William D Watson, John E Buonora, Angela M Yarnell, Jessica J Lucky, Michaela I D'Acchille, David C McMullen, Andrew G Boston, Andrew V Kuczmarski, William S Kean, Ajay Verma, Neil E Grunberg, Jeffrey T Cole
Traumatic brain injury (TBI) pathophysiology can be attributed to either the immediate, primary physical injury, or the delayed, secondary injury which begins minutes to hours after the initial injury and can persist for several months or longer. Because these secondary cascades are delayed and last for a significant time period post-TBI, they are primary research targets for new therapeutics. To investigate changes in mitochondrial function after a brain injury, both the cortical impact site and ipsilateral hippocampus of adult male rats 7 and 17 days after a controlled cortical impact (CCI) injury were examined...
2013: Frontiers in Neuroenergetics