M L A Fehrmann, W J Huinck, M E G Thijssen, L Haer-Wigman, H G Yntema, L J C Rotteveel, J C C Widdershoven, T Goderie, M F van Dooren, E H Hoefsloot, M P van der Schroeff, E A M Mylanus, C P Lanting, R J E Pennings
BACKGROUND: The spiral ganglion hypothesis suggests that pathogenic variants in genes preferentially expressed in the spiral ganglion nerves (SGN), may lead to poor cochlear implant (CI) performance. It was long thought that TMPRSS3 was particularly expressed in the SGNs. However, this is not in line with recent reviews evaluating CI performance in subjects with TMPRSS3-associated sensorineural hearing loss (SNHL) reporting overall beneficial outcomes. These outcomes are, however, based on variable follow-up times of, in general, 1 year or less...
December 15, 2023: Journal of Otolaryngology—Head & Neck Surgery