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Oxidative Medicine and Cellular Longevity

Jing Jye Lim, Wan Ngah Wan Zurinah, Vincent Mouly, Abdul Karim Norwahidah
Human skeletal muscle is a vital organ involved in movement and force generation. It suffers from deterioration in mass, strength, and regenerative capacity in sarcopenia. Skeletal muscle satellite cells are involved in the regeneration process in response to muscle loss. Tocotrienol, an isomer of vitamin E, was reported to have a protective effect on cellular aging. This research is aimed at determining the modulation of tocotrienol-rich fraction (TRF) on the gene expressions of stress-induced premature senescence (SIPS) human skeletal muscle myoblasts (CHQ5B)...
2019: Oxidative Medicine and Cellular Longevity
Vassilios Liakopoulos, Stefanos Roumeliotis, Andreas Bozikas, Theodoros Eleftheriadis, Evangelia Dounousi
The disruption of balance between production of reactive oxygen species and antioxidant systems in favor of the oxidants is termed oxidative stress (OS). To counteract the damaging effects of prooxidant free radicals, all aerobic organisms have antioxidant defense mechanisms that are aimed at neutralizing the circulating oxidants and repair the resulting injuries. Antioxidants are either endogenous (the natural defense mechanisms produced by the human body) or exogenous, found in supplements and foods. OS is present at the early stages of chronic kidney disease, augments progressively with renal function deterioration, and is further exacerbated by renal replacement therapy...
2019: Oxidative Medicine and Cellular Longevity
Donato Cappetta, Loreta Pia Ciuffreda, Anna Cozzolino, Grazia Esposito, Cristina Scavone, Luigi Sapio, Silvio Naviglio, Domenico D'Amario, Filippo Crea, Francesco Rossi, Liberato Berrino, Antonella De Angelis, Konrad Urbanek
Cardiovascular diseases frequently coexist with chronic kidney disease that constitutes a major determinant of outcome in patients with heart failure. Dysfunction of both organs is related to chronic inflammation, endothelial dysfunction, oxidative stress, and fibrosis. Widespread expression of serine protease DPP4 that degrades varieties of substrates suggests its involvement in numerous physiological processes. In this study, we tested the effects of selective DPP4 inhibition on the progression of renal disease in a nondiabetic model of hypertensive heart disease using Dahl salt-sensitive rats...
2019: Oxidative Medicine and Cellular Longevity
Paulina Gil-Kulik, Arkadiusz Krzyżanowski, Ewa Dudzińska, Jolanta Karwat, Piotr Chomik, Małgorzata Świstowska, Adrianna Kondracka, Anna Kwaśniewska, Maria Cioch, Mariusz Jojczuk, Adam Nogalski, Janusz Kocki
The BIRC5 gene encodes a survivin protein belonging to class III of inhibitors of apoptosis, IAP. This protein serves a dual role. First, it regulates cell death, and second, it is an important regulator of mitosis progression, although its physiological regulatory function has not been fully understood. Many studies have shown and confirmed that survivin is practically absent in mature tissues in nature, while its overexpression has been reported in many cancerous tissues. There is little information about the significance of BIRC5 expression in normal adult human stem cells...
2019: Oxidative Medicine and Cellular Longevity
Rômulo Dias Novaes, Antônio Lúcio Teixeira, Aline Silva de Miranda
No abstract text is available yet for this article.
2019: Oxidative Medicine and Cellular Longevity
Li Zhang, Li Zhang, Zhengquan Huang, Runlin Xing, Xiaochen Li, Songjiang Yin, Jun Mao, Nongshan Zhang, Wei Mei, Liang Ding, Peimin Wang
Fibroblast-like synoviocytes (FLSs) are the main effector cells of knee osteoarthritis (KOA) synovial fibrosis. Our last report showed that NLRP1 and NLRP3 inflammasomes may mediate LPS/ATP-induced FLSs pyroptosis in KOA. In the present study, we found an elevated hypoxia-inducible factor-1 α (HIF-1 α ) level in the synovial tissue of KOA model rats, and inhibiting the increase of HIF-1 α could improve synovial fibrosis in rats. Subsequently, we established LPS/ATP-induced model in FLSs mimicking the inflammatory environment of KOA...
2019: Oxidative Medicine and Cellular Longevity
Mei-Ling Cheng, Jui-Fen Lin, Cheng-Yu Huang, Guan-Jie Li, Lu-Min Shih, Daniel Tsun-Yee Chiu, Hung-Yao Ho
We have previously shown that GSH depletion alters global metabolism of cells. In the present study, we applied a metabolomic approach for studying the early changes in metabolism in hydrogen peroxide- (H2 O2 -) treated hepatoma cells which were destined to die. Levels of fructose 1,6-bisphosphate and an unusual metabolite, sedoheptulose 1,7-bisphosphate (S-1,7-BP), were elevated in hepatoma Hep G2 cells. Deficiency in G6PD activity significantly reduced S-1,7-BP formation, suggesting that S-1,7-BP is formed in the pentose phosphate pathway as a response to oxidative stress...
2019: Oxidative Medicine and Cellular Longevity
Maha A Aldubayan, Rehab M Elgharabawy, Amira S Ahmed, Ehab Tousson
Interest is growing in finding natural sources of effective antitumor agents that generate fewer side effects than conventional chemotherapeutic drugs. Avenanthramides (Avns) are such compounds; these phenolic molecules naturally occur in oats and have antioxidant, anti-inflammatory, and antiproliferative effects making them worthy of further research. The aim of this study is to characterise Avns' curative ability and antineoplastic activity on solid-form Ehrlich tumors. For the study, 75 female mice were randomly and equally allocated to five groups (group 1-control, group 2-DMSO, group 3-positive control receiving Avns, group 4-mice with Ehrlich solid tumor, and group 5-Ehrlich solid tumor treated with Avns)...
2019: Oxidative Medicine and Cellular Longevity
Xu Wu, Haiying Ji, Yuli Wang, Chenlin Gu, Wenyu Gu, Lijuan Hu, Lei Zhu
Melatonin is a well-known anti-inflammatory and antioxidant molecule, which plays a crucial role in various physiological functions. In this study, mice received a single dose of 15 Gy radiation delivered to the lungs and daily intraperitoneal administration of melatonin. After 7 days, mice were processed to harvest either bronchoalveolar lavage fluid for cytokine assays or lungs for flow cytometry and histopathological studies. Herein, we showed that melatonin markedly alleviated the oxidative stress and injury, especially suppressing the infiltration of macrophages (CD11b+CD11c-) and neutrophils (CD11b+Ly6G+) to the irradiated lungs...
2019: Oxidative Medicine and Cellular Longevity
Jinming Peng, Tianyong Hu, Jin Li, Jing Du, Kerui Zhu, Baohui Cheng, Kaikai Li
Shepherd's purse ( Capsella bursa-pastoris (L.) Medik.), a wild herb as a traditional herbal medicine, has been proved with multiple healthy benefits. In this study, the chemical constituents of shepherd's purse were identified by UPLC-QTOF-MS/MS. The antioxidative and anti-inflammatory potential of shepherd's purse extract (SPE) were also investigated applying lipopolysaccharide- (LPS-) induced inflammation in RAW 264.7 macrophages and a carrageenan-induced mice paw edema model. Twenty-four chemical compounds were identified mainly including phenolic acids and flavonoids...
2019: Oxidative Medicine and Cellular Longevity
Tânia Soares, Daniela Rodrigues, Mafalda Sarraguça, Sílvia Rocha, José L F C Lima, Daniela Ribeiro, Eduarda Fernandes, Marisa Freitas
The purpose of an experimental design is to improve the productivity of experimentation. It is an efficient procedure for planning experiments, so the data obtained can be analyzed to yield a valid and objective conclusion. This approach has been used as an important tool in the optimization of different analytical approaches. A D-optimal experimental design was used here, for the first time, to optimize the experimental conditions for the detection of reactive oxygen species (ROS) produced by human blood from healthy donors, a biological matrix that better resembles the physiologic environment, following stimulation by a potent inflammatory mediator, phorbol-12-myristate-13-acetate (PMA)...
2019: Oxidative Medicine and Cellular Longevity
Anke Schmidt, Sander Bekeschus, Katja Jarick, Sybille Hasse, Thomas von Woedtke, Kristian Wende
Small reactive oxygen and nitrogen species (ROS/RNS) driven signaling plays a significant role in wound healing processes by controlling cell functionality and wound phase transitions. The application of cold atmospheric pressure plasma (CAP), a partially ionized gas expelling a variety of ROS and RNS, was shown to be effective in chronic wound management and contrastingly also in malignant diseases. The underlying molecular mechanisms are not well understood but redox signaling events are involved. As a central player, the cellular tumor antigen p53 governs regulatory networks controlling proliferation, death, or metabolism, all of which are grossly modulated by anti- and prooxidant signals...
2019: Oxidative Medicine and Cellular Longevity
Heba M A Abdelrazek, Manal M A Mahmoud, Hend M Tag, Sahar M Greish, Dalia A Eltamany, Mohammed T A Soliman
Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause. The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolism. Thirty healthy cyclic female Wistar rats were used in this experiment. Ten females were sham-operated, and 20 females were subjected to ovariectomy. Overiectomized (OVX) female rats were randomly divided into 2 groups: the control group (G1, OVX/casein) was fed a casein-based diet, and the second group (G2, OVX/soy) was fed a high soy isoflavone diet...
2019: Oxidative Medicine and Cellular Longevity
Lingling Xu, Xiaopu Lin, Meiping Guan, Yanmei Zeng, Yingshan Liu
Diabetic neuropathy (DN) is a common and severe complication of diabetes mellitus. There is still a lack of an effective treatment to DN because of its complex pathogenesis. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of thioredoxin, has been shown to be associated with diabetic retinopathy and nephropathy. Herein, we aim to investigate the role of TXNIP in prediabetic neuropathy and therapeutic potential of verapamil which has been shown to inhibit TXNIP expression. The effects of mediating TXNIP on prediabetic neuropathy and its exact mechanism were performed using high-fat diet- (HFD-) induced diabetic mice and palmitate-treated neurons...
2019: Oxidative Medicine and Cellular Longevity
Andy Wai Kan Yeung, Nikolay T Tzvetkov, Osama S El-Tawil, Simona G Bungǎu, Mohamed M Abdel-Daim, Atanas G Atanasov
Antioxidants are abundant in natural dietary sources, and the consumption of antioxidants has a lot of potential health benefits. However, there has been no literature analysis on this topic to evaluate its scientific impact in terms of citations. This study is aimed at identifying and analysing the antioxidant publications in the existing scientific literature. In this context, a literature search was performed with the Web of Science database. Full records and cited references of the 299,602 identified manuscripts were imported into VOSviewer for bibliometric analysis...
2019: Oxidative Medicine and Cellular Longevity
Monica De Luise, Vito Guarnieri, Claudio Ceccarelli, Leonardo D'Agruma, Anna Maria Porcelli, Giuseppe Gasparre
The Von Hippel-Lindau (VHL) syndrome has been rarely associated with renal oncocytomas, and tumors usually show HIF1 α chronic stabilization. By contrast, oncocytomas mainly associated with respiratory chain (RC) defects due to severe mitochondrial DNA (mtDNA) mutations are incapable of stabilizing HIF1 α , since oxygen consumption by the RC is dramatically diminished and prolylhydroxylase activity is increased by α -ketoglutarate accumulation following Krebs cycle slowdown. Here, we investigate the cooccurrence of a pseudohypoxic condition with oncocytic transformation in a case of VHL-associated renal oncocytoma...
2019: Oxidative Medicine and Cellular Longevity
Li-Ming Yu, Xue Dong, Jian Zhang, Zhi Li, Xiao-Dong Xue, Hong-Jiang Wu, Zhong-Lu Yang, Yang Yang, Hui-Shan Wang
Endoplasmic reticulum (ER) stress and oxidative stress contribute greatly to myocardial ischemia-reperfusion (MI/R) injury. Naringenin, a flavonoid derived from the citrus genus, exerts cardioprotective effects. However, the effects of naringenin on ER stress as well as oxidative stress under MI/R condition and the detailed mechanisms remain poorly defined. This study investigated the protective effect of naringenin on MI/R-injured heart with a focus on cyclic guanosine monophosphate- (cGMP-) dependent protein kinase (PKG) signaling...
2019: Oxidative Medicine and Cellular Longevity
Daria Maria Monti, Maria Manuela Rigano, Simona Maria Monti, Herbenya Silva Peixoto
No abstract text is available yet for this article.
2019: Oxidative Medicine and Cellular Longevity
Qinmei Liu, Yun Gao, Xinxin Ci
Transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of antioxidant response element- (ARE-) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress. Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cytoplasm and promotes the degradation of Nrf2 by the 26S proteasome. Nevertheless, stresses including highly oxidative microenvironments, impair the ability of Keap1 to target Nrf2 for ubiquitination and degradation, and induce newly synthesized Nrf2 to translocate to the nucleus to bind with ARE...
2019: Oxidative Medicine and Cellular Longevity
Fei Liu, Xin Huang, Zhenhua Luo, Jingjun He, Farhan Haider, Ci Song, Ling Peng, Ting Chen, Buling Wu
In order to use stem cells as a resource for tissue regeneration, it is necessary to induce expansion in vitro . However, during culture, stem cells often lose functional properties and become senescent. Increasing evidence indicates that hypoxic preconditioning with physiological oxygen concentration can maintain the functional properties of stem cells in vitro . The purpose of the current study was to test the hypothesis that hypoxic preconditioning with physiological oxygen concentration can maintain the functional properties of stem cells in culture by reducing oxidative stress...
2019: Oxidative Medicine and Cellular Longevity
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