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Advances in Urology

Michael Kennelly, Nikesh Thiruchelvam, Márcio Augusto Averbeck, Charalampos Konstatinidis, Emmanuel Chartier-Kastler, Pernille Trøjgaard, Rikke Vaabengaard, Andrei Krassioukov, Birte Petersen Jakobsen
A risk factor model for urinary tract infections in patients with adult neurogenic lower urinary tract dysfunction performing clean intermittent catheterisation was developed; it consists of four domains, namely, (1) general (systemic) conditions in the patient, (2) individual urinary tract conditions in the patient, (3) routine aspects related to the patient, and (4) factors related to intermittent catheters per se . The conceptual model primarily concerns patients with spinal cord injury, spina bifida, multiple sclerosis, or cauda equina where intermittent catheterisation is a normal part of the bladder management...
2019: Advances in Urology
Ghanendra Kumar Yadav, Mrinal Pahwa, Mahendra Singh, Vipin Tyagi, Sudhir Chadha
Testosterone deficiency syndrome (TDS) is a gradual age-related phenomenon that occurs in a large proportion of the aging male population. This current prospective study was done with the objective to estimate the prevalence of age-associated TDS in India and its clinical profile. A total of 800 male patients aged ≥40 year were approached to participate in the study. A brief history and focused examination was done. Based on our exclusion criteria, 55 patients were excluded. Androgen deficiency in aging male (ADAM) questionnaire was administered to all remaining 745 patients...
2019: Advances in Urology
Keri Rowley, Deepak Pruthi, Osamah Al-Bayati, Joseph Basler, Michael A Liss
Background: The aim of this study was to investigate the effectiveness of surgical simulators created using household items and to determine their potential role in surgical skills training. Methods: Ten urology residents attended a surgical skills workshop and practiced using surgical simulators and models. These included a wound closure model, an open prostatectomy model, a delicate tissue simulation, a knot-tying station, and a laparoscopic simulator. After the workshop, the residents completed a 5-point Likert questionnaire...
2019: Advances in Urology
Ivan M Petyaev, Naylia A Zigangirova, Elena Y Morgunova, Nigel H Kyle, Elena D Fedina, Yuriy K Bashmakov
In the present paper, we report that C. trachomatis can be efficiently propagated and affect mRNA expression for two major cytokines, relevant to tumor progression, in CWR-R1 cells, a malignant prostate cell line. CWR-R1 and McCoy cells, a classic cell line for chlamydial research, were grown and infected with C. trachomatis under similar conditions. Cell monolayers were harvested for RNA analysis and immunostaining with major outer membrane protein (MOMP) antibody at 24, 48, and 72 hours of the postinfection (hpi) period...
2019: Advances in Urology
Diomidis Kozyrakis, Dionyssios Paridis, Stefanos Perikleous, Konstantinos Malizos, Anastasios Zarkadas, Antonios Tsagkalis
Purpose: Prostate cancer (PCa) is one of the most frequently diagnosed malignancies worldwide. Hormonal deprivation therapy is a well-established treatment for locally advanced or metastatic diseases but exposes patients to the risk of osteoporosis and fragility fractures. Furthermore, the tropism of the PCa cells to osseous metastases increases the incidence of skeletal-related events (SREs). Methods: A nonsystematic review of the international literature was performed in respect to the use of osteoclast inhibitors zoledronic acid (ZA) and denosumab (DEN) in PCa patients...
2018: Advances in Urology
Kaan Kaltalioglu, Fatmanur Tugcu-Demiroz, Fusun Acarturk, Barbaros Balabanli, Sule Coskun-Cevher
Oxybutynin is an important anticholinergic agent that prevents uncontrolled contractions in the treatment of overactive bladder (OAB). However, drugs containing oxybutynin have significant side effects such as dry eyes, dry mouth, increased heart rate, constipation, blurred vision, and confusion. In recent years, new delivery methods for this agent are being searched. One of them is vaginal delivery. In this study, we aimed to compare the effects of oxybutynin on oxidative parameters in the potential target tissues of the oral and vaginal delivery...
2018: Advances in Urology
Clíodhna Browne, Catherine M Dowling, Patrick O'Malley, Nadeem Nusrat, Kilian Walsh, Syed Jaffry, Eamonn Rogers, Garrett C Durkan, Frank T D'Arcy
Background: A combined urology clinic staffed by four consultants and four non-consultant hospital doctors (NCHDs) was introduced in our institution in October 2015. This clinic is supported by a pre-clinic radiology meeting and a synchronous urology clinical nurse specialist (CNS) clinic with protected uroflow/trial of void slots. Herein, we report on the outcomes of this clinic in comparison with the standard format of urology outpatient review. Methods: We carried out a retrospective review of clinic attendances from May to July 2016...
2018: Advances in Urology
Ajaydeep S Sidhu, Eric Marten, Nikita Bodoukhin, George Wayne, Elizabeth Nagoda, Akshay Bhandari, Alan M Nieder
Surgical site infection rates remain a common postoperative problem that continues to affect patients undergoing urologic surgery. Our study seeks to evaluate the difference in surgical site infection rates in patients undergoing open radical cystectomy when comparing the Bookwalter vs. the Alexis wound retractors. After institutional review board approval, we performed a retrospective chart review from February 2010 through August 2017 of patients undergoing open radical cystectomy with urinary diversion for bladder cancer...
2018: Advances in Urology
Dwayne T S Chang, Robert Abouassaly, Nathan Lawrentschuk
Introduction: To compare (1) the quality of prostate cancer health information on the Internet, (2) the difference in quality between websites appearing earlier or later in the search, and (3) the sources of sponsorship for each of these websites. Materials and methods: The top 150 listed websites on the Google search engine for each of the 11 search terms related to prostate cancer were analysed. Quality was assessed on whether the website conforms to the principles of the Health On the Net Foundation...
2018: Advances in Urology
Walid Shahrour, Pankaj Joshi, Craig B Hunter, Vikram S Batra, Hazem Elmansy, Sandesh Surana, Sanjay Kulkarni
Introduction and Objective: The proper evaluation of urethral strictures is an essential part of the surgical planning in urethral reconstruction. The proper evaluation of the stricture can be challenging in certain situations, especially when the meatus is involved. We propose that the use of a small caliber ureteroscope (4.5 Fr and 6.5 Fr) can offer additional help and use for the surgical planning in urethroplasty. Methods: We prospectively collected data on 76 patients who underwent urethroplasties in Kulkarni Reconstructive Urology Center, Pune, India and Thunder Bay Regional Health Sciences Center, Thunder Bay, Canada...
2018: Advances in Urology
Felipe Monnerat Lott, Deborah Siqueira, Hermano Argolo, Bernardo Lindberg Nóbrega, Franz Santos Campos, Luciano Alves Favorito
Objective: To assess the learning curve in robot-assisted radical prostatectomy (RARP) performed by surgeons without previous experience in laparoscopic prostatectomy. Materials and Methods: We analyzed 119 patients submitted to RARP performed by two surgeons without previous experience in laparoscopic prostatectomy, with emphasis on the relevant outcomes such as continence, erectile function, and oncologic control with a minimum follow-up of 24 months. We used Fisher's exact test and the chi-square test to investigate the existence of a relationship between the variables and analysis of variance (ANOVA) to verify possible statistically significant differences between groups, at the 5% level...
2018: Advances in Urology
Shabir Ahmad Dar, Rajandeep Singh Bali, Yawar Zahoor, Arshad Rashid Kema, Rajni Bhardwaj
Background: Cryptorchidism or undescended testes is the most common disorder of the male endocrine glands in children. With the advancements in laparoscopic techniques and instruments, laparoscopic orchidopexy has become the standard procedure in the management of nonpalpable undescended testes. Aim: To evaluate and determine the therapeutic role, sensitivity, and specificity of laparoscopy in localizing nonpalpable testes and the mean operative time, the conversion rate (and reasons thereof), postoperative wound infection, postoperative stay, and time taken for return to daily activities following laparoscopic orchidopexy or orchidectomy...
2018: Advances in Urology
Mahmoudreza Moradi, Abolhassan Seyedzadeh, Saeed Gharakhloo, Aref Teymourinezhad, Kaveh Kaseb, Haress Rezaee
Introduction: Vesicoureteral reflux (VUR) is a common urologic anomaly in children. Many techniques have been offered to manage this condition, in which one of them is modified Gil-Vernet antireflux surgery. The study fullfiled to evaluate the efficacy and safety of modified Gil-Vernet antireflux surgery in correction of high-grade VUR. Materials and Methods: A retrospective study in which we evaluated efficacy, safety, and complications of modified Gil-Vernet antireflux surgery as a choice procedure for high-grade reflux in all patients who underwent it since 2000 to 2016 at 2 hospitals of Kermanshah University of medical sciences that all of them were done by one surgeon...
2018: Advances in Urology
Aditya Bagrodia, Costantine Albany, Timothy A Masterson
No abstract text is available yet for this article.
2018: Advances in Urology
Raúl Vozmediano-Chicharro, Blanca Madurga, Pedro Blasco
Objectives: Evaluation of changes in symptoms among patients with overactive bladder syndrome treated with transdermal oxybutynin and tolerability after 12 months of follow-up. Methods: This was a multicenter, retrospective, single-cohort, observational study. Changes in symptoms were evaluated primarily with a 3-day voiding diary. Results were compared to baseline. Subgroup analyses were performed in patients previously treated for OAB or not and aged < 65 years versus ≥65 years...
2018: Advances in Urology
Anthony Wanjala, Henry Mwangi, Hillary Mabeya
Background: Ureteric pathology arises from surgical misadventures, trauma, and congenital anomalies. Early detection and treatment is of the essence. Objectives: To determine the types/etiology and outcome of ureteric pathology presenting to Gynocare Fistula Centre, Eldoret, Kenya. Methods: Descriptive retrospective study that evaluated patients presenting with ureteric pathology at Gynocare between 1st January 2012 and 31st December 2016...
2018: Advances in Urology
Zeyad R Schwen, Mohit Gupta, Phillip M Pierorazio
Objectives: The robotic-assisted laparoscopic retroperitoneal lymph node dissection (R-RPLND) represents a new frontier in the surgical management of testicular cancer in the realm of minimally invasive urologic oncology. We aimed to review the early outcomes as compared to the laparoscopic and open approaches as well as describe the operative technique for the R-RPLND. Materials and Methods: We reviewed all the literature related to the R-RPLND based on an electronic PubMed search up until July 2017...
2018: Advances in Urology
Timothy A Masterson, Clint Cary
The surgical management of both early and advanced stage germ cell tumors of the testis remains a complex process of surgical decision making to maximize oncologic control while minimizing morbidity. Over the past 5 decades, the evolution of the surgical template for retroperitoneal lymphadenectomy (RPLND) has resulted in important modifications to achieve these goals. In this review, we will characterize the historical motivating factors that led to the modified template, outline patient and clinical factors in selecting these approaches in both early and advanced stage disease, and briefly discuss future horizons for their implementation...
2018: Advances in Urology
Robert A Huddart, Alison M Reid
Testicular germ cell tumours are the commonest tumours of young men and are broadly managed either as pure seminomas or as 'nonseminomas'. The management of Stage 1 nonseminomatous germ cell tumours (NSGCTs), beyond surgical removal of the primary tumour at orchidectomy, is somewhat controversial. Cancer-specific survival rates in these patients are in the order of 99% regardless of whether surveillance, retroperitoneal lymph node dissection, or adjuvant chemotherapy is employed. However, the toxicities of these treatment modalities differ...
2018: Advances in Urology
Elizabeth B Roth, John V Kryger, Charles T Durkee, Melissa A Lingongo, Ruth M Swedler, Travis W Groth
Purpose: To evaluate the impact of prophylactic antibiotics after distal hypospadias repair on postoperative bacteriuria, symptomatic urinary tract infection, and postoperative complications in a prospective, randomized trial. Materials and Methods: Consecutive patients aged 6 months to 2 years were enrolled at our institution between June 2013 and May 2017. Consenting patients were randomized to antibiotic prophylaxis with trimethoprim-sulfamethoxazole versus no antibiotic...
2018: Advances in Urology
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