Journals Tuberculosis and Respiratory D...

Tuberculosis and Respiratory Diseases
Eun Chong Yoon, Hyewon Lee, Hee-Young Yoon
BACKGROUND: Chronic airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are increasingly being treated with inhaled corticosteroids (ICS). However, ICSs carry potential infection risks, particularly nontuberculous mycobacteria (NTM). This study investigated the association between ICS use and NTM infection risk using national insurance data, particularly for individuals with chronic airway diseases. METHODS: We conducted a nationwide population-based study using data from the National Health Insurance Service-National Sample Cohort in South Korea from 2002 to 2019...
June 5, 2024: Tuberculosis and Respiratory Diseases
Da Hyun Kang, Chang-Min Choi, Cheol-Kyu Park, In-Jae Oh, Young-Chul Kim, Seong Hoon Yoon, Yoonjoo Kim, Jeong Eun Lee
BACKGROUND: The use of immune checkpoint inhibitors (ICIs) in patients with advanced lung cancer is increasing. Despite ongoing studies to predict the efficacy of ICIs, its use in clinical practice remains difficult. Thus, we aimed to discover a predictive marker by analyzing blood cell characteristics and developing a scoring system for patients treated with ICIs. METHODS: This was a prospective multicenter study in patients with advanced non-small cell lung cancer (NSCLC) who received ICIs as second-line treatment from June 2021 to November 2022...
May 14, 2024: Tuberculosis and Respiratory Diseases
Kang-Mo Gu, Jae-Woo Jung, Min-Jong Kang, Deog Kyeom Kim, Hayoung Choi, Young-Jae Cho, Seung Hun Jang, Chang-Hoon Lee, Yeon Mok Oh, Ji Sook Park, Jae Yeol Kim
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) expressing eosinophilia experience slightly fewer episodes of community-acquired pneumonia (CAP) than those without eosinophilia. However, the severity and burden of hospitalized pneumonia patients with COPD concerning eosinophilia have not been assessed. METHODS: We evaluated the differences in clinical characteristics between patients with CAP and COPD with or without eosinophilia by a post-hoc analysis of a prospective, multi-center, cohort study data...
May 3, 2024: Tuberculosis and Respiratory Diseases
Heesang Han, Ji-Hee Lee, Sung Jun Chung, Beong Ki Kim, Yedham Kang, Hangseok Choi, Hee-Jin Kim, Seung Heon Lee
BACKGROUND: The government of Korea implemented a strategy of prevention and early diagnosis in high-risk groups to reduce the tuberculosis (TB) burden. This study aims to investigate the TB epidemiology and gap in understanding of TB prevalence among homeless individuals by analyzing active TB chest X-ray (CXR) screening results in Korea. METHODS: The Korean National Tuberculosis Association conducted active TB screening with CXR for homeless groups from January 1 to December 31, 2021...
May 3, 2024: Tuberculosis and Respiratory Diseases
Ji Soo Choi, Se Hyun Kwak, Min Chul Kim, Chang Hwan Seol, Seok-Jae Heo, Sung Ryeol Kim, Eun Hye Lee
BACKGROUND: : Bronchiectasis is a chronic respiratory disease that leads to airway inflammation, destruction, and airflow limitation, which reflects its severity. Impulse oscillometry (IOS) is a non-invasive method that uses sound waves to estimate lung function and airway resistance. The aim of this study was to assess the usefulness of IOS in predicting the severity of bronchiectasis. METHODS: : We retrospectively reviewed the IOS parameters and clinical characteristics in 145 patients diagnosed with bronchiectasis between March 2020 and May 2021...
April 30, 2024: Tuberculosis and Respiratory Diseases
Hyung-Jun Kim
Nontuberculous mycobacterial pulmonary disease (NTM-PD) arises from the exposure of susceptible hosts to a diverse group of environmental mycobacteria. The emphasis on non-pharmacological strategies is motivated by widespread presence of nontuberculous mycobacteria (NTM) in various environments and the inconsistent success rates of pharmacological treatments. Modifiable factors contributing to NTM-PD development include impaired airway clearance, low body mass index, gastroesophageal reflux disease, and exposure to NTM habitats...
April 25, 2024: Tuberculosis and Respiratory Diseases
Seong Hwan Youn, Hyun Jung Kim, Jae Seok Park, Sun Hyo Park, Yong Shik Kwon, Mi-Ae Kim
BACKGROUND: Inhalation therapy efficacy hinges on proper peak inspiratory flow rate (PIFR) attainment, yet the prevalence of inappropriate PIFR among patients with chronic obstructive pulmonary disease (COPD) remains unstudied in Korea. This study aimed to assess the prevalence of inappropriate PIFR, its correlation with COPD assessment test (CAT) scores, and factors associated with suboptimal PIFR. METHODS: We enrolled 108 patients with COPD who had been using the same inhaler for at least one year without exacerbations...
April 25, 2024: Tuberculosis and Respiratory Diseases
Leila Alimardanian, Bahram Mohammad Soltani, Shiva Irani, Mojgan Sheikhpour
BACKGROUND: Lung cancer is one of the most dangerous diseases among cancers and tuberculosis is one of the deadliest infectious diseases in the world. Many studies have mentioned the connection between lung cancer and tuberculosis, and also the microRNAs that play a significant role in the development of these two diseases. This study aims to use different databases to find effective miRNAs and their role on different genes on lung and tuberculosis diseases. Also determining the role of miR-34a and miR-182 in lung cancer and tuberculosis...
April 15, 2024: Tuberculosis and Respiratory Diseases
Geunin Lee, Sol Kim, Shihwan Chang, Hojoon Sohn, Young Ae Kang, Youngmok Park
RATIONALE: Despite the global increase in nontuberculous mycobacterial pulmonary disease (NTM-PD), there are geographical variations in clinical characteristics. We investigated the clinical characteristics of patients with NTM-PD in South Korea. METHODS: We systematically reviewed articles about patients with NTM-PD in South Korea until February 2022. Individual participant data, regardless of treatment, were collected using a standard case report form. RESULTS: The data of 6,489 patients from 11 hospitals between 2002 and 2019 were analyzed...
April 9, 2024: Tuberculosis and Respiratory Diseases
Jinsoo Min, Yoolwon Jeong
No abstract text is available yet for this article.
April 9, 2024: Tuberculosis and Respiratory Diseases
Natasha Cordeiro Dos Santos, Aquiles Assunção Camelier, Anne Karine Menezes, Victor Durier Cavalcanti de Almeida, Roberto Rodrigues Bandeira Tosta Maciel, Fernanda Warken Rosa Camelier
INTRODUCTION: Cardiovascular comorbidity is common in individuals with Chronic obstructive pulmonary disease (COPD). These factor interferes in pharmacological treatment. The use of beta-blockers has been proposed for their known cardioprotective effects. However, there is a reluctance to use them due to adverse reactions and the risk of causing bronchospasm. OBJECTIVE: To summarize existing evidences on the effects of beta-blocker use in COPD associated with cardiovascular comorbidities in relation to disease severity, exacerbation and mortality outcomes...
April 4, 2024: Tuberculosis and Respiratory Diseases
Da Hyun Kang, Chaeuk Chung
Stage III non-small cell lung cancer (NSCLC) exhibits significant diversity, making it challenging to define an optimal treatment. A collaborative multidisciplinary approach is essential in crafting individualized treatments. Previously, targeted therapies and immunotherapies were commonly used to treat patients with advanced and metastatic lung cancer. Such treatments are now being extended to individuals considered surgery, as well as patients once considered unsuitable for surgery. These changes have increased surgical success and substantially reduced postoperative recurrence...
March 28, 2024: Tuberculosis and Respiratory Diseases
Saerom Kim, Jung Seop Eom, Jeongha Mok
In cases where pulmonary tuberculosis (PTB) is not microbiologically diagnosed via sputum specimens, bronchoscopy has been the conventional method to enhance diagnostic rates. Although the additional benefit of bronchoscopy in diagnosing PTB is well-known, its overall effectiveness remains suboptimal. This review introduces several strategies for improving PTB diagnosis via bronchoscopy. First, it discusses how bronchoalveolar lavage or an increased number of bronchial washings can increase specimen abundance...
March 28, 2024: Tuberculosis and Respiratory Diseases
Yong Jun Choi, Min Kwang Byun
No abstract text is available yet for this article.
March 19, 2024: Tuberculosis and Respiratory Diseases
Jinwoo Seok, Hee-Young Yoon
BACKGROUND: Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with various health issues. Although some studies have suggested an association between reduced lung function and OSA, this association remains unclear. Our study aimed to explore this relationship using data from a nationally representative population-based survey. METHODS: We performed an analysis of data from the 2019 Korea National Health and Nutrition Examination Survey. Our study encompassed 3,675 participants aged 40 years and older...
March 18, 2024: Tuberculosis and Respiratory Diseases
Hyung Koo Kang, Jin Woo Song
Interstitial lung diseases (ILDs) are a diverse collection of lung disorders sharing similar features, such as inflammation and fibrosis. The diagnosis and management of ILD require a multidisciplinary approach using clinical, radiological, and pathological evaluation. Progressive pulmonary fibrosis (PPF) is a distinct form of progressive and fibrotic disease, occurring in ILD cases other than in idiopathic pulmonary fibrosis (IPF). It is defined based on clinical symptoms, lung function, and chest imaging, regardless of the underlying condition...
April 2024: Tuberculosis and Respiratory Diseases
Sudipt Adhikari, Vikas Marwah, Robin Choudhary, I M Pandey, Tentu Ajai Kumar, Virender Malik, Arpita Pemmaraju, Shrinath V, Suraj Kapoor
INTRODUCTION: Intrapleural fibrinolytic therapy is being used as an effective agent since 1949 in managing complicated pleural effusion and empyema. Several agents like streptokinase (STK), urokinase (UK), and recombinant tissue plasminogen activator (rt-PA) are found to effective with variable effectiveness. However, head-to-head controlled trial to compare the efficacy of the most frequently used i.e., UK and rt-PA (alteplase) in managing complicated pleural effusion has rarely been reported...
March 7, 2024: Tuberculosis and Respiratory Diseases
Bo-Guen Kim, Sun Hye Shin, Jung-Wan Yoo, Yong Suk Jo, Hye Yun Park
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is known to useful biomarker for detecting eosinophilic airway inflammation. However, there is a lack of evidence regarding the role of FeNO in chronic obstructive pulmonary disease (COPD). We aimed to assess whether elevated FeNO and its impact on treatment change into an inhaled corticosteroid (ICS)-containing regimen and association with acute exacerbation (AE) in patients with COPD. METHODS: We retrospectively analyzed 107 COPD patients without history of asthma from March 2016 to December 2019...
March 5, 2024: Tuberculosis and Respiratory Diseases
Sang Hyuk Kim, Youlim Kim
The continuously increasing prevalence of severe asthma has imposed an increasing burden worldwide. Despite the emergence of novel therapeutic agents, management of severe asthma remains challenging. Insights garnered from big data may be helpful in the effort to determine the complex nature of severe asthma. In the field of asthma research, a vast amount of big data from various sources, including electronic health records, national claims data, and international cohorts, is now available. However, understanding of the strengths and limitations is required for proper utilization of specific datasets...
March 5, 2024: Tuberculosis and Respiratory Diseases
Song I Lee, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim
BACKGROUND: Increasing age has been observed among patients admitted to the intensive care unit(ICU). Age traditionally considered a risk factor for ICU mortality. We investigated how the epidemiology and clinical outcomes of older ICU patients have changed over a decade. METHODS: We analyzed patients admitted to the ICU at a university hospital in Seoul, South Korea. We defined patients aged 65 and older as older patients. Changes in age groups and mortality risk factors over the study period were analyzed...
February 29, 2024: Tuberculosis and Respiratory Diseases
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