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Journal of the International AIDS Society

Jessica E Haberer, Bosco M Bwana, Catherine Orrell, Stephen Asiimwe, Gideon Amanyire, Nicholas Musinguzi, Mark J Siedner, Lynn T Matthews, Alexander C Tsai, Ingrid T Katz, Kathleen Bell, Annet Kembabazi, Stephen Mugisha, Victoria Kibirige, Anna Cross, Nicola Kelly, Bethany Hedt-Gauthier, David R Bangsberg
INTRODUCTION: The success of universal antiretroviral therapy (ART) access and aspirations for an AIDS-free generation depend on high adherence in individuals initiating ART during early-stage HIV infection; however, adherence may be difficult in the absence of illness and associated support. METHODS: From March 2015 to October 2017, we prospectively observed three groups initiating ART in routine care in Uganda and South Africa: men and non-pregnant women with early-stage HIV infection (CD4 > 350 cells/μL), pregnant women with early-stage HIV infection and men and non-pregnant women with late-stage HIV infection (CD4 < 200 cells/μL)...
February 2019: Journal of the International AIDS Society
Sofia R Bartlett, Tanya L Applegate, Brendan P Jacka, Marianne Martinello, Francois Mj Lamoury, Mark Danta, Daniel Bradshaw, David Shaw, Andrew R Lloyd, Margaret Hellard, Gregory J Dore, Gail V Matthews, Jason Grebely
INTRODUCTION: Over the last two decades, the incidence of hepatitis C virus (HCV) co-infection among men who have sex with men (MSM) living with HIV began increasing in post-industrialized countries. Little is known about transmission of acute or recent HCV, in particular among MSM living with HIV co-infection, which creates uncertainty about potential for reinfection after HCV treatment. Using phylogenetic methods, clinical, epidemiological and molecular data can be combined to better understand transmission patterns...
February 2019: Journal of the International AIDS Society
Mohammad Alhaj, Alemayehu Amberbir, Emmanuel Singogo, Victor Banda, Monique van Lettow, Alfred Matengeni, Gift Kawalazira, Joe Theu, Megh R Jagriti, Adrienne K Chan, Joep J van Oosterhout
INTRODUCTION: Since June 2016, the national HIV programme in Malawi has adopted Universal Test and Treat (UTT) guidelines requiring that all persons who test HIV positive will be referred to start antiretroviral therapy (ART). Although there is strong evidence from clinical trials that early initiation of ART leads to reduced morbidity and mortality, the impact of UTT on retention on ART in real-life programmatic settings in Africa is not yet known. METHODS: We conducted a retrospective cohort study in Zomba district, Malawi to compare ART outcomes of patients who initiated ART under 2016 UTT guidelines and those who started ART prior to rollout of UTT (pre-UTT)...
February 2019: Journal of the International AIDS Society
R Brad Jones
No abstract text is available yet for this article.
February 2019: Journal of the International AIDS Society
Jing Han, Jennifer Zh Bouey, Liming Wang, Guodong Mi, Zihuang Chen, Ying He, Tara Viviani, Fujie Zhang
INTRODUCTION: HIV incidence among men who have sex with men (MSM) is high in China. Pre-exposure prophylaxis (PrEP) is a promising mean to prevent HIV transmission but it is not widely available in China. We conducted a large Internet-based online survey to assess the willingness of Chinese MSM to take PrEP and associated factors to their uptake preferences. METHODS: Between 19 January and 6 February, 2017, 4581 MSM aged over 15 years were recruited via a social networking app to take an online PrEP survey...
February 2019: Journal of the International AIDS Society
Shona Horter, Alison Wringe, Zanele Thabede, Velibanti Dlamini, Bernhard Kerschberger, Munyaradzi Pasipamire, Nomthandazo Lukhele, Barbara Rusch, Janet Seeley
INTRODUCTION: Treat-all is being implemented in several African settings, in accordance with 2015 World Health Organisation guidelines. The factors known to undermine adherence to antiretroviral therapy (ART) may change in the context of Treat-all, where people living with HIV (PLHIV) increasingly initiate ART at earlier, asymptomatic stages of disease, soon after diagnosis. This paper aimed to examine the asymptomatic PLHIV's experiences engaging with early ART initiation under the Treat-all policy, including how they navigate treatment-taking over the longer term...
January 2019: Journal of the International AIDS Society
Jessica L Castilho, Maria M Escuder, Valdiléa Veloso, Jackeline O Gomes, Karu Jayathilake, Sayonara Ribeiro, Rosa A Souza, Maria L Ikeda, Paulo R de Alencastro, Unai Tupinanbas, Carlos Brites, Catherine C McGowan, Alexandre Grangeiro, Beatriz Grinsztejn
INTRODUCTION: People living with HIV (PLHIV) on antiretroviral therapy (ART) experience high rates of non-communicable diseases (NCDs). These co-morbidities often accumulate and older adults may suffer from multimorbidity. Multimorbidity has been associated with loss of quality of life, polypharmacy, and increased risk of frailty and mortality. Little is known of the trends or predictors NCD multimorbidity in PLHIV in low- and middle-income countries. METHODS: We examined NCD multimorbidity in adult PLHIV initiating ART between 2003 and 2014 using a multi-site, observational cohort in Brazil...
January 2019: Journal of the International AIDS Society
Win M Han, Awachana Jiamsakul, Sasisopin Kiertiburanakul, Oon T Ng, Benedict Lh Sim, Ly P Sun, Kinh Van Nguyen, Jun Y Choi, Man P Lee, Wing W Wong, Adeeba Kamarulzaman, Nagalingeswaran Kumarasamy, Fujie Zhang, Junko Tanuma, Cuong D Do, Romanee Chaiwarith, Tuti P Merati, Evy Yunihastuti, Sanjay Pujari, Rossana Ditangco, Suwimon Khusuwan, Jeremy Ross, Anchalee Avihingsanon
INTRODUCTION: Comorbidities including diabetes mellitus (DM) among people living with HIV (PLHIV) are of increasing clinical concerns in combination antiretroviral therapy (cART) era. We aimed to determine the incidence and risk factors of new-onset DM among PLHIV in Asian settings. METHODS: PLHIV from a regional observational cohort without DM prior to antiretroviral therapy (ART) initiation were included in the analysis. DM was defined as having a fasting blood glucose ≥126 mg/dL, glycated haemoglobin ≥6...
January 2019: Journal of the International AIDS Society
Jessie K Edwards, Peter Arimi, Freddie Ssengooba, Grace Mulholland, Milissa Markiewicz, Elizabeth A Bukusi, Judy T Orikiiriza, Arti Virkud, Sharon Weir
INTRODUCTION: HIV care and treatment in cross-border areas in East Africa face challenges perhaps not seen to the same extent in other geographic areas, particularly for mobile and migrant populations. Here, we estimate the proportion of people with HIV found in these cross-border areas in each stage of the HIV care and treatment cascade, including the proportion who knows their status, the proportion on treatment and the proportion virally suppressed. METHODS: Participants (n = 11,410) working or socializing in public places in selected East Africa cross border areas were recruited between June 2016 and February 2017 using the Priorities for Local AIDS Control Efforts method and administered a behavioural survey and rapid HIV test...
January 2019: Journal of the International AIDS Society
Jack J Olney, Jeffrey W Eaton, Paula Braitstein, Joseph W Hogan, Timothy B Hallett
No abstract text is available yet for this article.
January 2019: Journal of the International AIDS Society
Reuben Granich, Somya Gupta, Brian G Williams
No abstract text is available yet for this article.
January 2019: Journal of the International AIDS Society
Annalisa Mondi, Alessandro Cozzi-Lepri, Alessandro Tavelli, Stefano Rusconi, Francesca Vichi, Francesca Ceccherini-Silberstein, Andrea Calcagno, Andrea De Luca, Franco Maggiolo, Giulia Marchetti, Andrea Antinori, Antonella d'Arminio Monforte
INTRODUCTION: Concerns about dolutegravir (DTG) tolerability in the real-life setting have recently arisen. We aimed to estimate the risk of treatment discontinuation and virological failure of DTG-based regimens from a large cohort of HIV-infected individuals. METHODS: We performed a multicentre, observational study including all antiretroviral therapy (ART)-naïve and virologically suppressed treatment-experienced (TE) patients from the Icona (Italian Cohort Naïve Antiretrovirals) cohort who started, for the first time, a DTG-based regimen from January 2015 to December 2017...
January 2019: Journal of the International AIDS Society
Marcel Yotebieng, Ellen Brazier, Diane Addison, April D Kimmel, Morna Cornell, Olivia Keiser, Angela M Parcesepe, Amobi Onovo, Kathryn E Lancaster, Barbara Castelnuovo, Pamela M Murnane, Craig R Cohen, Rachel C Vreeman, Mary-Ann Davies, Stephany N Duda, Constantin T Yiannoutsos, Rose S Bono, Robert Agler, Charlotte Bernard, Jennifer L Syvertsen, Jean d'Amour Sinayobye, Radhika Wikramanayake, Annette H Sohn, Per M von Groote, Gilles Wandeler, Valeriane Leroy, Carolyn F Williams, Kara Wools-Kaloustian, Denis Nash
INTRODUCTION: "Treat All" - the treatment of all people with HIV, irrespective of disease stage or CD4 cell count - represents a paradigm shift in HIV care that has the potential to end AIDS as a public health threat. With accelerating implementation of Treat All in sub-Saharan Africa (SSA), there is a need for a focused agenda and research to identify and inform strategies for promoting timely uptake of HIV treatment, retention in care, and sustained viral suppression and addressing bottlenecks impeding implementation...
January 2019: Journal of the International AIDS Society
Edith Nakku-Joloba, Emily E Pisarski, Monique A Wyatt, Timothy R Muwonge, Stephen Asiimwe, Connie L Celum, Jared M Baeten, Elly T Katabira, Norma C Ware
INTRODUCTION: Pre-exposure prophylaxis (PrEP) to prevent HIV infection is being rolled out in Africa. The uptake of PrEP to date has varied across populations and locations. We seek to understand the drivers of demand for PrEP through analysis of qualitative data collected in conjunction with a PrEP demonstration project involving East African HIV serodiscordant couples. Our goal was to inform demand creation by understanding what PrEP means - beyond HIV prevention - for the lives of users...
January 2019: Journal of the International AIDS Society
Emily L Tuthill, Cecilia Tomori, Meredith Van Natta, Jenell S Coleman
INTRODUCTION: Currently, the United States (U.S.) recommends that infants born to women living with HIV (WLHIV) be fed formula, whereas many low-resource settings follow the World Health Organization's recommendation to exclusively breastfeed with ongoing antiretroviral therapy. Evidence on infant feeding among WLHIV in high-resource countries suggest that these contrasting recommendations create challenges for providers and patients. Our study used multiple methods to understand providers' infant feeding perspectives on caring for their pregnant and post-partum WLHIV in the U...
January 2019: Journal of the International AIDS Society
Véronique Avettand-Fenoel, Tatiana Bayan, Elise Gardiennet, Faroudy Boufassa, Pauline Lopez, Camille Lecuroux, Nicolas Noel, Pauline Trémeaux, Valérie Monceaux, Brigitte Autran, Laurence Meyer, Asier Saez-Cirion, Olivier Lambotte, Christine Rouzioux
INTRODUCTION: HIV controllers (HIC) maintain viraemia at low levels without antiretroviral treatment and have small HIV reservoirs. Nevertheless, they are heterogeneous regarding their risk of infection progression. The study of reservoirs can help elucidate this control. This study aimed to explore the factors implicated in the pathogenesis of HIV infection that are potentially associated with HIV reservoirs and their dynamics in HIC. METHODS: Individuals living with HIV included in the ANRS-CODEX cohort with at least two HIV-DNA measurements between 2009 and 2016 were selected...
January 2019: Journal of the International AIDS Society
In Young Jung, Dhanushi Rupasinghe, Ian Woolley, Catherine C O'Connor, Michelle Giles, Raja Isr Azwa, Jun Yong Choi
INTRODUCTION: AIDS-related deaths in people living with HIV/AIDS have been decreasing in number since the introduction of combination antiretroviral treatment (cART). However, data on recent causes of death in the Asia-Pacific region are limited. Hence, we analysed and compared AIDS-related and non-AIDS-related mortality in high- and low-income settings in the region. METHODS: Patients from the TREAT Asia HIV Observational Database (TAHOD) and Australian HIV Observational Database (AHOD) receiving cART between 1999 and 2017 were included...
January 2019: Journal of the International AIDS Society
Simukai Shamu, Thato Farirai, Locadiah Kuwanda, Jean Slabbert, Geoffrey Guloba, Suzanne Johnson, Sikhulile Khupakonke, Nomea Masihleho, Julius Kamera, Nkhensani Nkhwashu
INTRODUCTION: Although HIV testing services (HTS) have been successfully task-shifted to lay counsellors, no model has tested the franchising of HTS to lay counsellors as independent small-scale business owners. This paper evaluates the effectiveness of a social franchisee (SF) HTS-managed pilot project compared to the Foundation for Professional Development (FPD) employee-managed HTS programme in testing and linking clients to care. METHODS: Unemployed, formally employed or own business individuals were engaged as franchisees, trained and supported to deliver HTS services under a common brand in high HIV-prevalent communities in Tshwane district between 2016 and 2017...
December 2018: Journal of the International AIDS Society
Marcellin N Nouaman, Michael Vinikoor, Moussa Seydi, Didier K Ekouevi, Patrick A Coffie, Lloyd Mulenga, Aristophane Tanon, Matthias Egger, François Dabis, Antoine Jaquet, Gilles Wandeler
INTRODUCTION: Excessive alcohol consumption leads to unfavourable outcomes in people living with HIV (PLHIV), including reduced adherence to antiretroviral therapy (ART) and engagement into care. However, there is limited information on alcohol consumption patterns among PLHIV in sub-Saharan Africa. METHODS: Using a cross-sectional approach, the Alcohol Use Disorders Identification Test (AUDIT-C) was administered to PLHIV attending HIV clinics in Côte d'Ivoire, Togo, Senegal and Zambia (2013 to 2015)...
December 2018: Journal of the International AIDS Society
Chloe A Teasdale, Katharine Yuengling, Peter Preko, Maureen Syowai, Felix Ndagije, Miriam Rabkin, Elaine J Abrams, Wafaa M El-Sadr
INTRODUCTION: Despite increasing focus on test and treat strategies for people living with HIV (PLHIV), many continue to enrol late in care and initiate antiretroviral therapy (ART) when they have advanced HIV disease. METHODS: We analyzed PLHIV ≥15 years of age starting ART in Ethiopia, Kenya, Mozambique and Tanzania from 2005 to 2015 based on CD4+ groups at ART initiation (≥200, 100 to 199, 50 to 99 and <50 cells/mm3 ) to examine attrition (loss to follow-up (LTF) and death) using Kaplan-Meier estimators and Cox proportional hazards models...
December 2018: Journal of the International AIDS Society
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