journal
https://read.qxmd.com/read/29456775/interethnic-variations-and-clinical-features-of-spondyloarthropathies-in-a-middle-eastern-country
#21
JOURNAL ARTICLE
Mohammed Kamil Quraishi, Humeira Badsha, Bhavna Khan, Muhammad Shahzeb, Srilakshmi Hegde, Ayman Mofti, Kong Kok Ooi
Objectives: The study aimed to demonstrate the interethnic differences and clinical features of Spondyloarthropathy(SpA) patients in a diverse Middle Eastern Country. Methods: A retrospective review of medical records to collect the required data was conducted for SpA patients at two study institutions in the United Arab Emirates. Results: Of 141 SpA patients found, 88 AS(Ankylosing Spondylitis) patients and 53 'other SpA' patients were identified...
2018: Open Rheumatology Journal
https://read.qxmd.com/read/29387286/long-term-outcomes-in-puerto-ricans-with-rheumatoid-arthritis-ra-receiving-early-treatment-with-disease-modifying-anti-rheumatic-drugs-using-the-american-college-of-rheumatology-definition-of-early-ra
#22
JOURNAL ARTICLE
Noemí Varela-Rosario, Mariangelí Arroyo-Ávila, Ruth M Fred-Jiménez, Leyda M Díaz-Correa, Naydi Pérez-Ríos, Noelia Rodríguez, Grissel Ríos, Luis M Vilá
Background: Early treatment of rheumatoid arthritis (RA) results in better long-term outcomes. However, the optimal therapeutic window has not been clearly established. Objective: To determine the clinical outcome of Puerto Ricans with RA receiving early treatment with conventional and/or biologic disease-modifying anti-rheumatic drugs (DMARDs) based on the American College of Rheumatology (ACR) definition of early RA. Methods: A cross-sectional study was performed in a cohort of Puerto Ricans with RA...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/29296125/dose-escalation-and-co-therapy-intensification-between-etanercept-adalimumab-and-infliximab-the-cadura-study
#23
JOURNAL ARTICLE
Carter Thorne, Gilles Boire, Andrew Chow, Kirsten Garces, Fang Liu, Melanie Poulin-Costello, Valery Walker, Boulos Haraoui
Objective: To compare anti-TNF dose escalation, DMARD and/or glucocorticoid intensification, switches to another biologic, and drug and drug-related costs over 12 and 18 months for rheumatoid arthritis (RA) patients initiating etanercept (ETN), adalimumab (ADA), or infliximab (IFX) in routine clinical practice across Canada. Methods: A retrospective chart review of biologic-naïve adult RA patients newly initiating ADA, ETN, or IFX between January 01, 2006 and December 31, 2012 from 11 practices across Canada...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/29290848/sle-and-serum-complement-causative-concomitant-or-coincidental
#24
JOURNAL ARTICLE
Vaneet Sandhu, Michele Quan
BACKGROUND: Systemic Lupus Erythematosus (SLE) is an incurable autoimmune disorder with complement activation playing a key role in the pathogenesis of immune-mediated tissue injury. While quantifying complement to monitor SLE disease activity has been the standard of care since the 1950s, decreased complement levels are not consistently associated with flares. OBJECTIVE: We seek to clarify the SLE phenotype in which complement deficiency is causative, concomitant, or coincidental...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/29290847/predictor-of-the-simplified-disease-activity-index-50-sdai-50-at-month-3-of-bdmard-treatment-in-patients-with-long-established-rheumatoid-arthritis
#25
JOURNAL ARTICLE
Yusuke Miwa, Mayu Saito, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama
Objectives: The Simplified Disease Activity Index (SDAI) 50 has good agreement with European League Against Rheumatism (EULAR) response measures for early Rheumatoid Arthritis (RA). There have been reports on early RA, but not on long-established RA. In this study, we analysed the relationships between various baseline factors and SDAI 50 after three months of treatment with biological disease-modifying antirheumatic drugs (bDMARDs) to determine the prognostic factors for long-established RA...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28932330/is-male-rheumatoid-arthritis-an-occupational-disease-a-review
#26
JOURNAL ARTICLE
Dan Murphy, David Hutchinson
BACKGROUND: Rheumatoid arthritis (RA) is a systemic, inflammatory disease with an estimated global prevalence of 0.3-1.0%. An unexplained association exists between low formal education and the development of RA independent of smoking. It is established that RA is initiated in the lungs and that various occupations associated with dust, fume and metal inhalation can increase the risk of RA development. OBJECTIVE: The objective of this review is to evaluate published clinical reports related to occupations associated with RA development...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28761564/predictive-value-of-serum-infliximab-levels-at-induction-phase-in-rheumatoid-arthritis-patients
#27
JOURNAL ARTICLE
Jurado Teresa, Plasencia-Rodríguez Chamaida, Martínez-Feito Ana, Navarro-Compán Victoria, Rispens Theo, Vries Annick, Bloem Karien, Olariaga Eva-María, Diego Cristina, Villalba Alejandro, Peiteado Diana, Nuño Laura, Bonilla Maria-Gema, Balsa Alejandro, Pascual-Salcedo Dora
BACKGROUND: The Infliximab, has proven effective in treating rheumatoid arthritis (RA). A good clinical response is usually associated with high serum drug levels. Development of antibodies toward Infliximab (ATI) can increase drug clearance, leading to treatment failure. AIMS: To analyze whether serum Infliximab trough levels (ITL) at the induction phase are associated with Infliximab clearance and clinical outcomes at week(W) 54 and to investigate the association with immunogenicity development...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28659999/biological-effects-of-phosphocitrate-on-osteoarthritic-articular-chondrocytes
#28
JOURNAL ARTICLE
Yubo Sun, Atiya M Franklin, David R Mauerhan, Edward N Hanley
BACKGROUND: Phosphocitrate (PC) inhibits osteoarthritis (OA) in Hartley guinea pigs. However, the underlying molecular mechanisms remain poorly understood. OBJECTIVE: This study sought to examine the biological effect of PC on OA chondrocytes and test the hypothesis that PC may exert its OA disease modifying effect, in part, by inhibiting the expression of genes implicated in OA disease process and stimulating the production of extracellular matrices. METHOD: OA chondrocytes were cultured in the absence or presence of PC...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28659998/axial-spondyloarthritis-and-cigarette-smoking
#29
JOURNAL ARTICLE
Irène Kona Kaut, Fatima Ezzhara Abourazzak, Essouri Jamila, Florine Awassi Sènami, Desiré Diketa, Harzy Taoufik
BACKGROUND: Smoking is one of the main environmental risk factors involved in several rheumatic diseases according to ACR 2014, it is included among the risk factors for severe axial spondyloarthritis. OBJECTIVES: The objective is to study the association between smoking and the activity of the disease, the functional impact and the severity of the axial spondyloarthritis. METHODS: It is a transversal study with a descriptive and analytical aim, during the period between January 2014 and December 2015 conducted in the department of rheumatology at the CHU Hassan II of Fes...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28567148/hip-abductor-strengthening-improves-physical-function-following-total-knee-replacement-one-year-follow-up-of-a-randomized-pilot-study
#30
JOURNAL ARTICLE
Karvannan Harikesavan, Raj D Chakravarty, Arun G Maiya, Sanjay P Hegde, Shivakumar Y Shivanna
BACKGROUND: Total knee replacement (TKR) is the commonest surgical procedure for patients with severe pain and impaired physical function following end stage knee osteoarthritis. The hip abductors are well renowned in stabilization of the trunk and hip during walking, maintaining the lower limb position, and transferring the forces from the lower limbs to the pelvis. OBJECTIVE: To assess the efficacy of hip abductor strengthening exercise on functional outcome using performance based outcome measures following total knee replacement...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28553419/the-use-of-patient-reported-outcome-measures-for-rheumatoid-arthritis-in-japan-a-systematic-literature-review
#31
REVIEW
Ann Chuo Tang, Hyunchung Kim, Bruce Crawford, Taeko Ishii, Tamas Treuer
BACKGROUND: Patient-reported outcomes (PRO) obtained through routine medical care may identify patients' day-to-day burden and help tackle the disease from the patients' perspective. However, there is a paucity of information regarding the availability of PRO data and PRO tools for rheumatoid arthritis (RA) in Japan. OBJECTIVE: We reviewed the literature on PRO data availability and to identify PRO measures implemented in Japan for RA patients. METHOD: We conducted a systematic literature review using ICHUSHI and the PubMed databases on PRO measures for RA published from January 2011 to August 2015 in Japan...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28400869/serum-cytokine-profile-in-asian-indian-patients-with-takayasu-arteritis-and-its-association-with-disease-activity
#32
JOURNAL ARTICLE
Ruchika Goel, Jayakanthan Kabeerdoss, Babu Ram, John Antony Jude Prakash, Sudhir Babji, Aswin Nair, Lakshmanan Jeyaseelan, Visalakshi Jeyaseelan, John Mathew, Veeraraghavan Balaji, George Joseph, Debashish Danda
BACKGROUND: Arterial inflammation Takayasu arteritis (TA) is an outcome of balance between pro- and anti-inflammatory cytokines. Comprehensive assessment of these cytokines is important for understanding pathogenesis and assessing disease activity. OBJECTIVE: To study pro- and anti-inflammatory cytokines representing different T-helper cell pathway in serum samples of Asian Indian patients with TA and to assess their association with disease activity. METHODS: Consecutive Indian patients with TA were assayed for serum interferon-γ, interleukin-6, interleukin-23, interleukin-17, interleukin-10 and transforming growth factor- β levels at baseline and follow up visit...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28400868/use-of-saline-as-a-placebo-in-intra-articular-injections-in-osteoarthritis-potential-contributions-to-nociceptive-pain-relief
#33
REVIEW
David Bar-Or, Leonard T Rael, Edward N Brody
BACKGROUND: Osteoarthritis of the knee (OAK) is a severe debilitating condition characterized by joint pain, stiffness, and resultant limited mobility. In recent years, intra-articular (IA) injections have been used to relieve symptoms and have succeeded to varying degrees either with sodium hyaluronate preparations or with a biologic. OBJECTIVE: The objective of this review is to evaluate multiple studies that demonstrate some relief from the symptoms of OAK in the saline arm of various clinical trials...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28400867/evaluation-of-autoantibodies-in-patients-with-primary-and-secondary-sjogren-s-syndrome
#34
JOURNAL ARTICLE
Ellen De Langhe, Xavier Bossuyt, Long Shen, Kishore Malyavantham, Julian L Ambrus, Lakshmanan Suresh
BACKGROUND: Antibodies to salivary gland protein 1 (SP1), carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP) were discovered in an animal model of Sjogren's syndrome (SS). Their expression was noted in patients with SS, especially those with lower focus scores on lip biopsies and those with early disease lacking antibodies to Ro and La. OBJECTIVE: The current studies evaluated these autoantibodies in patients with long-standing SS expressing high levels of anti-Ro antibodies and in patients with Sjogren's syndrome secondary to systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and mixed connective tissue disease (MCTD)...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28400866/association-of-erap1-il23r-and-ptger4-polymorphisms-with-radiographic-severity-of-ankylosing-spondylitis
#35
JOURNAL ARTICLE
Gulsen Ozen, Rabia Deniz, Fatih Eren, Can Erzik, Ali Ugur Unal, Sule Yavuz, Sibel Zehra Aydin, Nevsun Inanc, Haner Direskeneli, Pamir Atagunduz
BACKGROUND: Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early. OBJECTIVE: To study the association between ERAP1 , IL23R and PTGER4 single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients. METHODS: rs27044 and rs30187 ( ERAP1 ), rs11209032 ( IL23R ) and rs10440635 ( PTGER4 ) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria...
2017: Open Rheumatology Journal
https://read.qxmd.com/read/28144368/the-correlation-of-muscle-biopsy-scores-with-the-clinical-variables-in-idiopathic-inflammatory-myopathies
#36
JOURNAL ARTICLE
Suparaporn Wangkaew, Songkiet Suwansirikul, Kantawut Aroonrungwichian, Nuntana Kasitanon, Worawit Louthrenoo
OBJECTIVES: To compare the muscle pathology findings among subgroups of idiopathic inflammatory myopathies (IIM) patients, and to determine the correlations of muscle biopsy scores with muscle power and creatine kinase (CK). METHODS: The medical records of IIM patients consisting of the demographic data, clinical parameters and laboratory conducted were retrospectively reviewed. Their initial muscle biopsies were reviewed, and four domains were scored: inflammation, vascular, muscle, and connective tissue...
2016: Open Rheumatology Journal
https://read.qxmd.com/read/28077980/a-review-of-chikungunya-virus-induced-arthralgia-clinical-manifestations-therapeutics-and-pathogenesis
#37
JOURNAL ARTICLE
Brad A Goupil, Christopher N Mores
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. Recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. Infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. Additionally, the current literature reports that CHIKV can result in a severe chronic arthralgia and/or arthritis that can last months to years following the initial infection...
2016: Open Rheumatology Journal
https://read.qxmd.com/read/28077979/anti-mda5-antibody-dermatomyositis-overlap-with-systemic-lupus-erythematosus-a-case-report-and-review-of-the-literature
#38
Emily C Milam, Jacobo Futran, Andrew G Franks
BACKGROUND: Dermatomyositis (DM) is an autoimmune connective tissue disease that primarily targets the muscle, skin, and lungs. Many patients have autoantibodies that correspond to distinct clinical phenotypes. Melanoma differentiation-associated gene 5 (anti-MDA5) antibody, a specific antibody that targets the melanoma differentiation-associated gene 5 (MDA5), has been reported in DM cases and is significant for a distinct cutaneous presentation and rapidly progressive interstitial lung disease...
2016: Open Rheumatology Journal
https://read.qxmd.com/read/28077978/fibromyalgia-outcomes-over-time-results-from-a-prospective-observational-study-in-the-united-states
#39
JOURNAL ARTICLE
Caroline P Schaefer, Edgar H Adams, Margarita Udall, Elizabeth T Masters, Rachael M Mann, Shoshana R Daniel, Heather J McElroy, Joseph C Cappelleri, Andrew G Clair, Markay Hopps, Roland Staud, Philip Mease, Stuart L Silverman
BACKGROUND: Longitudinal research on outcomes of patients with fibromyalgia is limited. OBJECTIVE: To assess clinician and patient-reported outcomes over time among fibromyalgia patients. METHODS: At enrollment (Baseline) and follow-up (approximately 2 years later), consented patients were screened for chronic widespread pain (CWP), attended a physician site visit to determine fibromyalgia status, and completed an online questionnaire assessing pain, sleep, function, health status, productivity, medications, and healthcare resource use...
2016: Open Rheumatology Journal
https://read.qxmd.com/read/28077977/two-subsets-of-large-vessel-vasculitis-characterized-by-the-absence-or-presence-of-spondyloarthritis-or-its-associated-diseases
#40
JOURNAL ARTICLE
Diana Ernst, Niklas Bearlecken, Reinhold Ernst Schmidt, Torsten Witte
BACKGROUND: Whilst large vessel vasculitis (LVV) predominantly occurs in isolation, associations with other infectious and non-infectious diseases have been reported. Limited data describing associations with various autoimmune diseases (AI), including spondyloarthritis exists. The aim of this study was to characterize the association of LVV and spondyloarthritis or its associated diseases (SpAD). METHODS: A single centre, retrospective study of patients ≥50yrs with first presentation LVV between 01...
2016: Open Rheumatology Journal
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