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Cancer Prevention Research

Rafael Guerrero-Preston, Fahcina Lawson, Sebastian Rodriguez-Torres, Maartje G Noordhuis, Francesca Pirini, Laura Manuel, Blanca Valle, Tal Hadar, Bianca L Rivera, Oluwasina Folawiyo, Adriana Báez, Luigi Marchionni, Wayne M Koch, William H Westra, Young J Kim, James R Eshleman, David Sidransky
To inform novel personalized medicine approaches for race and socioeconomic disparities in head and neck cancer. We examined germ-line and somatic mutations, immune signatures, and epigenetic alterations linked to neighborhood determinants of health in Black and Non-Latino White (NLW) head and neck cancer patients. Cox proportional hazards revealed that Black HNSCC patients with PAX5 (p=0.06) and PAX1 (p=0.017) promoter methylation had worse survival than NLW patients, after controlling for education, zipcode and TNM stage (n=118)...
February 18, 2019: Cancer Prevention Research
Vinod Vijayakurup, Arun Kumar T Thulasidasan, Mohan Shankar G, Archana P Retnakumari, C Devika Nandan, Jannet Somaraj, Jayesh Antony, Vijai V Alex, Balachandran S Vinod, Vijayasteltar Belsamma Liju, Sankar Sundaram, G S Vinod Kumar, Ruby John Anto
The rate of lung cancer incidence is alarmingly mounting, despite the decline of smoking and tobacco consumption. Recent reports indicate a very high correlation between the growing fast food culture and lung cancer incidence. Benzo[a]pyrene is a potent carcinogen abundantly present in grilled and deep fried food and in tobacco smoke. Our previous studies have proved the efficacy of curcumin in curbing B[a]P-induced lung carcinogenesis. However, the poor pharmacokinetic profile of the compound considerably hampers its potential as an effective chemopreventive...
February 13, 2019: Cancer Prevention Research
Wanshui Yang, Li Liu, NaNa Keum, Zhi Rong Qian, Jonathan A Nowak, Tsuyoshi Hamada, Mingyang Song, Yin Cao, Katsuhiko Nosho, Stephanie A Smith-Warner, Sui Zhang, Yohei Masugi, Kimmie Ng, Keisuke Kosumi, Yanan Ma, Wendy S Garrett, Molin Wang, Hongmei Nan, Marios Giannakis, Jeffrey A Meyerhardt, Andrew T Chan, Charles S Fuchs, Reiko Nishihara, Kana Wu, Edward L Giovannucci, Shuji Ogino, Xuehong Zhang
Calcium intake has been associated with a lower risk of colorectal cancer. Calcium signaling may enhance T cell proliferation and differentiation, and contribute to T-cell mediated antitumor immunity. In this prospective cohort study, we investigated the association between calcium intake and colorectal cancer risk according to tumor immunity status to provide additional insights into the role of calcium in colorectal carcinogenesis. The densities of tumour-infiltrating T-cell subsets (CD3+, CD8+, CD45RO (PTPRC)+, or FOXP3+ cell) were assessed using immunohistochemical and computer-assisted image analysis in 736 cancer cases that developed among 136,249 individuals in two cohorts...
February 13, 2019: Cancer Prevention Research
Di Zhang, Ana S Leal, Sarah Carapellucci, Pritika H Shahani, Jaskaran S Bhogal, Samir Ibrahim, San Raban, Peter W Jurutka, Pamela A Marshall, Michael B Sporn, Carl E Wagner, Karen T Liby
Rexinoids, selective ligands for retinoid X receptors (RXRs), have shown promise in preventing many types of cancer. However, the limited efficacy and undesirable lipidemic side-effects of the only clinically approved rexinoid, bexarotene, drive the search for new and better rexinoids. Here we report the evaluation of novel pyrimidinyl (Py) analogs of two known chemopreventive rexinoids, bexarotene (Bex) and LG100268 (LG268) in a new paradigm. We show that these novel derivatives were more effective agents than bexarotene for preventing lung carcinogenesis induced by carcinogen...
February 13, 2019: Cancer Prevention Research
Li Jiao, Suman Maity, Cristian Coarfa, Kimal Rajapakshe, Liang Chen, Feng Jin, Vasanta Putluri, Lesley F Tinker, Qianxing Mo, Fengju Chen, Subrata Sen, Haleh Sangi-Haghpeykar, Hashem B El-Serag, Nagireddy Putluri
To examine the association between metabolic deregulation and pancreatic cancer, we conducted a two-stage case-control targeted metabolomics study using pre-diagnostic sera collected one year before diagnosis in the Women's Health Initiative study. We used the liquid chromatography-mass spectrometry to quantitate 470 metabolites in 30 matched case/control pairs. From 180 detectable metabolites, we selected 14 metabolites to be validated in additional 18 matched case/control pairs. We used the paired t-test to compare the concentrations of each metabolite between cases and controls and used the log fold change (FC) to indicate the magnitude of difference...
February 5, 2019: Cancer Prevention Research
Su-Hyeong Kim, Shivendra V Singh
Cancer chemoprevention by benzyl isothiocyanate (BITC), which is derived from cruciferous vegetables like garden cress, in a transgenic mouse model of breast cancer is associated with inhibition of breast cancer stem-like cells (bCSC) but the molecular regulators of this effect remain elusive. This study demonstrates a protective effect of Krüppel-like factor 4 (KLF4)-p21CIP1 axis in bCSC inhibition by BITC. Exposure of human breast cancer cells (MCF-7, MDA-MB-231, and SUM159) to plasma achievable concentrations of BITC resulted in a robust induction of KLF4 mRNA and its protein expression as determined by quantitative real-time polymerase chain reaction and western blotting or confocal microscopy...
February 5, 2019: Cancer Prevention Research
Amy P Skubitz, Kristin Lm Boylan, Kate A Geschwind, Qing Cao, Timothy K Starr, Melissa A Geller, Joseph Celestino, Robert C Bast, Karen H Lu, Joseph S Koopmeiners
The best known ovarian cancer biomarker, CA125, is neither adequately sensitive nor specific for screening the general population. By using a combination of proteins for screening, it may be possible to increase the sensitivity and specificity over CA125 alone. In this study, we used Proseek® Multiplex Oncology II plates to simultaneously measure the expression of 92 cancer-related proteins in serum using proximity extension assays. This technology combines the sensitivity of the polymerase chain reaction with the specificity of antibody-based detection methods, allowing multiplex biomarker detection and high throughput quantification...
February 1, 2019: Cancer Prevention Research
Nobumi Suzuki, Ryota Niikura, Sozaburo Ihara, Yohko Hikiba, Hiroto Kinoshita, Naoko Higashishima, Yoku Hayakawa, Atsuo Yamada, Yoshihiro Hirata, Ryo Nakata, Makoto Okamoto, Munetaka Sano, Akifumi Kushiyama, Mari Ichinose, Susan L Woods, Daniel Worthley, Yasuhiko Iwamoto, Kazuhiko Koike
A retrospective case-controlled analysis was performed to identify drug candidates in the current use that may prevent colorectal cancer (CRC), outside of aspirin. A total of 37,510 patients aged ≥20 years were assessed to identify subjects who had been diagnosed with CRC by colonoscopy without a previous diagnosis of CRC, inflammatory bowel disease (IBD), or gastrointestinal symptoms; 1560 patients were identified who were diagnosed with CRC by colonoscopy. The CRC patients were matched with 1560 age-, gender-, family history of CRC-and comorbidity-matched control patients who were not diagnosed with CRC at colonoscopy...
January 30, 2019: Cancer Prevention Research
Andreas J Gescher, Andrea DeCensi
January 30, 2019: Cancer Prevention Research
(no author information available yet)
No abstract text is available yet for this article.
January 29, 2019: Cancer Prevention Research
Nádia P Castro, Maria C Rangel, Anand S Merchant, Gabriel M MacKinnon, Frank Cuttitta, David S Salomon, Young S Kim
Triple-negative breast cancer (TNBC) represents the poorest prognosis among all of breast cancer subtypes with no currently available effective therapy. In this study, we hypothesized that sulforaphane (SFN), a dietary component abundant in broccoli and its sprouts, can inhibit malignant cell proliferation and tumor sphere formation of cancer stem-like cells (CSCs) in TNBC. CSC population was isolated using fluorescently activated cell sorting (FACS) analysis with the combined stem cell surface markers, CD44+/CD24-/CD49f+...
January 24, 2019: Cancer Prevention Research
(no author information available yet)
No abstract text is available yet for this article.
January 18, 2019: Cancer Prevention Research
Philip E Castle, Vânia R S Silva, Marcia E L Consolaro, Nádia Kienen, Lorna Bittencourt, Sandra M Pelloso, Edward E Partridge, Amanda Pierz, Camila Buziquia Dartibale, Nelson S Uchimura, Isabel C Scarinci
Most cervical cancers occur in women who do not participate in cervical-cancer screening. We therefore evaluated adherence to screening for clinic-based Pap testing, self-collected sampling for HPV testing, and choice of the two among 483 un/under-screened women in Brazil. Three public Basic Health Units (BHUs) were each randomly assigned to three arms: (1) Pap testing at the BHU (N=160), (2) "Self&HPV" (self-collection for HPV testing) (N=161), and (3) "Choice" between self-collection and HPV testing and Pap test at the local BHU (N=162)...
January 16, 2019: Cancer Prevention Research
Kazim Sahin, Engin Yenice, Birdal Bilir, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Ibrahim H Ozercan, Nashwa Kabil, Bulent Ozpolat, Omer Kucuk
Genistein, the major isoflavone in soybean, has been reported to exert anticancer effects on various types of cancer including ovarian cancer; however, its chemopreventive effects and mechanisms of action in ovarian cancer have not been fully elucidated in spontaneously developing ovarian cancer models. In the present study, we demonstrated the preventive effects and mechanisms of genistein in the laying hen model that develops spontaneous ovarian cancer at high incidence rates. Laying hens were randomized to three groups: control (3...
January 16, 2019: Cancer Prevention Research
Arthur R Galbraith, Donna E Seabloom, Beverly R Wuertz, Jennifer D Antonides, Vernon E Steele, Lee W Wattenberg, Frank G Ondrey
Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in the treatment of asthma, were evaluated to determine their individual and combinational chemopreventive efficacy on benzo(a)pyrene induced lung tumors in female A/J mice. Nicotinamide fed at a dietary concentration of 0.75% significantly inhibited tumor multiplicity. Nicotinamide by aerosol inhalation at doses up to 15 mg/kg/day did not result in a statistically significant reduction in tumor multiplicity. Finally, dietary nicotinamide was administered with aerosol budesonide and tumor multiplicity reduced by 90% at 1 week and 49% at 8 weeks post last carcinogen dose...
January 3, 2019: Cancer Prevention Research
Zeni Wu, Ting-Yuan Li, Ming-Yue Jiang, Lulu Yu, Jing Zhao, Hairui Wang, Xun Zhang, Wen Chen, You-Lin Qiao
Factors that differentiate risk of cervical cancer associated with infection with single versus multiple HPV types are yet undefined. We hypothesize that E6 oncoprotein is one determining factor. This cross-sectional, multicenter study was performed between 2013 and 2017. A total of 1,781 women were recruited from six hospitals. Samples were tested for presence of 14 types of high-risk HPV DNA. HPV16/18 positive samples were also tested for HPV16/18-E6 oncoprotein. Of 1781 subjects, 687 (38.6%) tested positive for HPV16/18...
January 3, 2019: Cancer Prevention Research
Sarah E Jackson, Kate Williams, Rebecca J Beeken, Andrew Steptoe
Emerging evidence suggests cancer survivors suffer impairments in health and wellbeing that pre-date their diagnosis. This study prospectively examine changes from 4-6y pre-diagnosis to 0-2y post-diagnosis. Data were from 477 cancer survivors and 5,451 cancer-free comparisons participating in the English Longitudinal Study of Ageing. We examined group-by-time interactions for self-rated health, quality of life (QoL), depression, life satisfaction and impairments in mobility, activities of daily living (ADLs) and instrumental ADLs (IADLs)...
January 3, 2019: Cancer Prevention Research
Raymond N DuBois, Michael N Pollak
No abstract text is available yet for this article.
December 27, 2018: Cancer Prevention Research
James Y Dai, Michael LeBlanc, Phyllis J Goodman, M Scott Lucia, Ian M Thompson, Catherine M Tangen
In the Prostate Cancer Prevention Trial (PCPT), genotypes that may modify the effect of finasteride on the risk of prostate cancer have not been identified. Germline Genetic data from 1157 prostate cancer cases in PCPT were analyzed by case-only methods. Genotypes included 357 single nucleotide polymorphisms (SNPs) from 83 candidate genes in androgen metabolism, inflammation, circadian rhythm and other pathways. Univariate case-only analysis was conducted to evaluate whether individual SNPs modified the finasteride effect on the risk of high-grade and low-grade prostate cancer...
December 11, 2018: Cancer Prevention Research
Michael T Marrone, Elizabeth Selvin, John R Barber, Elizabeth A Platz, Corinne E Joshu
The association between hyperglycemia and prostate cancer risk is inconsistent, and its association with prostate cancer mortality is understudied. Thus, we investigated the association between hyperglycemia and prostate cancer risk and mortality using multiple biomarkers simultaneously to classify hyper- and normoglycemia. We conducted a prospective analysis of 5,162 cancer-free men attending visit 2 (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) study followed for total (N=671) and lethal (N=69) prostate cancer incidence and prostate cancer mortality (N=64) through 2012...
December 11, 2018: Cancer Prevention Research
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