journal
https://read.qxmd.com/read/38390554/assessment-of-serum-soluble-cd40-ligand-levels-in-patients-with-chronic-rhinosinusitis
#1
JOURNAL ARTICLE
Zhichen Liu, Yuhui Fan, Aina Zhou, Jisheng Liu, Qingqing Jiao
Chronic rhinosinusitis (CRS) is a disease highly associated with abnormal regulation of T and B cells. The underlying pathophysiology of inflammatory pathways has critical implications for the diagnosis and management of CRS. Soluble CD40-ligand (sCD40L) is a cleaved form of CD40L present in plasma which functions the same way as CD40L, which has been observed as an inflammatory biomarker in many diseases. CD40L-positive cells control B-cell maturation, proliferation, apoptosis, and antibody production by binding to its receptor CD40 on B-cells...
March 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38380106/diagnostic-biomarkers-for-chronic-rhinosinusitis-in-adult-asthmatics-in-real-world-practice
#2
JOURNAL ARTICLE
Jae-Hyuk Jang, Eun-Mi Yang, Youngsoo Lee, Yoo Seob Shin, Young-Min Ye, Hae-Sim Park
BACKGROUND: Chronic rhinosinusitis (CRS) is a common comorbid condition of asthma that affects the long-term outcome of asthmatic patients. CRS is a heterogeneous disease requiring multiple biomarkers to explain its pathogenesis. This study aimed to develop potential biomarkers for predicting CRS in adult asthmatic patients in a real-world clinical setting. METHODS: This study enrolled 108 adult asthmatic patients who had maintained anti-asthmatic medications, including medium-to-high doses of inhaled corticosteroid plus long-acting β2-agonists, and compared clinical characteristics between patients with CRS (CRS group) and those without CRS (non-CRS group)...
March 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38361746/how-to-manage-drug-virus-interplay-underlying-skin-eruptions-in-children
#3
REVIEW
Francesca Mori, Giulia Liccioli, Leonardo Tomei, Simona Barni, Mattia Giovannini, Lucrezia Sarti, Benedetta Pessina, María José Torres
The majority of viral rashes occurring during an antibiotic therapy are considered as a drug hypersensitivity reaction (DHR). Differentiating a viral rash versus a DHR is difficult or even impossible. In delayed DHRs the interplay between viruses and drugs is summarized according to the recent literature. The question is if the same reaction will again occur in case of drug re-exposure in absence of the concomitant viral infection because of persistent immune reactivity. Epstein Barr Virus (EBV) and Human Herpes virus 6 (HHV-6) models are analyzed in case of maculopapular exanthemas (MPEs) and drug reaction with eosinophilia and systemic symptoms (DRESS) over a course of drug therapy...
March 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38361745/updated-grading-system-for-systemic-allergic-reactions-joint-statement-of-the-world-allergy-organization-anaphylaxis-committee-and-allergen-immunotherapy-committee
#4
REVIEW
Paul J Turner, Ignacio J Ansotegui, Dianne E Campbell, Victoria Cardona, Stuart Carr, Adnan Custovic, Stephen Durham, Motohiro Ebisawa, Mario Geller, Alexei Gonzalez-Estrada, Paul A Greenberger, Elham Hossny, Carla Irani, Agnes S Y Leung, Michael E Levin, Antonella Muraro, John J Oppenheimer, José Antonio Ortega Martell, Guillaume Pouessel, Manuel J Rial, Gianenrico Senna, Luciana K Tanno, Dana V Wallace, Margitta Worm, Mário Morais-Almeida
There is a lack of consensus over the description and severity assignment of allergic adverse reactions to immunotherapy, although there seems to be a consensus at least in terms of using the World Allergy Organization (WAO) grading systems to describe local adverse events for Sublingual Immunotherapy (SLIT) and Systemic Allergic Reactions (SARs) to Subcutaneous Immunotherapy (SCIT) amongst the major national/regional allergy societies. In this manuscript, we propose a modification of the previous WAO Grading system for SARs, which aligns with the newly-proposed Consortium for Food Allergy Research (CoFAR) Grading Scale for Systemic Allergic Reactions in Food Allergy (version 3...
March 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38370132/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-secondary-to-antimicrobial-therapy-in-pediatric-bone-and-joint-infections
#5
JOURNAL ARTICLE
Sema Yildirim Arslan, Zumrut Sahbudak Bal, Gizem Guner Ozenen, Nimet Melis Bilen, Gulhadiye Avcu, Ece Erci, Zafer Kurugol, Huseyin Gunay, İpek Tamsel, Ferda Ozkinay
BACKGROUND: Bone and joint infections are common in children, particularly those under 10 years of age. While antimicrobial therapy can often successfully treat these infections, surgical drainage may also be necessary. It is important to note that prolonged courses of treatment have been associated with adverse events and drug reactions. Among these, drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome is particularly severe and potentially life-threatening. We aimed to evaluate the cases of DRESS syndrome that develop during the treatment of bone and joint infections...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38370131/the-association-of-air-pollution-in-respiratory-allergy-its-impact-in-an-industrial-city
#6
JOURNAL ARTICLE
Cindy Elizabeth de Lira-Quezada, Sandra Nora González-Díaz, Angel Gabriel Cotera-de Lira, Carlos Macouzet-Sánchez, Natalhie Acuña-Ortega, Rosa Ivett Guzman-Avilán, Alejandra Macías-Weinmann
BACKGROUND: Asthma and allergic diseases have increased in recent decades and are more common in industrialized countries. Industrial areas with a considerably high number of inhabitants and vehicles can favor the presence of serious air pollution and therefore the appearance and exacerbation of respiratory allergy symptoms. The objective of this study was to determine the relationship between exposure to environmental pollutants with exacerbation of respiratory allergy. METHODS: A total of 240 subjects above 6 years old who lived in the metropolitan area of Monterrey, Nuevo León, Mexico, with diagnosis of allergic rhinitis and/or asthma, were included...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38351904/maternal-smoking-around-birth-and-its-influence-on-offspring-allergic-diseases-a-mendelian-randomization-study
#7
JOURNAL ARTICLE
Qiqi Ruan, Yu Jiang, Yuan Shi
OBJECTIVE: The influence of maternal smoking around birth (MSAB) on offspring allergic diseases, specifically childhood asthma (CA), allergic rhinitis (AR), allergic conjunctivitis (AC), and atopic dermatitis (AD) remains incompletely understood. We performed a rigorous mendelian randomization (MR) study to obtain the unconfounded association between MSAB and allergic diseases in offspring with and without adjustment for the effect of breastfeeding. METHODS: Utilizing publicly available information of MSAB, breastfeeding, CA, AR, AC, and AD from large-scale genome-wide association studies (GWAS), we performed a two-sample mendelian randomization (TSMR) analysis to assess the respective causal relationship of MSAB and breastfeeding to allergic diseases in offspring...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38351903/bypassing-the-build-up-phase-for-oral-immunotherapy-in-shrimp-allergic-children
#8
JOURNAL ARTICLE
Ann-Marie M Schoos, Edmond S Chan, Tiffany Wong, Stephanie C Erdle, Alanna Chomyn, Lianne Soller, Raymond Mak
BACKGROUND: Oral immunotherapy is an effective treatment for food allergies; however, its use in clinical practice is limited by resources and lack of standardized protocols for foods other than peanut. Previous studies have suggested that shrimp has a higher threshold for reaction than other allergenic foods, suggesting it may be safe to directly administer maintenance doses of immunotherapy. METHODS: Children aged 3-17 years who had 1) skin prick test ≥3 mm and/or specific IgE level ≥0...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38317770/corrigendum-to-relationship-between-growth-and-food-avoidance-with-food-allergy-at-age-3-years-the-japan-environment-and-children-s-study-jecs-world-allergy-organ-j-2023-100826
#9
Midori Saito, Hideki Hasunuma, Masumi Okuda, Aki Hotta, Tetsuro Fujino, Yasuhiro Takeshima, Masayuki Shima
[This corrects the article DOI: 10.1016/j.waojou.2023.100826.].
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38317769/blood-transcriptome-differentiates-clinical-clusters-for-asthma
#10
JOURNAL ARTICLE
Jin An, Seungpil Jeong, Kyungtaek Park, Heejin Jin, Jaehyun Park, Eunsoon Shin, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Jong Eun Lee, Sungho Won, Tae-Bum Kim
BACKGROUND: In previous studies, several asthma phenotypes were identified using clinical and demographic parameters. Transcriptional phenotypes were mainly identified using sputum and bronchial cells. OBJECTIVE: We aimed to investigate asthma phenotypes via clustering analysis using clinical variables and compare the transcription levels among clusters using gene expression profiling of the blood. METHODS: Clustering analysis was performed using 6 parameters: age of asthma onset, body mass index, pack-years of smoking, forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity, and blood eosinophil counts...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38312493/outcomes-of-endoscopic-sinus-surgery-in-patients-with-central-compartment-atopic-disease
#11
JOURNAL ARTICLE
Yuanyuan Guo, Zhiying Nie, Chuxin Chen, Zhaofeng Xu, Wendong Liu, Yinyan Lai, Yunping Fan, Jianbo Shi, Fenghong Chen
BACKGROUND: Central compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis (CRS). Research focusing on the endoscopic sinus surgery (ESS) outcomes of CCAD is limited. This study aimed to evaluate the outcomes of ESS in CCAD and compared to 2 following subtypes: chronic rhinosinusitis with nasal polyps (CRSwNP) and concomitant polypoid disease in the central compartment (CRSwNP/CC) and CRSwNP not otherwise specified (CRSwNP NOS). METHODS: This case-control study enrolled patients with bilateral CRSwNP who underwent ESS and had at least 1 year of follow-up...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38304621/prevalence-of-medication-adherence-among-adult-asthmatic-patients-in-four-african-countries-a-systematic-review-and-meta-analysis
#12
REVIEW
Segenet Zewdie, Basaiznew Mekuria, Belete Kassa Alemu, Ewunetie Mekashaw Bayked, Hussein NurAhmed Toleha, Wondim Ayenew, Assefa Andargie
Non-adherence to medications has many deleterious effects including poor treatment outcomes, increased economic burden, increased morbidity, hospitalization rate, health care utilization, productivity loss, and mortality. Therefore, this review aimed to estimate the pooled prevalence of medication adherence among asthmatic adults in 4 African countries. Primary studies were extensively searched from databases such as PubMed, HINARI, Cochrane Library, CINHALand, Google Scholar, and Google search engines. After screening and assessing the quality of studies, data were extracted using a checklist...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38298830/role-of-autophagy-and-mitophagy-of-group-2-innate-lymphoid-cells-in-allergic-and-local-allergic-rhinitis
#13
JOURNAL ARTICLE
Chen Wang, Jin-Jing Zhuo, Wen-Qian Li, Min-Li Zhou, Ke-Jia Cheng
BACKGROUND: Roles of ILC2s in allergic rhinitis (AR) and local allergic rhinitis (LAR) are unclear. In this study, we are determined to find the levels of autophagy and mitophagy of ILC2s in allergic nasal inflammation. METHODS: ELISA was used to detect type 2 inflammatory cytokines. Hematoxylin and eosin (H&E) staining were used to compare the eosinophil (EOS) infiltration of nasal tissue specimens. Flow cytometry was used to detect the levels of ILC2s and Th2 cells...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38298829/atopic-dermatitis-associated-genetic-variants-regulate-loc100294145-expression-implicating-interleukin-27-production-and-type-1-interferon-signaling
#14
JOURNAL ARTICLE
Wei Yi Teo, Yi Ying Eliza Lim, Yang Yie Sio, Yee-How Say, Kavita Reginald, Fook Tim Chew
BACKGROUND: Atopic dermatitis (AD) is a complex inflammatory disease with a strong genetic component. A singular approach of genome wide association studies (GWAS) can identify AD-associated genetic variants, but is unable to explain their functional relevance in AD. This study aims to characterize AD-associated genetic variants and elucidate the mechanisms leading to AD through a multi-omics approach. METHODS: GWAS identified an association between genetic variants at 6p21...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38293275/erratum-to-does-nsaid-exacerbated-respiratory-disease-n-erd-accompanying-severe-asthma-affect-biological-treatment-response-efficacy-of-omalizumab-and-mepolizumab-in-n-erd-world-allergy-organ-2023-100817
#15
Fatma Merve Tepetam, Şeyma Özden, Fatma Kübra Kılıç, Cihan Örçen, Tuğçe Yakut
[This corrects the article DOI: 10.1016/j.waojou.2023.100817.].
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38293274/mendelian-randomization-analysis-of-atopic-dermatitis-and-esophageal-cancer-in-east-asian-and-european-populations
#16
JOURNAL ARTICLE
Yixin Liu, Yimin Gu, Jianfeng Zhou, Hanlu Zhang, Qixin Shang, Yushang Yang, Longqi Chen
BACKGROUND: Emerging observational studies showed an association between atopic dermatitis (AD) and gastrointestinal cancers. However, it remains unclear whether this association is causal, particularly in the case of cancers like esophageal cancer, which exhibit ancestral genetic traits. METHODS: To assess the potential causal relationship between AD and esophageal cancer across diverse ancestral backgrounds, we conducted a 2-sample Mendelian randomization study...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38293273/long-waitlists-for-outpatient-drug-allergy-referrals-an-australian-tertiary-centre-experience
#17
JOURNAL ARTICLE
Syed Ali, Tiffany Hughes, Anthony Smith
Drug allergy clinic waitlist time data are limited. A 24-month retrospective study of drug allergy referrals was undertaken at a tertiary hospital in Australia. One hundred six patients were reviewed with a median age of 50 years (IQR 40.5-67.3) and a female predominance (n = 76, 71%). Face-to-face consultations were common (n = 83, 78.3%) with the remainder being telephone consultations. General practitioners comprised just over one-third (n = 38, 35.9%) of the referrers but majority being from within the hospital, such as the emergency department (n = 22, 20...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38283080/relationship-between-indoor-inhalant-allergen-concentrations-serum-ige-and-allergic-diseases-a-cross-sectional-study-from-the-nhanes-2005-2006-program
#18
JOURNAL ARTICLE
Fei Ye, Gongkai He, Hui Gan
This research analyzed data from 5106 participants in the National Health and Nutrition Examination Survey 2005-2006 to explore the link between indoor allergen concentrations, serum IgE levels, and allergic diseases. The study found that 14.9% of participants reported having asthma, with significant differences noted in the concentrations of certain indoor allergens, specifically dust dog, mite, and cat allergens, between asthma and non-asthma groups. Furthermore, positivity rates for inhalant allergen-specific IgE and total IgE were higher in the asthma group...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38283079/clinical-features-of-adult-patients-with-allergic-parotitis
#19
JOURNAL ARTICLE
Shiyu Gao, Sheng Li, Heming Wu, Yi Yuan, Xu Ding, Jing Zhao, Ailing Wang, Xiumeng Cao, Hongming Du
BACKGROUND: Allergic parotitis (AP), due to its non-specific symptoms, frequently poses a diagnostic challenge, leading to cases being overlooked or misdiagnosed by clinicians. OBJECTIVE: This study aimed to elucidate detailed clinical characteristics and common diagnostic indicators of AP. METHODS: A comprehensive review and analysis of medical records was conducted from patients diagnosed with AP, encompassing demographic, clinical, and laboratory data, at the Affiliated Stomatological Hospital of Nanjing Medical University between January 2019 and March 2022...
February 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38283996/vernal-keratoconjunctivitis-and-eosinophilic-esophagitis-a-rare-combination
#20
JOURNAL ARTICLE
Maria Cristina Artesani, Sara Urbani, Carla Riccardi, Mariacristina Esposito, Paola De Angelis, Francesca Rea, Renato Tambucci, Monica Malamisura, Luca Buzzonetti, Alessandro Giovanni Fiocchi
Vernal keratoconjunctivitis (VKC) is a bilateral ocular inflammatory disease with a conjunctival and corneal involvement and typical onset during childhood. Eosinophilic esophagitis (EoE) is a chronic disease characterized by eosinophilic inflammation of the mucosa (≥15 eosinophils/HPF) and symptoms of esophageal dysfunction. EoE and VKC are both immune-mediated diseases sharing a similar pathogenetic mechanism and a high association with other allergic diseases. Nevertheless, no data are currently available about their clinical association...
January 2024: World Allergy Organization Journal
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