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Journals Therapeutic Advances in Gastro...

Therapeutic Advances in Gastroenterology

https://read.qxmd.com/read/38774388/are-anti-tnf-agents-safe-in-cirrhotics-the-question-remains-unanswered
#1
JOURNAL ARTICLE
Suprabhat Giri
No abstract text is available yet for this article.
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38766477/impact-of-inflammatory-bowel-disease-on-women-s-reproductive-life-a-questionnaire-based-study
#2
JOURNAL ARTICLE
Fabiana Zingone, Alessandro Borsato, Daria Maniero, Francesco Della Loggia, Greta Lorenzon, Annalisa Zanini, Cristina Canova, Brigida Barberio, Edoardo Vincenzo Savarino
BACKGROUND: Inflammatory bowel diseases (IBDs) have a peak incidence between the second and fourth decades of life and can affect women's reproductive life. OBJECTIVES: Our study aimed to assess the impact of IBD on the reproductive life of female patients with this condition. DESIGN: Cross-sectional study. METHODS: Women with IBD followed at our IBD Unit and a group of healthy controls were enrolled. Data on reproductive life were collected using a dedicated questionnaire...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38757097/the-relationship-of-kras-expression-with-kras-status-prognosis-and-tumor-infiltrated-t-lymphocytes-in-colorectal-cancer
#3
JOURNAL ARTICLE
Yebohao Zhou, Ziwei Zeng, Ze Li, Lei Ruan, Hao Xie, Fujin Ye, Liang Huang, Huashan Liu, Liang Kang
BACKGROUND: The significance of Kirsten rat sarcoma viral oncogene (KRAS) mutation in colorectal cancer (CRC) is well established; yet, its association with KRAS expression and prognosis warrants further investigation. While high KRAS expression is commonly linked with poorer prognosis in other cancers, its role in CRC remains relatively understudied. OBJECTIVE: To explore the correlation between KRAS expression, KRAS status, prognosis, and tumor-infiltrating T lymphocyte density in CRC...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38751605/p-cab-versus-ppi-in-the-eradication-of-helicobacter-pylori-a-systematic-review-and-network-meta-analysis
#4
JOURNAL ARTICLE
Yutong Jiang, Rongrong Zhang, Yuxuan Fang, Ruixia Zhao, Yu Fu, Pingping Ren, Qingqing Zhan, Mingyi Shao
BACKGROUND: The efficacy and safety of potassium-competitive acid blockers (P-CABs) in the eradication of Helicobacter pylori (Hp) remains controversial when compared with proton pump inhibitors (PPIs). OBJECTIVES: The current study set out to compare the differences in the eradication rate and adverse reactions between eradication regimens based on P-CAB or PPI drugs and the differences between the vonoprazan-based and the tegoprazan-based regimens to explore the efficacy and safety of different Hp eradication regimens...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38741927/differences-in-the-risk-of-clinical-failure-between-thiopurine-and-methotrexate-in-bio-na%C3%A3-ve-patients-with-crohn-s-disease-a-korean-nationwide-population-based-study
#5
JOURNAL ARTICLE
Yu Kyung Jun, Eunjeong Ji, Hye Ran Yang, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon
BACKGROUND: Although immunomodulators are widely prescribed in patients with Crohn's disease (CD), it is unclear whether there is a difference in treatment outcomes between thiopurines and methotrexate (MTX). OBJECTIVE: To compare the risk of clinical failure between thiopurines and MTX in bio-naïve patients with CD. DESIGN: Nationwide, population-based study. METHODS: We used claims data from the Korean National Health Insurance Service...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38737913/biomarkers-in-inflammatory-bowel-disease-a-practical-guide
#6
REVIEW
Jennie Clough, Michael Colwill, Andrew Poullis, Richard Pollok, Kamal Patel, Sailish Honap
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a costly condition in terms of morbidity and healthcare utilization, with an increasing prevalence now approaching 1% in the Western world. Endoscopic assessment of IBD remains the gold standard for diagnosis, evaluation of treatment response and determination of post-operative recurrence, but is expensive and invasive. Biomarkers can facilitate non-invasive disease assessment, with C-reactive protein and faecal calprotectin as the most widely available biomarkers in current clinical practice...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38737912/explorative-cost-effectiveness-analysis-of-colorectal-cancer-recurrence-detection-with-next-generation-sequencing-liquid-biopsy-in-spain-france-and-germany
#7
JOURNAL ARTICLE
Wendelin Schramm, Yasmin Hollenbenders, Maximilian Kurscheidt
BACKGROUND: Next-generation sequencing liquid biopsy (NGS-LB) for colorectal cancer (CRC) detection and surveillance remains an expensive technology as economies of scale have not yet been realized. Nevertheless, the cost of sequencing has decreased while sensitivity has increased, raising the question of whether cost-effectiveness (CE) has already been achieved from the perspective of European healthcare systems. OBJECTIVES: This health economic (HE) modeling study explores the CE of NGS-LB for CRC based on direct treatment costs compared to standard care without liquid biopsy in Spain, France, and Germany...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38655034/long-term-real-world-data-of-ustekinumab-in-crohn-s-disease-the-stockholm-ustekinumab-study
#8
JOURNAL ARTICLE
Francesca Bello, Samer Muhsen, Haider Sabhan, Alexandra Borin, Fredrik Johansson, Charlotte Höög, Ole Forsberg, Christina Wennerström, Charlotte Söderman, Mikael Lördal, Sven Almer
BACKGROUND: Ustekinumab is used to treat inflammatory bowel disease mainly in patients failing anti-tumour necrosis factor (TNF)-agents. OBJECTIVES: To provide real-world data in unselected patients with Crohn's disease (CD), treated with ustekinumab. DESIGN: Longitudinal retrospective study at four hospitals in Stockholm, Sweden. METHODS: Disease activity (Harvey-Bradshaw index and physician global assessment), laboratory parameters, endoscopic findings and drug persistence were assessed...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38645513/the-emerging-therapies-are-reshaping-the-first-line-treatment-for-advanced-hepatocellular-carcinoma-a-systematic-review-and-network-meta-analysis
#9
JOURNAL ARTICLE
Wei Peng, Yangxun Pan, Lan Xie, Zhoutian Yang, Zhiwei Ye, Jinbin Chen, Juncheng Wang, Dandan Hu, Li Xu, Zhongguo Zhou, Minshan Chen, Aiping Fang, Yaojun Zhang
BACKGROUND: Given the superior performance of various therapies over sorafenib in advanced hepatocellular carcinoma (HCC) and the absence of direct comparisons, it is crucial to explore the efficacy of these treatments in phase III randomized clinical trials. OBJECTIVES: The goal is to identify which patients are most likely to benefit significantly from these emerging therapies, contributing to more personalized and informed clinical decision-making. DESIGN: Systematic review and network meta-analysis...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38617123/in-era-of-immunotherapy-the-value-of-trastuzumab-beyond-progression-in-patients-with-trastuzumab-resistant-her2-positive-advanced-or-metastatic-gastric-cancer
#10
JOURNAL ARTICLE
Hui Wang, Caiyun Nie, Weifeng Xu, Jing Li, He Gou, Huifang Lv, Beibei Chen, Jianzheng Wang, Yingjun Liu, Yunduan He, Jing Zhao, Xiaobing Chen
BACKGROUND: For patients with human epidermal growth factor receptor-2 (HER2)-positive advanced or metastatic gastric cancer who have progressed on first-line trastuzumab therapy, the clinical value of the continuous use of trastuzumab beyond progression (TBP) is controversial. OBJECTIVES: The present study was conducted to evaluate the efficacy and explore new treatment strategies of TBP for patients with trastuzumab-resistant HER2-positive advanced or metastatic gastric cancer in the era of cancer immunotherapy...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38601815/long-term-safety-of-tenapanor-in-people-with-irritable-bowel-syndrome-with-constipation-from-the-t3mpo-3-study-plain-language-summary-of-publication
#11
JOURNAL ARTICLE
Anthony J Lembo, Susan Edelstein, David P Rosenbaum, Ceciel Rooker, Jeffrey D Roberts, William D Chey
No abstract text is available yet for this article.
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38560428/systematic-review-of-metabolomic-alterations-in-ulcerative-colitis-unveiling-key-metabolic-signatures-and-pathways
#12
REVIEW
Meiling Liu, Siyi Guo, Liang Wang
BACKGROUND: Despite numerous metabolomic studies on ulcerative colitis (UC), the results have been highly variable, making it challenging to identify key metabolic abnormalities in UC. OBJECTIVES: This study aims to uncover key metabolites and metabolic pathways in UC by analyzing existing metabolomics data. DESIGN: A systematic review. DATA SOURCES AND METHODS: We conducted a comprehensive search in databases (PubMed, Cochrane Library, Embase, and Web of Science) and relevant study references for metabolomic research on UC up to 28 December 2022...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38560427/evolutionary-relationship-between-antimitochondrial-antibody-positivity-and-primary-biliary-cholangitis-in-taiwan-a-16-year-hospital-cohort-study
#13
JOURNAL ARTICLE
Ming-Ling Chang, Jur-Shan Cheng, Puo-Hsien Le, Wei-Ting Chen, Hsin-Ping Ku, Rong-Nan Chien
BACKGROUND: How antimitochondrial antibody (AMA)-positive patients evolve to have primary biliary cholangitis (PBC) in viral hepatitis-endemic areas is unknown. OBJECTIVES: We aimed to investigate this evolution in Taiwan. DESIGN/METHODS: A 16-year medical center-based cohort study of 2,095,628 subjects was conducted in Taiwan, an Asian country endemic to viral hepatitis. AMA-positive subjects were those with positive AMA with alkaline phosphatase (ALP) ⩽1...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38529070/retrospective-subgroup-analysis-of-fecal-microbiota-live-jslm-rebyota-%C3%A2-administered-by-colonoscopy-under-enforcement-discretion-for-the-prevention-of-recurrent-clostridioides-difficile-infection
#14
JOURNAL ARTICLE
Whitfield L Knapple, David S Yoho, Alexander Sheh, Joan Thul, Paul Feuerstadt
BACKGROUND: Fecal microbiota, live-jslm (RBL; REBYOTA® ), is the first Food and Drug Administration (FDA)-approved, single-dose, rectally administered, microbiota-based live biotherapeutic product for preventing Clostridioides difficile infection (CDI) recurrence. Alternative routes of administration are of clinical interest. OBJECTIVES: Evaluate the safety and efficacy of RBL administration via colonoscopy. DESIGN: Retrospective analysis of electronic medical records of participants administered RBL via colonoscopy under FDA enforcement discretion...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38524790/accuracy-of-the-pancolonic-modified-mayo-score-in-predicting-the-long-term-outcomes-of-ulcerative-colitis-a-promising-scoring-system
#15
JOURNAL ARTICLE
Péter Bacsur, Panu Wetwittayakhlang, Tamás Resál, Emese Földi, Béla Vasas, Bernadett Farkas, Mariann Rutka, Talat Bessissow, Waqqas Afif, Anita Bálint, Anna Fábián, Renáta Bor, Zoltán Szepes, Klaudia Farkas, Peter L Lakatos, Tamás Molnár
BACKGROUND: Different endoscopic scoring systems for assessing ulcerative colitis (UC) severity are available. However, most of them are not correlated with disease extent. OBJECTIVES: Our study aimed to compare the predictive value of the PanMay score versus the endoscopic Mayo (MES), Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and Dublin score in predicting long-term outcomes of UC. DESIGN: This retrospective study enrolled consecutive UC patients who underwent colonoscopy before at least a 3-year follow-up...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38524789/patient-journey-in-gastroesophageal-reflux-disease-real-world-perspectives-from-italian-gastroenterologists-primary-care-physicians-and-ent-specialists
#16
JOURNAL ARTICLE
Andrea Pasta, Filippo Pelizzaro, Elisa Marabotto, Francesco Calabrese, Elena Formisano, Shirin Djahandideh Sheijani, Giovanni Brandimarte, Giampiero Manes, Antonietta Gerarda Gravina, Edoardo Vincenzo Savarino
BACKGROUND: Gastroesophageal reflux disease (GERD) is a challenging condition that involves different physicians, such as general practitioners (GPs), gastroenterologists, and ears, nose and throat (ENT) specialists. A common approach consists of proton-pump inhibitors (PPIs) administration. Adjunctive pharmacological treatment may have a role in the management of non-responders to PPIs. OBJECTIVES: We aimed to survey GPs and different medical specialists to investigate the medical approaches to patients reporting GERD symptoms...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38510459/the-association-between-drugs-and-repeated-treatment-with-budesonide-in-patients-with-microscopic-colitis-a-retrospective-observational-study
#17
JOURNAL ARTICLE
Oliver Bjurström, Pontus Karling
BACKGROUND: Smoking and the use of non-steroidal anti-inflammatory drugs (NSAIDs) acetylsalicylic acid (ASA), proton pump inhibitors (PPIs), serotonin reuptake inhibitors (SSRIs), and statins have been associated with microscopic colitis (MC). OBJECTIVES: We investigated whether these factors were associated with repeated budesonide treatments in patients diagnosed with MC. DESIGN: Retrospective observational study. METHODS: All patients with a histologically verified diagnosis of MC at our clinic between the years 2006 and 2022 were identified...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38510458/comparison-of-long-term-outcomes-of-endoscopic-ultrasound-guided-hepaticogastrostomy-and-choledochoduodenostomy-for-distal-malignant-biliary-obstruction-a-multicenter-retrospective-study
#18
JOURNAL ARTICLE
Dongwook Oh, Sung Yong Han, Sang Hyub Lee, Seong-Hun Kim, Woo Hyun Paik, Hyung-Ku Chon, Tae Jun Song, Se Woo Park, Jae Hee Cho
BACKGROUND: Endoscopic ultrasound-guided biliary drainage (EUS-BD), classified as choledochoduodenostomy (CDS) and hepaticogastrostomy (HGS), is a feasible and effective alternative for distal malignant biliary obstruction (MBO) in failed endoscopic retrograde cholangiopancreatography. However, the preferred technique for better outcomes has not yet been evaluated. OBJECTIVES: We compared the long-term outcomes between the techniques. DESIGN: Retrospective comparative study...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38486818/the-synergy-of-dual-faecal-immunochemical-and-faecal-calprotectin-testing-for-accurate-assessment-of-endoscopic-and-histological-activity-in-inflammatory-bowel-disease
#19
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Diana Lewis, Jonathan P Segal, Olga Newiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Faecal biomarkers are increasingly utilized for disease assessment in inflammatory bowel disease (IBD). OBJECTIVES: To characterize the relative and combined accuracy of faecal calprotectin (FC) and faecal immunochemical testing (FIT) for detecting endoscopic and histologically active disease in Crohn's disease (CD) and ulcerative colitis (UC), subdivided by disease location. DESIGN: A prospective cohort study. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited and performed both FC and FIT ±30 days of ileocolonoscopy...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38450104/splenectomy-versus-non-splenectomy-for-gastrointestinal-bleeding-from-left-sided-portal-hypertension-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Minghui Liu, Ning Wei, Yuhu Song
OBJECTIVES: Left-sided portal hypertension (LSPH) leads to life-threatening gastrointestinal (GI) bleeding. There are no recommendations or consensus about the management of GI bleeding caused by LSPH. This systematic review and meta-analysis were conducted to evaluate the incidence of GI bleeding and the mortality of patients with LSPH receiving different therapeutic strategies. DESIGN: A systematic review and meta-analysis were performed to determine the efficacy of different therapeutic strategies for GI bleeding caused by LSPH...
2024: Therapeutic Advances in Gastroenterology
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