Han Ke, Fan Bai, Zihan Li, Yanbing Zhu, Chunjia Zhang, Yan Li, Zuliyaer Talifu, Yunzhu Pan, Wubo Liu, Xin Xu, Feng Gao, Degang Yang, Liangjie Du, Yan Yu, Jianjun Li
INTRODUCTION: Spinal cord injury (SCI) is a severely disabling disease. Hyperactivation of neuroinflammation is one of the main pathophysiological features of secondary SCI, with phospholipid metabolism playing an important role in regulating inflammation. Phospholipase D (PLD), a critical lipid-signaling molecule, is known to be involved in various physiological processes, including the regulation of inflammation. Despite this knowledge, the specific role of PLD in SCI remains unclear...
2024: Frontiers in Cellular Neuroscience