Journals Journal of Otolaryngology - He...

Journal of Otolaryngology - Head & Neck Surgery
Takao Goto, Rumi Ueha, Taku Sato, Tatsuya Yamasoba
BACKGROUND: Research on regenerative medicine using basic fibroblast growth factor (bFGF) has recently advanced in the field of laryngology. We previously reported that local administration of bFGF 1 month after recurrent laryngeal nerve (RLN) paralysis compensated for atrophy of the thyroarytenoid muscle. The objective of this study was to elucidate the effects of early bFGF administration on the thyroarytenoid muscle after RLN transection and to investigate the underlying mechanisms...
July 24, 2023: Journal of Otolaryngology—Head & Neck Surgery
Garret Horton, Elysia Grose, Tanya Chen, Oluwaseun Daniel Davies, Dongho Shin, Ian Witterick, Paolo Campisi, Yvonne Chan
BACKGROUND: The Canadian landscape of racial diversity in academic OHNS programs is currently unknown, as to date Canadian medical organizing bodies have refrained from collecting race-based data. However, new policy guidelines by the Canadian Medical Association support the collection of data that may be used to support equity, diversity and inclusion programs. This study aims to describe the representation of visible minorities amongst academic OHNS departments and divisions in Canada at various levels of academic seniority...
July 19, 2023: Journal of Otolaryngology—Head & Neck Surgery
Jeong Heon Kim, Yeonjoo Choi, Woo Seok Kang, Hong Ju Park, Joong Ho Ahn, Jong Woo Chung
BACKGROUND: The present study describes the treatment of patients at a tertiary institution who experienced device failure after Cochlear Implantation (CI), as well as identifying prodromic symptoms that could assist in the timely identification and management of device failure. STUDY DESIGN: Retrospective database review (January 2000-May 2017). SETTING: Single tertiary hospital. METHODS: Factors recorded included the etiology of hearing loss; age at first and revision CI surgeries; surgical information, including operation time and approach; electrical outcomes after implantation; device implanted; symptoms of device failure; history of head trauma; and audiologic outcomes as determined by categories of auditory performance (CAP)...
July 17, 2023: Journal of Otolaryngology—Head & Neck Surgery
Justin M Pyne, Clayton M Davis, Ryan Kelm, Claudine Bussolaro, Walter Dobrovolsky, Hadi Seikaly
INTRODUCTION: Resection of the mandible and temporomandibular joint (TMJ) without formal reconstruction is a devastating condition that negatively affects all aspects of the patient's life. We have approached the reconstruction of mandibular defects that include the condyle with simultaneous reconstruction with a vascularized free fibular flap (FFF) using Surgical Design and Simulation (SDS) and alloplastic TMJ prosthesis. The objective of this study is to report the functional and quality of life (QOL) outcomes in a cohort of patients that had undergone our reconstructive protocol...
July 3, 2023: Journal of Otolaryngology—Head & Neck Surgery
Shireen Samargandy, Elysia Grose, Jonathan Yip, John M Lee
BACKGROUND: Patients with chronic rhinosinusitis (CRS) and immunoglobulin deficiencies (ID) have more recalcitrant sinonasal disease and a subset of these patients undergo surgical management for their CRS. However, there is a paucity of literature on the surgical outcomes in this patient population and appropriate treatment algorithms for CRS in patients with ID. The objective of this study was to better elucidate the outcomes of endoscopic sinus surgery (ESS) in patients with ID in terms of disease-specific quality-of-life scores and the need for revision surgery...
June 29, 2023: Journal of Otolaryngology—Head & Neck Surgery
Manuele Casale, Antonio Moffa, Lucrezia Giorgi, Michelangelo Pierri, Rodolfo Lugo, Ofer Jacobowitz, Peter Baptista
BACKGROUND: Surgical treatment for nasal obstruction caused by nasal valve collapse requires a significant recovery period and risks of complications, while nasal dilators are uncomfortable. Recently, radiofrequency treatment of lateral walls has been used under local anesthesia as an office base surgery. This work aims to assess the efficacy of a new radiofrequency device, the Vivaer™ System (Aerin Medical, Sunnyvale, CA), to treat nasal obstruction through a systematic review and meta-analysis...
June 22, 2023: Journal of Otolaryngology—Head & Neck Surgery
Patrick Pearson, Kendra Smith, Nilita Sood, Elizabeth Chia, Alicia Follett, Michael B Prystowsky, Simon Kirby, Thomas J Belbin
BACKGROUND: Krüppel-type zinc finger protein genes located on chromosome 19q13 are aberrantly hypermethylated with high frequency in all anatomic sub-sites of head and neck cancers as well as other epithelial tumours resulting in decreased expression. METHODS: We examined prognostic significance of ZNF154 and ZNF132 expression and DNA methylation in independent patient cohort of about 500 head and neck cancer patients in the Cancer Genome Atlas (TCGA). We also overexpressed these genes in HEK-293 cells, as well as the oral cancer cell line UM-SCC-1...
May 30, 2023: Journal of Otolaryngology—Head & Neck Surgery
Zhimou Cai, Huijun Yue, Lin Chen, Yang Xv, Yun Li, Bingjie Tang, Yu Lin, Wenbin Lei
BACKGROUND: For recurrent laryngeal cancer, the feasibility of salvage transoral laser microsurgery (TLM) remains controversial. This study compared the efficacy of TLM and open partial laryngectomy (OPL) for treatment of early local recurrence of glottic squamous cell cancer (GSCC) and confirm the effectiveness of salvage TLM as a treatment option. METHODS: This retrospective study involved 55 patients with early local recurrent GSCC treated with TLM, and the oncologic outcomes, functional outcomes, hospitalization time and complications were compared with a group of 40 recurrent GSCC patients matched for clinical variables of TLM group, treated by OPL by the same team of surgeons...
May 29, 2023: Journal of Otolaryngology—Head & Neck Surgery
Kendra Naismith, Khrystyna Ioanidis, Agnieszka Dzioba, S Danielle MacNeil, Josee Paradis, Smriti Nayan, Julie E Strychowsky, M Elise Graham
BACKGROUND: Previous literature demonstrates that female surgeons face difficulties in family planning, meeting breastfeeding goals, leadership and advancement opportunities. These issues have received limited attention in Canadian surgeons despite different maternity leave patterns compared to the general Canadian population. We sought to describe the experience of otolaryngologist-head and neck surgeons in family planning, fertility, and lactation and to identify the role of gender and career stage in these experiences...
May 23, 2023: Journal of Otolaryngology—Head & Neck Surgery
Grace Yi, Jennifer Payandeh, Dorsa Mavedatnia, Penelope Neocleous, Jacob Davidson, Jennifer Siu, Molly Zirkle, Julie E Strychowsky, M Elise Graham, Yvonne Chan
BACKGROUND: The gender disparity in surgical disciplines, specifically in speakers across North American medical and surgical specialty conferences, has been highlighted in recent literature. Improving gender diversity at society meetings and panels may provide many benefits. Our aim was to determine the state of gender diversity amongst presenters and speakers at the annual Canadian Society of Otolaryngology-Head and Neck Surgery (CSO) meetings. METHODS: Scientific programs for the CSO annual meetings from 2008 to 2020 were obtained from the national society website...
May 11, 2023: Journal of Otolaryngology—Head & Neck Surgery
Veeral Desai, Gianluca Sampieri, Amirpouyan Namavarian, John M Lee
BACKGROUND: ClariFix is a novel intranasal cryotherapy device developed for clinic-based cryosurgical ablation of the posterior nasal nerves region. As a relatively new technology, there is a paucity of studies within the literature assessing the efficacy and safety profile of ClariFix for chronic rhinitis. METHODS: A systematic review was completed in accordance with PRISMA guidelines. Databases searched included: Ovid Medline, Ovid EMBASE, Pubmed, Cochrane and Web of Science...
April 29, 2023: Journal of Otolaryngology—Head & Neck Surgery
Lukas Anschuetz, Ralph Hohenberger, Christoph Kaecker, Olgun Elicin, Roland Giger, Marco Caversaccio
BACKGROUND: To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. METHODS: Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 2019. A chart review on patient and tumor characteristics, treatment and long-term outcome was performed. RESULTS: Most frequent histological types were squamous cell carcinoma (SCC) (n = 74), adenocarcinoma (n = 24) and mucosal melanoma (n = 18)...
April 28, 2023: Journal of Otolaryngology—Head & Neck Surgery
Esther ShinHyun Kang, Sena Turkdogan, Jeffrey C Yeung
BACKGROUND: Patients undergoing supraglottoplasty are often routinely admitted post-operatively to the pediatric intensive care unit (PICU) due to rare but potentially fatal complications such as airway compromise. A systematic review was performed to determine the rate of post-operative PICU-level respiratory support required by pediatric patients following supraglottoplasty, to identify risk factors for patients who may benefit from post-operative PICU admission and limit unnecessary use of intensivist resources...
April 27, 2023: Journal of Otolaryngology—Head & Neck Surgery
Sheila Yu, Elysia Grose, Daniel J Lee, Vincent Wu, Mitchell Pellarin, John M Lee
BACKGROUND: Sinonasal inverted papillomas (IP) are benign tumours arising from the mucosal lining of the nasal cavity and paranasal sinuses with a high propensity for recurrence and malignant transformation. Advances in endoscopic surgery and improved radiologic navigation have increased the role of endoscopic surgical resection in the treatment of IPs. The current study aims to evaluate the rate of IP recurrence after endoscopic endonasal resection and to evaluate factors which impact recurrence...
April 27, 2023: Journal of Otolaryngology—Head & Neck Surgery
Amr F Hamour, John Jw Lee, Ewa Wasilewski, Eric Monteiro, John M Lee, Allan Vescan, Lakshmi P Kotra
BACKGROUND: Chronic rhinosinusitis (CRS) is a complex inflammatory disease of the sinonasal tract. To understand this disease entity and develop targeted treatments, a reproducible animal model is paramount. AIMS/OBJECTIVES: To optimize a murine model of eosinophilic CRS by establishing benchmark histological markers and validate its fidelity in evaluating intranasal treatments. MATERIAL AND METHODS: Forty-five Balb/c mice were included in the 7-week protocol...
April 25, 2023: Journal of Otolaryngology—Head & Neck Surgery
Alice Q Liu, Yunqi Ji, Amanda Hu
BACKGROUND: In-office vocal fold injections (VFI) are an effective treatment for glottic insufficiency. The primary objective of this study was to assess if patients reported decisional regret after VFI. Secondary objectives included determining if variables were associated with lower decisional regret. METHODS: Case-control study of patients who underwent in-office VFIs for glottic insufficiency from August 2017 to December 2019 at a tertiary laryngology clinic...
April 25, 2023: Journal of Otolaryngology—Head & Neck Surgery
Khrystyna Ioanidis, Kendra Naismith, Agnieszka Dzioba, S Danielle MacNeil, Josée Paradis, Smriti Nayan, Julie E Strychowsky, M Elise Graham
INTRODUCTION: Women in surgical specialties face different challenges than their male peers. However, there is a paucity of literature exploring these challenges and their effects on a Canadian surgeon's career. METHODS: A REDCap® survey was distributed to Canadian Otolaryngology-Head and Neck Surgery (OHNS) staff and residents in March 2021 using the national society listserv and social media. Questions examined practice patterns, leadership positions, advancement, and experiences of harassment...
April 24, 2023: Journal of Otolaryngology—Head & Neck Surgery
Yuehong Liu, Siyi Yang, Yulu Wang, Jiahua Hu, Hongbo Xie, Tianyi Ni, Zhao Han
BACKGROUNDS: Tinnitus is a meaningless sound signal perceived by the patients in the absence of auditory stimuli. Due to the complex etiology and unclear mechanism, specific therapies for tinnitus are still in the exploratory stage. In recent years, personalized and customized music therapy has been proposed as an effective method for tinnitus treatment. The aim of this study was to explore the efficacy of customized therapy with a well-designed follow-up system in the treatment of tinnitus through a large sample one arm study and to identify the relevant factors affecting the treatment outcome...
April 24, 2023: Journal of Otolaryngology—Head & Neck Surgery
Andrew V Thamboo, Melissa Lee, Mohit Bhutani, Charles Chan, Yvonne Chan, Ken R Chapman, Christopher J Chin, Lori Connors, Del Dorscheid, Anne K Ellis, Richard M Gall, Krystelle Godbout, Arif Janjua, Amin Javer, Shaun Kilty, Harold Kim, Gordon Kirkpatrick, John M Lee, Richard Leigh, Catherine Lemiere, Eric Monteiro, Helen Neighbour, Paul K Keith, George Philteos, Jaclyn Quirt, Brian Rotenberg, Juan C Ruiz, John R Scott, Doron D Sommer, Leigh Sowerby, Marc Tewfik, Susan Waserman, Ian Witterick, Erin D Wright, Cory Yamashita, Martin Desrosiers
BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) often coexists with lower airway disease. With the overlap between upper and lower airway disease, optimal management of the upper airways is undertaken in conjunction with that of the lower airways. Biologic therapy with targeted activity within the Type 2 inflammatory pathway can improve the clinical signs and symptoms of both upper and lower airway diseases. Knowledge gaps nevertheless exist in how best to approach patient care as a whole...
April 24, 2023: Journal of Otolaryngology—Head & Neck Surgery
Robin Rupp, Matthias Balk, Matti Sievert, Victoria Leibl, Stephan Schleder, Moritz Allner, Heinrich Iro, Ulrich Hoppe, Joachim Hornung, Antoniu-Oreste Gostian
BACKGROUND: When performing magnetic resonance imaging (MRI) in patients with a cochlear implant (CI), complication rates vary widely in the literature. The primary objective of this retrospective study was to determine the prevalence of complications, in particular magnet dislocation, in patients with CI undergoing 1.5 Tesla (T) MRI. As a secondary objective, the prevalence of magnet dislocation for specific cochlear implant device types was elaborated. METHODS: In a single-center retrospective study, all patients with a cochlear implant presenting for an MRI examination at 1...
April 21, 2023: Journal of Otolaryngology—Head & Neck Surgery
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