Journals Journal of Otolaryngology - He...

Journal of Otolaryngology - Head & Neck Surgery
Zachary Elwell, David Mancuso, Nikolaus E Wolter, Evan J Propst, Tulio Valdez, Patrick Scheffler
OBJECTIVE: To describe the incidence of respiratory complications, postoperative hemorrhage, length of stay, and cost of care in children with mucopolysaccharidosis (MPS) undergoing adenotonsillectomy (AT). METHODS: Analysis of the 2009, 2012, and 2016 editions of the Healthcare Cost and Utilization Project Kids' Inpatient Database (HCUP KID) identified 24,700 children who underwent AT (40 children with MPS). Demographics, respiratory complications, postoperative hemorrhage, length of stay, and total cost were compared across children with and without MPS...
December 24, 2023: Journal of Otolaryngology—Head & Neck Surgery
Hai-Tao Liu, Wei-Peng Jiang, Gang Xia, Jia-Min Liao
OBJECTIVE: To quantify the results of superficial parotidectomy (SP) and partial SP (PSP) for benign parotid tumours using a systematic evaluation method. METHODS: A systematic search of English and Chinese databases (PubMed, Web of Science, Cochrane Library, China Knowledge Network, Wanfang and Vipshop) was conducted to include studies comparing the treatment outcomes of SP with PSP. RESULTS: Twenty-three qualified, high-quality studies involving 2844 patients were included in this study...
December 22, 2023: Journal of Otolaryngology—Head & Neck Surgery
Jing Fei, Xiao-Wen Peng, Ting-Yu Yang, Xue-Li Shen, Lin Gao, Na Liao, Lei-Ji Li
OBJECTIVE: To discuss the management of sigmoid sinus thrombophlebitis secondary to middle ear cholesteatoma. METHODS: We retrospectively analyzed all cases of sigmoid sinus thrombophlebitis caused by middle ear cholesteatoma over a period of 7 years. 7 male and 2 female patients, ranging in age from 9 to 66 years, were diagnosed with sigmoid sinus thrombophlebitis by clinical presentation and radiological examination. By executing a modified mastoidectomy and tympanoplasty (canal wall-down tympanoplasty) to entirely remove the cholesteatoma-like mastoid epithelium, all patients were effectively treated surgically without opening the sigmoid sinus...
December 19, 2023: Journal of Otolaryngology—Head & Neck Surgery
Matthew Newman, Thomas Boi Vu Nguyen, Tobial McHugh, Kesava Reddy, Doron Dov Sommer
BACKGROUND: Juvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1-6]. Significant androgen stimulation is hypothesized to explain the strong predisposition for JNA to present in young adolescent males. However, considerable variability in age at diagnosis exists with rare involvement of very young patients incongruent with typical male pubertal growth patterns...
December 19, 2023: Journal of Otolaryngology—Head & Neck Surgery
Marc Levin, Yvonne Chan, Doron D Sommer, Andrew Thamboo, John M Lee
BACKGROUND: Aspirin exacerbated respiratory disease (AERD) in patients who have had sinus surgery remains a management challenge. Aspirin desensitization and biologics are additional treatment options. It remains unclear if patients require a more comprehensive surgery prior to implementing such additional therapies. The purpose of this study was to quantify prior surgery completeness in AERD patients at a tertiary rhinology practice. METHODS: Paranasal sinus CT scans were reviewed by four academic rhinologists to assess surgery completeness...
December 17, 2023: Journal of Otolaryngology—Head & Neck Surgery
M L A Fehrmann, W J Huinck, M E G Thijssen, L Haer-Wigman, H G Yntema, L J C Rotteveel, J C C Widdershoven, T Goderie, M F van Dooren, E H Hoefsloot, M P van der Schroeff, E A M Mylanus, C P Lanting, R J E Pennings
BACKGROUND: The spiral ganglion hypothesis suggests that pathogenic variants in genes preferentially expressed in the spiral ganglion nerves (SGN), may lead to poor cochlear implant (CI) performance. It was long thought that TMPRSS3 was particularly expressed in the SGNs. However, this is not in line with recent reviews evaluating CI performance in subjects with TMPRSS3-associated sensorineural hearing loss (SNHL) reporting overall beneficial outcomes. These outcomes are, however, based on variable follow-up times of, in general, 1 year or less...
December 15, 2023: Journal of Otolaryngology—Head & Neck Surgery
Zhengcai Lou, Zihan Lou, Tian Lv, Zhengnong Chen
OBJECTIVE: The objective of this study was to compare the graft outcome and postoperative infection of with and without the use of antibiotic ointment following myringoplasty for the treatment of chronic perforations. STUDY DESIGN: Randomized controlled trial. MATERIAL AND METHODS: 135 chronic perforations were prospectively randomized to use of antibiotic ointment group (UAO, n = 68) or no use of antibiotic ointment group (NAO, n = 67) following myringoplasty...
December 13, 2023: Journal of Otolaryngology—Head & Neck Surgery
Jérôme R Lechien, Stéphane Hans
OBJECTIVE: To investigate epidemiological, clinical and oncological outcomes of patients with laryngeal verrucous carcinomas (LVC). METHODS: Two independent authors investigated PubMed, Scopus and Cochrane Library for studies dedicated to epidemiological, clinical and oncological outcomes of patients with LVC. The following outcomes were investigated with PRISMA criteria: age; gender; tobacco/alcohol consumption; HPV infection; anatomical, pathological, therapeutic and survival outcomes...
December 13, 2023: Journal of Otolaryngology—Head & Neck Surgery
Xiwu Liu, Bincan Jiang, Ailan Cheng, Youwei Guo, Lei Wang, Weidong Liu, Wen Yin, Yihan Li, Xingjun Jiang, Caiping Ren
OBJECTIVE: Our research group in the early stage identified CD109 as the target of aptamer S3 in nasopharyngeal carcinoma (NPC). This study was to use S3 to connect DNA tetrahedron (DT) and load doxorubicin (Dox) onto DT to develop a targeted delivery system, and explore whether S3-DT-Dox can achieve targeted therapy for NPC. METHODS: Aptamer S3-conjugated DT was synthesized and loaded with Dox. The effects of S3-DT-Dox on NPC cells were investigated with laser confocal microscopy, flow cytometry, and MTS assays...
December 12, 2023: Journal of Otolaryngology—Head & Neck Surgery
Yuhang Zhou, Chaoyou Fang, Ling Yuan, Mengchen Guo, Xinyi Xu, Anwen Shao, Anke Zhang, Danyang Zhou
Noise exposure is an important cause of acquired hearing loss. Studies have found that noise exposure causes dysregulated redox homeostasis in cochlear tissue, which has been recognized as a signature feature of hearing loss. Oxidative stress plays a pivotal role in many diseases via very complex and diverse mechanisms and targets. Reactive oxygen species are products of oxidative stress that exert toxic effects on a variety of physiological activities and are considered significant in noise-induced hearing loss (NIHL)...
December 11, 2023: Journal of Otolaryngology—Head & Neck Surgery
Maxime Fieux, Florent Carsuzaa, Jeremy Charriot, Justin Michel, Fabien Subtil, Leigh J Sowerby, Thomas Radulesco, Valentin Favier
BACKGROUND: Chronic rhinosinusitis (CRS), encompasses many different clinical patterns with variable response to treatment. Precise criteria specifying disease severity and control are lacking in the current literature. Our aim was to perform a cross-cultural adaptation of the CRS-PRO, creating a French version for use as a routine questionnaire in the assessment of patients with CRS. METHODS: The CRS-PRO questionnaire was translated according to the recommendations of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) through a three-step procedure including a backward translation...
December 9, 2023: Journal of Otolaryngology—Head & Neck Surgery
Carlos O'Connor Reina, Laura Rodriguez Alcala, Jose Maria Ignacio, María Teresa Garcia Iriarte, Marina Carrasco Llatas, Juan Carlos Casado Morente, David Perez Del Rey, Irene Marbán Alvarez, Gema Marbán Ibarburu, Peter Baptista, Guillermo Plaza
A recent Letter published, in the Journal of Otolaryngology-Head & Neck Surgery in response to our original article "Risk of diabetes in patients with sleep apnea: comparison of surgery versus Continous Positive Airway Pressure in a long-term follow-up study" raised some issues we would like to address here. However, we thank the authors for their effort and time in analyzing our manuscript and we want to facilitate a balanced discussion on this topic with our reply.
December 1, 2023: Journal of Otolaryngology—Head & Neck Surgery
Faris F Brkic, David T Liu, Iris Rücklinger, Nicholas James Campion, Tina Josefin Bartosik, Erich Vyskocil, Victoria Stanek, Aldine Tu, Katharina Gangl, Sven Schneider
BACKGROUND: Dupilumab is a monoclonal antibody against interleukin 4 receptor alpha and has proven to be clinically effective in treating patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, a certain number of patients are non- or partial responders. This study aims to investigate the relevance of inflammatory markers with regard to therapy response to dupilumab in CRSwNP patients. METHODS: All patients with CRSwNP treated with dupilumab at a tertiary healthcare center with available pretreatment inflammatory markers were included...
November 25, 2023: Journal of Otolaryngology—Head & Neck Surgery
Yanyan Niu, Yongli Zhang, Hong Huo, Xiaofeng Jin, Jian Wang
BACKGROUND: Biofilm formation on voice prostheses disrupts the function and limits the lifespan of voice prostheses. There is still no effective clinical strategy for inhibiting or removing these biofilms. Silver sulfadiazine (SSD), as an exogenous antibacterial agent, has been widely used in the prevention and treatment of infection, however, its effect on voice prosthesis biofilms is unknown. The purpose of this study was to explore the effect of SSD on the mature mixed bacterial biofilms present on voice prostheses...
November 21, 2023: Journal of Otolaryngology—Head & Neck Surgery
Justin T Lui, Valerie Dahm, Christoph Arnoldner, Philip W Lam, Trung N Le, Joseph M Chen, Vincent Y Lin
BACKGROUND: Within otologic surgery, a paucity of well-controlled studies assessing the use of systemic antibiotic to reduce surgical site infections exists. Moreover, discrepancies in wound classification of procedures challenge consensus in antimicrobial prescribing patterns. We sought to compare surgeons from two different health systems to examine how surgeons' prescribing habits compared to practice guidelines for numerous otologic procedures. METHODS: An online questionnaire was distributed to 33 Canadian and 32 Austrian surgeons who regularly perform otologic surgery...
November 9, 2023: Journal of Otolaryngology—Head & Neck Surgery
Yibin Liu, Nan Huang, Junxiao Gao, Bin He, Hongming Huang, Liangcai Wan, Qinming Cai, Zhenchao Zhu, Suizi Zhou, Jing Wang, Xiaohui Wang, Qianhui Qiu, Fei Han
BACKGROUND: The management of locally advanced recurrent nasopharyngeal carcinoma (rNPC) is challenging. The objective of our study was to compare salvage endoscopic nasopharyngectomy (ENPG) with intensity-modulated radiotherapy (IMRT) in clinical outcomes and complications of locally advanced rNPC. METHODS: Patients with histologically confirmed rNPC in rT3-4 N0-3 M0 stages were retrospectively enrolled between January 2013 and December 2019 in this multicenter, case-matched study...
November 6, 2023: Journal of Otolaryngology—Head & Neck Surgery
Chung-Sheng Wu, David Hsin-Kuang Chen, Yuan-Chun Ko, Chyi-Huey Bai, Po-Yueh Chen, Wen-Te Liu, Yi-Chih Lin
BACKGROUND: Continuous positive airway pressure (CPAP) therapy is the first-line treatment for obstructive sleep apnea (OSA). However, the low acceptance rate of CPAP remains a challenging clinical issue. This study aimed to determine the factors that influence the acceptance rate of CPAP. METHODS: This retrospective cohort study was conducted at the sleep center of Shuang-Ho Hospital. Initially, 1186 OSA patients who received CPAP therapy between December 2013 and December 2017 were selected, and finally, 1016 patients were analyzed...
October 28, 2023: Journal of Otolaryngology—Head & Neck Surgery
Alice Q Liu, Oleksandr Butskiy, Veronique Wan Fook Cheung, Donald W Anderson
No abstract text is available yet for this article.
October 26, 2023: Journal of Otolaryngology—Head & Neck Surgery
Jee Won Moon, Seok-Youl Choi, Su-Jong Kim, Jae-Min Shin, Il-Ho Park
BACKGROUND: Biocompatibility and stability of three-dimensional printed polycaprolactone mesh grafts for nasal surgery are proven in both animal and human models. However, their safety and durability as batten grafts for caudal septal deviation has not been documented. This study was designed to investigate the efficacy and safety of three-dimensional printed polycaprolactone mesh batten graft in septoplasty using the wedge resection technique for the correction of caudal septal deviation...
October 24, 2023: Journal of Otolaryngology—Head & Neck Surgery
Francois Bobin, Jérôme R Lechien
OBJECTIVE: To investigate the association between obstructive sleep apnea (OSA) and laryngopharyngeal reflux (LPR) through oropharyngeal pH-monitoring and pepsin saliva measurements. DESIGN: Prospective uncontrolled study. METHODS: Patients with sleep disturbances and reflux symptoms underwent polysomnography, 24-h oropharyngeal pH-monitoring and saliva pepsin collections. The prevalence of LPR was investigated in OSA patients according to oropharyngeal pH-monitoring and pepsin measurements...
October 14, 2023: Journal of Otolaryngology—Head & Neck Surgery
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