FXS. In the present study, we followed families who had participated in our previous randomized controlled trial of FCT to evaluate the longer-term effects of FCT on challenging behaviors in this population...
September 30, 2022: Journal of Neurodevelopmental Disorders
Carrie R Jonak, Ernest V Pedapati, Lauren M Schmitt, Samantha A Assad, Manbir S Sandhu, Lisa DeStefano, Lauren Ethridge, Khaleel A Razak, John A Sweeney, Devin K Binder, Craig A Erickson
BACKGROUND: Fragile X syndrome (FXS) is the most common inherited form of neurodevelopmental disability. It is often characterized, especially in males, by intellectual disability, anxiety, repetitive behavior, social communication deficits, delayed language development, and abnormal sensory processing. Recently, we identified electroencephalographic (EEG) biomarkers that are conserved between the mouse model of FXS (Fmr1 KO mice) and humans with FXS. METHODS: In this report, we evaluate small molecule target engagement utilizing multielectrode array electrophysiology in the Fmr1 KO mouse and in humans with FXS...
September 27, 2022: Journal of Neurodevelopmental Disorders
Joshua K Lee, An Chuen Billy Cho, Derek S Andrews, Sally Ozonoff, Sally J Rogers, David G Amaral, Marjorie Solomon, Christine Wu Nordahl
BACKGROUND: Intellectual disability affects approximately one third of individuals with autism spectrum disorder (autism). Yet, a major unresolved neurobiological question is what differentiates autistic individuals with and without intellectual disability. Intelligence quotients (IQs) are highly variable during childhood. We previously identified three subgroups of autistic children with different trajectories of intellectual development from early (2-3½ years) to middle childhood (9-12 years): (a) persistently high: individuals whose IQs remained in the normal range; (b) persistently low: individuals whose IQs remained in the range of intellectual disability (IQ < 70); and (c) changers: individuals whose IQs began in the range of intellectual disability but increased to the normal IQ range...
September 15, 2022: Journal of Neurodevelopmental Disorders
Jessica C McAfee, Jessica L Bell, Oleh Krupa, Nana Matoba, Jason L Stein, Hyejung Won
A growing number of variants associated with risk for neurodevelopmental disorders have been identified by genome-wide association and whole genome sequencing studies. As common risk variants often fall within large haplotype blocks covering long stretches of the noncoding genome, the causal variants within an associated locus are often unknown. Similarly, the effect of rare noncoding risk variants identified by whole genome sequencing on molecular traits is seldom known without functional assays. A massively parallel reporter assay (MPRA) is an assay that can functionally validate thousands of regulatory elements simultaneously using high-throughput sequencing and barcode technology...
September 9, 2022: Journal of Neurodevelopmental Disorders
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