Jonathan P Segal, Benjamin H Mullish, Mohammed Nabil Quraishi, Animesh Acharjee, Horace R T Williams, Tariq Iqbal, Ailsa L Hart, Julian R Marchesi
The aetiopathogenesis of inflammatory bowel diseases (IBD) involves the complex interaction between a patient's genetic predisposition, environment, gut microbiota and immune system. Currently, however, it is not known if the distinctive perturbations of the gut microbiota that appear to accompany both Crohn's disease and ulcerative colitis are the cause of, or the result of, the intestinal inflammation that characterizes IBD. With the utilization of novel systems biology technologies, we can now begin to understand not only details about compositional changes in the gut microbiota in IBD, but increasingly also the alterations in microbiota function that accompany these...
2019: Therapeutic Advances in Gastroenterology