journal
https://read.qxmd.com/read/38370131/the-association-of-air-pollution-in-respiratory-allergy-its-impact-in-an-industrial-city
#21
JOURNAL ARTICLE
Cindy Elizabeth de Lira-Quezada, Sandra Nora González-Díaz, Angel Gabriel Cotera-de Lira, Carlos Macouzet-Sánchez, Natalhie Acuña-Ortega, Rosa Ivett Guzman-Avilán, Alejandra Macías-Weinmann
BACKGROUND: Asthma and allergic diseases have increased in recent decades and are more common in industrialized countries. Industrial areas with a considerably high number of inhabitants and vehicles can favor the presence of serious air pollution and therefore the appearance and exacerbation of respiratory allergy symptoms. The objective of this study was to determine the relationship between exposure to environmental pollutants with exacerbation of respiratory allergy. METHODS: A total of 240 subjects above 6 years old who lived in the metropolitan area of Monterrey, Nuevo León, Mexico, with diagnosis of allergic rhinitis and/or asthma, were included...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38351904/maternal-smoking-around-birth-and-its-influence-on-offspring-allergic-diseases-a-mendelian-randomization-study
#22
JOURNAL ARTICLE
Qiqi Ruan, Yu Jiang, Yuan Shi
OBJECTIVE: The influence of maternal smoking around birth (MSAB) on offspring allergic diseases, specifically childhood asthma (CA), allergic rhinitis (AR), allergic conjunctivitis (AC), and atopic dermatitis (AD) remains incompletely understood. We performed a rigorous mendelian randomization (MR) study to obtain the unconfounded association between MSAB and allergic diseases in offspring with and without adjustment for the effect of breastfeeding. METHODS: Utilizing publicly available information of MSAB, breastfeeding, CA, AR, AC, and AD from large-scale genome-wide association studies (GWAS), we performed a two-sample mendelian randomization (TSMR) analysis to assess the respective causal relationship of MSAB and breastfeeding to allergic diseases in offspring...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38351903/bypassing-the-build-up-phase-for-oral-immunotherapy-in-shrimp-allergic-children
#23
JOURNAL ARTICLE
Ann-Marie M Schoos, Edmond S Chan, Tiffany Wong, Stephanie C Erdle, Alanna Chomyn, Lianne Soller, Raymond Mak
BACKGROUND: Oral immunotherapy is an effective treatment for food allergies; however, its use in clinical practice is limited by resources and lack of standardized protocols for foods other than peanut. Previous studies have suggested that shrimp has a higher threshold for reaction than other allergenic foods, suggesting it may be safe to directly administer maintenance doses of immunotherapy. METHODS: Children aged 3-17 years who had 1) skin prick test ≥3 mm and/or specific IgE level ≥0...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38317770/corrigendum-to-relationship-between-growth-and-food-avoidance-with-food-allergy-at-age-3-years-the-japan-environment-and-children-s-study-jecs-world-allergy-organ-j-2023-100826
#24
Midori Saito, Hideki Hasunuma, Masumi Okuda, Aki Hotta, Tetsuro Fujino, Yasuhiro Takeshima, Masayuki Shima
[This corrects the article DOI: 10.1016/j.waojou.2023.100826.].
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38317769/blood-transcriptome-differentiates-clinical-clusters-for-asthma
#25
JOURNAL ARTICLE
Jin An, Seungpil Jeong, Kyungtaek Park, Heejin Jin, Jaehyun Park, Eunsoon Shin, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Jong Eun Lee, Sungho Won, Tae-Bum Kim
BACKGROUND: In previous studies, several asthma phenotypes were identified using clinical and demographic parameters. Transcriptional phenotypes were mainly identified using sputum and bronchial cells. OBJECTIVE: We aimed to investigate asthma phenotypes via clustering analysis using clinical variables and compare the transcription levels among clusters using gene expression profiling of the blood. METHODS: Clustering analysis was performed using 6 parameters: age of asthma onset, body mass index, pack-years of smoking, forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity, and blood eosinophil counts...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38312493/outcomes-of-endoscopic-sinus-surgery-in-patients-with-central-compartment-atopic-disease
#26
JOURNAL ARTICLE
Yuanyuan Guo, Zhiying Nie, Chuxin Chen, Zhaofeng Xu, Wendong Liu, Yinyan Lai, Yunping Fan, Jianbo Shi, Fenghong Chen
BACKGROUND: Central compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis (CRS). Research focusing on the endoscopic sinus surgery (ESS) outcomes of CCAD is limited. This study aimed to evaluate the outcomes of ESS in CCAD and compared to 2 following subtypes: chronic rhinosinusitis with nasal polyps (CRSwNP) and concomitant polypoid disease in the central compartment (CRSwNP/CC) and CRSwNP not otherwise specified (CRSwNP NOS). METHODS: This case-control study enrolled patients with bilateral CRSwNP who underwent ESS and had at least 1 year of follow-up...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38304621/prevalence-of-medication-adherence-among-adult-asthmatic-patients-in-four-african-countries-a-systematic-review-and-meta-analysis
#27
REVIEW
Segenet Zewdie, Basaiznew Mekuria, Belete Kassa Alemu, Ewunetie Mekashaw Bayked, Hussein NurAhmed Toleha, Wondim Ayenew, Assefa Andargie
Non-adherence to medications has many deleterious effects including poor treatment outcomes, increased economic burden, increased morbidity, hospitalization rate, health care utilization, productivity loss, and mortality. Therefore, this review aimed to estimate the pooled prevalence of medication adherence among asthmatic adults in 4 African countries. Primary studies were extensively searched from databases such as PubMed, HINARI, Cochrane Library, CINHALand, Google Scholar, and Google search engines. After screening and assessing the quality of studies, data were extracted using a checklist...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38298830/role-of-autophagy-and-mitophagy-of-group-2-innate-lymphoid-cells-in-allergic-and-local-allergic-rhinitis
#28
JOURNAL ARTICLE
Chen Wang, Jin-Jing Zhuo, Wen-Qian Li, Min-Li Zhou, Ke-Jia Cheng
BACKGROUND: Roles of ILC2s in allergic rhinitis (AR) and local allergic rhinitis (LAR) are unclear. In this study, we are determined to find the levels of autophagy and mitophagy of ILC2s in allergic nasal inflammation. METHODS: ELISA was used to detect type 2 inflammatory cytokines. Hematoxylin and eosin (H&E) staining were used to compare the eosinophil (EOS) infiltration of nasal tissue specimens. Flow cytometry was used to detect the levels of ILC2s and Th2 cells...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38298829/atopic-dermatitis-associated-genetic-variants-regulate-loc100294145-expression-implicating-interleukin-27-production-and-type-1-interferon-signaling
#29
JOURNAL ARTICLE
Wei Yi Teo, Yi Ying Eliza Lim, Yang Yie Sio, Yee-How Say, Kavita Reginald, Fook Tim Chew
BACKGROUND: Atopic dermatitis (AD) is a complex inflammatory disease with a strong genetic component. A singular approach of genome wide association studies (GWAS) can identify AD-associated genetic variants, but is unable to explain their functional relevance in AD. This study aims to characterize AD-associated genetic variants and elucidate the mechanisms leading to AD through a multi-omics approach. METHODS: GWAS identified an association between genetic variants at 6p21...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38293275/erratum-to-does-nsaid-exacerbated-respiratory-disease-n-erd-accompanying-severe-asthma-affect-biological-treatment-response-efficacy-of-omalizumab-and-mepolizumab-in-n-erd-world-allergy-organ-2023-100817
#30
Fatma Merve Tepetam, Şeyma Özden, Fatma Kübra Kılıç, Cihan Örçen, Tuğçe Yakut
[This corrects the article DOI: 10.1016/j.waojou.2023.100817.].
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38293274/mendelian-randomization-analysis-of-atopic-dermatitis-and-esophageal-cancer-in-east-asian-and-european-populations
#31
JOURNAL ARTICLE
Yixin Liu, Yimin Gu, Jianfeng Zhou, Hanlu Zhang, Qixin Shang, Yushang Yang, Longqi Chen
BACKGROUND: Emerging observational studies showed an association between atopic dermatitis (AD) and gastrointestinal cancers. However, it remains unclear whether this association is causal, particularly in the case of cancers like esophageal cancer, which exhibit ancestral genetic traits. METHODS: To assess the potential causal relationship between AD and esophageal cancer across diverse ancestral backgrounds, we conducted a 2-sample Mendelian randomization study...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38293273/long-waitlists-for-outpatient-drug-allergy-referrals-an-australian-tertiary-centre-experience
#32
JOURNAL ARTICLE
Syed Ali, Tiffany Hughes, Anthony Smith
Drug allergy clinic waitlist time data are limited. A 24-month retrospective study of drug allergy referrals was undertaken at a tertiary hospital in Australia. One hundred six patients were reviewed with a median age of 50 years (IQR 40.5-67.3) and a female predominance (n = 76, 71%). Face-to-face consultations were common (n = 83, 78.3%) with the remainder being telephone consultations. General practitioners comprised just over one-third (n = 38, 35.9%) of the referrers but majority being from within the hospital, such as the emergency department (n = 22, 20...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38283080/relationship-between-indoor-inhalant-allergen-concentrations-serum-ige-and-allergic-diseases-a-cross-sectional-study-from-the-nhanes-2005-2006-program
#33
JOURNAL ARTICLE
Fei Ye, Gongkai He, Hui Gan
This research analyzed data from 5106 participants in the National Health and Nutrition Examination Survey 2005-2006 to explore the link between indoor allergen concentrations, serum IgE levels, and allergic diseases. The study found that 14.9% of participants reported having asthma, with significant differences noted in the concentrations of certain indoor allergens, specifically dust dog, mite, and cat allergens, between asthma and non-asthma groups. Furthermore, positivity rates for inhalant allergen-specific IgE and total IgE were higher in the asthma group...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38283079/clinical-features-of-adult-patients-with-allergic-parotitis
#34
JOURNAL ARTICLE
Shiyu Gao, Sheng Li, Heming Wu, Yi Yuan, Xu Ding, Jing Zhao, Ailing Wang, Xiumeng Cao, Hongming Du
BACKGROUND: Allergic parotitis (AP), due to its non-specific symptoms, frequently poses a diagnostic challenge, leading to cases being overlooked or misdiagnosed by clinicians. OBJECTIVE: This study aimed to elucidate detailed clinical characteristics and common diagnostic indicators of AP. METHODS: A comprehensive review and analysis of medical records was conducted from patients diagnosed with AP, encompassing demographic, clinical, and laboratory data, at the Affiliated Stomatological Hospital of Nanjing Medical University between January 2019 and March 2022...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38283996/vernal-keratoconjunctivitis-and-eosinophilic-esophagitis-a-rare-combination
#35
JOURNAL ARTICLE
Maria Cristina Artesani, Sara Urbani, Carla Riccardi, Mariacristina Esposito, Paola De Angelis, Francesca Rea, Renato Tambucci, Monica Malamisura, Luca Buzzonetti, Alessandro Giovanni Fiocchi
Vernal keratoconjunctivitis (VKC) is a bilateral ocular inflammatory disease with a conjunctival and corneal involvement and typical onset during childhood. Eosinophilic esophagitis (EoE) is a chronic disease characterized by eosinophilic inflammation of the mucosa (≥15 eosinophils/HPF) and symptoms of esophageal dysfunction. EoE and VKC are both immune-mediated diseases sharing a similar pathogenetic mechanism and a high association with other allergic diseases. Nevertheless, no data are currently available about their clinical association...
January 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38274710/allergy-in-pathogenesis-of-eustachian-tube-dysfunction
#36
REVIEW
Xuan Yu, Huimin Zhang, Shimin Zong, Hongjun Xiao
Eustachian tube dysfunction (ETD) is a condition where the Eustachian tube (ET) fails to function normally, resulting in symptoms such as aural fullness, tinnitus, autophony, and hearing loss. ETD can further lead to middle ear diseases such as otitis media effusion and adhesive otitis media, which is becoming more common in the field of otology. Although the pathogenesis of ETD remains unclear, recent animal studies and clinical experiments have found allergic reactions and allergic diseases are closely related to the occurrence of ETD...
January 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38259299/association-between-dietary-antioxidant-intakes-and-chronic-respiratory-diseases-in-adults
#37
JOURNAL ARTICLE
Shidong Wang, Hong Teng, Lin Zhang, Liang Wu
BACKGROUND: Chronic respiratory diseases (CRDs) pose a significant global health burden. Antioxidant-rich diets have been associated with improved lung health, but the specific relationship with CRDs remains unclear. METHODS: This study examined the relationship between dietary antioxidant intakes and CRDs using data from the 2001-2018 National Health and Nutrition Examination Survey (NHANES). Information on dietary antioxidant intakes, including vitamins A, C, and E, zinc, selenium, and carotenoid, were collected from the 2 24-h recall interviews to calculate composite dietary antioxidant index (CDAI)...
January 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38235262/hypersensitivity-reactions-with-first-line-antituberculosis-drugs-and-outcomes-of-rapid-desensitizations
#38
JOURNAL ARTICLE
Gozde Koycu Buhari, Ferda Oner Erkekol, Ilkay Koca Kalkan, Hale Ates, Gurgun Tugce Vural Solak, Ozgur Akkale, Kurtulus Aksu
BACKGROUND: Data about drug hypersensitivity reactions with first-line antituberculosis drugs and their management is limited. Rapid drug desensitization seems to be an appropriate management. OBJECTIVE: Evaluate the efficacy of the rapid desensitization protocols in patients who had a reaction phenotypically compatible with immediate-type drug hypersensitivity with first-line antituberculosis drugs and identify possible risk factors of breakthrough reactions during the protocols...
January 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38235261/analysis-of-questionnaire-survey-to-determine-worldwide-trends-in-prescriptions-of-biologics-for-the-treatment-of-unresponsive-chronic-urticaria
#39
JOURNAL ARTICLE
Christine J Rubeiz, Ricardo Asero, Stephen Betschel, Timothy Craig, Anete Grumach, Michihiro Hide, David Lang, Michael Levin, Hilary Longhurst, Eli Magan, Marcus Maurer, Romi Saini, Gordon Sussman, Elias Toubi, Dinh Nguyen Van, Torsten Zuberier, Jonathan A Bernstein
BACKGROUND: Chronic spontaneous urticaria (CSU) is a common condition treated by allergist/immunologists, but the only FDA-approved biologic medication, omalizumab, may be underutilized globally. OBJECTIVE: This study was performed to determine the global prescription of omalizumab for treatment of CSU by allergists/immunologists. METHODS: Anonymous questionnaire surveys were distributed online to World Allergy Organization (WAO) members worldwide...
January 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38235260/antibiotic-prophylaxis-in-immunosuppressed-patients-missed-opportunities-from-trimethoprim-sulfamethoxazole-allergy-label
#40
REVIEW
Wei-I Lee, Lydia Lam, Stephen Bacchi, Melinda Jiang, Joshua M Inglis, William Smith, Pravin Hissaria
Trimethoprim-sulfamethoxazole (TMP-SMX) is a broad spectrum antibiotic in use for more than 50 years. It has an important indication as first line agent in the prophylaxis of opportunistic infections, particularly Pneumocystis jirovecii pneumonia (PJP), in immunosuppressed patients. For those who have a history of allergy or severe intolerance to TMP-SMX, pentamidine, dapsone or atovaquone may be substituted; however there is evidence that TMP-SMX offers superior coverage for PJP, toxoplasmosis, and nocardiosis...
January 2024: World Allergy Organization Journal
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