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Journal of Gastrointestinal Cancer

Muslim Atiq, Kay Dosch, Ashley Miller, Ramu G Sudhagoni
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related mortality in the United States. Descriptive epidemiology of pancreatic cancer in South Dakota has not been studied before. MATERIALS AND METHODS: All cases of pancreatic cancer reported to the SD Cancer Registry between January 2005 and December 2014 were included in the study. Variables collected included demographics, geographical location including county of residence and zip codes, date of diagnosis, date of last contact or follow-up, size and location of the tumor, grade of the tumor, diagnostic modality as well as therapeutic interventions...
March 23, 2019: Journal of Gastrointestinal Cancer
Narendra Pandit, Tek Narayan Yadav, Robal Lacoul, Laligen Awale
No abstract text is available yet for this article.
March 23, 2019: Journal of Gastrointestinal Cancer
Masatsugu Hiraki, Toshiya Tanaka, Futa Koga, Akimasa Saito, Noriko Oza, Osamu Ikeda, Tatsuya Manabe, Atsushi Miyoshi, Kenji Kitahara, Seiji Sato, Hirokazu Noshiro
No abstract text is available yet for this article.
March 23, 2019: Journal of Gastrointestinal Cancer
Mushegh А Sahakyan, Artak Gabrielyan, Hmayak Petrosyan, Shushan Yesayan, Sevak S Shahbazyan, Arthur M Sahakyan
PURPOSE: This study reports single-surgeon experience with extended gastrectomy including en-bloc resection of adjacent organs/structures for T4b stage gastric adenocarcinoma. Time-related changes in patient selection criteria and outcomes were also analyzed. METHODS: All consecutive gastrectomies for adenocarcinoma performed between May 2004 and December 2017 were extracted from prospectively collected database to study surgical and oncologic results. Time-related changes in outcomes were examined according to three time periods...
March 21, 2019: Journal of Gastrointestinal Cancer
Marcus A Alvarez, Júlia Pedó Freitas, S Mazher Hussain, Evan S Glazer
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancerrelated mortality in the USA, and the overall incidence of the disease is increasing such that it is expected to be the third leading cause of cancer-related deaths in the next decade. Minimal improvements in therapy have not changed the overall mortality rate over the past decade for patients with PDAC. The purpose of this review is to identify new data regardign the role of Transforming growth factor beta (TGF-β) based therapeuics in patients with PDAC...
March 20, 2019: Journal of Gastrointestinal Cancer
Oren Gal, Dan Feldman, Amir Mari, Fadi Abu Baker, Dan Hebron, Yael Kopelman
BACKGROUND: Rectal cancer represents a leading cause of mortality worldwide. Staging defines the local and distant extent of the disease, guides management, and predicts prognosis. Different modalities are available for staging including TRUS (transrectal ultrasound), CT (computed tomography), and MRI (magnetic resonance imaging). OBJECTIVE: The objective of this study was to screen and isolate CT imaging parameters suggestive of advanced rectal cancer and its utility as a tool in simplifying the staging protocol making further imaging studies unnecessary...
March 11, 2019: Journal of Gastrointestinal Cancer
Sanjeev Kumar Shukla, Prabhat Pant, Govind Singh, Bhuvan, K S Shahi
Gall stones are one of the major causes of morbidity and mortality all over the world and common health problems throughout in developing countries. Cholecystectomy is one of the most common surgical practices and postoperative analysis of cholecystectomy specimen has a great value since histopathological reports may document some entities with significant clinical significances. Gallbladder carcinomas in cholecystectomy specimens are received in our histopathology laboratory to analyse their clinicopathological features...
March 8, 2019: Journal of Gastrointestinal Cancer
João Cortez Pinto, Isadora Rosa, Catarina Martins, Inês Marques, João Pereira da Silva, Ricardo Fonseca, João Freire, António Dias Pereira
PURPOSE: To determine prognostic factors for stage IIA colon cancer (CC) recurrence in patients undergoing curative intent surgery without adjuvant treatment. METHODS: Single-centre cohort study. All patients with stage IIA CC discussed in a multidisciplinary colorectal cancer clinic from January 2010 to December 2012 were evaluated. Clinical data, laboratory data and tumour features, including expression of DNA repair proteins (EDRP), were analysed. Assessment of overall and disease free survival, recurrence, recurrence site and recurrence's method of diagnosis was performed...
March 4, 2019: Journal of Gastrointestinal Cancer
Abdul Ahad Rana, Abdullah Rana, Peter Hewett
No abstract text is available yet for this article.
February 28, 2019: Journal of Gastrointestinal Cancer
Zoya Najafi, Mohammadreza Sharifi, Gholamreza Javadi
PURPOSE: Dysregulation of microRNAs (miRNAs) has been shown to be involved in the pathogenesis and progression of many malignancies. Human hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the third cause of cancer-related deaths. Recent data suggest that microRNA-23b (miR-23b) is significantly high in different types of cancer, specifically human hepatocellular carcinoma. Locked nucleic acid (LNA)-modified oligonucleotides have recently been suggested as a novel approach for targeting miRNAs as antisense-based gene silencing...
February 28, 2019: Journal of Gastrointestinal Cancer
Georgios D Lianos, Christina D Bali, Natasha Hasemaki, Georgios K Glantzounis, Michail Mitsis, Stefano Rausei
BACKGROUND: Early gastric cancer (EGC) is more common nowadays and is related a to low percentage of lymph node metastasis. For this reason, there is enormous interest to implicate minimally invasive approaches. Recently, special efforts have been made towards a potential intraoperative (real-time) lymph node metastasis (LNM) assessment, as nodal disease status could not be identified with precision before or during surgery. In this direction, accurate prediction of the LNM status through sentinel LN mapping has been attempted, as an approach to the intraoperative detection of sentinel lymph nodes (SLNs)...
February 28, 2019: Journal of Gastrointestinal Cancer
Gunjan S Desai, Prasad Pande, Rajiv C Shah, Palepu Jagannath
PURPOSE: Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is a rare neoplasm comprising of exocrine and neuroendocrine elements, each representing ≥ 30% lesion. It is commonly misdiagnosed as adenocarcinoma or grade-3 neuroendocrine neoplasm (NEN). Management is not well-defined. METHODS: Retrospective analysis of prospectively entered data at our centre from January 2011 to January 2018 revealed 16 MiNENs off 130 neuroendocrine neoplasms (NENs). These were analysed for demographics, clinicopathological characteristics, management strategies and prognosis...
February 20, 2019: Journal of Gastrointestinal Cancer
Osama H Labib, Ola A Harb, Osama H Khalil, Taha A Baiomy, Loay M Gertallah, Rham Z Ahmed
BACKGROUND: Early detection of small HCC and differentiation between HCC from AC metastatic to the liver is very essential for surgical pathologists, due to different treatment modalities. Immunohistochemistry plays a very important role in such conditions. In our study, we aimed to identify the diagnostic benefits of Arginase-1, FTCD& MOC-31 in the early detection of HCC in normal or cirrhotic liver, differentiation between HCC and metastatic ACs to the liver, and for early detection of small micro-metastases from ACs to liver...
February 16, 2019: Journal of Gastrointestinal Cancer
Stefania Brozzetti, Antonio V Sterpetti
No abstract text is available yet for this article.
February 15, 2019: Journal of Gastrointestinal Cancer
Ronald Samuel, Timothy Krill, Shehzad Merwat
No abstract text is available yet for this article.
February 14, 2019: Journal of Gastrointestinal Cancer
Mohammad Mahdi Forghanifard, Pegah Naeimi Khorasanizadeh, Mohammad Reza Abbaszadegan, Afsaneh Javdani Mallak, Meysam Moghbeli
PURPOSE: Apoptosis is one of the main involved processes during development and organogenesis and its aberration may result in tumorigenesis. In the present study, due to the role of death inducer-obliterator 1 (DIDO1) in activation of caspases 9 and 3 during the apoptosis process, the role of DIDO1 as the shortest splicing variant of the DIDO gene was assessed for the first time in esophageal squamous cell carcinoma (ESCC) patients. METHODS: DIDO1 mRNA expression in tumor tissues from 50 ESCC patients was compared to their corresponding margin normal tissues using the real-time polymerase chain reaction (RT-PCR)...
February 14, 2019: Journal of Gastrointestinal Cancer
Mohamed Ali Chaouch, Mohamed Wejih Dougaz, Wael Ferjaoui, Esma Leila Gouta, Ramzi Nouira, Ibtissem Bouasker, Chadli Dziri
No abstract text is available yet for this article.
February 9, 2019: Journal of Gastrointestinal Cancer
Soheil Hassanipour, Majid Mohammadzadeh, Fariborz Mansour-Ghanaei, Mohammad Fathalipour, Farahnaz Joukar, Hamid Salehiniya, Elham Abdzadeh, Ali Akbar Samadani, Hossein-Ali Nikbakht, Morteza Arab-Zozani
PURPOSE: Hepatocellular carcinoma or liver cancer (LC) is one of most important cancer around the world. There are several reports about LC incidence from various Iranian locations with conflicting results. The present study aimed to accomplish a systematic review to estimate the accurate incidence rate of LC among Iranian people. METHODS: This systematic review was performed based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist in 2018...
February 6, 2019: Journal of Gastrointestinal Cancer
Tohid Hassanalilou, Saeid Ghavamzadeh, Leila Khalili
BACKGROUND AND AIM: Gastric cancer, as the fourth cause of death in women and third in men with malignant tumors, is now threatening people's lives worldwide. Natural anti-tumor products are potential anti-cancer agents with fewer by-effects. Curcumin, an herbal product, has been used as a cosmetic and food additive and as a traditional herbal medicine for thousands of years in Asian countries. Several studies revealed that curcumin can inhibit the invasion and proliferation of gastric cancer cells...
February 6, 2019: Journal of Gastrointestinal Cancer
Alexander M Sy, Maureen Whitsett, Xiaodong Li, Neil D Theise, Nabil N Dagher, Sonja Olsen
No abstract text is available yet for this article.
February 4, 2019: Journal of Gastrointestinal Cancer
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