Leopoldo Pérez de Isla, Jose L Díaz-Díaz, Manuel J Romero, Ovidio Muñiz-Grijalvo, Juan D Mediavilla, Rosa Argüeso, Raimundo de Andrés, Francisco Fuentes, Juan F Sánchez Muñoz-Torrero, Patricia Rubio, Pilar Álvarez-Baños, Dolores Mañas, Lorena Suárez Gutierrez, Adriana Saltijeral Cerezo, Pedro Mata
BACKGROUND: Intensive lipid-lowering therapy may induce coronary atherosclerosis regression. Nevertheless, the factors underlying the effect of lipid-lowering therapy on disease regression remain poorly characterized. Our aim was to determine which characteristics of atherosclerotic plaque are associated with a greater reduction in coronary plaque burden (PB) after treatment with alirocumab in patients with familial hypercholesterolemia. METHODS: The ARCHITECT study (Effect of Alirocumab on Atherosclerotic Plaque Volume, Architecture and Composition) is a phase IV, open-label, multicenter, single-arm clinical trial to assess the effect of the treatment with alirocumab for 78 weeks on the coronary atherosclerotic PB and its characteristics in subjects with familial hypercholesterolemia without clinical atherosclerotic cardiovascular disease...
January 2024: Circulation. Cardiovascular Imaging